-
1
-
-
0001152543
-
Konstitution des aldosterons, des neuen mineralocorticoids
-
Simpson SA, Tait JF, Wettstein A, et al. Konstitution des aldosterons, des neuen mineralocorticoids. Experientia. 1953;10:132-3.
-
(1953)
Experientia
, vol.10
, pp. 132-3
-
-
Simpson, S.A.1
Tait, J.F.2
Wettstein, A.3
-
2
-
-
2342642610
-
Primary aldosteronism, a new clinical syndrome
-
Conn JW. Primary aldosteronism, a new clinical syndrome. J Lab Clin Med. 1955;45:3-7.
-
(1955)
J Lab Clin Med
, vol.45
, pp. 3-7
-
-
Conn, J.W.1
-
3
-
-
84856347698
-
Aldosterone and mineralocorticoid receptors: A personal reflection
-
Funder JW. Aldosterone and mineralocorticoid receptors: a personal reflection. Mol Cell Endocrinol. 2012;350:146-50.
-
(2012)
Mol Cell Endocrinol
, vol.350
, pp. 146-50
-
-
Funder, J.W.1
-
4
-
-
0015295870
-
Specific aldosterone binding in rat kidney and parotid
-
Funder JW, Feldman D, Edelman I. Specific Aldosterone binding in rat kidney and parotid. J Steroid Biochem. 1972;3:209-18.
-
(1972)
J Steroid Biochem
, vol.3
, pp. 209-18
-
-
Funder, J.W.1
Feldman, D.2
Edelman, I.3
-
6
-
-
0023221667
-
Cloning of human mineralocorticoid receptor complementary dna: Structural and functional kinship with the glucocorticoid receptor
-
Arriza JW, Weinberger C, Cerelli G, et al. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science. 1987;237:268-75.
-
(1987)
Science
, vol.237
, pp. 268-75
-
-
Arriza, J.W.1
Weinberger, C.2
Cerelli, G.3
-
7
-
-
38749154752
-
The mineralocorticoid receptor: Insights into its molecular and (patho)physiological biology
-
Viengchareun S, Le Menuet D, Martinerie L, et al. The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology. Nucl Recept Signal. 2007;5:e012.
-
(2007)
Nucl Recept Signal
, vol.5
-
-
Viengchareun, S.1
Le Menuet, D.2
Martinerie, L.3
-
8
-
-
0020858445
-
Aldosterone binding in isolated tubules. Iii. Autoradiography along the rat nephron
-
Farman N, Bonvalet JP. Aldosterone binding in isolated tubules. III. Autoradiography along the rat nephron. Am J Physiol. 1983;245:F606-614.
-
(1983)
Am J Physiol
, vol.245
-
-
Farman, N.1
Bonvalet, J.P.2
-
9
-
-
0026078582
-
Immunolocalization of gluco-and mineralocorticoid receptors in rabbit kidney
-
Farman N, Oblin ME, Lombes M, et al. Immunolocalization of gluco-and mineralocorticoid receptors in rabbit kidney. Am J Physiol. 1991;260:C226-233.
-
(1991)
Am J Physiol
, vol.260
-
-
Farman, N.1
Oblin, M.E.2
Lombes, M.3
-
10
-
-
21244485815
-
Mineralocorticoid receptors: Distribution and activation
-
Funder JW. Mineralocorticoid receptors: distribution and activation. Heart Fail Rev. 2005;10:15-22.
-
(2005)
Heart Fail Rev
, vol.10
, pp. 15-22
-
-
Funder, J.W.1
-
11
-
-
0022383620
-
Two receptor systems for coticosterone in rat brain: Microdistribution and differential occupation
-
Reul JMH, De Kloet ER. Two receptor systems for coticosterone in rat brain: microdistribution and differential occupation. Endocrinology. 1985;117:2505-11.
-
(1985)
Endocrinology
, vol.117
, pp. 2505-11
-
-
Reul, J.M.H.1
De Kloet, E.R.2
-
13
-
-
32644432179
-
Development of a panel of monoclonal antibodies against the mineralocorticoid receptor
-
Gomez-Sanchez CE, de Rodriguez AF, Romero DG, et al. Development of a panel of monoclonal antibodies against the mineralocorticoid receptor. Endocrinology. 2006;147:1343-8.
-
(2006)
Endocrinology
, vol.147
, pp. 1343-8
-
-
Gomez-Sanchez, C.E.1
De Rodriguez, A.F.2
Romero, D.G.3
-
14
-
-
1642281192
-
Brain mineralocorticoid receptors: Orchestrators of hypertension and end-organ disease
-
Gomez-Sanchez EP. Brain mineralocorticoid receptors: orchestrators of hypertension and end-organ disease. Curr Opin Nephrol Hypertens. 2004;13:191-6.
