4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma

Toxicology Letters

Volumn 216, Issue 1, 2013, Pages 16-22

  Chung, Chi Jung ^a,b   Pu, Yeong Shiau ^c   Shiue, Horng Sheng ^d   Lee, Hui Ling ^e   Lin, Pinpin ^f   Yang, Hsiu Yuan ^g   Su, Chien Tien ^h   Hsueh, Yu Mei ^g,i  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^e FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^f NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^g TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^h TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

ⁱ TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

CYP2A13; NNAL; NNK; Polymorphism; UGT2B7; Urothelial carcinoma

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CYTOCHROME P450; CYTOCHROME P450 2A13; GLUCURONOSYLTRANSFERASE 2B7; UNCLASSIFIED DRUG;

ADULT; ANALYSIS OF COVARIANCE; ARTICLE; CANCER RISK; CARCINOGENESIS; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; METABOLITE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PILOT STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SMOKING; TAIWAN; TANDEM MASS SPECTROMETRY; TRANSITIONAL CELL CARCINOMA; URINE LEVEL;

ARYL HYDROCARBON HYDROXYLASES; CARCINOMA; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOTYPE; GLUCURONOSYLTRANSFERASE; HUMANS; MALE; MIDDLE AGED; NITROSAMINES; PILOT PROJECTS; POLYMORPHISM, GENETIC; RISK FACTORS; SMOKING; UROLOGIC NEOPLASMS; UROTHELIUM;

EID: 84870539785     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.11.002     Document Type: Article

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