Development of fully amorphous dispersions of a low Tg drug via co-spray drying with hydrophilic polymers

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 82, Issue 3, 2012, Pages 572-579

  Zhao, Min ^a   Barker, Susan A ^a   Belton, Peter S ^a   McGregor, Caroline ^b   Craig, Duncan Q M ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Acetaminophen; Amorphous; Paracetamol; Pyrrolidone; Solid dispersion; Spray drying

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; PARACETAMOL; POLYMER; POVIDONE;

AQUEOUS SOLUTION; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SOLUBILITY; GLASS TRANSITION TEMPERATURE; HEATING; HYDROGEN BOND; HYDROPHILICITY; INFRARED SPECTROSCOPY; MELTING POINT; MISCIBILITY; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; THERMOGRAVIMETRY; VISCOMETRY; VISCOSITY; X RAY POWDER DIFFRACTION;

ACETAMINOPHEN; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; DRUG STABILITY; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; POLYMERS; POVIDONE; PYRROLIDINES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE; THERMOGRAVIMETRY; TRANSITION TEMPERATURE; VINYL COMPOUNDS; VISCOSITY; X-RAY DIFFRACTION;

EID: 84870540084     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.07.012     Document Type: Article

References (21)

1. S. Qi, P. Avalle, R. Saklatvala, and D.Q.M. Craig An investigation into the effects of thermal history on the crystallization behavior of amorphous paracetamol Eur. J. Pharm. Biopharm. 69 2008 364 371
2. B.C. Hancock, and G. Zografi Characteristics and significance of the amorphous state in pharmaceutical systems J. Pharm. Sci. 86 1 1997 1 12
3. M. Gordon, and J.S. Taylor Ideal copolymers and the 2nd-order transitions of synthetic rubbers 1. Non-crystalline copolymers J. Appl. Chem. 2 1952 493 500
4. T.G. Fox, and P.J. Flory Second-order transition temperatures and related properties of polystyrene J. Appl. Phys. 21 1950 581 591
5. L.S. Taylor, and G. Zografi Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions Pharm. Res. 14 1997 1691 1698
6. T. Matsumoto, and G. Zografi Physical properties of solid molecular dispersions of indomethacin with poly (vinylpyrrolidone) and poly (vinylpyrrolidone-co-vinyl-acetate) in relation to indomethacin crystallization Pharm. Res. 16 1999 1722 1728
7. J.-S. Kim, M.-S. Kim, H.J. Park, S.-J. Jin, S. Lee, and S.-J. Hwang Physicochemical properties and oral bioavailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS process Int. J. Pharm. 359 1-2 2008 211 219
8. J.E. Patterson, M.B. James, A.H. Forster, R.W. Lancaster, J.M. Butler, and T. Rades Preparation of glass solutions of three poorly water soluble drugs by spray drying, melt extrusion and ball milling Int. J. Pharm. 336 1 2007 22 34
9. A. Paradkar, A.A. Ambike, B.K. Jadhav, and K.R. Mahadik Characterization of curcumin-PVP solid dispersion obtained by spray drying Int. J. Pharm. 271 2004 281 286
10. I. Weuts, D. Kempen, G. Verreck, A. Decorte, K. Heymans, J. Peeters, M. Brewster, and G. Van den Mooter Study of the physicochemical properties and stability of solid dispersions of loperamide and PEG6000 prepared by spray drying Eur. J. Pharm. Biopharm. 59 2005 119 126
11. M. Zhao, Y. You, Y.C. Ren, Y. Zhang, and X. Tang Formulation, characteristics and aerosolization performance of azithromycin DPI prepared by spray-drying Powder Technol. 187 3 2008 214 221
12. H. Takeuchi, S. Nagira, H. Yamamoto, and Y. Kawashima Solid dispersion particles of amorphous indomethacin with fine porous silica particles by using spray drying method Int. J. Pharm. 293 2005 155 164
13. B. Chauhan, S. Shimpi, and A. Paradkar Preparation and evaluation of glibenclamide-polyglycolized glycerides solid dispersions with silicon dioxide by spray drying technique Eur. J. Pharm. Sci. 26 2005 219 230
14. S. Hussain, C. Keary, and D.Q.M. Craig A thermoreological investigation into the gelation and phase separation of hydroxypropyl methylcellulose aqueous systems Polymer 43 21 2002 5623 5628
15. D.T. Friesen, R. Shanker, M. Crew, D.T. Smithey, W.J. Curatolo, and J.A.S. Nightingale Hydroxypropyl methylcellulose acetate succinate-based spray-dried dispersions: an overview Mol. Pharm. 5 6 2008 1003 1019
16. H. McPhillips, D.Q.M. Craig, P.G. Royal, and V.L. Hill Characterisation of glass transition of HPMC using modulated temperature differential scanning calorimetry Int. J. Pharm. 180 1 1999 83 90
17. T. Bee, and M. Rahman Using polymer technology to enhance bioavailability - a review of major technology Pharm. Technol. 34 9 2010
18. B. Zimmermann, and G. Baranović Thermal analysis of paracetamol polymorphs by FT-IR spectroscopies J. Pharm. Biomed. Anal. 54 2011 295 302
19. G.R. Lloyd, D.Q.M. Craig, and A. Smith An investigation into the production of paracetamol solid dispersions in PEG 4000 using hot stage differential interference contrast microscopy Int. J. Pharm. 158 1 1997 39 46
20. H.A. Moynihan, and I.P. O'Hare Spectroscopic characterisation of the monoclinic and orthorhombic forms of paracetamol Int. J. Pharm. 247 2002 179 185
21. B.B. Ivanova Monoclinic and orthorhombic polymorphs of paracetamol-solid state linear dichroic infrared spectral analysis J. Mol. Struct. 738 2005 233 238