Digital quantification of precursor frequency in the fallopian tube and its significance

Modern Pathology

Volumn 25, Issue 12, 2012, Pages 1654-1661

  Bijron, Jonathan G ^a   Ning, Gang ^b   Laury, Anna R ^c   Quick, Charles M ^d   Betensky, Rebecca A ^e   Monte, Nicolas M ^a   King, Emily ^a   McKeon, Frank D ^b,f   Xian, Wa ^f   Crum, Christopher P ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UCLA MEDICAL CENTER   (United States)

^d UNIVERSITY OF ARKANSAS MEDICAL CENTER   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

Author keywords

fallopian tube; precancer; secretory cell; serous cancer

Indexed keywords

ADULT; AGED; ARTICLE; CANCER RISK; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM; FEMALE; HUMAN; NEOPLASM; PERIMETER; PRECURSOR; PRIORITY JOURNAL; TOPOGRAPHY; UTERINE TUBE;

ADULT; AGED; AGED, 80 AND OVER; CYSTADENOCARCINOMA, SEROUS; FALLOPIAN TUBE NEOPLASMS; FALLOPIAN TUBES; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MIDDLE AGED; PAX2 TRANSCRIPTION FACTOR; PRECANCEROUS CONDITIONS; TUMOR MARKERS, BIOLOGICAL;

EID: 84870541086     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2012.100     Document Type: Article

References (36)

