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Volumn 14, Issue 5, 2012, Pages 468-472

The kidney and hypertension: Pathogenesis of salt-sensitive hypertension

Author keywords

2 adrenoceptor; Angiotensin II; Blood pressure; Distal tubule; ENaC; Epigenetics; Glucocorticoid receptor; HDAC8; Histone acetylation; Hypertension; Kidney; Mineralocorticoid receptor; MR; NCC; Oxidative stress; Rac1; Renal injury; RhoGDI; Roximal tubule; Salt sensitive hypertension; SgK1; Sympathetic nerve; WNK4

Indexed keywords

ALDOSTERONE; BETA 2 ADRENERGIC RECEPTOR; GLUCOCORTICOID RECEPTOR; GUANOSINE TRIPHOSPHATASE; HISTONE; HISTONE DEACETYLASE 8; MINERALOCORTICOID RECEPTOR; PROTEIN KINASE WNK4; RAC1 PROTEIN; SODIUM; SODIUM CHLORIDE COTRANSPORTER;

EID: 84870508903     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-012-0284-5     Document Type: Review
Times cited : (9)

References (39)
  • 1
    • 0018821821 scopus 로고
    • Factors influencing blood pressure in salt-sensitive patients with hypertension
    • Fujita T, Henry W, Bartter F, Lake C, Delea C. Factors influencing blood pressure in salt-sensitive patients with hypertension. Am J Med. 1980;69:334-44.
    • (1980) Am J Med , vol.69 , pp. 334-44
    • Fujita, T.1    Henry, W.2    Bartter, F.3    Lake, C.4    Delea, C.5
  • 2
    • 0031581585 scopus 로고    scopus 로고
    • Sodium sensitivity and cardiovascular events in patients with essential hypertension
    • Morimoto A, Uzu T, Fujii T, Nishimura M, Kuroda S, Nakamura S, et al. Sodium sensitivity and cardiovascular events in patients with essential hypertension. Lancet. 1997;350:1734-7.
    • (1997) Lancet , vol.350 , pp. 1734-7
    • Morimoto, A.1    Uzu, T.2    Fujii, T.3    Nishimura, M.4    Kuroda, S.5    Nakamura, S.6
  • 3
    • 0025817650 scopus 로고
    • Blood pressure control-special role of the kidneys and body fluids
    • Guyton AC. Blood pressure control-special role of the kidneys and body fluids. Science. 1991;252:1813-16.
    • (1991) Science , vol.252 , pp. 1813-16
    • Guyton, A.C.1
  • 5
  • 6
    • 4644240440 scopus 로고    scopus 로고
    • A novel pathway of epithelial sodium channel activation involves a serum-and glucocorticoid-inducible kinase consensus motif in the c terminus of the channel's alphasubunit
    • Diakov A, Korbmacher C. A novel pathway of epithelial sodium channel activation involves a serum-and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alphasubunit. J Biol Chem. 2004;279:38134-42.
    • (2004) J Biol Chem , vol.279 , pp. 38134-42
    • Diakov, A.1    Korbmacher, C.2
  • 7
    • 80052774337 scopus 로고    scopus 로고
    • Epithelial sodium channel regulation by cell surface-associated serum-and glucocorticoid-regulated kinase 1
    • Thomas SV, Kathpalia PP, Rajagopal M, Charlton C, Zhang J, Eaton DC, et al. Epithelial sodium channel regulation by cell surface-associated serum-and glucocorticoid-regulated kinase 1. J Biol Chem. 2011;286:32074-85.
    • (2011) J Biol Chem , vol.286 , pp. 32074-85
    • Thomas, S.V.1    Kathpalia, P.P.2    Rajagopal, M.3    Charlton, C.4    Zhang, J.5    Eaton, D.C.6
  • 9
    • 33847402692 scopus 로고    scopus 로고
    • Salt, sodium channels, and sgk1
    • Pearce D, Kleyman TR. Salt, sodium channels, and SGK1. J Clin Invest. 2007;117:592-5.
    • (2007) J Clin Invest , vol.117 , pp. 592-5
    • Pearce, D.1    Kleyman, T.R.2
  • 10
    • 33847412788 scopus 로고    scopus 로고
    • Aldosterone-induced sgk1 relieves dot1a-af9-mediated transcriptional repression of epithelial na+channel alpha
    • Zhang W, Xia X, Reisenauer MR, Rieg T, Lang F, Kuhl D, et al. Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+channel alpha. J Clin Invest. 2007;117:773-83.
