UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism in bladder cancer cases

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 71, Issue 13-14, 2008, Pages 911-914

  Zimmermann, Anna ^a   Blaszkewicz, Meinolf ^a   Roth, Gerhard ^b   Seidel, Thilo ^b   Dietrich, Holger ^b   Schutschkow, Olga ^c   Bolt, Hermann M ^a   Golka, Klaus ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^b Paul Gerhardt Foundation   (Germany)

^c TU DORTMUND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC AMINE; BENZIDINE; GLUCURONOSYLTRANSFERASE 2B7;

ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CANCER RISK; CAUCASIAN; CHEMICAL INDUSTRY; CHINESE; CONTROLLED STUDY; ENZYME ACTIVITY; ETHNIC DIFFERENCE; GENE FREQUENCY; GENE LOCUS; GENETIC POLYMORPHISM; GENOTYPE; GERMANY; HUMAN; MAJOR CLINICAL STUDY; OCCUPATIONAL EXPOSURE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RUBBER INDUSTRY;

CASE-CONTROL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GERMANY; GLUCURONOSYLTRANSFERASE; HUMANS; ODDS RATIO; POLYMORPHISM, GENETIC; RISK FACTORS; SMOKING; URINARY BLADDER NEOPLASMS;

EID: 47349123244     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390801988772     Document Type: Article

References (20)

1. Bhasker, C. R., McKinnon, W., Stone, A., Lo, A. C., Kubota, T., Ishizaki, T., and Miners, J. O. 2000. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: Ethnic diversity of alleles and potential clinical significance. Pharmacogenetics 10:679-685.
2. Ciotti, M., Lakshmi, V. M., Basu, N., Davis, B. B., Owens, I. S., and Zenser, T. V. 1999. Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferase and pH stability of glucuronides. Carcinogenesis 20:1963-1969.
3. Golka, K., Prior, V., Blaszkewicz, M., and Bolt H. M. 2002. The enhanced bladder cancer susceptibility of NAT2 slow acetylators towards aromatic amines: A review considering ethnic differences. Toxicol. Lett. 128:229-241.
4. Guillemette, C. 2003. Pharmacogenomics of human UDP- glucuronosyltransferase enzymes. Pharmacogenomics J. 3:136-158.
5. Guillemette, C., Millikan, R. C., Newman, B., and Housman, D. E. 2000. Genetic polymorphisms in uridine diphospho-glucuronosyltransferase IAI and association with breast cancer among African Americans. Cancer Res. 60:950-956.
6. Holthe, M., Klepstad, P., Zahlsen, K., Borchgrevink, P. C., Hagen, L., Dale, O., Kaasa, S., Krokan, H. E., and Skorpen, F. 2002. Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy. Eur. J. Clin. Pharmacol. 58:353-356.
7. Jin, C. J., Miners, J. O., Burchell, B., and Mackenzie, P. I. 1993a. The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyltransferases. Carcinogenesis 14:2637-2639.
8. Jin, C. J, Miners, J. O., Lillywhite, K. J., and Mackenzie, P. I. 1993b. Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. J. Pharmacol. Exp. Ther. 264:475-479.
9. Lampe, J. W., Bigler, J., Bush, A. C., and Potter, J. D. 2000. Prevalence of polymorphism in the human UDP-glucuronosyltransferase 2B family: UGT2B4 (D458E), UGT2B7 (H268Y), and UGT2B15 (D85Y). Cancer Epidemiol. Biomarkers Prev. 9:329-333.
10. 268Tyr) polymorphism with bladder cancer in benzidine-exposed workers in China. Toxicol. Sci. 85:502-506.
11. Mackenzie, P. I., Bock, K. W., Burchell, B., Guillemette, C., Ikushiro, S., Iyanagi, T., Miners, J. O., Owens, I. S., and Nebert, D. W. 2005. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet. Genomics 15:677-685.
12. Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Bairoch, A., Belanger, A., Fournel-Gigleux, S., Green, M., Hum, D. W., Iyanagi, T., Lancet, D., Louisot, P., Magdalou, J., Chowdhury, J. R., Ritter, J. K., Schachter, H., Tephly, T. R., Tipton, K. F., and Nebert, D. W. 1997. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 7:255-269.
13. Ockenga, J., Vogel, A., Teich, N., Keim, V., Manns, M. P., and Strassburg, C. P. 2003. UDP glucuronosyltransferase (UGTIA7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer. Gastroenterology 124:1802-1808.
14. Radominska-Pandya, A., Little, J. M., and Czernik, P. I. 2001. Human UDP-glucuronosyltransferase 2B7. Curr. Drug. Metab. 2:283-289.
15. R Development Core Team. 2004. R: A language and environment for statistical computing. R-Foundation for Statistical Computing, Vienna, Austria. http://www.R-project.org
16. Vineis, P., Marinelli, D., Autrup, H., Brockmöller, J., Cascorbi, I., Daly, A. K., Golka, K., Okkels, H., Risch, A., Rothman, N., Sim, E., and Taioli, E. 2001. Current smoking, occupation, N-acetyltransferase-2 and bladder cancer: A pooled analysis of genotype-based studies. Cancer Epidemiol. Biomarkers Prev. 10:1249-1252.
17. Wallig, M. A., 2004. Glucuronidation and susceptibility to chemical carcinogenesis. Toxicol. Sci. 78:1-2.
18. Zenser, T. V., Lakshmi, V. M., Hsu, F. F., and Davis, B. B. 2002. Metabolism of N-acetylbenzidine and initiation of bladder cancer. Mutat. Res. 506-507:29-40.
19. Zheng, Z., Fang, J. L., and Lazarus, P. 2002. Glucuronidation: An important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues. Drug Metab. Dispos. 30:397-403.
20. Zheng, Z., Park, J. Y., Guillemette, C., Schantz, S. P., and Lazarus, P. 2001. Tobacco carcinogene-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk. J. Natl. Cancer Inst. 93:1411-1418.