메뉴 건너뛰기




Volumn 26, Issue 12, 2012, Pages 1967-1979

Vav3 enhances androgen receptor splice variant activity and is critical for castration-resistant prostate cancer growth and survival

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; PLECKSTRIN; PROTEIN VAV3; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 84870352810     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2012-1165     Document Type: Article
Times cited : (47)

References (45)
  • 3
    • 33746623315 scopus 로고    scopus 로고
    • Molecular regulation of androgen action in prostate cancer
    • Dehm SM, Tindall DJ 2006 Molecular regulation of androgen action in prostate cancer. J Cell Biochem 99:333-344
    • (2006) J Cell Biochem , vol.99 , pp. 333-344
    • Dehm, S.M.1    Tindall, D.J.2
  • 4
    • 33748949049 scopus 로고    scopus 로고
    • Androgen receptor action in hormonedependent and recurrent prostate cancer
    • Agoulnik IU, Weigel NL 2006 Androgen receptor action in hormonedependent and recurrent prostate cancer. J Cell Biochem 99:362-372
    • (2006) J Cell Biochem , vol.99 , pp. 362-372
    • Agoulnik, I.U.1    Weigel, N.L.2
  • 5
    • 23144434218 scopus 로고    scopus 로고
    • Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells
    • Hååg P, Bektic J, Bartsch G, Klocker H, Eder IE 2005 Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells. J Steroid Biochem Mol Biol 96: 251-258
    • (2005) J Steroid Biochem Mol Biol , vol.96 , pp. 251-258
    • Hååg, P.1    Bektic, J.2    Bartsch, G.3    Klocker, H.4    Eder, I.E.5
  • 6
    • 77952554163 scopus 로고    scopus 로고
    • Partners in crime: Deregulation of AR activity and androgen synthesis in prostate cancer
    • Knudsen KE, Penning TM 2010 Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer. Trends Endocrinol Metab 21:315-324
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 315-324
    • Knudsen, K.E.1    Penning, T.M.2
  • 7
    • 0036170838 scopus 로고    scopus 로고
    • Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells
    • Zegarra-Moro OL, Schmidt LJ, Huang H, Tindall DJ 2002 Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells. Cancer Res 62:1008-1013
    • (2002) Cancer Res , vol.62 , pp. 1008-1013
    • Zegarra-Moro, O.L.1    Schmidt, L.J.2    Huang, H.3    Tindall, D.J.4
  • 8
    • 33751270698 scopus 로고    scopus 로고
    • Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression
    • Cheng H, Snoek R, Ghaidi F, Cox ME, Rennie PS 2006 Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression. Cancer Res 66:10613-10620
    • (2006) Cancer Res , vol.66 , pp. 10613-10620
    • Cheng, H.1    Snoek, R.2    Ghaidi, F.3    Cox, M.E.4    Rennie, P.S.5
  • 9
    • 3843069106 scopus 로고    scopus 로고
    • Androgen receptor: A key molecule in the progression of prostate cancer to hormone independence
    • Taplin ME, Balk SP 2004 Androgen receptor: a key molecule in the progression of prostate cancer to hormone independence. J Cell Biochem 91:483-490
    • (2004) J Cell Biochem , vol.91 , pp. 483-490
    • Taplin, M.E.1    Balk, S.P.2
  • 11
    • 4744347762 scopus 로고    scopus 로고
    • Mechanisms of androgen-refractory prostate cancer
    • Debes JD, Tindall DJ 2004 Mechanisms of androgen-refractory prostate cancer. N Engl J Med 351:1488-1490
    • (2004) N Engl J Med , vol.351 , pp. 1488-1490
    • Debes, J.D.1    Tindall, D.J.2
  • 12
    • 80054931284 scopus 로고    scopus 로고
    • Alternatively spliced androgen receptor variants
    • Dehm SM, Tindall DJ 2011 Alternatively spliced androgen receptor variants. Endocr Relat Cancer 18:R183-R196
    • (2011) Endocr Relat Cancer , vol.18
    • Dehm, S.M.1    Tindall, D.J.2
  • 13
    • 79961013987 scopus 로고    scopus 로고
    • A new trick of an old molecule: Androgen receptor splice variants taking the stage
    • Guo Z, Qiu Y 2011 A new trick of an old molecule: androgen receptor splice variants taking the stage?! Int J Biol Sci 7:815-822
    • (2011) Int J Biol Sci , vol.7 , pp. 815-822
    • Guo, Z.1    Qiu, Y.2
  • 14
    • 0035496220 scopus 로고    scopus 로고
    • The development of androgen-independent prostate cancer
    • Feldman BJ, Feldman D 2001 The development of androgen-independent prostate cancer. Nat Rev Cancer 1:34-45
    • (2001) Nat Rev Cancer , vol.1 , pp. 34-45
    • Feldman, B.J.1    Feldman, D.2
