Cationized dextran nanoparticle-encapsulated CXCR4-siRNA enhanced correlation between CXCR4 expression and serum alkaline phosphatase in a mouse model of colorectal cancer

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 4159-4168

  Abedini, Fatemeh ^a   Hosseinkhani, Hossein ^b   Ismail, Maznah ^a   Domb, Abraham J ^c   Omar, Abdul Rahman ^a   Chong, Pei Pei ^a,b   Hong, Po Da ^b   Yu, Dah Shyong ^d   Farber, Ira Yudovin ^c  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Cationized dextran; Colorectal cancer; CXCR4; Nanoparticles; Serum ALP enzyme; SiRNA

Indexed keywords

ALKALINE PHOSPHATASE; CHEMOKINE RECEPTOR CXCR4; DEXTRAN SPERMINE NANOPARTICLE; MESSENGER RNA; NANOPARTICLE; SMALL INTERFERING RNA; SMALL INTERFERING RNA I DEXTRAN SPERMINE NANOPARTICLE; SMALL INTERFERING RNA II DEXTRAN SPERMINE NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GENE THERAPY; COLORECTAL CANCER; CONTROLLED STUDY; CXCR4 GENE; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME BLOOD LEVEL; FEMALE; GENE; GENE DELIVERY SYSTEM; GENE EXPRESSION REGULATION; GENE SILENCING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERNALIZATION; LIVER METASTASIS; MOUSE; NANOENCAPSULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PARTICLE SIZE; PROTEIN EXPRESSION; SURFACE CHARGE; ZETA POTENTIAL;

ALKALINE PHOSPHATASE; ANIMALS; CATIONS; COLORECTAL NEOPLASMS; DEXTRANS; DOWN-REGULATION; FEMALE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; NANOCAPSULES; PARTICLE SIZE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CXCR4; RNA, SMALL INTERFERING; SPERMINE;

ANIMALIA; MUS;

EID: 84870347082     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S29823     Document Type: Article

References (35)

