Leiomyoma fibrosis inhibited by liarozole, a retinoic acid metabolic blocking agent

Fertility and Sterility

Volumn 98, Issue 6, 2012, Pages 1557-1562

  Gilden, Melissa ^a   Malik, Minnie ^a   Britten, Joy ^a   Delgado, Tania ^a   Levy, Gary ^a,b   Catherino, William H ^a,b  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Extracellular matrix; leiomyomas; liarozole; retinoic acid

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1A1; COLLAGEN TYPE 4A2; FIBROMODULIN; FIBRONECTIN; LIAROZOLE; MESSENGER RNA; UNCLASSIFIED DRUG; VERSICAN;

ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MYOMETRIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE CULTURE; TUMOR CELL; UTERUS MYOMA; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, HORMONAL; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; FEMALE; HUMANS; IMIDAZOLES; LEIOMYOMA; TRETINOIN; TUMOR CELLS, CULTURED; UTERINE NEOPLASMS;

EID: 84870376648     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2012.07.1132     Document Type: Article

References (33)

1. A.D. Dragomir, J.C. Schroeder, A.M. Connolly, L.L. Kupper, M.C. Hill, and A.F. Olshan Potential risk factors associated with subtypes of uterine leiomyomata Reprod Sci 11 2010 1029 1035
2. M. Malik, M. Mendoza, M. Payson, and W.H. Catherino Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression Fertil Steril 81 2008 2177 2184
3. G.P. Flake, J. Andersen, and D. Dixon Etiology and pathogenesis of uterine leiomyomas: a review Environ Health Perspect 111 2003 1037 1054 (Pubitemid 36826884)
4. W. Kupke, R.E. Felberbaum, M. Krapp, T. Schill, E. Malik, and K. Diedrich Use of GnRH antagonists in the treatment of endometriosis Reprod Biomed Online 5 2002 12 16
5. A.J. Friedman, D. Harrison-Atlas, R.L. Barbieri, B. Benacerraf, R. Gleason, and I. Schiff A randomized, placebo-controlled, double-blind study evaluating the efficacy of leuprolide acetate depot in the treatment of uterine leiomyomata Fertil Steril 51 1989 251 256 (Pubitemid 19050523)
6. M. Malik, J. Webb, and W.H. Catherino Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells Clin Endocrinol 69 2008 462 470
7. D. Joseph, M. Malik, S. Nurudeen, and W.H. Catherino Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor β-3 Fertil Steril 93 2009 1500 1508
8. A. Chrobak, G.B. Gmyrek, R. Sozanski, U. Sieradzka, M. Paprocka, and M. Gabrys The influence of extracellular matrix proteins on T-cell proliferation and apoptosis in women with endometriosis or uterine leiomyoma Am J Reprod Immunol 2 2004 123 129 (Pubitemid 38239738)
9. X. Gao, L. Yu, L. Castro, A. Moore, T. Hermon, and C. Bortner An endocrine-disrupting chemical, fenvalerate, induces cell-cycle progression and collagen I type expression in human uterine leiomyoma and myometrial cells Toxicol Lett 196 2010 133 141
10. M. Malik, J. Norian, D. McCarthy-Keith, J. Britten, and W.H. Catherino Why leiomyomas are called fibroids: the central role of extracellular matrix in symptomatic women Semin Reprod Med 28 2010 169 179
11. E. Levens, X. Luo, L. Ding, R.S. Williams, and N. Chegini Fibromodulin is expressed in leiomyoma and myometrium and regulated by gonadotropin-releasing hormone analogue therapy and TGF-β through Smad and MAPK-mediated signaling Mol Hum Reprod 7 2005 489 494 (Pubitemid 41258235)
12. W.H. Catherino, P. Leppert, M. Stenmark, M. Payson, C. Potlog-Nahari, and L. Nieman Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids Genes Chromosomes Cancer 40 2004 204 217 (Pubitemid 38703097)
13. J.M. Norian, M. Malik, C. Parker, D. Joseph, P.C. Leppert, and J.H. Segars Transforming growth factor β3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas Reprod Sci 16 2009 1153 1164
14. W.H. Catherino, and M. Malik Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure Fertil Steril 87 2007 1388 1398 (Pubitemid 46829156)
