In vitro neuronal induction of adipose-derived stem cells and their fate after transplantation into injured mouse brain

Current Medicinal Chemistry

Volumn 19, Issue 30, 2012, Pages 5170-5177

  Pavlova, G ^a,b,e   Lopatina, T ^c   Kalinina, N ^c   Rybalkina, E ^a   Parfyonova, Y ^d   Tkachuk, V ^c   Revishchin, A ^a,b  

^a INSTITUTE OF GENE BIOLOGY   (Russian Federation)

^b OOO Institute of Medicine and Transplantation of Cells   (Russian Federation)

^c LOMONOSOV MOSCOW STATE UNIVERSITY   (Russian Federation)

^d INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

^e Apto Pharm Ltd   (Russian Federation)

Author keywords

5 azacytidine; Adipose derived stem cells; BDNF; Induction; Neural differentiation; Transplantation.

Indexed keywords

AZACITIDINE; BETA TUBULIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CD34 ANTIGEN; ENDOTHELIN 1; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MERCAPTOETHANOL; MICROTUBULE ASSOCIATED PROTEIN 2; NESTIN; NEURON SPECIFIC ENOLASE; RETINOIC ACID;

ADIPOSE DERIVED STEM CELL; ADIPOSE TISSUE; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CELL FATE; CELL ISOLATION; CELL MIGRATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MALE; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PHENOTYPE; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL TRANSPLANTATION;

ADIPOSE TISSUE; ADULT; ANIMALS; AZACITIDINE; BRAIN INJURIES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DIFFERENTIATION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MALE; MERCAPTOETHANOL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; NEURONS; NEUROPEPTIDES; PHOSPHOPYRUVATE HYDRATASE; RECEPTOR, TRKB; TRETINOIN; TUBULIN;

EID: 84870424623     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712803530557     Document Type: Article

References (26)

