Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging

Magnetic Resonance Imaging

Volumn 31, Issue 1, 2013, Pages 130-138

  Fujii, Hirotada G ^a   Sato Akaba, Hideo ^b   Emoto, Miho C ^a   Itoh, Kouichi ^c   Ishihara, Yasuhiro ^d   Hirata, Hiroshi ^e  

^a SAPPORO MEDICAL UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

^e HOKKAIDO UNIVERSITY   (Japan)

Author keywords

EPR; Imaging; Inflammation; LPS; Nitric oxide; Nitroxide; NOS; Oxidative stress; ROS; Superoxide

Indexed keywords

3 HYDROXYMETHYL 2,2,5,5 TETRAMETHYLPYRROLIDINE 1 OXYL; ALLOPURINOL; AMINOGUANIDINE; ENZYME INHIBITOR; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; NITROXIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN DISEASE; BRAIN REGION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; IMAGING SYSTEM; IN VIVO STUDY; MALE; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; SEPSIS; THREE DIMENSIONAL IMAGING;

ANIMALS; BRAIN; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENCEPHALITIS; ESCHERICHIA COLI INFECTIONS; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED ICR; OXIDATION-REDUCTION; PYRIMIDINES; REACTIVE OXYGEN SPECIES; TISSUE DISTRIBUTION;

ANIMALIA; MUS; RODENTIA;

EID: 84870383703     PISSN: 0730725X     EISSN: 18735894     Source Type: Journal    
DOI: 10.1016/j.mri.2012.06.021     Document Type: Article

References (30)

