Human insulin secreted from insulinogenic xenograft restores normoglycemia in type 1 diabetic mice without immunosuppression

Cell Transplantation

Volumn 21, Issue 10, 2012, Pages 2131-2147

  Kim, J ^a   Park, S ^a,b   Kang, H M ^a   Ahn, C W ^c   Kwon, H C ^d   Song, J H ^e   Lee, Y J ^e   Lee, K H ^f   Yang, H ^b   Baek, S Y ^g   Yoo, S H ^g   Kim, S H ^g   Kim, H ^b  

^a Bcellbio Inc   (South Korea)

^b Seoul Women University   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

^d Mirae and Heemang Ob/Gyn Clinic   (South Korea)

^e Medi i Women's Hospital   (South Korea)

^f Korea Institute of Radiation and Medical Science   (South Korea)

^g Korea Food and Drug Administration   (South Korea)

Author keywords

cells; Human amnion mesenchymal stem cells (hAMs); Immunocompetent; Insulin; Insulin secreting cells (ISCs); Type 1 diabetes

Indexed keywords

C PEPTIDE; CELL NUCLEUS ANTIGEN; DITHIZONE; GLUCAGON; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; HUMAN INSULIN; MESSENGER RNA; NEUROGENIN 3; PANCREAS POLYPEPTIDE; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; SOMATOSTATIN; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1;

ALU GENE; AMNION CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DIFFERENTIATION; CELL NUCLEUS; CONTROLLED STUDY; FEMALE; GC GENE; GCK GENE; GENE EXPRESSION; GLP1R GENE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GLUT1 GENE; GLUT2 GENE; GRAFT REJECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERGLYCEMIA; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; INS GENE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; ISL1 GENE; KIDNEY; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NEPHRECTOMY; NEUROD1 GENE; NEUROG3 GENE; NKX6 1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PC1 3 GENE; PC2 GENE; PDX1 GENE; PPY GENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; SST GENE; STREPTOZOCIN DIABETES; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALS; BLOOD GLUCOSE; C-PEPTIDE; CELL DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; TRANSPLANTATION, HETEROLOGOUS;

MUS;

EID: 84870433944     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368912X636803     Document Type: Article

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