-
(2004)
Curr Opin Nephrol Hypertens
, vol.13
, pp. 191-6
-
-
Gomez-Sanchez, E.P.1
-
15
-
-
67651166733
-
Immunohistochemical demonstration of the mineralocorticoid receptor, 11{beta}-hydroxysteroid dehydrogenase-1 and -2, and hexose-6-phosphate dehydrogenase in rat ovary
-
Gomez-Sanchez EP, Gomez-Sanchez MT, de Rodriguez AF, et al. Immunohistochemical Demonstration of the Mineralocorticoid Receptor, 11{beta}-Hydroxysteroid Dehydrogenase-1 and -2, and Hexose-6-phosphate Dehydrogenase in Rat Ovary. J Histochem Cytochem. 2009;57:633-41.
-
(2009)
J Histochem Cytochem
, vol.57
, pp. 633-41
-
-
Gomez-Sanchez, E.P.1
Gomez-Sanchez, M.T.2
De Rodriguez, A.F.3
-
16
-
-
81155155589
-
Diverse immunostaining patterns of mineralocorticoid receptor monoclonal antibodies
-
Gomez-Sanchez CE, Warden M, Gomez-Sanchez MT, et al. Diverse immunostaining patterns of mineralocorticoid receptor monoclonal antibodies. Steroids. 2011;76:1541-5.
-
(2011)
Steroids
, vol.76
, pp. 1541-5
-
-
Gomez-Sanchez, C.E.1
Warden, M.2
Gomez-Sanchez, M.T.3
-
17
-
-
0020535352
-
Aldosterone blocks the response to corticosterone in the raphe-hippocampal serotonin system
-
De Kloet ER, Versteeg DHG, Kovacs GL. Aldosterone blocks the response to corticosterone in the raphe-hippocampal serotonin system. Brain Res. 1983;264:323-7.
-
(1983)
Brain Res
, vol.264
, pp. 323-7
-
-
De Kloet, E.R.1
Versteeg, D.H.G.2
Kovacs, G.L.3
-
18
-
-
0030444810
-
Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: In vivo binding studies
-
Funder J, Myles K. Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: in vivo binding studies. Endocrinology. 1996;137:5264-8.
-
(1996)
Endocrinology
, vol.137
, pp. 5264-5268
-
-
Funder, J.1
Myles, K.2
-
19
-
-
2542624590
-
Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity
-
Krozowski ZS, Funder JW. Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity. Proc Natl Acad Sci U S A. 1983;80:6056-60.
-
(1983)
Proc Natl Acad Sci U S A
, vol.80
, pp. 6056-6060
-
-
Krozowski, Z.S.1
Funder, J.W.2
-
20
-
-
0023743171
-
Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated
-
Funder JW, Pearce PT, Smith R, Smith AI. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science. 1988;242:583-5.
-
(1988)
Science
, vol.242
, pp. 583-5
-
-
Funder, J.W.1
Pearce, P.T.2
Smith, R.3
Smith, A.I.4
-
21
-
-
0023761690
-
Localisation of 11bhydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor
-
Edwards CRW, Burt D, McIntyre MA, et al. Localisation of 11bhydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet. 1988;ii:986-9.
-
(1988)
Lancet
, vol.2
, pp. 986-9
-
-
Edwards, C.R.W.1
Burt, D.2
McIntyre, M.A.3
-
22
-
-
0023242981
-
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
-
Stewart PM, Wallace AM, Valentino R, et al. Mineralocorticoid activity of liquorice: 11-Beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet. 1987;ii:821-4.
-
(1987)
Lancet
, vol.2
, pp. 821-4
-
-
Stewart, P.M.1
Wallace, A.M.2
Valentino, R.3
-
23
-
-
79955521340
-
Human mineralocorticoid receptor (mr) gene haplotypes modulate mr expression and transactivation: Implication for the stress response
-
van Leeuwen N, Bellingrath S, de Kloet ER, et al. Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: implication for the stress response. Psychoneuroendocrinology. 2011;36:699-709.
-
(2011)
Psychoneuroendocrinology
, vol.36
, pp. 699-709
-
-
Van Leeuwen, N.1
Bellingrath, S.2
De Kloet, E.R.3
-
25
-
-
74049157084
-
The mammalian mineralocorticoid receptor: Tying down a promiscuous receptor
-
Gomez-Sanchez EP. The mammalian mineralocorticoid receptor: tying down a promiscuous receptor. Exp Physiol. 2010;95:13-8.
-
(2010)
Exp Physiol
, vol.95
, pp. 13-8
-
-
Gomez-Sanchez, E.P.1
-
26
-
-
22444431688
-
Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions
-
Grossmann C, Benesic A, Krug AW, et al. Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions. Mol Endocrinol. 2005;19:1697-710.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 1697-1710
-
-
Grossmann, C.1
Benesic, A.2
Krug, A.W.3
-
27
-
-
18844367745
-
The nongenomic actions of aldosterone
-
Funder JW. The nongenomic actions of aldosterone. Endocr Rev. 2005;26:313-21.
