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Volumn 14, Issue 5, 2012, Pages 387-394

Philadelphia-positive acute lymphoblastic leukemia: Current treatment options

Author keywords

ALL; Allogeneic stem cell transplant; Philadelphia chromosome; Tyrosine kinase inhibitors

Indexed keywords

BOSUTINIB; CYCLOPHOSPHAMIDE; DASATINIB; DEXAMETHASONE; DOXORUBICIN; IMATINIB; NILOTINIB; PONATINIB; PROTEIN TYROSINE KINASE INHIBITOR; REBASTINIB; VINCRISTINE;

EID: 84870549149     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-012-0247-7     Document Type: Article
Times cited : (81)

References (71)
  • 1
    • 0033153105 scopus 로고    scopus 로고
    • Prospective karyotype analysis in adult acute lymphoblastic leukemia: The cancer and leukemia Group B experience
    • Wetzler M, Dodge RK, Mrozek K, et al. Prospective karyotype analysis in adult acute lymphoblastic leukemia: The cancer and leukemia Group B experience. Blood. 1999;93:3983-93.
    • (1999) Blood. , vol.93 , pp. 3983-3993
    • Wetzler, M.1    Dodge, R.K.2    Mrozek, K.3
  • 2
    • 0141675132 scopus 로고    scopus 로고
    • The biology and therapy of adult acute lymphoblastic leukemia
    • Faderl S, Jeha S, Kantarjian HM. The biology and therapy of adult acute lymphoblastic leukemia. Cancer. 2003;98:1337-54.
    • (2003) Cancer. , vol.98 , pp. 1337-1354
    • Faderl, S.1    Jeha, S.2    Kantarjian, H.M.3
  • 3
    • 50949089832 scopus 로고    scopus 로고
    • Patients' age and BCR-ABL frequency in adult B-precursorALL: A retrospective analysis from the GMALL study group
    • Burmeister T, Schwartz S, Bartram CR, Gokbuget N, Hoelzer D, Thiel E. Patients' age and BCR-ABL frequency in adult B-precursorALL: A retrospective analysis from the GMALL study group. Blood. 2008;112:918-9.
    • (2008) Blood. , vol.112 , pp. 918-919
    • Burmeister, T.1    Schwartz, S.2    Bartram, C.R.3    Gokbuget, N.4    Hoelzer, D.5    Thiel, E.6
  • 4
    • 0015694748 scopus 로고
    • Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973;243:290-3.
    • (1973) Nature. , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 5
    • 0025854412 scopus 로고
    • Philadelphia positive acute lymphoblastic leukemia in adults: Age distribution BCR breakpoint and prognostic significance
    • Secker-Walker LM, Craig JM, Hawkins JM, Hoffbrand AV. Philadelphia positive acute lymphoblastic leukemia in adults: Age distribution, BCR breakpoint and prognostic significance. Leukemia. 1991;5:196-9.
    • (1991) Leukemia. , vol.5 , pp. 196-199
    • Secker-Walker, L.M.1    Craig, J.M.2    Hawkins, J.M.3    Hoffbrand, A.V.4
  • 6
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006;354:166-78.
    • (2006) N Engl J Med. , vol.354 , pp. 166-178
    • Pui, C.H.1    Evans, W.E.2
  • 7
    • 0036493694 scopus 로고    scopus 로고
    • Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: A prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis
    • Gleissner B, Gokbuget N, Bartram CR, et al. Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: A prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis. Blood. 2002;99:1536-43.
    • (2002) Blood. , vol.99 , pp. 1536-1543
    • Gleissner, B.1    Gokbuget, N.2    Bartram, C.R.3
  • 8
    • 33748909536 scopus 로고    scopus 로고
    • The changing scene of adult acute lymphoblastic leukemia
    • Vitale A, Guarini A, Chiaretti S, Foa R. The changing scene of adult acute lymphoblastic leukemia. Curr Opin Oncol. 2006;18:652-9.
    • (2006) Curr Opin Oncol. , vol.18 , pp. 652-659
    • Vitale, A.1    Guarini, A.2    Chiaretti, S.3    Foa, R.4
  • 9
    • 66549084080 scopus 로고    scopus 로고
    • Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: Results from the International ALL Trial MRC UKALLXII/ECOG2993
    • Fielding AK, Rowe JM, Richards SM, et al. Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: Results from the International ALL Trial MRC UKALLXII/ECOG2993. Blood. 2009;113:4489-96.
