Electrophysiological properties of prion-positive cardiac progenitors derived from murine embryonic stem cells

Circulation Journal

Volumn 76, Issue 12, 2012, Pages 2875-2883

  Fujii, Hiroshi ^a   Ikeuchi, Yu ^a   Kurata, Yasutaka ^e   Ikeda, Nobuhito ^a   Bahrudin, Udin ^a,h   Li, Peili ^a   Nakayama, Yuji ^b   Endo, Ryo ^a   Hasegawa, Akira ^a   Morikawa, Kumi ^a   Miake, Junichiro ^c   Yoshida, Akio ^a   Hidaka, Kyoko ^f   Morisaki, Takayuki ^g   Ninomiya, Haruaki ^a,d   Shirayoshi, Yasuaki ^a   Yamamoto, Kazuhiro ^c   Hisatome, Ichiro ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c TOTTORI UNIVERSITY HOSPITAL   (Japan)

^d TOTTORI UNIVERSITY   (Japan)

^e KANAZAWA MEDICAL UNIVERSITY   (Japan)

^f UNIVERSITY OF KITAKYUSHU   (Japan)

^g NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^h DIPONEGORO UNIVERSITY   (Indonesia)

Author keywords

Automaticity; HCN4; Murine embryonic stem cell; Nkx2.5; Prion protein

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY) PHENYL] ETHYL] ISOTHIOUREA METHANESULFONATE; CALCIUM CHANNEL L TYPE; CARBACHOL; CELL SURFACE MARKER; HCN4 PROTEIN; ISOPRENALINE; MESSENGER RNA; NITRENDIPINE; PRION PROTEIN; SODIUM CHANNEL; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CARDIAC PROGENITOR CELL; CELL DIFFERENTIATION; CHRONOTROPISM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYOID BODY; EMBRYONIC STEM CELL; FLOW CYTOMETRY; HEART MUSCLE FIBER MEMBRANE STEADY POTENTIAL; HEART MUSCLE POTENTIAL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; ION CURRENT; MOUSE; NONHUMAN; PATCH CLAMP; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL;

ACTION POTENTIALS; ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CELL SEPARATION; COCULTURE TECHNIQUES; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; EMBRYONIC STEM CELLS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; MICE; MICE, 129 STRAIN; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PERIODICITY; PRIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84870548691     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-12-0126     Document Type: Article

References (27)

1. Lafamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 2007; 25: 1015-1024.
2. van Laake LW, Passier R, Doevendans PA, Mummery CL. Human embryonic stem cell-derived cardiomyocytes and cardiac repair in rodents. Circ Res 2008; 102: 1008-1010.
3. Choi SH, Jung SY, Kwon SM, Baek SH. Perspectives on stem cell therapy for cardiac regeneration: Advances and challenges. Circ J 2012; 76: 1307-1312.
4. Nelson TJ, Faustino RS, Chiriac A, Crespo-Diaz R, Behfar A, Terzic A. CXCR4+/FLK-1+ biomarkers select a cardiopoietic lineage from embryonic stem cells. Stem Cells 2008; 26: 1464-1473.
5. Hidaka K, Shirai M, Lee JK, Wakayama T, Kodama I, Schneider MD, et al. The cellular prion protein identifes bipotential cardiomyogenic progenitors. Circ Res 2010; 106: 111-119.
6. Morikawa K, Bahrudin U, Miake J, Igawa O, Kurata Y, Nakayama Y, et al. Identifcation, isolation and characterization of HCN4-positive pacemaking cells derived from murine embryonic stem cells during cardiac differentiation. Pacing Clin Electrophysiol 2010; 33: 290-303.
7. Hidaka K, Lee JK, Kim HS, Ihm CH, Iio A, Ogawa M, et al. Cham-ber-specifc differentiation of Nkx2.5-positive cardiac precursor cells from murine embryonic stem cells. FASEB J 2003; 17: 740-742.
8. Bahrudin U, Morisaki H, Morisaki T, Ninomiya H, Higaki K, Nanba E, et al. Ubiquitin-proteasome system impairment caused by a mis-sense cardiac myosin-binding protein C mutation and associated with cardiac dysfunction in hypertrophic cardiomyopathy. J Mol Biol 2008; 384: 896-907.
9. 2+ channel in mouse ES cell-derived cardiocytes carrying human chromosome 21. Biochem Biophys Res Commun 2006; 351: 126-132.
10. 2+ channels from Cav3.2 to Cav3.1 during differentiation of embryonic stem cells to cardiac cell lineage. Circ J 2005; 69: 1284-1289.
11. Kodo K, Yamagishi H. A decade of advances in the molecular embryology and genetics underlying congenital heart defects. Circ J 2011; 75: 2296-2304.
12. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, et al. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversifcation. Cell 2006; 127: 1151-1165.
13. Yamaguchi TP, Dumont DJ, Conlon RA, Breitman ML, Rossant J. Fk-1, an ft-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development 1993; 118: 489-498.
14. Kattman SJ, Huber TL, Keller GM. Multipotent fk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell 2006; 11: 723-732.
15. Boyett MR, Kodama I, Honjo H, Arai A, Suzuki R, Toyama J. Ionic basis of the chronotropic effect of acetylcholine on the rabbit sino-atrial node. Cardiovasc Res 1995; 29: 867-878.
16. Demir SS, Clark JW, Giles WR. Parasympathetic modulation of si-noatrial node pacemaker activity in rabbit heart: A unifying model. Am J Physiol 1999; 276: H2221-H2244.
17. Mommersteeg MT, Hoogaars WM, Prall OW, de Gier-de Vries C, Wiese C, Clout DE, et al. Molecular pathway for the localized formation of the sinoatrial node. Circ Res 2007; 100: 354-362.
18. Christoffels VM, Mommersteeg MT, Trowe MO, Prall OW, de Gier-de Vries C, Soufan AT, et al. Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Circ Res 2006; 98: 1555-1563.
19. Stieber J, Herrmann S, Feil S, Löster J, Feil R, Biel M, et al. The hy-perpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci USA 2003; 100: 15235-15240.
20. Altomare C, Terragni B, Brioschi C, Milanesi R, Pagliuca C, Viscomi C, et al. Heteromeric HCN1-HCN4 channels: A comparison with native pacemaker channels from the rabbit sinoatrial node. J Physiol 2003; 549: 347-359.
21. Azene EM, Xue T, Marbán E, Tomaselli GF, Li RA. Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers. Cardiovasc Res 2005; 67: 263-273.
22. Chen PS, Joung B, Shinohara T, Das M, Chen Z, Lin SF. The initiation of the heart beat. Circ J 2010; 74: 221-225.
23. Zhang H, Joung B, Shinohara T, Mei X, Chen PS, Lin SF. Synergis-tic dual automaticity in sinoatrial node cell and tissue models. Circ J 2010; 74: 2079-2088.
24. Shinohara T, Park HW, Joung B, Maruyama M, Chua SK, Han S, et al. Selective sinoatrial node optical mapping and the mechanism of sinus rate acceleration. Circ J 2012; 76: 309-316.
25. Zahanich I, Sirenko SG, Maltseva LA, Tarasova YS, Spurgeon HA, Boheler KR, et al. Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling. J Mol Cell Cardiol 2011; 50: 66-76.
26. 2+ exchanger in sinoatrial node pacemaking: Insights from bifurcation analysis of mathematical models. Am J Physiol Heart Circ Physiol 2012; 302: H2285-H2300.
27. Tanaka H, Nishimaru K, Aikawa T, Hirayama W, Tanaka Y, Shigenobu K. Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents. Br J Pharmacol 2002; 135: 1096-1100.