-
(2005)
Endocr Rev
, vol.26
, pp. 313-21
-
-
Funder, J.W.1
-
28
-
-
84857041524
-
Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling
-
Groeneweg FL, Karst H, de Kloet ER, Joels M. Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling. Mol Cell Endocrinol. 2011.
-
Mol Cell Endocrinol
, vol.2011
-
-
Groeneweg, F.L.1
Karst, H.2
De Kloet, E.R.3
Joels, M.4
-
29
-
-
79953235261
-
Gpr30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone
-
Gros R, Ding Q, Sklar LA, et al. GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone. Hypertension. 2011;57:442-51.
-
(2011)
Hypertension
, vol.57
, pp. 442-51
-
-
Gros, R.1
Ding, Q.2
Sklar, L.A.3
-
30
-
-
0038314371
-
Production of nephrosclerosis and cardiac hypertrophy in the rat by desoxycorticosterone acetate overdosage
-
Selye H, Hall CE. Production of nephrosclerosis and cardiac hypertrophy in the rat by desoxycorticosterone acetate overdosage. Am Heart J. 1943;27:338-44.
-
(1943)
Am Heart J
, vol.27
, pp. 338-44
-
-
Selye, H.1
Hall, C.E.2
-
31
-
-
85047680324
-
Myocardial fibrosis: Functional significance and regulatory factors
-
Weber KT, Brilla CG, Janicki JS. Myocardial fibrosis: functional significance and regulatory factors. Cardiovasc Res. 1993;27:341-8.
-
(1993)
Cardiovasc Res
, vol.27
, pp. 341-348
-
-
Weber, K.T.1
Brilla, C.G.2
Janicki, J.S.3
-
32
-
-
0028360454
-
Increased cardiac types i and iii collagen mrnas in aldosterone-salt hypertension
-
Robert V, Van Thiem N, Cheav SL, et al. Increased cardiac types I and III collagen mRNAs in aldosterone-salt hypertension. Hypertension. 1994;24:30-6.
-
(1994)
Hypertension
, vol.24
, pp. 30-6
-
-
Robert, V.1
Van Thiem, N.2
Cheav, S.L.3
-
33
-
-
0027499223
-
Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension
-
Brilla CG, Matsubara LS, Weber KT. Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension. Am J Card. 1993;71:12A-6A.
-
(1993)
Am J Card
, vol.71
-
-
Brilla, C.G.1
Matsubara, L.S.2
Weber, K.T.3
-
35
-
-
0033745021
-
Aldosterone: A mediator of myocardial necrosis and renal arteriopathy
-
Rocha R, Stier CT, Kifor I, et al. Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. Endocrinology. 2000;141:3871-8.
-
(2000)
Endocrinology
, vol.141
, pp. 3871-8
-
-
Rocha, R.1
Stier, C.T.2
Kifor, I.3
-
36
-
-
0028290539
-
Mineralocorticoids, hypertension, and cardiac fibrosis
-
Young M, Fullerton M, Dilley R, Funder J. Mineralocorticoids, hypertension, and cardiac fibrosis. J Clin Invest. 1994;93:2578-83.
-
(1994)
J Clin Invest
, vol.93
, pp. 2578-83
-
-
Young, M.1
Fullerton, M.2
Dilley, R.3
Funder, J.4
-
37
-
-
0028901442
-
Mineralocorticoid modulation of central control of blood pressure
-
Gomez-Sanchez EP. Mineralocorticoid modulation of central control of blood pressure. Steroids. 1995;60:69-72.
-
(1995)
Steroids
, vol.60
, pp. 69-72
-
-
Gomez-Sanchez, E.P.1
-
38
-
-
84856346254
-
Mechanisms of mineralocorticoid saltinduced hypertension and cardiac fibrosis
-
Young MJ, Rickard AJ. Mechanisms of mineralocorticoid saltinduced hypertension and cardiac fibrosis. Mol Cell Endocrinol. 2012;350:248-55.
-
(2012)
Mol Cell Endocrinol
, vol.350
, pp. 248-55
-
-
Young, M.J.1
Rickard, A.J.2
-
39
-
-
0028914059
-
Escape of aldosterone production in patients with left ventricular dysfunction treated with an angiotensin converting enzyme inhibitor: Implications for therapy
-
Pitt B. "Escape" of aldosterone production in patients with left ventricular dysfunction treated with an angiotensin converting enzyme inhibitor: implications for therapy. Cardiovasc Drugs Ther. 1995;9:145-9.
-
(1995)
Cardiovasc Drugs Ther
, vol.9
, pp. 145-9
-
-
Pitt, B.1
-
40
-
-
0025088737
-
Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. Consensus trial study group
-
Swedberg K, Eneroth P, Kjekshus J, Wilhelmsen L. Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group. Circulation. 1990;82:1730-6.