    • (2009) Blood. , vol.113 , pp. 4489-4496
    • Fielding, A.K.1    Rowe, J.M.2    Richards, S.M.3
  • 10
    • 0037105560 scopus 로고    scopus 로고
    • A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias
    • Ottmann OG, Druker BJ, Sawyers CL, et al. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood. 2002;100:1965-71.
    • (2002) Blood. , vol.100 , pp. 1965-1971
    • Ottmann, O.G.1    Druker, B.J.2    Sawyers, C.L.3
  • 11
    • 33745603988 scopus 로고    scopus 로고
    • Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
    • Hughes T, Deininger M, Hochhaus A, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood. 2006;108:28-37.
    • (2006) Blood. , vol.108 , pp. 28-37
    • Hughes, T.1    Deininger, M.2    Hochhaus, A.3
  • 12
    • 34547221085 scopus 로고    scopus 로고
    • Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL
    • Pfeifer H, Wassmann B, Pavlova A, et al. Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Blood. 2007;110:727-34.
    • (2007) Blood. , vol.110 , pp. 727-734
    • Pfeifer, H.1    Wassmann, B.2    Pavlova, A.3
  • 13
    • 2442465000 scopus 로고    scopus 로고
    • Requirement of src kinases lyn hck and fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
    • Hu Y, Liu Y, Pelletier S, et al. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet. 2004;36:453-61.
    • (2004) Nat Genet. , vol.36 , pp. 453-461
    • Hu, Y.1    Liu, Y.2    Pelletier, S.3
  • 14
    • 33750937577 scopus 로고    scopus 로고
    • Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
    • Hu Y, Swerdlow S, Duffy TM, Weinmann R, Lee FY, Li S. Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci U S A. 2006;103:16870-5.
    • (2006) Proc Natl Acad Sci U S A. , vol.103 , pp. 16870-1685
    • Hu, Y.1    Swerdlow, S.2    Duffy, T.M.3    Weinmann, R.4    Lee, F.Y.5    Li, S.6
  • 15
    • 19944428353 scopus 로고    scopus 로고
    • Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
    • Lombardo LJ, Lee FY, Chen P, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004;47:6658-61.
    • (2004) J Med Chem. , vol.47 , pp. 6658-6661
    • Lombardo, L.J.1    Lee, F.Y.2    Chen, P.3
  • 16
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • O'Hare T, Walters DK, Stoffregen EP, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res. 2005;65:4500-5.
    • (2005) Cancer Res. , vol.65 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3
  • 17
    • 52449100460 scopus 로고    scopus 로고
    • Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: Therapeutic implications
    • Hiwase DK, Saunders V, Hewett D, et al. Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: Therapeutic implications. Clin Cancer Res. 2008;14:3881-8.
    • (2008) Clin Cancer Res. , vol.14 , pp. 3881-3888
    • Hiwase, D.K.1    Saunders, V.2    Hewett, D.3
  • 18
    • 38549130207 scopus 로고    scopus 로고
    • Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia
    • Li S. Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia. Leuk Lymphoma. 2008;49:19-26.
    • (2008) Leuk Lymphoma. , vol.49 , pp. 19-26
    • Li, S.1
  • 19
    • 78149348878 scopus 로고    scopus 로고
    • How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Fielding AK. How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 2010;116:3409-17.
    • (2010) Blood. , vol.116 , pp. 3409-3417
    • Fielding, A.K.1
  • 20
    • 84870574192 scopus 로고    scopus 로고
    • SPRYCEL® (dasatinib) [package Insert]
    • SPRYCEL® (dasatinib) [package insert].
  • 21
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinibresistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinibresistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006;354:2531-41.
    • (2006) N Engl J Med. , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 22
    • 34948829146 scopus 로고    scopus 로고
    • Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a phase 2 study
    • Ottmann O, Dombret H, Martinelli G, et al. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a phase 2 study. Blood. 2007;110:2309-15.
    • (2007) Blood. , vol.110 , pp. 2309-2315
    • Ottmann, O.1    Dombret, H.2    Martinelli, G.3
  • 23
    • 65749098290 scopus 로고    scopus 로고
    • Dasatinib efficacy in patients with imatinib-resistant-intolerant philadelphiachromosome-positive acute lymphoblastic leukemia: 24-month Data From START-L
    • (EHA 2008 abstract
    • Porkka K, Martinelli G, Ottmann OG, et al. Dasatinib efficacy in patients with imatinib-resistant/-intolerant Philadelphiachromosome-positive acute lymphoblastic leukemia: 24-month data from START-L. Haematologica. 2008;93 Suppl 1:1(EHA 2008 abstract).