1. Geoghegan JG, Scheele J. Treatment of colorectal liver metastases. Br J Surg. 1999;86:158-169.
2. Muller A, Homey B, Soto H, etal. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410:50-56.
3. Alenius H, Muller A, Soto H, etal. Involvement of chemokine receptors in breast cancer metastasis. J Nat Med. 2002;8:157-165.
4. Tachibana K, Hirota S, Iizasa H, etal. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 1998;393:591-594.
5. Ottaiano A, Napolitano M, Tatangelo F, Acquaviva AM, Ascierto PA, Scala S. Inhibitory effects of anti-CXCR4 antibodies on human colon cancer cells. Cancer Immunol Immunother. 2005;54:781-791.
6. Liang Z, Yoon Y, Votaw J, etal. Silencing of CXCR4 blocks breast cancer metastasis. Cancer Res. 2005;65:967-971.
7. Friedman LS, Martin P, Munoz SJ. Liver function tests and the objective evaluation of the patient with liver disease. In: Hepatology: a textbook of liver disease. Zakim D, Boyer TD, editors. Philadelphia, PA: WB Saunders. 1996:791-833.
8. Reichling JJ, Kaplan MM. Clinical use of serum enzymes in liver diseases. Dig Dis Sci. 1988;33:1601-1614.
9. Saif W, Alexander D, Charles M. Serum alkaline phosphatase level as a prognostic tool in colorectal cancer: a study of 105 patients. J Appl Res. 2005;5(1):88-95.
10. Kohne CH, Cunningham D, Di CF, etal. Clinical determinants of survival in patients with 5-fluorouracil-based treatment for metastatic colorectal cancer: results of a multivariate analysis of 3825 patients. Ann Oncol. 2002;13:308-317.
11. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2002;411(6836):494-498.
12. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by doublestranded RNA in Caenorhabditis elegans. Nature. 1998;391:806-811.
13. Liang Z, Wu T, Lou H. Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4. Cancer Res. 2004;64:4302-4308.
14. Banan M, Puri N. The ins and outs of RNAi in mammalian cells. Curr Pharm Biotechnol. 2004;5:441-450.
15. Dorsett Y, Tuschl T. siRNAs: applications in functional genomics and potential as therapeutics. Nature reviews. Drug Discovery. 2004;3:318-329.
16. Bartlett DW, Davis ME. Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res. 2006;34:322-333.
17. Azzam T, Raskin A, Makovitzki A, Brem H, Vierling P, Lineal M. Cationic polysaccharides for gene delivery. Macromolecules. 2002;35:9947-9953.
18. Azzam T, Eliyahu H, Makovitzki A, Domb AJ. Dextran-spermine conjugate: an efficient vector for gene delivery. Macromol Symp. 2003;195:247-261.
19. Hosseinkhani H, Azzam, T, Tabata Y, Domb AJ. Dextran-spermine polycation: an efficient non-viral vector for in vitro and in vivo gene transfection. Gene Therapy. 2004;11:194-203.
20. Eliyahu H, Makovitzki A, Azzam T, Zlotkin A, Joseph A, Gazit D. Novel dextran-spermine conjugates as transfecting agents: comparing water-soluble and micellar polymers. Gene Therapy. 2005;12:494-503.
21. Hosseinkhani H, Hosseinkhani M, Khademhosseini A, Gabrielson NP, Pack DW, Kobayashi H. DNA nanoparticles encapsulated in 3-D tissue engineered scaffold enhance osteogenic differentiation of mesenchymal stem cells. J Biomed Mater Res A. 2008;85:47-60.
22. Hosseinkhani H, Inatsugu Y, Hiraoka Y, Inoue S, Shimokawa H, Tabata Y. Impregnation of plasmid DNA into three-dimensional scaffolds and medium perfusion enhance in vitro DNA expression of mesenchymal stem cells. J Tissue Eng. 2005;11:1459-1475.
23. Hosseinkhani H, Tabata Y. Self assembly of DNA complexes with polycations for the delivery of genetic materials into cells. J Nanosci Nanotechnol. 2006;6:1-9.
24. Nagane K, Jo J, Tabata Y. Promoted adipogenesis of rat mesenchymal stem cells by transfection of small interfering RNA complexed with a cationized dextran. J Tissue Eng Part A. 2010;16(1):21-31.
25. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods. 2001;25:402-408.
26. Robby A, Joseph M. Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov. 2010;9:615-627.
27. Mohanraj VJ, Chen Y. Nanoparticles, a review. TJPR. 2006;5:561-573.
28. Eliyahu H, Joseph A, Schillemans JP, Azzam T, Domb AJ, Barenholz Y. Characterization and in vivo performance of dextran-spermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically. Biomaterials. 2007;28:2339-2349.
29. Abedini F, Hosseinkhani H, Ismail M, etal. In vitro intracellular trafficking of biodegradable nanoparticles dextran-spermine in cancer cell lines. Int J Nanotechnol. 2011;8:712-723.
30. Abedini F, Ismail M, Hosseinkhani H, etal. Toxicity evaluation of dextran-spermine polycation as a tool for genetherapy in vitro. J Cell Animal Biol. 2010;4:170-176.
31. Nie S, Xing Y, Kim GJ, Simons JW. Nanotechnology applications in cancer. Annu Rev Biomed Eng. 2007;9:257-288.
32. Siddiqui IA, Adhami VM, Chamcheu JC, Mukhtar H. Impact of nanotechnology in cancer: emphasis on nanochemoprevention. Int J Nanomedicine. 2012;7:591-605.
33. Zeelenberg S, Ruuls-Van Stalle L. The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res. 2003;63:3833-3839.
34. Rossi D, Zlotnik A. The biology of chemokines and their receptors. Annu Rev Immunol. 2000;18:217-242.
35. Abedini F, Ismail M, Hosseinkhani H, etal. Effects of CXCR4siRNA/dextran-spermine nanoparticles on CXCR4 expression and serum LDH levels in a mouse model of colorectal cancer Metastasis to liver. Cancer Manag Res. 2011;3:301-309.