-
(1990)
Circulation
, vol.82
, pp. 1730-6
-
-
Swedberg, K.1
Eneroth, P.2
Kjekshus, J.3
Wilhelmsen, L.4
-
41
-
-
0030939082
-
Remodeling of the left ventricle in primary aldosteronism due to conn's adenoma
-
Rossi GP, Sacchetto A, Pavan E, et al. Remodeling of the left ventricle in primary aldosteronism due to Conn's adenoma. Circulation. 1997;95:1471-8.
-
(1997)
Circulation
, vol.95
, pp. 1471-8
-
-
Rossi, G.P.1
Sacchetto, A.2
Pavan, E.3
-
42
-
-
0033517302
-
The effect of spironolactone on mobidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators
-
Pitt B, Zannad F, Cody R, et al. The effect of spironolactone on mobidity and mortality in patients with severe heart failure. Randomized Aldactone evaluation study investigators. N Engl J Med. 1999;341:709-17.
-
(1999)
N Engl J Med
, vol.341
, pp. 709-17
-
-
Pitt, B.1
Zannad, F.2
Cody, R.3
-
43
-
-
0037417252
-
Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
-
Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309-21.
-
(2003)
N Engl J Med
, vol.348
, pp. 1309-1321
-
-
Pitt, B.1
Remme, W.2
Zannad, F.3
-
44
-
-
78650399880
-
Eplerenone in patients with systolic heart failure and mild symptoms
-
This paper extended the benefit of the use of mineralocorticoid receptor antagonists in patients with mild systolic congestive heart failure
-
Zannad F, McMurray JJ, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011;364:11-21. This paper extended the benefit of the use of mineralocorticoid receptor antagonists in patients with mild systolic congestive heart failure.
-
(2011)
N Engl J Med
, vol.364
, pp. 11-21
-
-
Zannad, F.1
McMurray, J.J.2
Krum, H.3
-
45
-
-
80054975039
-
Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects. Insights from an ephesus (eplerenone post-acute myocardial infarction heart failure efficacy and survival study) substudy
-
This study clarified that the beneficial effects of mineralocorticoid receptor antagonists were more direct rather than just as a potassium-sparing diuretic
-
Rossignol P, Menard J, Fay R, et al. Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects. Insights from an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) substudy. J Am Coll Cardiol. 2011;58:1958-66. This study clarified that the beneficial effects of mineralocorticoid receptor antagonists were more direct rather than just as a potassium-sparing diuretic.
-
(2011)
J Am Coll Cardiol
, vol.58
, pp. 66
-
-
Rossignol, P.1
Menard, J.2
Fay, R.3
-
46
-
-
0142085752
-
Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4e-left ventricular hypertrophy study
-
Pitt B, Reichek N, Willenbrock R, et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation. 2003;108:1831-8.
-
(2003)
Circulation
, vol.108
, pp. 1831-8
-
-
Pitt, B.1
Reichek, N.2
Willenbrock, R.3
-
47
-
-
3442886513
-
Rates of hyperkalemia after publication of the randomized aldactone evaluation study
-
Juurlink DN, Mamdani MM, Lee DS, et al. Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med. 2004;351:543-51.
-
(2004)
N Engl J Med
, vol.351
, pp. 543-51
-
-
Juurlink, D.N.1
Mamdani, M.M.2
Lee, D.S.3
-
48
-
-
82555168277
-
Rationale and design of the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial: A randomized, controlled study of spironolactone in patients with symptomatic heart failure and preserved ejection fraction
-
e910
-
Desai AS, Lewis EF, Li R, et al. Rationale and design of the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial: a randomized, controlled study of spironolactone in patients with symptomatic heart failure and preserved ejection fraction. Am Heart J. 2011;162:966-72. e910.
-
(2011)
Am Heart J
, vol.162
, pp. 966-72
-
-
Desai, A.S.1
Lewis, E.F.2
Li, R.3
-
49
-
-
77957955333
-
Rationale for an early aldosterone blockade in acute myocardial infarction and design of the albatross trial
-
Beygui F, Vicaut E, Ecollan P, et al. Rationale for an early aldosterone blockade in acute myocardial infarction and design of the ALBATROSS trial. Am Heart J. 2010;160:642-8.
-
(2010)
Am Heart J
, vol.160
, pp. 642-8
-
-
Beygui, F.1
Vicaut, E.2
Ecollan, P.3
-
50
-
-
84856339877
-
Aldosterone, mineralocorticoid receptor, and heart failure
-
Messaoudi S, Azibani F, Delcayre C, Jaisser F. Aldosterone, mineralocorticoid receptor, and heart failure. Mol Cell Endocrinol. 2012;350:266-72.
-
(2012)
Mol Cell Endocrinol
, vol.350
, pp. 266-72
-
-
Messaoudi, S.1
Azibani, F.2
Delcayre, C.3
Jaisser, F.4
-
51
-
-
73349119698
-
Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction
-
Mihailidou AS, Le Loan TY, Mardini M, Funder JW. Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction. Hypertension. 2009;54:1306-12.