    • (2008) Haematologica. , vol.93 , Issue.SUPPL. 1 , pp. 1
    • Porkka, K.1    Martinelli, G.2    Ottmann, O.G.3
  • 24
    • 77249091826 scopus 로고    scopus 로고
    • Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph-positive acute lymphoblastic leukemia who failed imatinib: Results from a phase 3 study
    • Lilly MB, Ottmann OG, Shah NP, et al. Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph-positive acute lymphoblastic leukemia who failed imatinib: Results from a phase 3 study. Am J Hematol. 2010;85:164-70.
    • (2010) Am J Hematol. , vol.85 , pp. 164-170
    • Lilly, M.B.1    Ottmann, O.G.2    Shah, N.P.3
  • 25
    • 77950437520 scopus 로고    scopus 로고
    • Combination of the hypercvad regimen with Dasatinib is effective in patients with relapsed Philadelphia chromosome (Ph) positive acute lymphoblastic leukemia (ALL) and lymphoid blast phase chronic myeloid leukemia (CML-LB
    • Ravandi F, Kantarjian HM, Cortes J, et al. Combination of the hypercvad regimen with Dasatinib is effective in patients with relapsed Philadelphia chromosome (Ph) positive acute lymphoblastic leukemia (ALL) and lymphoid blast phase chronic myeloid leukemia (CML-LB). Blood. 2009;114:806-7.
    • (2009) Blood. , vol.114 , pp. 806-807
    • Ravandi, F.1    Kantarjian, H.M.2    Cortes, J.3
  • 26
    • 84870542328 scopus 로고    scopus 로고
    • Combination of the hypercvad regimen with dasatinib in patients with relapsed Philadelphia chromosome (Ph) positive acute lymphoblastic leukemia (ALL) or lymphoid blast phase of chronic myeloid leukemia (CML-LB). ASH Annual Meeting Abstracts
    • Liu-Dumlao T, O'Brien S, Cortes JE, et al. Combination of the hypercvad regimen with dasatinib in patients with relapsed Philadelphia chromosome (Ph) positive acute lymphoblastic leukemia (ALL) or lymphoid blast phase of chronic myeloid leukemia (CML-LB). ASH Annual Meeting Abstracts. Blood. 2011;118:2578.
    • (2011) Blood , vol.118 , pp. 2578
    • Liu-Dumlao, T.1    O'Brien, S.2    Cortes, J.E.3
  • 27
    • 82155175738 scopus 로고    scopus 로고
    • Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Foa R, Vitale A, Vignetti M, et al. Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 2011;118:6521-8.
    • (2011) Blood. , vol.118 , pp. 6521-6528
    • Foa, R.1    Vitale, A.2    Vignetti, M.3
  • 28
    • 77957191745 scopus 로고    scopus 로고
    • First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia
    • Ravandi F, O'Brien S, Thomas D, et al. First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia. Blood. 2010;116:2070-7.
    • (2010) Blood. , vol.116 , pp. 2070-2077
    • Ravandi, F.1    O'Brien, S.2    Thomas, D.3
  • 29
    • 84870559567 scopus 로고    scopus 로고
    • Long-term follow-up of combined hypercvad (hCVAD) regimen with dasatinib (Db) in the front line therapy of patients (pts) with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). ASH Annual Meeting Abstracts
    • Lee HJ, Kantarjian HM, Thomas DA, et al. Long-term follow-up of combined hypercvad (hCVAD) regimen with dasatinib (Db) in the front line therapy of patients (pts) with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). ASH Annual Meeting Abstracts. Blood. 2011;118:1512.
    • (2011) Blood , vol.118 , pp. 1512
    • Lee, H.J.1    Kantarjian, H.M.2    Thomas, D.A.3
  • 30
    • 79951846176 scopus 로고    scopus 로고
    • Dasatinib (sprycel) and chemotherapy for first-line treatment in elderly patients with de novo philadelphia positive all (EWALL-Ph-01): Analysis of response and resistance
    • (EHA 2009 abstract
    • Rousselot P, Cayuela JM, Hayette S, et al. Dasatinib (sprycel) and chemotherapy for first-line treatment in elderly patients with de novo Philadelphia positive ALL (EWALL-Ph-01): Analysis of response and resistance. Haematologica. 2009;94 Suppl 2:195(EHA 2009 abstract).
    • (2009) Haematologica. , vol.94 , Issue.SUPPL. 2 , pp. 195
    • Rousselot, P.1    Cayuela, J.M.2    Hayette, S.3
  • 31
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinibresistant CML and Philadelphia chromosome-positive ALL
    • TASIGNA® (nilotinib) [package Insert]
    • Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinibresistant CML and Philadelphia chromosome-positive ALL. N Engl J Med. 2006;354:2542-51. TASIGNA® (nilotinib) [package Insert].
