Precursor lesions of early onset pancreatic cancer

Virchows Archiv

Volumn 458, Issue 4, 2011, Pages 439-451

  Liszka, Łukasz ^a   Pająk, Jacek ^a   Mrowiec, Sławomir ^a   Zielińska Pająk, Ewa ^a   Gołka, Dariusz ^a,b   Lampe, Paweł ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b BLACKPOOL VICTORIA HOSPITAL   (United Kingdom)

Author keywords

Intraepithelial carcinoma; Pancreas; Pancreatic ductal carcinoma; Pancreatic ducts; Pancreatic neoplasms

Indexed keywords

ADULT; ARTICLE; CANCER GRADING; CONTROLLED STUDY; EARLY CANCER; EARLY ONSET PANCREATIC CANCER; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; MAJOR CLINICAL STUDY; MALE; NEUROENDOCRINE TUMOR; PANCREAS CANCER; PANCREATIC INTRAEPITHELIAL NEOPLASIA; PRECURSOR; PRIORITY JOURNAL;

EID: 79956227165     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-011-1056-3     Document Type: Article

References (56)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics, 2009. CA: A Cancer Journal for Clinicians 59:225-249
2. Wisnoski NC, Townsend CM Jr, Nealon WH, Freeman JL, Riall TS (2008) 672 patients with acinar cell carcinoma of the pancreas: a population-based comparison to pancreatic adenocarcinoma. Surgery 144:141-148
3. Bergmann F, Aulmann S, Wente MN, Penzel R, Esposito I, Kleeff J, Friess H, Schirmacher P (2006) Molecular characterization of pancreatic ductal adenocarcinoma in patients under 40. J Clin Pathol 59:580-584 (Pubitemid 43886040)
4. Duffy A, Capanu M, Allen P, Kurtz R, Olson SH, Ludwig E, Klimstra DS, O'Reilly EM (2009) Pancreatic adenocarcinoma in a young patient population-12-year experience at Memorial Sloan Kettering Cancer Center. J Surg Oncol 100:8-12
5. Baxter NN, Whitson BA, Tuttle TM (2007) Trends in the treatment and outcome of pancreatic cancer in the United States. Ann Surg Oncol 14:1320-1326 (Pubitemid 46536816)
6. Raimondi S, Maisonneuve P, Lohr JM, Lowenfels AB (2007) Early onset pancreatic cancer: evidence of a major role of smoking and genetic factors. Canc Epidemiol Biomarkers Prev 16:1894-1897 (Pubitemid 47450523)
7. Brune KA, Lau B, Palmisano E, Canto M, Goggins MG, Hruban RH, Klein AP (2010) Importance of age of onset in pancreatic cancer kindreds. J Natl Cancer Inst 102:119-126
8. Soliman AS, El-Ghawalby N, Ezzat F, Bondy ML, Soultan A, Abdel-Wahab M, Fathy O, Ebidi G, Bassiouni N, El-Ghawalbi A, Levin B, Abbruzzese JL (2002) Unusually high rate of young-onset pancreatic cancer in the East Nile Delta region of Egypt. Int J Gastrointest Cancer 32:143-151 (Pubitemid 36749003)
9. Lüttges J, Stigge C, Pacena M, Klöppel G (2004) Rare ductal adenocarcinoma of the pancreas in patients younger than age 40 years. Cancer 100:173-182
10. Bleyer A (2007) Young adult oncology: the patients and their survival challenges. CA: A Cancer Journal for Clinicians 57:242-255
11. Bleyer A, Barr R, Hayes-Lattin B, Thomas D, Ellis C, Anderson B (2008) Biology and clinical trials subgroups of the US National Cancer Institute progress review group in adolescent and young adult oncology. The distinctive biology of cancer in adolescents and young adults. Nat Rev Canc 8:288-298
12. Zogopoulos G, Rothenmund H, Eppel A, Ash C, Akbari MR, Hedley D, Narod SA, Gallinger S (2007) The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer. Hum Genet 121:635-637 (Pubitemid 46706075)
13. James TA, Sheldon DG, Rajput A, Kuvshinoff BW, Javle MM, Nava HR, Smith JL, Gibbs JF (2004) Risk factors associated with earlier age of onset in familial pancreatic carcinoma. Cancer 101:2722-2726 (Pubitemid 39603179)
14. Hruban RH, Fukushima N (2007) Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs. Mod Pathol 20:S61-S70 (Pubitemid 46733656)
15. Singh M, Maitra A (2007) Precursor lesions of pancreatic cancer: molecular pathology and clinical implications. Pancreatology 7:9-19 (Pubitemid 46725717)
16. Sipos B, Frank S, Gress T, Hahn S, Kloppel G (2009) Pancreatic intraepithelial neoplasia revisited and updated. Pancreatology 9:45-54