-
(2009)
Hypertension
, vol.54
, pp. 1306-12
-
-
Mihailidou, A.S.1
Le Loan, T.Y.2
Mardini, M.3
Funder, J.W.4
-
52
-
-
80051953603
-
Aldosterone as a modulator of immunity: Implications in the organ damage
-
Herrada AA, Campino C, Amador CA, et al. Aldosterone as a modulator of immunity: implications in the organ damage. J Hypertens. 2011;29:1684-92.
-
(2011)
J Hypertens
, vol.29
, pp. 1684-92
-
-
Herrada, A.A.1
Campino, C.2
Amador, C.A.3
-
53
-
-
0035726581
-
Involvement of brain mineralocorticoid receptor in salt-enhanced hypertension in spontaneously hypertensive rats
-
Rahmouni K, Barthelmebs M, Grima M, et al. Involvement of brain mineralocorticoid receptor in salt-enhanced hypertension in spontaneously hypertensive rats. Hypertension. 2001;38:902-6.
-
(2001)
Hypertension
, vol.38
, pp. 902-6
-
-
Rahmouni, K.1
Barthelmebs, M.2
Grima, M.3
-
54
-
-
77954503924
-
Activation ofmineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats
-
YoungMJ,Morgan J, Brolin K, et al. Activation ofmineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats. Endocrinology. 2010;151:2622-8.
-
(2010)
Endocrinology
, vol.151
, pp. 2622-8
-
-
Young, M.J.1
Morgan, J.2
Brolin, K.3
-
55
-
-
0029810416
-
Role of aldosterone in the remnant kidney model in the rat
-
Greene EL, Kren S, Hostetter TH. Role of aldosterone in the remnant kidney model in the rat. J Clin Invest. 1996;98:1063-8.
-
(1996)
J Clin Invest
, vol.98
, pp. 1063-8
-
-
Greene, E.L.1
Kren, S.2
Hostetter, T.H.3
-
56
-
-
0242366540
-
Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats
-
Blasi ER, Rocha R, Rudolph AE, et al. Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. Kidney Int. 2003;63:1791-800.
-
(2003)
Kidney Int
, vol.63
, pp. 1791-800
-
-
Blasi, E.R.1
Rocha, R.2
Rudolph, A.E.3
-
57
-
-
84862737919
-
Macrophage mineralocorticoid receptor signaling plays a key role in aldosteroneindependent cardiac fibrosis
-
Bienvenu LA, Morgan J, Rickard AJ, et al. Macrophage mineralocorticoid receptor signaling plays a key role in aldosteroneindependent cardiac fibrosis. Endocrinology. 2012;153:3416-25.
-
(2012)
Endocrinology
, vol.153
, pp. 3416-25
-
-
Bienvenu, L.A.1
Morgan, J.2
Rickard, A.J.3
-
58
-
-
70349257487
-
Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure
-
Rickard AJ, Morgan J, Tesch G, et al. Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure. Hypertension. 2009;54:537-43.
-
(2009)
Hypertension
, vol.54
, pp. 537-43
-
-
Rickard, A.J.1
Morgan, J.2
Tesch, G.3
-
59
-
-
84856318868
-
Mineralocorticoid receptors in the pathophysiology of chronic kidney diseases and the metabolic syndrome
-
This is an excellent review of the mechanisms and clinical importance of mineralocorticoid receptor antagonists in kidney diseases, including diabetes and the metabolic syndrome
-
Shibata S, Fujita T. Mineralocorticoid receptors in the pathophysiology of chronic kidney diseases and the metabolic syndrome. Mol Cell Endocrinol. 2012;350:273-80. This is an excellent review of the mechanisms and clinical importance of mineralocorticoid receptor antagonists in kidney diseases, including diabetes and the metabolic syndrome.
-
(2012)
Mol Cell Endocrinol
, vol.350
, pp. 273-80
-
-
Shibata, S.1
Fujita, T.2
-
60
-
-
84859907412
-
Mineralocorticoid receptor-associated hypertension and its organ damage: Clinical relevance for resistant hypertension
-
Shibata H, Itoh H. Mineralocorticoid receptor-associated hypertension and its organ damage: clinical relevance for resistant hypertension. Am J Hypertens. 2012.
-
(2012)
Am J Hypertens
-
-
Shibata, H.1
Itoh, H.2
-
61
-
-
20144365498
-
Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability
-
Nishiyama A, Yao L, Fan Y, et al. Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability. Hypertension. 2005;45:710-6.
-
(2005)
Hypertension
, vol.45
, pp. 710-6
-
-
Nishiyama, A.1
Yao, L.2
Fan, Y.3
-
62
-
-
33751236177
-
Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus
-
Guo C, Martinez-Vasquez D, Mendez GP, et al. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology. 2006;147:5363-73.
