Synthesis and imaging of blood-brain-barrier permeable nitroxyl-probes for free radical reactions in brain of living mice

Biochemistry and Molecular Biology International

Volumn 42, Issue 3, 1997, Pages 641-647

  Sano, Hiroaki ^a   Matsumoto, Ken Ichiro ^a   Utsumi, Hideo ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Active oxygen species; Blood brain barrier; EPR; ESR; ESR imaging; Free radicals; In vivo ESR; Nitoroxide probe; Nitroxyl radicals; Spin probe

Indexed keywords

ESTERASE; FREE RADICAL; NITROXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; FEMALE; HYDROLYSIS; IMAGING; MOUSE; NONHUMAN; PARTITION COEFFICIENT;

EID: 0031398294     PISSN: 10399712     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216549700203051     Document Type: Article

References (22)

1. Chan, P.H. (1996) Stroke 27, 1124-1129.
2. Cobbs, C.S., Levi, D.S., Aldape, K., and Israel, M.A. (1996) Cancer Res. 56, 3192-3195.
3. Caeney, J.M., Starke-Reed. P.E., Oliver, C.N., Landum, R.W., Cheng, M.S., Wu, J.F., and Floyd. R.A. (1991) Proc. Natl. Acad. Sci. USA 88, 3633-3636.
4. Rose, D.R., Siddique, T., Patterson, D., Figlewicz, D.Z., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J.P., Deng, H.-Q., Rahmani, Z., Krizus, A., McKenna-Yasek, D., Cayabyab, A., Gaston, S.M., Berger, R., Tanzi, R.E., Halperin, J.J., Herzfeld, B., van den Berg, R., Hung, W.-Y., Bird, T., Deng, G., Mulder, D.W., Smyth, C., Lang, N.G., Soriano, E., Perocak-Vance, M.A., Haines, J., Rouleau, G.A., Gusella, J.S., Horritz, H.R., and Brown R.H. Jr. (1993) Nature 362, 59-62.
5. Evans, P.H. (1993) Br. Med. Bull. 49, 577-587.
6. Utsumi, H., Muto, E., Masuda, S., and Hamada, A. (1990) Biochem. Biophys. Res. Commun. 172, 1342-1348.
7. Glockner, J.F., Chang, H.-C., and Swartz, H.M. (1991) Magn. Reson. Med. 20, 123-133.
8. Quaresima, V., Alecci, M., Ferrari, M., and Sotgiu, A. (1992) Biochem. Biophys. Res. Commun. 183, 829-835.
9. Komarov, A.M., Joseph, J., and Lai, C.-S. (1994) Biochem. Biophys. Res. Commun. 201, 1035-1042.
10. Kuppusamy, P., Chzhan, M., Vij, K., Shteynbuk, M., Lefer, D.J., Giannella, E., and Zweier, J.L. (1994) Proc. Natl. Acad. Sci. USA 91, 3388-3392.
11. Gomi, F., Utsumi, H., Hamada, A., and Matsuo, M. (1993) Life Sci. 52, 2027-2033.
12. Miura, Y., Utsumi, H., and Hamada, A. (1992) Biochem. Biophys. Res. Commun. 182, 1108-1114.
13. Utsumi, H., Takeshita, K., Miura, Y., Masuda, S., and Hamada, A. (1993) Free Rad. Res.Commun. 19, S219-S225.
14. Utsumi, H., Ichikawa, K., and Takeshita, K. (1995) Toxicol. Lett. 82/83, 561-565.
15. Miura, Y., Hamada, A., and Utsumi, H. (1995) Free Rad. Res. 22, 209-214.
16. Irie, T., Fukushi, K., Akimoto, Y., Tamagami, H., and Nozaki, T. (1994) Nucl. Med. Biol. 21, 801-808.
17. Keana, J.F.W., Keana, S.B., and Beetham, D. (1967) J. Amer. Chem. Soc. 89, 3055-3056.
18. Takeshita, K., Utsumi, H., and Hamada, A. (1991) Biochem. Biophys. Res. Commun. 177, 874-880.
19. Liebmann, J., Bourg, J., Krishna, C.M., Glass, J., Cook, J.A., and Mitchell, J.B. (1994) Life Sci. 54, PL503-509.
20. Shimshick, E.J., and McConnell, H.M. (1973) Biochemistry 12, 2351-2360.
21. Tsien, R.Y. (1981) Nature 290, 527-528.
22. Utsumi, H., and Takeshita, K. (1995) in Bioradicals Detected by ESR Spectroscopy (Ohya-Nishiguchi, H., and Packer, L., Eds.), pp. 321-334, Birkhauser Verlag Basel, Switzerland.