    • (2006) N Engl J Med. , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 32
    • 84870954362 scopus 로고    scopus 로고
    • Nilotinib combined with multiagent chemotherapy for adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia: Interim results of korean adult all working party phase 2 study. ASH annual meeting abstracts
    • Kim D-Y, Joo YD, Lee J-H, et al. Nilotinib combined with multiagent chemotherapy for adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia: Interim results of Korean Adult ALL Working Party Phase 2 Study. ASH Annual Meeting Abstracts. Blood. 2011;118:1517.
    • (2011) Blood , vol.118 , pp. 1517
    • Kim, D.-Y.1    Joo, Y.D.2    Lee, J.-H.3
  • 33
    • 84860785167 scopus 로고    scopus 로고
    • Nilotinib is effective in imatinib-resistant or-intolerant patients with chronic myeloid leukemia in blastic phase
    • Giles FJ, Kantarjian HM, le Coutre PD, et al. Nilotinib is effective in imatinib-resistant or-intolerant patients with chronic myeloid leukemia in blastic phase. Leukemia. 2011;26:959-62.
    • (2011) Leukemia. , vol.26 , pp. 959-962
    • Giles, F.J.1    Kantarjian, H.M.2    Le Coutre, P.D.3
  • 34
    • 84856693419 scopus 로고    scopus 로고
    • Clinical activity of bosutinib by mutational status in patients with previously treated Philadelphia chromosome-positive leukemias. ASH annual meeting abstracts
    • Gambacorti-Passerini C, Khoury HJ, Pinczowski H, et al. Clinical activity of bosutinib by mutational status in patients with previously treated Philadelphia chromosome-positive leukemias. ASH Annual Meeting Abstracts. Blood. 2010;116:3434.
    • (2010) Blood , vol.116 , pp. 3434
    • Gambacorti-Passerini, C.1    Khoury, H.J.2    Pinczowski, H.3
  • 35
    • 84860841611 scopus 로고    scopus 로고
    • Initial findings fromthe PACE trial: A pivotal phase 2 study of ponatinib in patients with CML and Ph+ ALL resistant or intolerant to dasatinib or nilotinib, or with the T315I mutation. ASH annual meeting abstracts
    • Cortes JE,KimD-W, Pinilla-Ibarz J, et al. Initial findings fromthe PACE trial: A pivotal phase 2 study of ponatinib in patients with CML and Ph+ ALL resistant or intolerant to dasatinib or nilotinib, or with the T315I mutation. ASH Annual Meeting Abstracts. Blood. 2011;118:109.
    • (2011) Blood. , vol.118 , pp. 109
    • Cortes, J.E.1    Kim, D.-W.2    Pinilla-Ibarz, J.3
  • 36
    • 84864335408 scopus 로고    scopus 로고
    • A Phase 1 study of DCC-2036, a novel oral inhibitor of BCR-ABL kinase, in patients with Philadelphia chromosome positive (Ph+) leukemias including patients with T315I mutation. ASH Annual Meeting Abstracts
    • Cortes JE, Talpaz M, Kantarjian HM, et al. A Phase 1 Study of DCC-2036, a novel oral inhibitor of BCR-ABL kinase, in patients with Philadelphia chromosome positive (Ph+) leukemias including patients with T315I mutation. ASH Annual Meeting Abstracts. Blood. 2011;118:601.
    • (2011) Blood. , vol.118 , pp. 601
    • Cortes, J.E.1    Talpaz, M.2    Kantarjian, H.M.3
  • 37
    • 41349100708 scopus 로고    scopus 로고
    • In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: Final results of the International ALL Trial (MRC UKALL XII/ECOG E2993
    • Goldstone AH, Richards SM, Lazarus HM, et al. In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: Final results of the International ALL Trial (MRC UKALL XII/ECOG E2993). Blood. 2008;111:1827-33.
    • (2008) Blood. , vol.111 , pp. 1827-1833
    • Goldstone, A.H.1    Richards, S.M.2    Lazarus, H.M.3
  • 38
    • 0036936830 scopus 로고    scopus 로고
    • Nonmyeloablative stem cell transplantation in adults with high-risk ALL may be effective in early but not in advanced disease
    • Arnold R, Massenkeil G, Bornhauser M, et al. Nonmyeloablative stem cell transplantation in adults with high-risk ALL may be effective in early but not in advanced disease. Leukemia. 2002;16:2423-8.