-
(2006)
Endocrinology
, vol.147
, pp. 5363-73
-
-
Guo, C.1
Martinez-Vasquez, D.2
Mendez, G.P.3
-
63
-
-
84864023693
-
Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: A randomized placebo-controlled crossover study
-
This study demonstrates the effects of spironolactone improving the excretion of markers of renal dysfunction
-
Nielsen SE, Persson F, Frandsen E, et al. Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: a randomized placebo-controlled crossover study. Diabet Med. 2012. This study demonstrates the effects of spironolactone improving the excretion of markers of renal dysfunction.
-
(2012)
Diabet Med
-
-
Nielsen, S.E.1
Persson, F.2
Frandsen, E.3
-
64
-
-
33746566456
-
Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy
-
Schjoedt KJ, Rossing K, Juhl TR, et al. Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy. Kidney Int. 2006;70:536-42.
-
(2006)
Kidney Int
, vol.70
, pp. 536-42
-
-
Schjoedt, K.J.1
Rossing, K.2
Juhl, T.R.3
-
65
-
-
24144495285
-
Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: A randomized, double-masked, cross-over study
-
Rossing K, Schjoedt KJ, Smidt UM, et al. Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: a randomized, double-masked, cross-over study. Diabetes Care. 2005;28:2106-12.
-
(2005)
Diabetes Care
, vol.28
, pp. 2106-12
-
-
Rossing, K.1
Schjoedt, K.J.2
Smidt, U.M.3
-
66
-
-
0037222490
-
Effectiveness of aldosterone blockade in patients with diabetic nephropathy
-
Sato A, Hayashi K, Naruse M, Saruta T. Effectiveness of aldosterone blockade in patients with diabetic nephropathy. Hypertension. 2003;41:64-8.
-
(2003)
Hypertension
, vol.41
, pp. 64-8
-
-
Sato, A.1
Hayashi, K.2
Naruse, M.3
Saruta, T.4
-
67
-
-
84856997580
-
The safety and tolerability of spironolactone in patients with mild to moderate chronic kidney disease
-
Edwards NC, Steeds RP, Chue CD, et al. The safety and tolerability of spironolactone in patients with mild to moderate chronic kidney disease. Br J Clin Pharmacol. 2012;73:447-54.
-
(2012)
Br J Clin Pharmacol
, vol.73
, pp. 447-54
-
-
Edwards, N.C.1
Steeds, R.P.2
Chue, C.D.3
-
68
-
-
0033851802
-
The mineralocorticoid receptor mediates aldosterone-induced differentiation oft37i cells into brown adipocytes
-
Penfornis P, Viengchareun S, Le Menuet D, et al. The mineralocorticoid receptor mediates aldosterone-induced differentiation ofT37i cells into brown adipocytes. Am J Physiol Endocrinol Metab. 2000;279:386-94.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.279
, pp. 386-94
-
-
Penfornis, P.1
Viengchareun, S.2
Le Menuet, D.3
-
69
-
-
0034997787
-
Mineralocorticoid and glucocorticoid receptors inhibit ucp expression and function in brown adipocytes
-
Viengchareun S, Penfornis P, Zennaro MC, Lombes M. Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes. Am J Physiol Endocrinol Metab. 2001;280:E640-649.
-
(2001)
Am J Physiol Endocrinol Metab
, vol.280
-
-
Viengchareun, S.1
Penfornis, P.2
Zennaro, M.C.3
Lombes, M.4
-
71
-
-
11244311897
-
Fat cells may be the obesity-hypertension link: Human adipogenic factors stimulate aldosterone secretion from adrenocortical cells
-
Ehrhart-Bornstein M, Arakelyan K, Krug AW, et al. Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells. Endocr Res. 2004;30:865-70.
-
(2004)
Endocr Res
, vol.30
, pp. 865-70
-
-
Ehrhart-Bornstein, M.1
Arakelyan, K.2
Krug, A.W.3
-
72
-
-
33745713610
-
Adiponectin receptor expression in the human adrenal cortex and aldosteroneproducing adenomas
-
Rossi GP, Sticchi D, Giuliani L, et al. Adiponectin receptor expression in the human adrenal cortex and aldosteroneproducing adenomas. Int J Mol Med. 2006;17:975-80.
-
(2006)
Int J Mol Med
, vol.17
, pp. 975-80
-
-
Rossi, G.P.1
Sticchi, D.2
Giuliani, L.3
-
73
-
-
84860226019
-
Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: Implications in diabetes mellitus-associated obesity and vascular dysfunction
-
Briones AM, Cat AN, Callera GE, et al. Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension. 2012;59:1069-78.
-
(2012)
Hypertension
, vol.59
, pp. 1069-78
-
-
Briones, A.M.1
Cat, A.N.2
Callera, G.E.3
-
74
-
-
23144456873
-
Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes
-
Kraus D, Jager J, Meier B, et al. Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes. Horm Metab Res. 2005;37:455-9.
-
(2005)
Horm Metab Res
, vol.37
, pp. 455-9
-
-
Kraus, D.1
Jager, J.2
Meier, B.3
-
75
-
-
44049097881
-
Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines
-
Guo C, Ricchiuti V, Lian BQ, et al. Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines. Circulation. 2008;117:2253-61.