1. Kowaltowski A.J., de Souza-Pinto N.C., Castilho R.F., Vercesi A.E. Mitochondria and reactive oxygen species. Free Radic Biol Med 2009, 47:333-343.
2. Drechsel D.A., Patel M. Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease. Free Radic Biol Med 2008, 44:1873-1886.
3. Csányi G., Taylor W.R., Pagano P.J. NOX and inflammation in the vascular adventitia. Free Radic Biol Med 2009, 47:1254-1266.
4. Janssen-Heininger Y.M., Mossman B.T., Heintz N.H., Forman H.J., Kalyanaraman B., Finkel T., et al. Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med 2008, 45:1-17.
5. Zhang T., Feng Q. Nitric oxide and calcium signaling regulate myocardial tumor necrosis factor-α expression and cardiac function in sepsis. Can J Physiol Pharmacol 2010, 88:92-104.
6. Ejima K., Perrella M.A. Alteration in heme oxygenase-1 and nitric oxide synthase-2 gene expression during endotoxemia in cyclooxygenase-2-deficient mice. Antioxid Redox Signal 2004, 6:850-857.
7. Arimoto T., Kadiiska M.B., Sato K., Corbett J., Mason R.P. Synergistic production of lung free radicals by diesel exhaust particles and endotoxin. Am J Respir Crit Care Med 2005, 171:379-387.
8. Nakai K., Kadiiska M.B., Jiang J.J., Stadler K., Mason R.P. Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin. Proc Natl Acad Sci USA 2006, 103:4616-4621.
9. Gu Y., Dee C.M., Shen J. Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability. Front Biosci 2011, 3:1216-1231.
10. Hegde M.L., Hegde P.M., Rao K.S., Mitra S. Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword. J Alzheimers Dis 2011, 24(Suppl. 2):183-198.
11. Simonyi A., He Y., Sheng W., Sun A.Y., Wood W.G., Weisman G.A., et al. Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease. Mol Neurobiol 2010, 41:73-86.
12. Berliner L.J., Fujii H., Wan X.M., Lukiewicz S.J. Feasibility study of imaging a living murine tumor by electron paramagnetic resonance. Magn Reson Med 1987, 4:380-384.
13. Kuppusamy P., Chzhan M., Vij K., Shteynbuk M., Lefer D.J., Giannella E., et al. Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation. Proc Natl Acad Sci USA 1994, 91:3388-3392.
14. Yokoyama H., Lin Y., Itoh O., Ueda Y., Nakajima A., Ogata T., et al. EPR imaging for in vivo analysis of the half-life of a nitroxide radical in the hippocampus and cerebral cortex of rats after epileptic seizures. Free Radic Biol Med 1999, 27:442-448.
15. Utsumi H., Yasukawa K., Soeda T., Yamada K., Shigemi R., Yao T., et al. Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats. J Pharmacol Exp Ther 2006, 317:228-235.
16. Hyodo F., Matsumoto K., Matsumoto A., Mitchell J.B., Krishna M.C. Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents. Cancer Res 2006, 66:9921-9928.
17. Fujii H., Itoh K., Pandian R.P., Sakata M., Kuppusamy P., Hirata H. Measuring brain tissue oxygenation under oxidative stress by ESR/MR dual imaging system. Magn Reson Med Sci 2007, 6:83-89.
18. Hyodo F., Chuang K.H., Goloshevsky A.G., Sulima A., Griffiths G.L., Mitchell J.B., et al. Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent. J Cereb Blood Flow Metab 2008, 28:1165-1174.
19. Fujii H., Sato-Akaba H., Kawanishi K., Hirata H. Mapping of redox status in a brain-disease mouse model by three-dimensional EPR imaging. Magn Reson Med 2011, 65:295-303.
20. Sano H., Naruse M., Matsumoto K., Oi T., Utsumi H. A new nitroxyl-probe with high retention in the brain and its application for brain imaging. Free Radic Biol Med 2000, 28:959-969.
21. Kawada Y., Hirata H., Fujii H. Use of multi-coil parallel-gap resonators for co-registration EPR/NMR imaging. J Magn Reson 2007, 184:29-38.
22. Sato-Akaba H., Fujii H., Hirata H. Improvement of temporal resolution for three-dimensional continuous-wave electron paramagnetic resonance imaging. Rev Sci Instrum 2008, 79:123701.
23. Kubrina L.N., Caldwell W.S., Mordvintcev P.I., Malenkova I.V., Vanin A.F. EPR evidence for nitric oxide production from guanidino nitrogens of L-arginine in animal tissues in vivo. Biochim Biophys Acta 1992, 1099:233-237.
24. Fujii H., Berliner L.J. Ex vivo EPR detection of nitric oxide in brain tissue. Magn Reson Med 1999, 42:599-602.
25. Itoh K., Watanabe M. Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase. Neuroscience 2009, 159:735-743.
26. Sato-Akaba H., Kuwahara Y., Fujii H., Hirata H. Half-life mapping of nitroxyl radicals with three-dimensional electron paramagnetic resonance imaging at an interval of 3.6 seconds. Anal Chem 2009, 81:7501-7506.
27. Yokoyama H., Itoh O., Aoyama M., Obara H., Ohya H., Kamada H. In vivo temporal EPR imaging of the brain of rats by using two types of blood-brain barrier-permeable nitroxide radicals. Magn Reson Imaging 2002, 20:277-284.
28. Sano H., Matsumoto K., Utsumi H. Synthesis and imaging of blood-brain-barrier permeable nitroxyl-probes for free radical reactions in brain of living mice. Biochem Mol Biol Int 1997, 42:641-647.
29. Anzai K., Saito K., Takeshita K., Takahashi S., Miyazaki H., Shoji H., et al. Assessment of ESR-CT imaging by comparison with autoradiography for the distribution of a blood-brain-barrier permeable spin probe, MC-PROXYL, to rodent brain. Magn Reson Imaging 2003, 21:765-772.
30. Emoto M., Mito F., Yamasaki T., Yamada K.I., Sato-Akaba H., Hirata H., et al. A novel ascorbic acid-resistant nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse. Free Radic Res 2011, 45:1325-1332.