Hypoxia and PGE2 regulate MiTF-CX during cervical ripening

Molecular Endocrinology

Volumn 26, Issue 12, 2012, Pages 2031-2045

  Kishore, Annavarapu Hari ^a   Li, Xiang Hong ^a   Ann Word, R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; PROSTAGLANDIN E2;

ARTICLE; AUTOREGULATION; BINDING SITE; CELL NUCLEUS; CYCLOOXYGENASE 2 GENE; DIFFERENTIATED EMBRYO CHONDROCYTE EXPRESSED GENE 1; DOWN REGULATION; ENDOTHELIUM CELL; EPITHELIUM CELL; FEMALE; GENE CONTROL; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IL 8 GENE; LABOR; NUCLEOTIDE SEQUENCE; PREGNANCY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN STABILITY; REPRESSOR GENE; STROMA CELL; UPREGULATION; UTERINE CERVIX RIPENING;

CELL HYPOXIA; CELL NUCLEUS; CELLS, CULTURED; CERVICAL RIPENING; CYCLOOXYGENASE 2; DINOPROSTONE; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERLEUKIN-8; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; PREGNANCY; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; STROMAL CELLS;

EID: 84870354358     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2012-1100     Document Type: Article

References (29)

1. Read CP, Word RA, Ruscheinsky MA, Timmons BC, Mahendroo MS 2007 Cervical remodeling during pregnancy and parturition: molecular characterization of the softening phase in mice. Reproduction 134:327-340
2. Word RA, Li XH, Hnat M, Carrick K 2007 Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts. Semin Reprod Med 25:69-79
3. Goldenberg RL, Iams JD, Mercer BM, Meis PJ, Moawad AH, Copper RL, Das A, Thom E, Johnson F, McNellis D, Miodovnik M, Van Dorsten JP, Caritis SN, Thurnau GR, Bottoms SF 1998 The preterm prediction study: the value of new vs standard risk factors in predicting early and all spontaneous preterm births. NICHD MFMU network. Am J Public Health 88:233-238
4. Stjernholm-Vladic Y, Stygar D, Mansson C, Masironi B, Akerberg S, Wang H, Ekman-Ordeberg G, Sahlin L 2004 Factors involved in the inflammatory events of cervical ripening in humans. Reprod Biol Endocrinol 2:74
5. Kelly RW 2002 Inflammatory mediators and cervical ripening. J Reprod Immunol 57:217-224
6. Denison FC, Calder AA, Kelly RW 1999 The action of prostaglandin E2 on the human cervix: stimulation of interleukin 8 and inhibition of secretory leukocyte protease inhibitor. Am J Obstet Gynecol 180:614-620
7. Li XH, Kishore AH, Dao D, Zheng W, Roman CA, Word RA 2010 A novel isoform of micropthalmia-associated transcription factor inhibits IL-8 gene expression in human cervical stromal cells. Mol Endocrinol 24:1512-1528
8. Feige E, Yokoyama S, Levy C, Khaled M, Igras V, Lin RJ, Lee S, Widlund HR, Granter SR, Kung AL, Fisher DE 2011 Hypoxiainduced transcriptional repression of the melanoma-associated oncogene MITF. Proc Natl Acad Sci USA 108:E924-E933
9. Yuan Y, Hilliard G, Ferguson T, Millhorn DE 2003 Cobalt inhibits the interaction between hypoxia-inducible factor-+ and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-+. J Biol Chem 278:15911-15916
10. Mahendroo MS, Porter A, Russell DW, Word RA 1999 The parturition defect in steriod Salpha-reductase type 1 knockout mice is due to impaired cervical ripening. Mol Endocrinol 13:981-992
11. Vedernikov YP, Mayes M, Moore E, Gei A, Saade GR, Garfield RE 2000 The effects of pregnancy and smooth muscle contractility on cervical distensibility in the rat. Am J Obstet Gynecol 182:905-908
12. Havelock JC, Keller P, Muleba N, Mayhew BA, Casey BM, Rainey WE, Word RA 2005 Human myometrial gene expression before and during parturition. Biol Reprod 72:707-719