-
(2008)
Circulation
, vol.117
, pp. 2253-61
-
-
Guo, C.1
Ricchiuti, V.2
Lian, B.Q.3
-
76
-
-
78650805849
-
Antiadipogenic effects of the mineralocorticoid receptor antagonist drospirenone: Potential implications for the treatment of metabolic syndrome
-
Caprio M, Antelmi A, Chetrite G, et al. Antiadipogenic effects of the mineralocorticoid receptor antagonist drospirenone: potential implications for the treatment of metabolic syndrome. Endocrinology. 2011;152:113-25.
-
(2011)
Endocrinology
, vol.152
, pp. 113-25
-
-
Caprio, M.1
Antelmi, A.2
Chetrite, G.3
-
77
-
-
0009053718
-
Glucocorticosteroids and mineralocorticosteroid hormone target sites in the brain. Autoradiographic studies with corticosterone, aldosterone, deoxycorticosterone: In interaction within the brain-pituitary-adrenocortical system
-
In: Jones MT, Gillham B, Dallman MF, Chattopadhyay S. London, New York: Academic Press
-
Stumpf WE, Sar M. Glucocorticosteroids and mineralocorticosteroid hormone target sites in the brain. Autoradiographic studies with corticosterone, aldosterone, deoxycorticosterone: in interaction within the brain-pituitary- adrenocortical system. In: Jones MT, Gillham B, Dallman MF, Chattopadhyay S. Interactions within the Brain-Pituitary-Adrenocortical System. London, New York: Academic Press; 1979. pp. 137-147.
-
(1979)
Interactions within the Brain-Pituitary-Adrenocortical System
, pp. 137-147
-
-
Stumpf, W.E.1
Sar, M.2
-
78
-
-
84856351941
-
Central regulation of blood pressure by the mineralocorticoid receptor
-
Gomez-Sanchez EP, Gomez-Sanchez CE. Central regulation of blood pressure by the mineralocorticoid receptor. Mol Cell Endocrinol. 2012;350:289-98.
-
(2012)
Mol Cell Endocrinol
, vol.350
, pp. 289-98
-
-
Gomez-Sanchez, E.P.1
Gomez-Sanchez, C.E.2
-
79
-
-
32544438572
-
Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite
-
Geerling JC, Engeland WC, Kawata M, Loewy AD. Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite. J Neurosci. 2006;26:411-7.
-
(2006)
J Neurosci
, vol.26
, pp. 411-7
-
-
Geerling, J.C.1
Engeland, W.C.2
Kawata, M.3
Loewy, A.D.4
-
80
-
-
0023033295
-
Salt appetite is suppressed by interference with angiotensin ii and aldosterone
-
Sakai RR, Nicolaidis S, Epstein AN. Salt appetite is suppressed by interference with angiotensin II and aldosterone. Am J Physiol. 1986;251:R762-8.
-
(1986)
Am J Physiol
, vol.251
-
-
Sakai, R.R.1
Nicolaidis, S.2
Epstein, A.N.3
-
81
-
-
0030470427
-
Intracerebral administration of mineralocorticoid receptor antisense oligonucleotides attenuate adrenal steroid-induced salt appetite in rats
-
Sakai RR, Ma LY, Zhang DM, et al. Intracerebral administration of mineralocorticoid receptor antisense oligonucleotides attenuate adrenal steroid-induced salt appetite in rats. Neuroendocrinology. 1996;64:425-9.
-
(1996)
Neuroendocrinology
, vol.64
, pp. 425-9
-
-
Sakai, R.R.1
Ma, L.Y.2
Zhang, D.M.3
-
82
-
-
77957757456
-
Reversible sympathetic overactivity in hypertensive patients with primary aldosteronism
-
Kontak AC, Wang Z, Arbique D, et al. Reversible sympathetic overactivity in hypertensive patients with primary aldosteronism. J Clin Endocrinol Metab. 2010;95:4756-61.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 4756-61
-
-
Kontak, A.C.1
Wang, Z.2
Arbique, D.3
-
84
-
-
65249137181
-
Differential effects of chlorthalidone versus spironolactone on muscle sympathetic nerve activity in hypertensive patients
-
Menon DV, Arbique D, Wang Z, et al. Differential effects of chlorthalidone versus spironolactone on muscle sympathetic nerve activity in hypertensive patients. J Clin Endocrinol Metab. 2009;94:1361-6.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 1361-6
-
-
Menon, D.V.1
Arbique, D.2
Wang, Z.3
-
85
-
-
84864276593
-
Spironolactone prevents chlorthalidone-induced sympathetic activation and insulin resistance in hypertensive patients
-
This study demonstrates the effects of spironolactone improving the excretion of markers of renal dysfunction
-
Raheja P, Price A, Wang Z et al. Spironolactone Prevents Chlorthalidone-Induced Sympathetic Activation and Insulin Resistance in Hypertensive Patients. Hypertension. 2012;60:319-25. This study demonstrates the effects of spironolactone improving the excretion of markers of renal dysfunction.