    • (2002) Leukemia. , vol.16 , pp. 2423-2428
    • Arnold, R.1    Massenkeil, G.2    Bornhauser, M.3
  • 39
    • 0037512358 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in acute lymphoblastic leukemia: A feasibility study
    • Martino R, Giralt S, Caballero M, et al. Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in acute lymphoblastic leukemia: A feasibility study. Haematologica. 2003;88:555-60.
    • (2003) Haematologica. , vol.88 , pp. 555-560
    • Martino, R.1    Giralt, S.2    Caballero, M.3
  • 40
    • 40949131465 scopus 로고    scopus 로고
    • Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: A retrospective study from the European group for blood and marrow transplantation
    • Mohty M, Labopin M, Tabrizzi R, et al. Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: A retrospective study from the European Group for Blood and Marrow Transplantation. Haematologica. 2008;93:303-6.
    • (2008) Haematologica. , vol.93 , pp. 303-306
    • Mohty, M.1    Labopin, M.2    Tabrizzi, R.3
  • 41
    • 70350656355 scopus 로고    scopus 로고
    • Reduced-intensity conditioning followed by peripheral blood stem cell transplantation for adult patients with high-risk acute lymphoblastic leukemia
    • Stein AS, Palmer JM, O'Donnell MR, et al. Reduced-intensity conditioning followed by peripheral blood stem cell transplantation for adult patients with high-risk acute lymphoblastic leukemia. Biol Blood Marrow Transplant. 2009;15:1407-14.
    • (2009) Biol Blood Marrow Transplant. , vol.15 , pp. 1407-1414
    • Stein, A.S.1    Palmer, J.M.2    O'Donnell, M.R.3
  • 42
    • 58249104311 scopus 로고    scopus 로고
    • Prior treatment with the tyrosine kinase inhibitors dasatinib and nilotinib allows stem cell transplantation (SCT) in a less advanced disease phase and does not increase SCT Toxicity in patients with chronic myelogenous leukemia and philadelphia positive acute lymphoblastic leukemia
    • Shimoni A, Leiba M, Schleuning M, et al. Prior treatment with the tyrosine kinase inhibitors dasatinib and nilotinib allows stem cell transplantation (SCT) in a less advanced disease phase and does not increase SCT Toxicity in patients with chronic myelogenous leukemia and philadelphia positive acute lymphoblastic leukemia. Leukemia. 2009;23:190-4.
    • (2009) Leukemia. , vol.23 , pp. 190-194
    • Shimoni, A.1    Leiba, M.2    Schleuning, M.3
  • 43
    • 70449711127 scopus 로고    scopus 로고
    • Improved early event-free survival with imatinib in philadelphia chromosome-Positive acute lymphoblastic leukemia: A children's oncology group study
    • Schultz KR, Bowman WP, Aledo A, et al. Improved Early Event-Free Survival With Imatinib in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Children's Oncology Group Study. J Clin Oncol. 2009;27:5175-81.
    • (2009) J Clin Oncol. , vol.27 , pp. 5175-5181
    • Schultz, K.R.1    Bowman, W.P.2    Aledo, A.3
  • 44
    • 33947587233 scopus 로고    scopus 로고
    • Prophylactic administration of imatinib after hematopoietic cell transplantation for high-risk Philadelphia chromosome-positive leukemia
    • Carpenter PA, Snyder DS, Flowers ME, et al. Prophylactic administration of imatinib after hematopoietic cell transplantation for high-risk Philadelphia chromosome-positive leukemia. Blood. 2007;109:2791-3.
    • (2007) Blood. , vol.109 , pp. 2791-2793
    • Carpenter, P.A.1    Snyder, D.S.2    Flowers, M.E.3
  • 45
    • 84866314168 scopus 로고    scopus 로고
    • Updated long-term results of a randomized comparison of prophylactic and preemptive imatinib following allogeneic stem cell transplantation for Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL). ASH annual meeting abstracts
    • Pfeifer H, Wassmann B, Bethge WA, et al. Updated long-term results of a randomized comparison of prophylactic and preemptive imatinib following allogeneic stem cell transplantation for Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL). ASH Annual Meeting Abstracts. Blood. 2011;118:247.
    • (2011) Blood , vol.118 , pp. 247
    • Pfeifer, H.1    Wassmann, B.2    Bethge, W.A.3
  • 46
    • 84870490642 scopus 로고    scopus 로고
    • Detection of minimal residual leukemia predicts the outcome of patients with Philadelphia-chromosome positive acute lymphoblastic leukemia treated with tyrosine kinase inhibitors plus chemotherapy. ASH Annual Meeting Abstracts
    • Ravandi F, Thomas DA, O'Brien S, et al. Detection of minimal residual leukemia predicts the outcome of patients with Philadelphia-chromosome positive acute lymphoblastic leukemia treated with tyrosine kinase inhibitors plus chemotherapy. ASH Annual Meeting Abstracts. Blood. 2011;118:1453.