1. Gronthos, S.; Franklin, D.M.; Leddy, H.A.; Robey, P.G.; Storms, R.W.; Gimble, J.M. Surface protein characterization of human adipose tissuederived stromal cells. J. Cell Physiol., 2001, 189(1), 54-63
2. Ashjian, P.H.; Elbarbary, A.S.; Edmonds, B.; DeUgarte, D.; Zhu, M.; Zuk, P.A.; Lorenz, H.P.; Benhaim, P.; Hedrick, M.H. In vitro differentiation of human processed lipoaspirate cells into early neural progenitors. Plast. Reconstr. Surg., 2003, 111(6), 1922-1931
3. Seo, M.J.; Suh, S.Y.; Bae, Y.C.; Jung, J.S. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem. Biophys. Res. Commun., 2005, 328(1), 258-264
4. Mizuno, H.; Zuk, P.A.; Zhu, M.; Lorenz, H.P.; Benhaim, P.; Hedrick, M.H. Myogenic differentiation by human processed lipoaspirate cells. Plast. Reconstr. Surg., 2002, 109(1), 199-209; discussion 210-191
5. Planat-Benard, V.; Menard, C.; Andre, M.; Puceat, M.; Perez, A.; Garcia-Verdugo, J.M.; Penicaud, L.; Casteilla, L. Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ. Res., 2004, 94(2), 223-229
6. Brzoska, M.; Geiger, H.; Gauer, S.; Baer, P. Epithelial differentiation of human adipose tissue-derived adult stem cells. Biochem. Biophys. Res. Commun., 2005, 330(1), 142-150
7. Fujimura, J.; Ogawa, R.; Mizuno, H.; Fukunaga, Y.; Suzuki, H. Neural differentiation of adipose-derived stem cells isolated from GFP transgenic mice. Biochem. Biophys. Res. Commun., 2005, 333(1), 116-121
8. Arboleda, D.; Forostyak, S.; Jendelova, P.; Marekova, D.; Amemori, T.; Pivonkova, H.; Masinova, K.; Sykova, E. Transplantation of predifferentiated adipose-derived stromal cells for the treatment of spinal cord injury. Cell. Mol. Neurobiol., 2011, 31(7), 1113-1122
9. Liqing, Y.; Jia, G.; Jiqing, C.; Ran, G.; Fei, C.; Jie, K.; Yanyun, W.; Cheng, Z. Directed differentiation of motor neuron cell-like cells from human adipose-derived stem cells in vitro. Neuroreport, 2011, 22(8), 370-373
10. Yu, J.M.; Bunnell, B.A.; Kang, S.K. Neural differentiation of human adipose tissue-derived stem cells. Methods Mol. Biol., 2011, 702, 219-231
11. Kompisch, K.M.; Lange, C.; Steinemann, D.; Skawran, B.; Schlegelberger, B.; Muller, R.; Schumacher, U. Neurogenic transdifferentiation of human adipose-derived stem cells? A critical protocol reevaluation with special emphasis on cell proliferation and cell cycle alterations. Histochem. Cell Biol., 2010, 134(5), 453-468
12. Jang, S.; Cho, H.H.; Cho, Y.B.; Park, J.S.; Jeong, H.S. Functional neural differentiation of human adipose tissue-derived stem cells using bFGF and forskolin. BMC Cell Biol., 2010, 11, 25
13. Qian, D.X.; Zhang, H.T.; Ma, X.; Jiang, X.D.; Xu, R.X. Comparison of the efficiencies of three neural induction protocols in human adipose stromal cells. Neurochem. Res., 2010, 35(4), 572-579
14. Franco Lambert, A.P.; Fraga Zandonai, A.; Bonatto, D.; Cantarelli Machado, D.; Pegas Henriques, J.A. Differentiation of human adipose-derived adult stem cells into neuronal tissue: does it work? Differentiation, 2009, 77(3), 221-228
15. Dhar, S.; Yoon, E.S.; Kachgal, S.; Evans, G.R. Long-term maintenance of neuronally differentiated human adipose tissue-derived stem cells. Tissue Eng., 2007, 13(11), 2625-2632
16. Kim, B.J.; Seo, J.H.; Bubien, J.K.; Oh, Y.S. Differentiation of adult bone marrow stem cells into neuroprogenitor cells in vitro. Neuroreport, 2002, 13(9), 1185-1188
17. Lim, J.Y.; Park, S.I.; Oh, J.H.; Kim, S.M.; Jeong, C.H.; Jun, J.A.; Lee, K.S.; Oh, W.; Lee, J.K.; Jeun, S.S. Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways. J. Neurosci. Res., 2008, 86(10), 2168-2178
18. Rivera, F.J.; Sierralta, W.D.; Minguell, J.J.; Aigner, L. Adult hippocampus derived soluble factors induce a neuronal-like phenotype in mesenchymal stem cells. Neurosci. Lett., 2006, 406(1-2), 49-54
19. Reichardt, L.F. Neurotrophin-regulated signalling pathways. Philos. Trans. R. Soc. Lond. B Biol. Sci., 2006, 361(1473), 1545-1564
20. Zuk, P.A.; Zhu, M.; Mizuno, H.; Huang, J.; Futrell, J.W.; Katz, A.J.; Benhaim, P.; Lorenz, H.P.; Hedrick, M.H. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng., 2001, 7(2), 211-228
21. Miranville, A.; Heeschen, C.; Sengenes, C.; Curat, C.A.; Busse, R.; Bouloumie, A. Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. Circulation, 2004, 110(3), 349-355
22. Planat-Benard, V.; Silvestre, J.S.; Cousin, B.; Andre, M.; Nibbelink, M.; Tamarat, R.; Clergue, M.; Manneville, C.; Saillan-Barreau, C.; Duriez, M.; Tedgui, A.; Levy, B.; Penicaud, L.; Casteilla, L. Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation, 2004, 109(5), 656-663
23. Ning, H.; Lin, G.; Lue, T.F.; Lin, C.S. Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells. Differentiation, 2006, 74(9-10), 510-518
24. Yan, Q.; Radeke, M.J.; Matheson, C.R.; Talvenheimo, J.; Welcher, A.A.; Feinstein, S.C. Immunocytochemical localization of TrkB in the central nervous system of the adult rat. J. Comp. Neurol., 1997, 378(1), 135-157
25. Garcia-Suarez, O.; Gonzalez-Martinez, T.; Perez-Perez, M.; Germana, A.; Blanco-Gelaz, M.A.; Monjil, D.F.; Ciriaco, E.; Silos-Santiago, I.; Vega, J.A. Expression of the neurotrophin receptor TrkB in the mouse liver. Anat. Embryol. (Berl), 2006, 211(5), 465-473
26. Revishchin, A.V.; Korochkin, L.I.; Okhotin, V.E.; Pavlova, G.V. Neural stem cells in the mammalian brain. Int. Rev. Cytol., 2008, 265, 55-109