  • 15
  • 16
    • 0036645414 scopus 로고    scopus 로고
    • Molecular biology of the androgen receptor
    • Gelmann EP 2002 Molecular biology of the androgen receptor. J Clin Oncol 20:3001-3015
    • (2002) J Clin Oncol , vol.20 , pp. 3001-3015
    • Gelmann, E.P.1
  • 17
    • 0037112372 scopus 로고    scopus 로고
    • Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line
    • Tepper CG, Boucher DL, Ryan PE, Ma AH, Xia L, Lee LF, Pretlow TG, Kung HJ 2002 Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line. Cancer Res 62:6606-6614
    • (2002) Cancer Res , vol.62 , pp. 6606-6614
    • Tepper, C.G.1    Boucher, D.L.2    Ryan, P.E.3    Ma, A.H.4    Xia, L.5    Lee, L.F.6    Pretlow, T.G.7    Kung, H.J.8
  • 18
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitu-tively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm SM, Schmidt LJ, Heemers HV, Vessella RL, Tindall DJ 2008 Splicing of a novel androgen receptor exon generates a constitu-tively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res 68:5469-5477
    • (2008) Cancer Res , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 21
    • 78049280194 scopus 로고    scopus 로고
    • Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
    • Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, Viale A, Kim K, Sawyers CL 2010 Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci USA 107: 16759-16765
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 16759-16765
    • Watson, P.A.1    Chen, Y.F.2    Balbas, M.D.3    Wongvipat, J.4    Socci, N.D.5    Viale, A.6    Kim, K.7    Sawyers, C.L.8
  • 23
    • 79955719838 scopus 로고    scopus 로고
    • Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
    • Hörnberg E, Ylitalo EB, Crnalic S, Antti H, Stattin P, Widmark A, Bergh A, Wikström P 2011 Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PLoS One 6:e19059
    • (2011) PLoS One , vol.6
    • Hörnberg, E.1    Ylitalo, E.B.2    Crnalic, S.3    Antti, H.4    Stattin, P.5    Widmark, A.6    Bergh, A.7    Wikström, P.8
  • 24
    • 33746512473 scopus 로고    scopus 로고
    • Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity
    • Lyons LS, Burnstein KL 2006 Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity. Mol Endocrinol 20: 1061-1072
    • (2006) Mol Endocrinol , vol.20 , pp. 1061-1072
    • Lyons, L.S.1    Burnstein, K.L.2
  • 25
    • 40849113350 scopus 로고    scopus 로고
    • Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer
    • Lyons LS, Rao S, Balkan W, Faysal J, Maiorino CA, Burnstein KL 2008 Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer. Mol Endocrinol 22:597-608
    • (2008) Mol Endocrinol , vol.22 , pp. 597-608
    • Lyons, L.S.1    Rao, S.2    Balkan, W.3    Faysal, J.4    Maiorino, C.A.5    Burnstein, K.L.6
  • 26
    • 84856955553 scopus 로고    scopus 로고
    • A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer
    • Rao S, Lyons LS, Fahrenholtz CD, Wu F, Farooq A, Balkan W, Burnstein KL 2012 A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer. Oncogene 31:716-727
    • (2012) Oncogene , vol.31 , pp. 716-727
    • Rao, S.1    Lyons, L.S.2    Fahrenholtz, C.D.3    Wu, F.4    Farooq, A.5    Balkan, W.6    Burnstein, K.L.7
  • 27
    • 35148851505 scopus 로고    scopus 로고
    • Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice
    • Banach-Petrosky W, Jessen WJ, Ouyang X, Gao H, Rao J, Quinn J, Aronow BJ, Abate-Shen C 2007 Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice. Cancer Res 67:9089-9096
    • (2007) Cancer Res , vol.67 , pp. 9089-9096
    • Banach-Petrosky, W.1    Jessen, W.J.2    Ouyang, X.3    Gao, H.4    Rao, J.5    Quinn, J.6    Aronow, B.J.7    Abate-Shen, C.8
  • 29
    • 33749345249 scopus 로고    scopus 로고
    • Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer
    • Dong Z, Liu Y, Lu S, Wang A, Lee K, Wang LH, Revelo M, Lu S 2006 Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. Mol Endocrinol 20:2315-2325
    • (2006) Mol Endocrinol , vol.20 , pp. 2315-2325
    • Dong, Z.1    Liu, Y.2    Lu, S.3    Wang, A.4    Lee, K.5    Wang, L.H.6    Revelo, M.7    Lu, S.8
  • 30
    • 84862546529 scopus 로고    scopus 로고
    • Vav3-rac1 signaling regulates prostate cancer metastasis with elevated vav3 expression correlating with prostate cancer progression and posttreatment recurrence