15. M. Zaitseva, B.J. Vollenhoven, and P.A.W. Rogers Retinoic acid pathway genes show significantly altered expression in uterine fibroids when compared with normal myometrium Mol Hum Reprod 13 2007 577 585 (Pubitemid 47241911)
16. M. Zaitseva, B.J. Vollenhoven, and P.A.W. Rogers Retinoids regulate genes involved in retinoic acid synthesis and transport in human myometrial and fibroid smooth muscle cells Hum Reprod 23 2008 1076 1086 (Pubitemid 351757344)
17. Y. Zhong, Y. Wu, R. Liu, Z. Li, Y. Chen, and T. Evans Novel retinoic acid receptor alpha agonists for treatment of kidney disease PLoS One 11 2011 e27945
18. A.L.A. Kuijpers, J.P.A. Van Pelt, M. Bergers, P.J. Boegheim, J.E.N. Den Bakker, and G. Siegenthaler The effects of oral liarozole on epidermal proliferation and differentiation in severe plaque psoriasis are comparable with those of acitretin Brit Dermatol 139 1998 380 389 (Pubitemid 28430452)
19. E. Pavez Loriè, A. Gånemo, M. Borgers, L. Wouters, S. Blockhuys, and L. van de Plassche Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole Acta Dermato-Venereol 89 2009 12 20
20. C.J. Verfaille, F.P. Vanhoutte, C. Blanchet-Bardon, M.A. Van Steensel, and P.M. Steijlen Oral liarozole vs. acitretin in the treatment of ichthyosis: a phase II/III multicentre, double-blind, randomized, active-controlled study Brit Dermatol 156 2007 965 973 (Pubitemid 46642812)
21. J. Berth-Jones, G. Todd, P.E. Hutchinson, K. Thestrup-Pedersen, and F.P. Vanhoutte Treatment of psoriasis with oral liarozole: a dose-ranging study Brit Dermatol 143 2000 1170 1176 (Pubitemid 32052751)
22. L. Denis, F. Debruyne, P. De Porre, and J. Bruynseels Early clinical experience with liarozole (Liazal) in patients with progressive prostate cancer Eur J Cancer 34 1998 469 475
23. P.E. Goss, K. Strasser, R. Marques, M. Clemons, A. Oza, and R. Goel Liarozole fumarate (R85246): in the treatment of ER negative, tamoxifen refractory or chemotherapy resistant postmenopausal metastatic breast cancer Breast Cancer Res Treat 64 2000 177 188 (Pubitemid 32010335)
24. P. Dockx, J. Decree, and H. Degreef Inhibition of the metabolism of endogenous retinoic acid as treatment for severe psoriasis: an open study with oral liarozole Br J Dermatol 133 1995 426 432
25. H. Ben-Sallson, A. Ben-Meir, A. Shushan, L. Karra, N. Rojansky, and B.Y. Klein All-trans-retinoic acid mediates changes in PI3K and retinoic acid signaling proteins of leiomyomas Fertil Steril 95 2011 2080 2086
26. M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 2001 e45
27. G. Weston, A.C. Trajstman, C.E. Gargett, U. Manuelpillai, B.Y. Vollenhoven, and P.A.W. Rogers Fibroids display an anti-angiogenic gene expression profile when compared with adjacent myometrium Mol Hum Reprod 9 2003 541 549 (Pubitemid 37220813)
28. V.A. Miller, J.R. Rigas, J.R.F. Muindi, W.P. Tong, E. Venkatraman, and M.G. Kris Modulation of all-trans retinoic acid pharmacokinetics by liarozole Cancer Chemother Pharmacol 34 1994 522 526 (Pubitemid 24306053)
29. J.J. Wei, L. Chiriboga, A.A. Arslan, J. Melamed, H. Yee, and K. Mittal Ethnic differences in expression of the dysregulated proteins of uterine leiomyomata Hum Reprod 21 2006 57 67 (Pubitemid 41794292)
30. M.E. Parsanezhad, M. Azmoon, S. Alborzi, A. Rajaeefard, A. Zarei, T. Kazerooni, V. Frank, and E.H. Schmidt A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status Fertil Steril 93 2010 192 198
31. G.J. Kelloff, R.A. Lubet, R. Lieberman, K. Eisenhauer, V.E. Steele, and J.A. Crowell Aromatase inhibitors as potential cancer chemopreventives Cancer Epidemiol Biomarkers Prev 7 1998 65 78 (Pubitemid 28087144)
32. M. Malik, and W.H. Catherino Novel method to characterize primary cultures of leiomyoma and myometrium using confirmatory biomarker gene arrays Fertil Steril 87 2007 1166 1172 (Pubitemid 46659932)
33. D.M. McCarthy-Keith, M. Malik, J. Britten, J. Segars, and W.H. Catherino Gonadotropin-releasing hormone agonist increases expression of osmotic response genes in leiomyoma cells Fertil Steril 95 2011 2383 2387