13. Ulmsten U, Wingerup L, Belfrage P, Ekman G, Wiqvist N 1982 Intracervical application of prostaglandin gel for induction of term labor. Obstet Gynecol 59:336-339
14. Woodward DF, Pepperl DJ, Burkey TH, Regan JW 1995 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. Biochem Pharmacol 50:1731-1733
15. Karakurum M, Shreeniwas R, Chen J, Pinsky D, Yan SD, Anderson M, Sunouchi K, Major J, Hamilton T, Kuwabara K 1994 Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J Clin Invest 93:1564-1570
16. Liu XH, Kirschenbaum A, Lu M, Yao S, Dosoretz A, Holland JF, Levine AC 2002 Prostaglandin E2 induces hypoxia-inducible factor-1+ stabilization and nuclear localization in a human prostate cancer cell line. J Biol Chem 277:50081-50086
17. Andersson S, Minjarez D, Yost NP, Word RA 2008 Estrogen and progesterone metabolism in the cervix during pregnancy and parturition. J Clin Endocrinol Metab 93:2366-2374
18. Hassan SS, Romero R, Haddad R, Hendler I, Khalek N, Tromp G, Diamond MP, Sorokin Y, Malone Jr J 2006 The transcriptome of the uterine cervix before and after spontaneous term parturition. Am J Obstet Gynecol 195:778-786
19. Hassan SS, Romero R, Pineles B, Tarca AL, Montenegro D, Erez O, Mittal P, Kusanovic JP, Mazaki-Tovi S, Espinoza J, Nhan-Chang CL, Draghici S, Kim CJ 2010 MicroRNA expression profiling of the human uterine cervix after term labor and delivery. Am J Obstet Gynecol 202:80. e1-80. e8
20. Pavlides S, Tsirigos A, Migneco G, Whitaker-Menezes D, Chiavarina B, Flomenberg N, Frank PG, Casimiro MC, Wang C, Pestell RG, Martinez-Outschoorn UE, Howell A, Sotgia F, Lisanti MP 2010 The autophagic tumor stroma model of cancer: role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle 9:3485-3505
21. Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Burgel T 2002 Normoxic induction of the hypoxia-inducible factor 1+ by insulin and interleukin-1+ involves the phosphatidylinositol 3-kinase pathway. FEBS Lett 512:157-162
22. Yoshida K, Kirito K, Yongzhen H, Ozawa K, Kaushansky K, Komatsu N 2008 Thrombopoietin (TPO) regulates HIF-1+ levels through generation of mitochondrial reactive oxygen species. Int J Hematol 88:43-51
23. Liu SP, Lee SD, Lee HT, Liu DD, Wang HJ, Liu RS, Lin SZ, Su CY, Li H, Shyu WC 2010 Granulocyte colony-stimulating factor activating HIF-1+ acts synergistically with erythropoietin to promote tissue plasticity. PloS One 5:e10093
24. Richard DE, Berra E, Pouyssegur J 2000 Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1+ in vascular smooth muscle cells. J Biol Chem 275:26765-26771
25. Gorlach A, Diebold I, Schini-Kerth VB, Berchner-Pfannschmidt U, Roth U, Brandes RP, Kietzmann T, Busse R 2001 Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: role of the p22(phox)-containing NADPH oxidase. Circ Res 89:47-54
26. Goldenberg RL, Iams JD, Mercer BM, Meis PJ, Moawad A, Das A, Miodovnik M, Vandorsten PJ, Caritis SN, Thurnau G, DombrowskiMP2001 The preterm prediction study: toward a multiplemarker test for spontaneous preterm birth. Am J Obstet Gynecol 185:643-651
27. van Uden P, Kenneth NS, Rocha S 2008 Regulation of hypoxiainducible factor-1+ by NF-+B. Biochem J 412:477-484
28. Therrien M, Drouin J 1993 Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene. Mol Cell Biol 13:2342-2353
29. Drewes PG, Yanagisawa H, Starcher B, Hornstra I, Csiszar K, Marinis SI, Keller P, Word RA 2007 Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina. Am J Pathol 170:578-589