The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation

Journal of Clinical Investigation

Volumn 122, Issue 12, 2012, Pages 4325-4328

  Holland, Andrew J ^a,b   Cleveland, Don W ^a,b  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CENTRIN; CYCLIN B1; SECURIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN SPECIFIC PROTEASE 44; UNCLASSIFIED DRUG;

ANEUPLOIDY; CARCINOGENESIS; CELL CYCLE CHECKPOINT; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CELL VIABILITY; CELLULAR DISTRIBUTION; CENTROMERE; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; DNA DAMAGE; EXCISION REPAIR; MICROTUBULE; MITOSIS; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANEUPLOIDY; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CENTROSOME; ENDOPEPTIDASES; GENES, TUMOR SUPPRESSOR; HUMANS; TUMOR SUPPRESSOR PROTEINS;

EID: 84870536691     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI66420     Document Type: Note

References (19)

1. Komander D, Clague MJ, Urbe S. Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol. 2009;10(8):550-563.
2. Zhang Y, et al. USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J Clin Invest. 2012;122(12):4362-4374.
3. Holland AJ, Cleveland DW. Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep. 2012;13(6):501-514.
4. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature. 1997;386(6625):623-627. (Pubitemid 27175430)
5. Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol. 2007;8(5):379-393. (Pubitemid 46643240)
6. Stegmeier F, et al. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 2007;446(7138):876-881.
7. Nilsson J, Yekezare M, Minshull J, Pines J. The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nature Cell Biol. 2008;10(12):1411-1420.
8. Varetti G, Guida C, Santaguida S, Chiroli E, Musacchio A. Homeostatic control of mitotic arrest. Mol Cell. 2011;44(5):710-720.
9. Holland AJ, Cleveland DW. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol. 2009;10(7):478-487.
10. Michel LS, et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature. 2001;409(6818):355-359. (Pubitemid 32151241)
11. Cimini D. Merotelic kinetochore orientation, aneuploidy, and cancer. Biochim Biophys Acta. 2008;1786(1):32-40.
12. Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature. 2009;460(7252):278-282.
13. Silkworth WT, Nardi IK, Scholl LM, Cimini D. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome missegregation in cancer cells. PLoS One. 2009;4(8):e6564.
14. Silkworth WT, Nardi IK, Paul R, Mogilner A, Cimini D. Timing of centrosome separation is important for accurate chromosome segregation. Mol Biol Cell. 2012;23(3):401-411.
15. Araki M, et al. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J Biol Chem. 2001;276(22):18665-18672.
16. Fuchs G, et al. RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Mol Cell. 2012;46(5):662-673.
17. Torres EM, et al. Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science. 2007;317(5840):916-924. (Pubitemid 47301313)
18. Williams BR, et al. Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science. 2008;322(5902):703-709.
19. Torres EM, et al. Identification of aneuploidy-tolerating mutations. Cell. 2010;143(1):71-83.