    • Lin KT, Gong J, Li CF, Jang TH, Chen WL, Chen HJ, Wang LH 2012 Vav3-rac1 signaling regulates prostate cancer metastasis with elevated vav3 expression correlating with prostate cancer progression and posttreatment recurrence. Cancer Res 72:3000-3009
    • (2012) Cancer Res , vol.72 , pp. 3000-3009
    • Lin, K.T.1    Gong, J.2    Li, C.F.3    Jang, T.H.4    Chen, W.L.5    Chen, H.J.6    Wang, L.H.7
  • 31
    • 51049083823 scopus 로고    scopus 로고
    • Targeted overexpression of vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate cancer
    • Liu Y, Mo JQ, Hu Q, Boivin G, Levin L, Lu S, Yang D, Dong Z, Lu S 2008 Targeted overexpression of vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate cancer. Cancer Res 68:6396-6406
    • (2008) Cancer Res , vol.68 , pp. 6396-6406
    • Liu, Y.1    Mo, J.Q.2    Hu, Q.3    Boivin, G.4    Levin, L.5    Lu, S.6    Yang, D.7    Dong, Z.8    Lu, S.9
  • 34
    • 0027255417 scopus 로고
    • Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
    • Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG 1993 Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 53:3976-3985
    • (1993) Cancer Res , vol.53 , pp. 3976-3985
    • Kaufmann, S.H.1    Desnoyers, S.2    Ottaviano, Y.3    Davidson, N.E.4    Poirier, G.G.5
  • 35
    • 79957640371 scopus 로고    scopus 로고
    • Alternative activation pathways for the androgen receptor in prostate cancer
    • Lamont KR, Tindall DJ 2011 Alternative activation pathways for the androgen receptor in prostate cancer. Mol Endocrinol 25:897-907
    • (2011) Mol Endocrinol , vol.25 , pp. 897-907
    • Lamont, K.R.1    Tindall, D.J.2
  • 37
    • 0025957233 scopus 로고
    • Transcriptional activation and nuclear targeting signals of the human androgen receptor
    • Simental JA, Sar M, Lane MV, French FS, Wilson EM 1991 Transcriptional activation and nuclear targeting signals of the human androgen receptor. J Biol Chem 266:510-518
    • (1991) J Biol Chem , vol.266 , pp. 510-518
    • Simental, J.A.1    Sar, M.2    Lane, M.V.3    French, F.S.4    Wilson, E.M.5
  • 39
    • 51449087794 scopus 로고    scopus 로고
    • Targeting the androgen receptor pathway in prostate cancer
    • Chen Y, Sawyers CL, Scher HI 2008 Targeting the androgen receptor pathway in prostate cancer. Curr Opin Pharmacol 8:440-448
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 440-4448
    • Chen, Y.1    Sawyers, C.L.2    Scher, H.I.3
  • 40
    • 68049140791 scopus 로고    scopus 로고
    • Starving the addiction: New opportunities for durable suppression of AR signaling in prostate cancer
    • Knudsen KE, Scher HI 2009 Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer. Clin Cancer Res 15:4792-4798
    • (2009) Clin Cancer Res , vol.15 , pp. 4792-4798
    • Knudsen, K.E.1    Scher, H.I.2
  • 41
    • 80052827038 scopus 로고    scopus 로고
    • Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
    • Mostaghel EA, Marck BT, Plymate SR, Vessella RL, Balk S, Matsumoto AM, Nelson PS, Montgomery RB 2011 Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 17:5913-5925
    • (2011) Clin Cancer Res , vol.17 , pp. 5913-5925
    • Mostaghel, E.A.1    Marck, B.T.2    Plymate, S.R.3    Vessella, R.L.4    Balk, S.5    Matsumoto, A.M.6    Nelson, P.S.7    Montgomery, R.B.8
  • 43
    • 84861728843 scopus 로고    scopus 로고
    • Androgen receptor splice variants activate AR target genes and support aberrant prostate cancer cell growth independent of the canonical AR nuclear localization signal
    • Chan SC, Li Y, Dehm SM 2012 Androgen receptor splice variants activate AR target genes and support aberrant prostate cancer cell growth independent of the canonical AR nuclear localization signal. J Biol Chem 287:19736-19749
    • (2012) J Biol Chem , vol.287 , pp. 19736-19749
    • Chan, S.C.1    Li, Y.2    Dehm, S.M.3
  • 45
    • 65249120225 scopus 로고    scopus 로고
    • Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes
    • Liu JY, Seno H, Miletic AV, Mills JC, Swat W, Stappenbeck TS 2009 Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes. J Cell Sci 122:324-334
    • (2009) J Cell Sci , vol.122 , pp. 324-334
    • Liu, J.Y.1    Seno, H.2    Miletic, A.V.3    Mills, J.C.4    Swat, W.5    Stappenbeck, T.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.