    • (2011) Blood , vol.118 , pp. 1453
    • Ravandi, F.1    Thomas, D.A.2    O'Brien, S.3
  • 47
    • 84870537518 scopus 로고    scopus 로고
    • Pre-transplant minimal residual disease detected by multiparameter flow cytometric analysis predicts for disease relapse in adult patients with acute lymphoblastic leukemia post allogeneic hematopoietic stem cell transplantation. ASH annual meeting abstracts
    • Zhou Y, Jorgensen JL, Saliba RM, et al. Pre-transplant minimal residual disease detected by multiparameter flow cytometric analysis predicts for disease relapse in adult patients with acute lymphoblastic leukemia post allogeneic hematopoietic stem cell transplantation. ASH Annual Meeting Abstracts. Blood. 2011;118:3072.
    • (2011) Blood , vol.118 , pp. 3072
    • Zhou, Y.1    Jorgensen, J.L.2    Saliba, R.M.3
  • 48
    • 84870478211 scopus 로고    scopus 로고
    • International standardization of minimal residual disease assessment for in Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) expressing m-BCR-ABL transcripts: Updated results of quality control procedures by the EWALL and ESG-MRD-ALL consortia. ASH annual meeting abstracts
    • Pfeifer H, Cazzaniga G, Spinelli O, et al. International standardization of minimal residual disease assessment for in Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) expressing m-BCR-ABL transcripts: Updated results of quality control procedures by the EWALL and ESG-MRD-ALL consortia. ASH Annual Meeting Abstracts. Blood. 2011;118:2535.
    • (2011) Blood , vol.118 , pp. 2535
    • Pfeifer, H.1    Cazzaniga, G.2    Spinelli, O.3
  • 49
    • 70349754444 scopus 로고    scopus 로고
    • Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Ravandi F, Kebriaei P. Philadelphia chromosome-positive acute lymphoblastic leukemia. Hematol Oncol Clin North Am. 2009;23:1043-63.
    • (2009) Hematol Oncol Clin North Am. , vol.23 , pp. 1043-1063
    • Ravandi, F.1    Kebriaei, P.2
  • 50
    • 0022653272 scopus 로고
    • Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia
    • Bloomfield CD, Goldman AI, Alimena G, et al. Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia. Blood. 1986;67:415-20.
    • (1986) Blood. , vol.67 , pp. 415-420
    • Bloomfield, C.D.1    Goldman, A.I.2    Alimena, G.3
  • 51
    • 0026535624 scopus 로고
    • Clinical and prognostic significance of the Philadelphia chromosome in adult patients with acute lymphoblastic leukemia
    • Gotz G, Weh HJ, Walter TA, et al. Clinical and prognostic significance of the Philadelphia chromosome in adult patients with acute lymphoblastic leukemia. Ann Hematol. 1992;64:97-100.
    • (1992) Ann Hematol. , vol.64 , pp. 97-100
    • Gotz, G.1    Weh, H.J.2    Walter, T.A.3
  • 52
    • 0028938844 scopus 로고
    • A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and leukemia group B study 8811
    • Larson RA, Dodge RK, Burns CP, et al. A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and leukemia group B study 8811. Blood. 1995;85:2025-37.
    • (1995) Blood. , vol.85 , pp. 2025-2037
    • Larson, R.A.1    Dodge, R.K.2    Burns, C.P.3
  • 53
    • 0029867127 scopus 로고    scopus 로고
    • Cytogenetic abnormalities in adult acute lymphoblastic leukemia: Correlations with hematologic findings outcome. A Collaborative Study of the Group Francais de Cytogenetique Hematologique
    • Cytogenetic abnormalities in adult acute lymphoblastic leukemia: Correlations with hematologic findings outcome. A Collaborative Study of the Group Francais de Cytogenetique Hematologique. Blood. 1996;87:3135-42.
    • (1996) Blood. , vol.87 , pp. 3135-3142
  • 54
    • 0031034526 scopus 로고    scopus 로고
    • Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA. MRC adult leukaemia working party
    • Secker-Walker LM, Prentice HG, Durrant J, Richards S, Hall E, Harrison G. Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA. MRC Adult Leukaemia Working Party. Br J Haematol. 1997;96:601-10.
