Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung and effect of cigarette smoke exposure on in vivo metabolism to biological reactive intermediates

Advances in Experimental Medicine and Biology

Volumn 500, Issue , 2001, Pages 451-454

  Tricker, A R ^a   Brown, B G ^b   Doolittle, D J ^b   Richter, E ^c  

^a FTR   (Switzerland)

^b RJ Reynolds Tobacco Co   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CANCER RISK; CARCINOGENESIS; CIGARETTE SMOKING; CONFERENCE PAPER; CONTROLLED STUDY; IN VIVO STUDY; LUNG CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CARCINOGENS; HUMANS; LUNG; MICE; MICE, INBRED A; MOLECULAR STRUCTURE; NITROSAMINES; SMOKING;

ANIMALIA;

EID: 0035701995     PISSN: 00652598     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-1-4615-0667-6_67     Document Type: Article

References (13)

1. 6-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
2. Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse
3. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke
4. Nitrosamines derived from nicotine and other tobacco alkaloids
5. Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet
6. Nicotine inhibits the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats
7. Use of precision-cut tissue slices in organ culture to study metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by hamster lung, liver and kidney
8. G to A transitions and G-T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents
9. Six-month exposure of strain A/J mice to cigarette sidestream smoke: Cell kinetics and lung tumor data
10. The carcinogenicity of environmental tobacco smoke
11. The carcinogenic potential of the gas phase of environmental tobacco smoke
12. Chemoprevention of tobacco-smoke lung carcinogenesis in mice after cessation of smoke exposure