β-casein-based nanovehicles for oral delivery of chemotherapeutic drugs: Drug-protein interactions and mitoxantrone loading capacity

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 6, Issue 4, 2010, Pages 547-555

  Shapira, Alina ^a   Markman, Gilad ^a   Assaraf, Yehuda G ^a   Livney, Yoav D ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

casein micelles; Cancer; Mitoxantrone; Nanoparticles; Oral delivery

Indexed keywords

ABSORPTION AND EMISSION SPECTRA; AMPHIPHILICS; AQUEOUS SOLUTIONS; ASSOCIATION CONSTANT; BASIC PROPERTIES; BETA-CASEIN; BIMODAL PARTICLES; CANCER; CASEIN MICELLES; CHEMOTHERAPEUTIC DRUGS; CO-ASSEMBLE; DELIVERY SYSTEMS; FLUORESCENT EMISSION; HYDROPHOBIC DRUG; LOADING CAPACITIES; MILK PROTEIN; MITOXANTRONE; MOLAR RATIO; NANOVEHICLES; OPTIMAL LOADING; ORAL DELIVERY; ORAL DRUG DELIVERY SYSTEM; PROTEIN INTERACTION; STATIC AND DYNAMIC LIGHT SCATTERING;

AMINO ACIDS; ASSOCIATION REACTIONS; CASEIN; CONTROLLED DRUG DELIVERY; EMISSION SPECTROSCOPY; FLUORESCENCE; MICELLES; NANOPARTICLES;

DRUG INTERACTIONS;

ANTINEOPLASTIC AGENT; BETA CASEIN; MITOXANTRONE; NANOPARTICLE; TRYPTOPHAN;

ARTICLE; CRITICAL MICELLE CONCENTRATION; DRUG DELIVERY SYSTEM; DRUG PROTEIN BINDING; LIGHT SCATTERING; PARTICLE SIZE; STOMACH TUMOR;

ADMINISTRATION, ORAL; ANTINEOPLASTIC AGENTS; CASEINS; DRUG DELIVERY SYSTEMS; DRUG INTERACTIONS; HYDROGEN-ION CONCENTRATION; MICELLES; MITOXANTRONE; NANOPARTICLES; PARTICLE SIZE; TRYPTOPHAN;

EID: 77955276587     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2010.01.003     Document Type: Article

References (21)

1. Livney Y.D., Schwan A.L., Dalgleish D.G. A study of beta-casein tertiary structure by intramolecular crosslinking and mass spectrometry. J Dairy Sci 2004, 87:3638-3647.
2. Swaisgood H.E. Chemistry of the caseins. Advanced dairy chemistry. Vol. 1, Proteins, Part A 2003, 139-201. Kluwer Academic/Plenum Publishers, New York. 3rd ed. P.F. Fox, P.L.H. McSweeney (Eds.).
3. Mikheeva L.M., Grinberg N.V., Grinberg V.Y., Khokhlov A.R., de Kruif C.G. Thermodynamics of micellization of bovine β-casein studied by high-sensitivity differential scanning calorimetry. Langmuir 2003, 19:2913-2921.
4. Portnaya I., Cogan U., Livney Y.D., Ramon O., Shimoni K., Rosenberg M., et al. Micellization of bovine beta casein studied by isothermal titration microcalorimetry and cryogenic transmission electron microscopy. J Agric Food Chem 2006, 54:5555-5561.
5. Semo E., Kesselman E., Danino D., Livney Y.D. Casein micelle as a natural nano-capsular vehicle for nutraceuticals. Food Hydrocolloids 2007, 21:936-942.
6. Shapira A., Assaraf Y.G., Livney Y.D. Beta-casein nanovehicles for oral delivery of chemotherapeutic drugs. Nanomed Nanotechnol Biol Med 2010, [published online 25 January 2010]. 10.1016/j.nano.2009.06.006.
7. Horne D.S. Casein structure, self-assembly and gelation. Curr Opin Colloid Interface Sci 2002, 7:456-461.
8. Zana R. Dynamics in micellar solutions of amphiphilic block copolymers. Dynamics of surfactant self-assemblies 2005, 161-231. CRC Press, Taylor & Francis Group, New York. A.T. Hubbard (Ed.).
9. 3 with bovine β-lactoglobulin A and β-Casein. J Agric Food Chem 2005, 53:8003-8009.
10. Lietaer E., Poiffait A., Adrian J. Interaction between casein and vitamin A. Lebens Wissen Technol 1991, 24:39-45.
11. Clark D.C., Wilde P.J., Wilson D.R., Wustneck R. The interaction of sucrose esters with β-lactoglobulin and β-casein from bovine milk. Food Hydrocolloids 1992, 6:173-186.
12. Etievant C., Barret J.M., Kruczynski A., Perrin D., Hill B.T. Vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro. Investig New Drugs 1998, 16:3-17.
13. Iyer S.S., Gao S., Zhang Z.P., Kellogg G.E., Karnes H.T. A molecular model to explain paclitaxel and docetaxel sensitivity changes through adduct formation with primary amines in electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 2005, 19:1221-1226.
14. Liu G., Franssen E., Fitch M.I., Warner E. Patient preferences for oral versus intravenous palliative chemotherapy. J Clin Oncol 1997, 15:110-115.
15. Regev R., Yeheskely-Hayon D., Katzir H., Eytan G.D. Transport of anthracyclines and mitoxantrone across membranes by a flip-flop mechanism. Biochem Pharmacol 2005, 70:161-169.
16. Saito H., Hirano H., Nakagawa H., Fukami T., Oosumi K., Murakami K., et al. A new strategy of high-speed screening and quantitative structure-activity relationship analysis to evaluate human ATP-binding cassette transporter ABCG2-drug interactions. J Pharmacol Exp Ther 2006, 317:1114-1124.
17. Hsin L.W., Wang H.P., Kao P.H., Lee O., Chen W.R., Chen H.W., et al. Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates. Bioorg Med Chem. 2008, 16:1006-1014.
18. Cogan U., Kopelman M., Mokady S., Shinitzky M. Binding affinities of retinol and related compounds to retinol binding proteins. Eur J Biochem 1976, 65:71-78.
19. Christiaens B., Symoens S., Vanderheyden S., Engelborghs Y., Joliot A., Prochiantz A., et al. Tryptophan fluorescence study of the interaction of penetratin peptides with model membranes. Eur J Biochem 2002, 269:2918-2926.
20. Bell D.H. Characterization of the fluorescence of the antitumor agent, mitoxantrone. Biochim Biophys Acta. Gene Struct Expr 1988, 949:132-137.
21. Lakowicz J.R., Malicka J., Huang J., Gryczynski Z., Gryczynski I. Ultrabright fluorescein-labeled antibodies near silver metallic surfaces. Biopolymers 2004, 74:467-475.