    • (1997) Br J Haematol. , vol.96 , pp. 601-610
    • Secker-Walker, L.M.1    Prentice, H.G.2    Durrant, J.3    Richards, S.4    Hall, E.5    Harrison, G.6
  • 55
    • 0033954540 scopus 로고    scopus 로고
    • Outcome of Philadelphia chromosome-positive adult acute lymphoblastic leukemia
    • Faderl S, Kantarjian HM, Thomas DA, et al. Outcome of Philadelphia chromosome-positive adult acute lymphoblastic leukemia. Leuk Lymphoma. 2000;36:263-73.
    • (2000) Leuk Lymphoma. , vol.36 , pp. 263-273
    • Faderl, S.1    Kantarjian, H.M.2    Thomas, D.A.3
  • 56
    • 0036786909 scopus 로고    scopus 로고
    • Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia-results of the prospective multicenter LALA-94 trial
    • Dombret H, Gabert J, Boiron JM, et al. Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia-results of the prospective multicenter LALA-94 trial. Blood. 2002;100:2357-66.
    • (2002) Blood. , vol.100 , pp. 2357-266
    • Dombret, H.1    Gabert, J.2    Boiron, J.M.3
  • 57
    • 0034611661 scopus 로고    scopus 로고
    • Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Arico M, Valsecchi MG, Camitta B, et al. Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia. N Engl J Med. 2000;342:998-1006.
    • (2000) N Engl J Med. , vol.342 , pp. 998-1006
    • Arico, M.1    Valsecchi, M.G.2    Camitta, B.3
  • 58
    • 0032532289 scopus 로고    scopus 로고
    • Philadelphia chromosomepositive (Ph+) childhood acute lymphoblastic leukemia: Good initial steroid response allows early prediction of a favorable treatment outcome
    • Schrappe M, Arico M, Harbott J, et al. Philadelphia chromosomepositive (Ph+) childhood acute lymphoblastic leukemia: Good initial steroid response allows early prediction of a favorable treatment outcome. Blood. 1998;92:2730-41.
    • (1998) Blood. , vol.92 , pp. 2730-2741
    • Schrappe, M.1    Arico, M.2    Harbott, J.3
  • 59
    • 33747598699 scopus 로고    scopus 로고
    • Imatinib and methylprednisolone alternated with chemotherapy improve the outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia: Results of the GRAALL AFR09 study
    • Delannoy A, Delabesse E, Lheritier V, et al. Imatinib and methylprednisolone alternated with chemotherapy improve the outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia: Results of the GRAALL AFR09 study. Leukemia. 2006;20:1526-32.
    • (2006) Leukemia. , vol.20 , pp. 1526-1532
    • Delannoy, A.1    Delabesse, E.2    Lheritier, V.3
  • 60
    • 84870530277 scopus 로고    scopus 로고
    • The Long-term Outcome Of Elderly Patients With Philadelphia-positive Acute Lymphoblastic Leukemia (Ph+ ALL) In The Imatinib Era
    • (EHA 2009 abstract
    • Delannoy A, Delabesse E, Lheritier V, et al. The long-term outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) in the imatinib era. Haematologica. 2009;Suppl 2:30(EHA 2009 abstract).
    • (2009) Haematologica. , Issue.SUPPL. 2 , pp. 30
    • Delannoy, A.1    Delabesse, E.2    Lheritier, V.3
  • 61
    • 33644845774 scopus 로고    scopus 로고
    • High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: A phase II study by the japan adult leukemia study group
    • Yanada M, Takeuchi J, Sugiura I, et al. High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: A phase II study by the Japan Adult Leukemia Study Group. J Clin Oncol. 2006;24:460-6.
    • (2006) J Clin Oncol. , vol.24 , pp. 460-466
    • Yanada, M.1    Takeuchi, J.2    Sugiura, I.3
  • 62
    • 33846916856 scopus 로고    scopus 로고
    • Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: Results of the GRAAPH-2003 study
    • de Labarthe A, Rousselot P, Huguet-Rigal F, et al. Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: Results of the GRAAPH-2003 study. Blood. 2007;109:1408-13.
    • (2007) Blood. , vol.109 , pp. 1408-1413
    • De Labarthe, A.1    Rousselot, P.2    Huguet-Rigal, F.3
  • 63
    • 73949115771 scopus 로고    scopus 로고
    • Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Final results of the CSTIBES02 trial
    • Ribera JM, Oriol A, Gonzalez M, et al. Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Final results of the CSTIBES02 trial. Haematologica. 2010;95:87-95.