    • (2007) J Clin Invest , vol.117 , pp. 773-83
    • Zhang, W.1    Xia, X.2    Reisenauer, M.R.3    Rieg, T.4    Lang, F.5    Kuhl, D.6
  • 11
    • 84856349666 scopus 로고    scopus 로고
    • The role of the enacregulatory complex in aldosterone-mediated sodium transport
    • Soundararajan R, Pearce D, Ziera T. The role of the ENaCregulatory complex in aldosterone-mediated sodium transport. Mol Cell Endocrinol. 2012;350:242-7.
    • (2012) Mol Cell Endocrinol , vol.350 , pp. 242-7
    • Soundararajan, R.1    Pearce, D.2    Ziera, T.3
  • 12
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators
    • Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999;341:709-17.
    • (1999) N Engl J Med , vol.341 , pp. 709-17
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6
  • 13
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309-21.
    • (2003) N Engl J Med , vol.348 , pp. 1309-21
    • Pitt, B.1    Remme, W.2    Zannad, F.3    Neaton, J.4    Martinez, F.5    Roniker, B.6
  • 14
    • 0034824358 scopus 로고    scopus 로고
    • A new human mr splice variant is a ligand-independent transactivator modulating corticosteroid action
    • Zennaro MC, Souque A, Viengchareun S, Poisson E, Lombes M. A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action.Mol Endocrinol. 2001;15:1586-98.
    • (2001) Mol Endocrinol , vol.15 , pp. 1586-98
    • Zennaro, M.C.1    Souque, A.2    Viengchareun, S.3    Poisson, E.4    Lombes, M.5
  • 15
    • 73349119698 scopus 로고    scopus 로고
    • Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction
    • Mihailidou AS, Le Loan TY, Mardini M, Funder JW. Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction. Hypertension. 2009;54:1306-12.
    • (2009) Hypertension , vol.54 , pp. 1306-12
    • Mihailidou, A.S.1    Le Loan, T.Y.2    Mardini, M.3    Funder, J.W.4
  • 16
    • 54449090744 scopus 로고    scopus 로고
    • Paradoxical mineralocorticoid receptor activation and left ventricular diastolic dysfunction under high oxidative stress conditions
    • Wang H, Shimosawa T, Matsui H, Kaneko T, Ogura S, Uetake Y, et al. Paradoxical mineralocorticoid receptor activation and left ventricular diastolic dysfunction under high oxidative stress conditions. J Hypertens. 2008;26:1453-62.
    • (2008) J Hypertens , vol.26 , pp. 1453-62
    • Wang, H.1    Shimosawa, T.2    Matsui, H.3    Kaneko, T.4    Ogura, S.5    Uetake, Y.6
  • 17
    • 57349168398 scopus 로고    scopus 로고
    • Modification of mineralocorticoid receptor function by rac1 gtpase: Implication in proteinuric kidney disease
    • This is the original paper that reported rac1 activate MR independent from aldosterone in the kidney, and this aldosterone-independent MR activation causes renal dysfunction
    • Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, et al. Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.NatMed. 2008;14:1370-6. This is the original paper that reported rac1 activate MR independent from aldosterone in the kidney, and this aldosterone-independent MR activation causes renal dysfunction.
    • (2008) NatMed , vol.14 , pp. 1370-6
    • Shibata, S.1    Nagase, M.2    Yoshida, S.3    Kawarazaki, W.4    Kurihara, H.5    Tanaka, H.6
  • 18
    • 79960972766 scopus 로고    scopus 로고
    • Rac1 gtpase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptordependent pathway
    • This paper reported that rac1-mediated MR activation causes salt-sensitive hypertension in several rodent model
    • Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, et al. Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptordependent pathway. J Clin Invest. 2011;121:3233-43. This paper reported that rac1-mediated MR activation causes salt-sensitive hypertension in several rodent model.