-
(2012)
Hypertension
, vol.60
, pp. 319-25
-
-
Raheja, P.1
Price, A.2
Wang, Z.3
-
86
-
-
3242723066
-
Hormones and the stressed brain
-
De Kloet ER. Hormones and the stressed brain. Ann N YAcad Sci. 2004;1018:1-15.
-
(2004)
Ann N YAcad Sci
, vol.1018
, pp. 1-15
-
-
De Kloet, E.R.1
-
87
-
-
77749246221
-
Improved quality of life, blood pressure, and biochemical status following laparoscopic adrenalectomy for unilateral primary aldosteronism
-
Sukor N, Kogovsek C, Gordon RD, et al. Improved quality of life, blood pressure, and biochemical status following laparoscopic adrenalectomy for unilateral primary aldosteronism. J Clin Endocrinol Metab. 2010;95:1360-4.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 1360-4
-
-
Sukor, N.1
Kogovsek, C.2
Gordon, R.D.3
-
88
-
-
78650899023
-
High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension
-
Yagi S, Akaike M, Aihara K, et al. High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension. Hypertens Res. 2011;34:74-8.
-
(2011)
Hypertens Res
, vol.34
, pp. 74-8
-
-
Yagi, S.1
Akaike, M.2
Aihara, K.3
-
90
-
-
23744467917
-
Increased plasma aldosterone in patients with clinical depression
-
Emanuele E, Geroldi D, Minoretti P, et al. Increased plasma aldosterone in patients with clinical depression. Arch Med Res. 2005;36:544-8.
-
(2005)
Arch Med Res
, vol.36
, pp. 544-8
-
-
Emanuele, E.1
Geroldi, D.2
Minoretti, P.3
-
92
-
-
84859400826
-
The protective side of the mineralocorticoid receptor
-
Gomez-Sanchez CE, Gomez-Sanchez EP. The protective side of the mineralocorticoid receptor. Endocrinology. 2012;153:1565-7.
-
(2012)
Endocrinology
, vol.153
, pp. 1565-7
-
-
Gomez-Sanchez, C.E.1
Gomez-Sanchez, E.P.2
-
93
-
-
77953844755
-
Mineralocorticoid receptor activation restores medial perforant path ltp in diabetic rats
-
Stranahan AM, Arumugam TV, Lee K, Mattson MP. Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats. Synapse. 2010;64:528-32.
-
(2010)
Synapse
, vol.64
, pp. 528-32
-
-
Stranahan, A.M.1
Arumugam, T.V.2
Lee, K.3
Mattson, M.P.4
-
94
-
-
77950939794
-
Modulation of the mineralocorticoid receptor as add-on treatment in depression: A randomized, double-blind, placebo-controlled proof-of-concept study
-
Otte C, Hinkelmann K, Moritz S, et al. Modulation of the mineralocorticoid receptor as add-on treatment in depression: a randomized, double-blind, placebo-controlled proof-of-concept study. J Psychiatr Res. 2010;44:339-46.
-
(2010)
J Psychiatr Res
, vol.44
, pp. 339-46
-
-
Otte, C.1
Hinkelmann, K.2
Moritz, S.3
-
95
-
-
84862544696
-
Neural stem cells and neurogenesis in the adult
-
Goritz C, Frisen J. Neural stem cells and neurogenesis in the adult. Cell Stem Cell. 2012;10:657-9.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 657-9
-
-
Goritz, C.1
Frisen, J.2
-
96
-
-
84857395722
-
Mineralocorticoid receptor overexpression facilitates differentiation and promotes survival of embryonic stem cell-derived neurons
-
Munier M, Law F, Meduri G et al. Mineralocorticoid receptor overexpression facilitates differentiation and promotes survival of embryonic stem cell-derived neurons. Endocrinology. 2012.
-
(2012)
Endocrinology
-
-
Munier, M.1
Law, F.2
Meduri, G.3
-
97
-
-
84856337738
-
Molecular pharmacology of the mineralocorticoid receptor: Prospects for novel therapeutics
-
This is an excellent review of the pharmacology of mineralocorticoid receptor antagonists, old and new
-
Kolkhof P, Borden SA. Molecular pharmacology of the mineralocorticoid receptor: prospects for novel therapeutics. Mol Cell Endocrinol. 2012;350:310-7. This is an excellent review of the pharmacology of mineralocorticoid receptor antagonists, old and new.
-
(2012)
Mol Cell Endocrinol
, vol.350
, pp. 310-7
-
-
Kolkhof, P.1
Borden, S.A.2
-
98
-
-
9244261055
-
Hypertensive retinopathy
-
Wong TY, Mitchell P. Hypertensive retinopathy. N Engl J Med. 2004;351:2310-7.
-
(2004)
N Engl J Med
, vol.351
, pp. 2310-7
-
-
Wong, T.Y.1
Mitchell, P.2
|