1. Piek JM, van Diest PJ, Zweemer RP, et al. Dysplastic changes in prophylactically removed fallopian tubes of women predisposed to developing ovarian cancer. J Pathol 2001;195:451-456. (Pubitemid 33069670)
2. Cass I, Holschneider C, Datta N, et al. BRCA-mutationassociated fallopian tube carcinoma: a distinct clinical phenotype? Obstet Gynecol 2005;106:1327-1334. (Pubitemid 41668953)
3. Medeiros F, Muto MG, Lee Y, et al. The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome. Am J Surg Pathol 2006;30:230-236. (Pubitemid 43740193)
4. Norquist BM, Garcia RL, Allison KH, et al. The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations. Cancer 2010;116: 5261-5271.
5. Finch A, Shaw P, Rosen B, et al. Clinical and pathologic findings of prophylactic salpingo-oophorectomies in 159 BRCA1 and BRCA2 carriers. Gynecol Oncol 2006;100:58-64. (Pubitemid 41815050)
6. Rabban JT, Krasik E, Chen LM, et al. Multistep level sections to detect occult fallopian tube carcinoma in risk-reducing salpingo-oophorectomies from women with BRCA mutations: implications for defining an optimal specimen dissection protocol. Am J Surg Pathol 2009;33:1878-1885.
7. Roh MH, Yassin Y, Miron A, et al. High-grade fimbrialovarian carcinomas are unified by altered p53, PTEN and PAX2 expression. Mod Pathol 2010;23:1316-1324.
8. Przybycin CG, Kurman RJ, Ronnett BM, et al. Are all pelvic (nonuterine) serous carcinomas of tubal origin? Am J Surg Pathol 2010;34:1407-1416.
9. Lee Y, Miron A, Drapkin R, et al. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol 2007;211:26-35. (Pubitemid 46092026)
10. Kindelberger DW, Lee Y, Miron A, et al. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol 2007;31:161-169. (Pubitemid 46175016)
11. Chen EY, Mehra K, Mehrad M, et al. Secretory cell outgrowth, PAX2 and serous carcinogenesis in the fallopian tube. J Pathol 2010;222:110-116.
12. Quick CM, Ning G, Bijron J, et al. PAX2-null secretory cell outgrowths in the oviduct and their relationship to pelvic serous cancer. Mod Pathol 2012;25:449-455.
13. Laury AR, Ning G, Quick CM, et al. Fallopian tube correlates of ovarian serous borderline tumors. Am J Surg Pathol 2011;35:1759-1765.
14. Mehra KK, Chang MC, Folkins AK, et al. The impact of tissue block sampling on the detection of p53 signatures in fallopian tubes from women with BRCA 1 or 2 mutations (BRCA+) and controls. Mod Pathol 2011; 24:152-156.
15. Shin A, Hong CW, Sohn DK, et al. Associations of cigarette smoking and alcohol consumption with advanced or multiple colorectal adenoma risks: a colonoscopy-based case-control study in Korea. Am J Epidemiol 2011;174:552-562.
16. Rosner G, Rozen P, Bercovich D, et al. A protocol for genetic evaluation of patients with multiple colorectal adenomas and without evidence of APC gene mutation. Isr Med Assoc J 2010;12:549-553.
17. Matsuda T, Saito Y, Hotta K, et al. Prevalence and clinicopathological features of nonpolypoid colorectal neoplasms: should we pay more attention to identifying flat and depressed lesions? Dig Endosc 2010; 22(Suppl 1):S57-S62.
18. Patel BB, Yu Y, Du J, et al. Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: a risk factor for colon cancer. Biochem Biophys Res Commun 2009;378:344-347.
19. Rebours V, Le'vy P, Mosnier JF, et al. Pathology analysis reveals that dysplastic pancreatic ductal lesions are frequent in patients with hereditary pancreatitis. Clin Gastroenterol Hepatol 2010;8:206-212.
20. Shi C, Klein AP, Goggins M, et al. Increased prevalence of precursor lesions in familial pancreatic cancer patients. Clin Cancer Res 2009;15:7737-7743.
21. Gokden N, Roehl KA, Catalona WJ, et al. High-grade prostatic intraepithelial neoplasia in nee e biopsy as risk factor for detection of adenocarcinoma: current level of risk in screening population. Urology 2005; 65:538-542. (Pubitemid 40386005)
22. Nasir A, Copeland J, Gillespie JW, et al. Preneoplastic lesions of the prostate-clinical, pathological and molecular biological aspects. In Vivo 2002;16:557-566. (Pubitemid 35460370)
23. Kronz JD, Allan CH, Shaikh AA, et al. Predicting cancer following a diagnosis of high-grade prostatic intraepithelial neoplasia on needle biopsy: data on men with more than one follow-up biopsy. Am J Surg Pathol 2001;25:1079-1085. (Pubitemid 32685907)
24. Bishara T, Ramnani DM, Epstein JI. High-grade prostatic intraepithelial neoplasia on needle biopsy: risk of cancer on repeat biopsy related to number of involved cores and morphologic pattern. Am J Surg Pathol 2004;28:629-633. (Pubitemid 38579565)
25. Shaw PA, Rouzbahman M, Pizer ES, et al. Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers. Mod Pathol 2009; 22:1133-1138.
26. Vicus D, Shaw PA, Finch A, et al. Risk factors for noninvasive lesions of the fallopian tube in BRCA mutation carriers. Gynecol Oncol 2010;118:295-298.
27. Owen RW. Biomarkers in colorectal cancer. IARC Sci Publ 2001;154:101-111.
28. Gaisa NT, Graham TA, McDonald SA, et al. Clonal architecture of human prostatic epithelium in benign and malignant conditions. J Pathol 2011;225:172-180.
29. Bai H, Li H, Zhang W, et al. Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice. Carcinogenesis 2011;32:1689-1696.
30. Hruban RH, Adsay NV, Albores-Saavedra J, et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001;25:579-586. (Pubitemid 32423354)
31. Koorstra JB, Feldmann G, Habbe N, et al. Morphogenesis of pancreatic cancer: role of pancreatic intraepithelial neoplasia (PanINs). Arch Surg 2008;393:561-570.
32. Andea A, Sarkar F, Adsay VN. Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod Pathol 2003;16:996-1006. (Pubitemid 37280815)
33. Sipos B, Frank S, Gress T, et al. Pancreatic intraepithelial neoplasia revisited and updated. Pancreatology 2009;9:45-54.
34. Brune K, Abe T, Canto M, et al. Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol 2006;30:1067-1076. (Pubitemid 44299338)
35. Ito R, Kondo F, Yamaguchi T, et al. Pancreatic intraepithelial neoplasms in the normal appearing pancreas: on their precise relationship with age. Hepatogastroenterology 2008;55:1103-1106. (Pubitemid 351975995)
36. Liszka L, Paak J, Mrowiec S, et al. Precursor lesions of early onset pancreatic cancer. Virchows Arch 2011; 458:439-451.