    • (2011) J Clin Invest , vol.121 , pp. 3233-43
    • Shibata, S.1    Mu, S.2    Kawarazaki, H.3    Muraoka, K.4    Ishizawa, K.5    Yoshida, S.6
  • 19
    • 0032523208 scopus 로고    scopus 로고
    • Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10
    • Rapp JP, Garrett MR, Deng AY. Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10. J Clin Invest. 1998;101:1591-5.
    • (1998) J Clin Invest , vol.101 , pp. 1591-5
    • Rapp, J.P.1    Garrett, M.R.2    Deng, A.Y.3
  • 20
    • 0035726878 scopus 로고    scopus 로고
    • Two linked blood pressure quantitative trait loci on chromosome 10 defined by dahl rat congenic strains
    • GarrettMR, Zhang X, Dukhanina OI, Deng AY, Rapp JP. Two linked blood pressure quantitative trait loci on chromosome 10 defined by dahl rat congenic strains. Hypertension. 2001;38:779-85.
    • (2001) Hypertension , vol.38 , pp. 779-85
    • Garrett, M.R.1    Zhang, X.2    Dukhanina, O.I.3    Deng, A.Y.4    Rapp, J.P.5
  • 22
    • 0031038067 scopus 로고    scopus 로고
    • Differential central modulation of the baroreflex by salt loading in normotensive and spontaneously hypertensive rats
    • Ono A, Kuwaki T, Kumada M, Fujita T. Differential central modulation of the baroreflex by salt loading in normotensive and spontaneously hypertensive rats. Hypertension. 1997;29:808-14.
    • (1997) Hypertension , vol.29 , pp. 808-14
    • Ono, A.1    Kuwaki, T.2    Kumada, M.3    Fujita, T.4
  • 23
    • 0026687065 scopus 로고
    • Role of hypothalamic-renal noradrenergic systems in hypotensive action of potassium
    • Fujita T, Sato Y. Role of hypothalamic-renal noradrenergic systems in hypotensive action of potassium. Hypertension. 1992;20:466-72.
    • (1992) Hypertension , vol.20 , pp. 466-72
    • Fujita, T.1    Sato, Y.2
  • 25
    • 84863012892 scopus 로고    scopus 로고
    • Increased expression of nad(p)h oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and saltsensitive hypertension
    • Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, et al. Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and saltsensitive hypertension. Cell Metab. 2012;15:201-8.
    • (2012) Cell Metab , vol.15 , pp. 201-8
    • Feng, D.1    Yang, C.2    Geurts, A.M.3    Kurth, T.4    Liang, M.5    Lazar, J.6
  • 26
    • 2442706556 scopus 로고    scopus 로고
    • Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats
    • Kishi T, Hirooka Y, Kimura Y, Ito K, Shimokawa H, Takeshita A. Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats. Circulation. 2004;109:2357-62.
    • (2004) Circulation , vol.109 , pp. 2357-62
    • Kishi, T.1    Hirooka, Y.2    Kimura, Y.3    Ito, K.4    Shimokawa, H.5    Takeshita, A.6
  • 27
    • 83655167069 scopus 로고    scopus 로고
    • Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease
    • Fujita M, Ando K, Kawarazaki H, Kawarasaki C, Muraoka K, Ohtsu H, et al. Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease. Hypertension. 2012;59:105-12.
    • (2012) Hypertension , vol.59 , pp. 105-12
    • Fujita, M.1    Ando, K.2    Kawarazaki, H.3    Kawarasaki, C.4    Muraoka, K.5    Ohtsu, H.6
  • 28
    • 78649876825 scopus 로고    scopus 로고
    • Renal sympathetic denervation in patients with treatment-resistant hypertension (the symplicity htn-2 trial): A randomised controlled trial
    • Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:1903-9.
    • (2010) Lancet , vol.9 , pp. 376
    • Esler, M.D.1    Krum, H.2    Sobotka, P.A.3    Schlaich, M.P.4    Schmieder, R.E.5    Bohm, M.6
  • 29
    • 64049084640 scopus 로고    scopus 로고
