Hesperidin inhibits cyclophosphamide-induced tumor growth delay in mice

Integrative Cancer Therapies

Volumn 11, Issue 3, 2012, Pages 251-256

  Hosseinimehr, Seyed Jalal ^a   Jalayer, Zoleikha ^b   Naghshvar, Farshad ^a   Mahmoudzadeh, Aziz ^c  

^a MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PAYAME NOOR UNIVERSITY   (Iran)

^c Novin Institute   (Iran)

Author keywords

cyclophosphamide; hematotoxicity; hesperidin; mice; tumor

Indexed keywords

CYCLOPHOSPHAMIDE; HESPERIDIN;

ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROTECTION; COLON CARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LEUKOCYTE; LEUKOCYTE COUNT; LEUKOPENIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TREATMENT DURATION; TUMOR GROWTH; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; COLONIC NEOPLASMS; CYCLOPHOSPHAMIDE; DRUG INTERACTIONS; HESPERIDIN; LEUKOCYTE COUNT; LEUKOPENIA; MALE; MICE; MICE, INBRED BALB C; TIME FACTORS;

EID: 84870473937     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735412448959     Document Type: Article

References (22)

1. Zhang J, Tian Q, Zhou S. Clinical pharmacology of cyclophosphamide and ifosfamide. Curr Drug Ther. 2006 ; 1: 55-84
2. Tiwari AK. Imbalance in antioxidant defence and human diseases: multiple approach of natural antioxidants therapy. Curr Sci. 2001 ; 81: 1179-1187 (Pubitemid 33620251)
3. Hosseinimehr SJ, Nemati A. Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells. Br J Radiol. 2006 ; 79: 415-418 (Pubitemid 43676345)
4. Ahmadi A, Hosseinimehr SJ, Naghshvar F, Hajir E, Ghahremani M. Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cells. Arch Pharm Res. 2008 ; 31: 794-797
5. Hosseinimehr SJ, Mahmoudzadeh A, Ahmadi A, Mohamadifar S, Akhlaghpoor S. Radioprotective effects of hesperidin against genotoxicity induced by gamma-irradiation in human lymphocytes. Mutagenesis. 2009 ; 24: 233-235
6. Garg A, Garg S, Zaneveled JD, Singla AK. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res. 2001 ; 15: 655-669 (Pubitemid 34016792)
7. Yang M, Tanaka T, Hirose Y, Deguchi T, Mori H, Kawada Y. Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine- induced urinary-bladder carcinogenesis in male ICR mice. Int J Cancer. 1997 ; 73: 719-724 (Pubitemid 127483070)
8. Lahouel M, Fillastre JP. Role of flavonoids in the prevention of haematoxicity due to chemotherapeutic agents. Haema. 2004 ; 7: 313-320 (Pubitemid 39071077)
9. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol. 1998 ; 62: 209-214 (Pubitemid 28493371)
10. Hosseinimehr SJ, Azadbakht M, Abadi AJ. Protective effect of hawthorn extract against genotoxicity induced by cyclophosphamide in mouse bone marrow cells. Environ Toxicol Pharmacol. 2008 ; 25: 51-56 (Pubitemid 350198999)
11. Hosseinimehr SJ, Karami M. Citrus extract modulates genotoxicity induced by cyclophosphamide in mice bone marrow cells. J Pharm Pharmacol. 2005 ; 57: 505-509 (Pubitemid 40515873)
12. Choa YA, Cho DH, Choi JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009 ; 61: 825-829
13. Uesawa Y, Mohri K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008 ; 29: 185-188 (Pubitemid 351722163)
14. Piao YJ, Choi JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008 ; 31: 518-522
15. Fujita T, Kawase A, Niwa T, et al. Comparative evaluation of 12 immature citrus fruit extracts for the inhibition of cytochrome p450 isoform activities. Biol Pharm Bull. 2008 ; 31: 925-930 (Pubitemid 351731998)
16. Doostdar H, Burke MD, Mayer RT. Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1. Toxicology. 2000 ; 144: 31-38 (Pubitemid 30201617)
17. Cancer Res. Somasundaram S Edmund NA Moore DT Small GW Shi YY Orlowski RZ, ed. 2002: 3868-3875.
18. Strauss G, Westhoff MA, Fischer-Posovszky P, et al. 4-Hydroperoxy- cyclophosphamide mediates caspase- independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008 ; 15: 332-343
19. Tsai-Turton M, Luong BT, Tan Y, Luderer U. Cyclophosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion. Toxicol Sci. 2007 ; 98: 216-230 (Pubitemid 47073834)
20. Murata M, Suzuki T, Midorikawa K, Oikawa S, Kawanishi S. Oxidative DNA damage induced by a hydroperoxide derivative of cyclophosphamide. Free Radic Biol Med. 2004 ; 37: 793-802 (Pubitemid 39078551)
21. Tanaka T, Kohno H, Murakami M, et al. Suppression of azoxymethane-induced colon carcinogenesis in male F344 rats by mandarin juices rich in beta-cryptoxanthin and hesperidin. Int J Cancer. 2000 ; 88: 146-150
22. Tanaka T, Makita H, Kawabata K, et al. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin. Carcinogenesis. 1997 ; 18: 957-965 (Pubitemid 28132340)