    • (2010) Haematologica. , vol.95 , pp. 87-95
    • Ribera, J.M.1    Oriol, A.2    Gonzalez, M.3
  • 64
    • 77955884680 scopus 로고    scopus 로고
    • Chemotherapy-phased imatinib pulses improve long-term outcome of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: Northern Italy Leukemia Group protocol 09/00
    • Bassan R, Rossi G, Pogliani EM, et al. Chemotherapy-phased imatinib pulses improve long-term outcome of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: Northern Italy Leukemia Group protocol 09/00. J Clin Oncol. 2010;28:3644-52.
    • (2010) J Clin Oncol. , vol.28 , pp. 3644-3652
    • Bassan, R.1    Rossi, G.2    Pogliani, E.M.3
  • 65
    • 33747045631 scopus 로고    scopus 로고
    • Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL
    • Wassmann B, Pfeifer H, Goekbuget N, et al. Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Blood. 2006;108:1469-77.
    • (2006) Blood. , vol.108 , pp. 1469-1477
    • Wassmann, B.1    Pfeifer, H.2    Goekbuget, N.3
  • 66
    • 79959618610 scopus 로고    scopus 로고
    • Long-term outcome of 335 adult patients receiving different schedules of imatinib and chemotherapy as front-line treatment for Philadelphia-positive acutelymphoblastic leukemia (Ph+ ALL). ASH Annual Meeting Abstracts
    • Pfeifer H, Goekbuget N, Volp C, et al. Long-term outcome of 335 adult patients receiving different schedules of imatinib and chemotherapy as front-line treatment for Philadelphia-positive acutelymphoblastic leukemia (Ph+ ALL). ASH Annual Meeting Abstracts. Blood. 2010;116:173.
    • (2010) Blood , vol.116 , pp. 173
    • Pfeifer, H.1    Goekbuget, N.2    Volp, C.3
  • 67
    • 78650637382 scopus 로고    scopus 로고
    • Imatinib significantly enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukaemia: Final results of the UKALLXII/ECOG2993 trial. ASH Annual Meeting Abstracts
    • Fielding AK, Buck G, Lazarus HM, et al. Imatinib significantly enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukaemia: Final results of the UKALLXII/ECOG2993 trial. ASH Annual Meeting Abstracts. Blood. 2010;116:169.
    • (2010) Blood , vol.116 , pp. 169
    • Fielding, A.K.1    Buck, G.2    Lazarus, H.M.3
  • 68
    • 2942567555 scopus 로고    scopus 로고
    • Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate
    • Thomas DA, Faderl S, Cortes J, et al. Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate. Blood. 2004;103:4396-407.
    • (2004) Blood , vol.103 , pp. 4396-4407
    • Thomas, D.A.1    Faderl, S.2    Cortes, J.3
  • 69
    • 79952548075 scopus 로고    scopus 로고
    • Long-term outcome after hyper-CVAD and imatinib (IM) for de novo or minimally treated Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL
    • (ASCO 2010 abstract #6506
    • Thomas DA, O'Brien SM, Faderl S, et al. Long-term outcome after hyper-CVAD and imatinib (IM) for de novo or minimally treated Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL). J Clin Oncol. 2010;28 Suppl 15:488s(ASCO 2010 abstract #6506).
    • (2010) J Clin Oncol. , vol.28 , Issue.SUPPL. 15
    • Thomas, D.A.1    O'Brien, S.M.2    Faderl, S.3
  • 70
    • 70349648230 scopus 로고    scopus 로고
    • Line treatment of adult Ph+ acute lymphoblastic leukemia (ALL) Patients. Final results of the GIMEMA LAL1205 Study. ASH annual meeting abstracts
    • Foa R, Vitale A, Guarini A, et al. Line Treatment of Adult Ph+ Acute Lymphoblastic Leukemia (ALL) Patients. Final results of the GIMEMA LAL1205 Study. ASH Annual Meeting Abstracts. Blood. 2008;112:305.
    • (2008) Blood , vol.112 , pp. 305
    • Foa, R.1    Vitale, A.2    Guarini, A.3
  • 71
    • 84870483518 scopus 로고    scopus 로고
    • First-line dasatinib plus conventional chemotherapy in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL): Interim analysis of the Korean Prospective Phase II Study
    • Lee S, Kim D-W, Kim Y-J, et al. First-line dasatinib plus conventional chemotherapy in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL): Interim analysis of the Korean Prospective Phase II Study. ASH Annual Meeting Abstracts. 2011;118:1516.
    • (2011) ASH Annual Meeting Abstracts. , vol.118 , pp. 1516
    • Lee, S.1    Kim, D.-W.2    Kim, Y.-J.3


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