    • Catheter-based renal sympathetic denervation for resistant hypertension: A multicentre safety and proof-of-principle cohort study
    • Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373:1275-81.
    • (2009) Lancet , vol.373 , pp. 1275-81
    • Krum, H.1    Schlaich, M.2    Whitbourn, R.3    Sobotka, P.A.4    Sadowski, J.5    Bartus, K.6
  • 32
    • 0037338688 scopus 로고    scopus 로고
    • Neural control of the kidney:past, present and future
    • DiBona GF. Neural control of the kidney:past, present and future. Hypertension. 2003;41:621-4.
    • (2003) Hypertension , vol.41 , pp. 621-4
    • DiBona, G.F.1
  • 33
    • 79953743181 scopus 로고    scopus 로고
    • At1a angiotensin receptors in the renal proximal tubule regulate blood pressure
    • It Has Been Postulated That Renal Rather Than Cardiac Or Vascular AT1 Receptor Plays An Important Role In Hypertension By These Authors. In this paper, they precisely investigated the AT1 receptor at proximal tubule increases sodium resorption to induce volumedependent hypertension
    • Gurley SB, Riquier-Brison AD, Schnermann J, Sparks MA, Allen AM, Haase VH, et al. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011;13:469-75. It has been postulated that renal rather than cardiac or vascular AT1 receptor plays an important role in hypertension by these authors. In this paper, they precisely investigated the AT1 receptor at proximal tubule increases sodium resorption to induce volumedependent hypertension.
    • (2011) Cell Metab. , vol.13 , pp. 469-75
    • Gurley, S.B.1    Riquier-Brison, A.D.2    Schnermann, J.3    Sparks, M.A.4    Allen, A.M.5    Haase, V.H.6
  • 34
    • 43549123915 scopus 로고    scopus 로고
    • Molecular physiology of the wnk kinases
    • This is a comprehensive review of WNK kinase
    • Kahle KT, Ring AM, Lifton RP. Molecular physiology of the WNK kinases. Annu Rev Physiol. 2008;70:329-55. This is a comprehensive review of WNK kinase.
    • (2008) Annu Rev Physiol , vol.70 , pp. 329-55
    • Kahle, K.T.1    Ring, A.M.2    Lifton, R.P.3
  • 36
    • 33749118898 scopus 로고    scopus 로고
    • Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule
    • Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, et al. Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet. 2006;38:1124-32.
    • (2006) Nat Genet , vol.38 , pp. 1124-32
    • Lalioti, M.D.1    Zhang, J.2    Volkman, H.M.3    Kahle, K.T.4    Hoffmann, K.E.5    Toka, H.R.6
  • 38
    • 34147120764 scopus 로고    scopus 로고
    • Function and regulation of epithelial sodium transporters in the kidney of a salt-sensitive hypertensive rat model
    • Li J, Wang DH. Function and regulation of epithelial sodium transporters in the kidney of a salt-sensitive hypertensive rat model. J Hypertens. 2007;25:1065-72.
    • (2007) J Hypertens , vol.25 , pp. 1065-72
    • Li, J.1    Wang, D.H.2
  • 39
    • 85027925594 scopus 로고    scopus 로고
    • Epigenetic modulation of the renal beta-adrenergic-wnk4 pathway in salt-sensitive hypertension
    • This paper showed that beta2 receptor-mediated HDAC8 inhibition leads to suppression of WNK4 and stimulates NCC to cause salt-sensitive hypertension
    • Mu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, et al. Epigenetic modulation of the renal beta-adrenergic-WNK4 pathway in salt-sensitive hypertension. Nat Med. 2011;17 (5):573-80. This paper showed that beta2 receptor-mediated HDAC8 inhibition leads to suppression of WNK4 and stimulates NCC to cause salt-sensitive hypertension.
    • (2011) Nat Med , vol.17 , Issue.5 , pp. 573-80
    • Mu, S.1    Shimosawa, T.2    Ogura, S.3    Wang, H.4    Uetake, Y.5    Kawakami-Mori, F.6


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