Topical application of aminopeptidase N-neutralizing antibody accelerates wound closure

Molecular and Cellular Biochemistry

Volumn 372, Issue 1-2, 2013, Pages 95-100

  Lai, Amy ^a   Hosseini Tabatabaei, Azadeh ^a   Hartwell, Ryan ^a   Rahmani Neishaboor, Elham ^a   Kilani, Ruhangiz Taghi ^a   Ghahary, Aziz ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Aminopeptidase N; Collagen deposition; Contraction; Wound healing

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA ACTIN; CELL ADHESION MOLECULE; COLLAGEN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN G1; MICROSOMAL AMINOPEPTIDASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCLONAL ANTIBODY WM15; NEUTRALIZING ANTIBODY; SCLEROPROTEIN; STRATIFIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CONTROLLED STUDY; DERMIS; EPIDERMIS; FEMALE; GRANULATION TISSUE; KERATINOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REGULATORY MECHANISM; SKIN FIBROBLAST; WOUND CLOSURE; WOUND CONTRACTION; WOUND HEALING;

ACTINS; ADMINISTRATION, TOPICAL; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD13; CELLS, CULTURED; COLLAGEN; ENZYME ACTIVATION; FEMALE; HUMANS; IMIDAZOLES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MOLECULAR TARGETED THERAPY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIDINES; SKIN; WOUND HEALING;

EID: 84870446583     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1449-x     Document Type: Article

References (19)

1. Ghahary A, Marcoux Y, Karimi-Busheri F et al (2005) Differentiated keratinocyte-releasable stratifin (14-3-3 sigma) stimulates MMP-1 expression in dermal fibroblasts. J Investig Dermatol 124:170-177
2. Ghaffari A, Li Y, Kilani RT et al (2010) 14-3-3{sigma} associates with cell surface aminopeptidase N in the regulation of matrix metalloproteinase-1. J Cell Sci 123:2996-3005
3. Lam E, Kilani RT, Li Y et al (2005) Stratifin-induced matrix metalloproteinase-1 in fibroblast is mediated by c-fos and p38 mitogen-activated protein kinase activation. J Investig Dermatol 125:230-238
4. Lai A, Ghaffari A, Li Y et al (2011) Paracrine regulation of fibroblast aminopeptidase N/CD13 expression by keratinocyte-releasable stratifin. J Cell Physiol 226(12):3114-3120
5. Lai A, Ghaffari A, Ghahary A (2010) Inhibitory effect of anti-aminopeptidase N/CD13 antibodies on fibroblast migration. Mol Cell Biochem 343(1-2):191-199
6. Escobar-Chavez JJ, Lopez-Cervantes M, Naik A et al (2006) Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations. J Pharm Pharm Sci 9:339-358
7. Rahmani-Neishaboor E, Yau FM, Jalili R et al (2010) Improvement of hypertrophic scarring by using topical anti-fibrogenic/anti-inflammatory factors in a rabbit ear model. Wound Repair Regen 18(4):401-408
8. Lenga Y, Koh A, Perera AS et al (2008) Osteopontin expression is required for myofibroblast differentiation. Circ Res 102:319-327
9. Lai A, Ghaffari A, Li Y et al (2012) Microarray-based identification of aminopeptidase N/CD13 target genes in keratinocyte conditioned medium-stimulated dermal fibroblasts. J Cell Biochem 113(3):1061-1068
10. Shimizu T, Tani K, Hase K et al (2002) CD13/aminopeptidase N-induced lymphocyte involvement in inflamed joints of patients with rheumatoid arthritis. Arthritis Rheum 46:2330-2338
11. Brubaker AL, Schneider DF, Kovacs EJ (2011) Neutrophils and natural killer T cells as negative regulators of wound healing. Expert Rev Dermatol 6:5-8
12. Fukasawa K, Fujii H, Saitoh Y et al (2006) Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis. Cancer Lett 243:135-143
13. Desmouliere A, Chaponnier C, Gabbiani G (2005) Tissue repair, contraction, and the myofibroblast. Wound Repair Regen 13:7-12
14. Serini G, Gabbiani G (1999) Mechanisms of myofibroblast activity and phenotypic modulation. Exp Cell Res 250:273-283
15. Hinz B, Gabbiani G, Chaponnier C (2002) The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo. J Cell Biol 157:657-663
16. Hinz B, Celetta G, Tomasek JJ et al (2001) Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell 12:2730-2741
17. Gabbiani G (2003) The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 200:500-503
18. Midwood KS, Schwarzbauer JE (2002) Tenascin-C modulates matrix contraction via focal adhesion kinase- and Rho-mediated signaling pathways. Mol Biol Cell 13:3601-3613
19. Mackie EJ, Halfter W, Liverani D (1988) Induction of tenascin in healing wounds. J Cell Biol 107:2757-2767