17. Andea AA, Basturk O, Adsay NV (2005) Pancreatic intra-epithelial neoplasia: current clinicopathological and molecular considerations. Curr Diagn Pathol 11:80-94 (Pubitemid 40261049)
18. Hruban RH, Takaori K, Klimstra DS, Adsay NV, Albores-Saavedra A, Biankin AV, Biankin SA, Compton CC, Fukushima N, Furukawa T, Goggins M, Kato Y, Kloppel G, Longnecker DS, Luttges J, Maitra A, Offerhaus GJA, Shimizu M, Yonezawa S (2004) An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 28:977-987 (Pubitemid 38971421)
19. Shi C, Klein AP, Goggins M, Maitra A, Canto M, Ali S, Schulick R, Palmisano E, Hruban RH (2009) Increased prevalence of precursor lesions in familial pancreatic cancer patients. Clin Cancer Res 15:7737-7743
20. Ottenhof NA, Milne AN, Morsink FH, Drillenburg P, Ten Kate FJ, Maitra A, Offerhaus GJ (2009) Pancreatic intraepithelial neoplasia and pancreatic tumorigenesis: of mice and men. Arch Pathol Lab Med 133:375-381
21. Lüttges J, Reinecke-Lüthge A, Möllmann B, Menke MA, Clemens A, Klimpfinger M, Sipos B, Klöppel G (1999) Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution. Virchows Arch 435:461-468
22. Shi C, Hong SM, Lim P, Kamiyama H, Khan M, Anders RA, Goggins M, Hruban RH, Eshleman JR (2009) KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol Cancer Res 7:230-236
23. Andea A, Sarkar F, Adsay VN (2003) Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod Pathol 16:996-1006 (Pubitemid 37280815)
24. Detlefsen S, Sipos B, Feyerabend B, Kloppel G (2005) Pancreatic fibrosis associated with age and ductal papillary hyperplasia. Virchows Arch 447:800-805 (Pubitemid 41728867)
25. Esposito I, Seiler C, Bergmann F, Kleeff J, Friess H, Schirmacher P (2007) Hypothetical progression model of pancreatic cancer with origin in the centroacinar-acinar compartment. Pancreas 35:212-217 (Pubitemid 47482512)
26. Brune K, Abe T, Canto M, O'Malley L, Klein AP, Maitra A, Volkan Adsay N, Fishman EK, Cameron JL, Yeo CJ, Kern SE, Goggins M, Hruban RH (2006) Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol 30:1067-1076 (Pubitemid 44299338)
27. Hruban RH, Adsay NV, Albores-Saavedra J, Anver MR, Biankin AV, Boivin GP, Furth EE, Furukawa T, Klein A, Klimstra DS, Kloppel G, Lauwers GY, Longnecker DS, Luttges J, Maitra A, Offerhaus GJ, Pérez-Gallego L, Redston M, Tuveson DA (2006) Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res 66:95-106 (Pubitemid 43166014)
28. Kloppel G, Detlefsen S, Feyerabend B (2004) Fibrosis of the pancreas: the initial tissue damage and the resulting pattern. Virchow Arch 445:1-8 (Pubitemid 39044262)
29. Kozuka S, Sassa R, Taki T, Masamoto K, Nagasawa S, Saga S, Hasegawa K, Takeuchi M (1979) Relation of pancreatic duct hyperplasia to carcinoma. Cancer 43:1418-1428 (Pubitemid 9180309)
30. Langer P, Kann PH, Fendrich V, Habbe N, Schneider M, Sina M, Slater EP, Heverhagen JT, Gress TM, Rothmund M, Bartsch DK (2009) Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer. Gut 58:1410-1418
31. Steinberg WM, Barkin JS, Bradley EL III, DiMagno E, Layer P, Canto MI, Levy MJ (2009) Should patients with a strong family history of pancreatic cancer be screened on a periodic basis for cancer of the pancreas? Pancreas 38:e137-e150
32. Poley JW, Kluijt I, Gouma DJ, Harinck F, Wagner A, Aalfs C, van Eijck CH, Cats A, Kuipers EJ, Nio Y, Fockens P, Bruno MJ (2009) The yield of first-time endoscopic ultrasonography in screening individuals at a high risk of developing pancreatic cancer. Am J Gastroenterol 104:2175-2181
33. Larghi A, Verna EC, Lecca PG, Costamagna G (2009) Screening for pancreatic cancer in high-risk individuals: a call for endoscopic ultrasound. Clin Cancer Res 15:1907-1914
34. Canto MI, Goggins M, Hruban RH, Petersen GM, Giardiello FM, Yeo C, Fishman EK, Brune K, Axilbund J, Griffin C, Ali S, Richman J, Jagannath S, Kantsevoy SV, Kalloo AN (2006) Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study. Clin Gastroenterol Hepatol 4:766-781 (Pubitemid 43825802)
35. Hruban RH, Pitman MB, Klimstra DS (2007) AFIP atlas of tumor pathology. Fourth series. Fascicle 6. Tumors of the pancreas. American Registry of Pathology-AFIP, Washington
36. Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) (2010) WHO classification of tumours of the digestive system. International Agency for Research on Cancer, Lyon
37. Stelow EB, Adams RB, Moskaluk CA (2006) The prevalence of pancreatic intraepithelial neoplasia in pancreata with uncommon types of primary neoplasms. Am J Surg Pathol 30:36-41 (Pubitemid 43740207)
38. Recavarren C, Labow DM, Liang J, Zhang L, Wong M, Zhu H, Wang J, Francis F, Xu R (2011) Histologic characteristics of pancreatic intraepithelial neoplasia associated with different pancreatic lesions. Human Pathol 42:18-24
39. Furukawa T, Kloppel G, Adsay NV, Albores-Saavedra J, Fukushima N, Horii A, Hruban RH, Kato Y, Klimstra DS, Longnecker DS, Lüttges J, Offerhaus GJ, Shimizu M, Sunamura M, Suriawinata A, Takaori K, Yonezawa S (2005) Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study. Virchows Arch 447:794-799 (Pubitemid 41728866)
40. Kloppel G (2004) Chronic pancreatitis of alcoholic and nonalcoholic origin. Semin Diagn Pathol 21:227-236
41. Lardon J, Bouwens L (2005) Metaplasia in the pancreas. Differentiation 73:278-286 (Pubitemid 41583374)
42. Oertel JE (1989) The pancreas. Nonneoplastic alterations. Am J Surg Pathol 13(Suppl 1):50-65
43. Othman M, Basturk O, Groisman G, Krasinskas A, Adsay NV (2007) Squamoid cyst of pancreatic ducts: a distinct type of cystic lesion in the pancreas. Am J Surg Pathol 31:291-297 (Pubitemid 46175031)
44. Kloppel G (2004) Acute pancreatitis. Semin Diagn Pathol 21:221-226
45. Liszka L, Paja̧k J, Zielińska-Paja̧k E, Gołka D (2008) Colloid carcinoma of the pancreas: review of selected pathological and clinical aspects. Pathology 40:655-663
46. Jorgensen MT, Mortensen MB, Gerdes AM, De Muckadell OB (2008) Familial pancreatic cancer. Scand J Gastroenterol 43:387-397 (Pubitemid 351450985)
47. Hassan MM, Bondy ML, Wolff RA, Abbruzzese JL, Vauthey JN, Pisters PW, Evans DB, Khan R, Chou TH, Lenzi R, Jiao L, Li D (2007) Risk factors for pancreatic cancer: case-control study. Am J Gastroenterol 102:2696-2707 (Pubitemid 350179330)
48. Shi C, Hruban RH, Klein AP (2009) Familial pancreatic cancer. Arch Pathol Lab Med 133:365-374
49. Rosty C, Geradts J, Sato N, Wilentz RE, Roberts H, Sohn T, Cameron JL, Yeo CJ, Hruban RH, Goggins M (2003) p16 inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. Am J Surg Pathol 27:1495-1501 (Pubitemid 37486610)
50. Ito R, Kondo F, Yamaguchi T, Kato K, Sakai Y, Saisho H, Yamazaki K (2008) Pancreatic intraepithelial neoplasms in the normal appearing pancreas: on their relationship with age. Hepatogastroenterology 55:1103-1106 (Pubitemid 351975995)
51. Cubilla AL, Fitzgerald PJ (1976) Morphological lesions associated with human primary invasive nonendocrine pancreas cancer. Cancer Res 36:2690-2698
52. Poultsides GA, Reddy S, Cameron JL, Hruban RH, Pawlik TM, Ahuja N, Jain A, Edil BH, Iacobuzio-Donahue CA, Schulick RD, Wolfgang CL (2010) Histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreas. Ann Surg 251:470-476
53. Meckler KA, Brentnall TA, Haggitt RC, Crispin D, Byrd DR, Kimmey MB, Bronner MP (2001) Familial fibrocystic pancreatic atrophy with endocrine cell hyperplasia and pancreatic carcinoma. Am J Surg Pathol 25:1047-1053 (Pubitemid 32685902)
54. Takaori K,Matsusue S, Fujikawa T, Kobashi Y, Ito T, Matsuo Y, Oishi H, Takeda H (1998) Carcinoma in situ of the pancreas associated with localized fibrosis: a clue to early detection of neoplastic lesions arising from pancreatic ducts. Pancreas 17:102-105 (Pubitemid 28293016)
55. Aimoto T, Uchida E, Nakamura Y, Matsushita A, Katsuno A, Chou K, Kawamoto M, Naito Z, Tajiri T (2008) Multicentric pancreatic intraepithelial neoplasias (PanINs) presenting with the clinical features of chronic pancreatitis. J Hepatobiliary Pancreat Surg 15:549-553
56. Liszka L, Pajak J, Zielinska-Pajak E, Golka D, Mrowiec S, Lampe P (2010) Different approaches to assessment of lymph nodes and surgical margin status in patients with ductal adenocarcinoma of the pancreas treated with pancreaticoduodenectomy. Pathology 42:138-146