메뉴 건너뛰기




Volumn 18, Issue 8, 2012, Pages 1209-1219

Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: Involvement of toll-like receptor 4 signaling

(22)  Petronilho, Fabricia a,b   Vuolo, Francieli b   Galant, Letícia Selinger b   Constantino, Larissa b   Tomasi, Cristiane Damiani b   Giombelli, Vinicius Renne b   de Souza, Cláudio Teodoro a   da Silva, Sabrina a   Barbeiro, Denise Frediani c   Soriano, Francisco Garcia c   Streck, Emílio Luiz b   Ritter, Cristiane b   Zanotto Filho, Alfeu d   Pasquali, Matheus Augusto d   Gelain, Daniel Pens d   Rybarczyk Filho, José Luiz d   Moreira, José Cláudio Fonseca d   Block, Norman L e   Roesler, Rafael d,f   Schwartsmann, Gilberto d,e   more..


Author keywords

[No Author keywords available]

Indexed keywords

GASTRIN RELEASING PEPTIDE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; RC 3095; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 84870336694     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2012.00083     Document Type: Article
Times cited : (17)

References (52)
  • 1
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE. (2003) The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348:138-50.
    • (2003) N. Engl. J. Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 2
    • 0038578608 scopus 로고    scopus 로고
    • Novel strategies for the treatment of sepsis
    • Riedemann NC, Guo RF, Ward PA. (2003) Novel strategies for the treatment of sepsis. Nat. Med. 9:517-24.
    • (2003) Nat. Med , vol.9 , pp. 517-524
    • Riedemann, N.C.1    Guo, R.F.2    Ward, P.A.3
  • 3
    • 0037394676 scopus 로고    scopus 로고
    • Neutrophils and acute lung injury
    • Abraham E. (2003) Neutrophils and acute lung injury. Crit. Care Med. 31:195-9.
    • (2003) Crit. Care Med , vol.31 , pp. 195-199
    • Abraham, E.1
  • 4
    • 34548405221 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis
    • Hedge A, Zhang H, Moochhala SM, Bhatia M. (2007) Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. J. Leukoc. Biol. 82:678-85.
    • (2007) J. Leukoc. Biol , vol.82 , pp. 678-685
    • Hedge, A.1    Zhang, H.2    Moochhala, S.M.3    Bhatia, M.4
  • 5
    • 1942500842 scopus 로고    scopus 로고
    • Neutrophil chemotaxis and receptor expression in clinical septic shock
    • Chishti AD, Shenton K, Kirby JA, Baudouin SV. (2004) Neutrophil chemotaxis and receptor expression in clinical septic shock. Intensive Care Med. 30:605-11.
    • (2004) Intensive Care Med , vol.30 , pp. 605-611
    • Chishti, A.D.1    Shenton, K.2    Kirby, J.A.3    Baudouin, S.V.4
  • 6
    • 62649121369 scopus 로고    scopus 로고
    • Regulation of chemokine receptor by toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis
    • Alves-Filho JC, et al. (2009) Regulation of chemokine receptor by toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis. Proc. Natl. Acad. Sci. U. S. A. 106:4018-23.
    • (2009) Proc. Natl. Acad. Sci. U. S. A , vol.106 , pp. 4018-4023
    • Alves-Filho, J.C.1
  • 7
    • 67649201746 scopus 로고    scopus 로고
    • Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis
    • Secher T, et al. (2009) Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis. J. Immunol. 182:7855-64.
    • (2009) J. Immunol , vol.182 , pp. 7855-7864
    • Secher, T.1
  • 8
    • 50549084162 scopus 로고    scopus 로고
    • A novel TLR4-binding peptide that inhibits LPS induced activation of NF-KappaB and vivo toxicity
    • Sugiyama K, Muroi M, Tanamoto K. (2008) A novel TLR4-binding peptide that inhibits LPS induced activation of NF-KappaB and vivo toxicity. Eur. J. Pharmacol. 10:152-6.
    • (2008) Eur. J. Pharmacol , vol.10 , pp. 152-156
    • Sugiyama, K.1    Muroi, M.2    Tanamoto, K.3
  • 9
    • 34247146479 scopus 로고    scopus 로고
    • A novel inhibitory peptide of toll-like receptor signaling limits lipopolysaccharide-induced production of inflammatory mediators and enhances survival in mice
    • Tsung A, et al. (2007) A novel inhibitory peptide of toll-like receptor signaling limits lipopolysaccharide-induced production of inflammatory mediators and enhances survival in mice. Shock. 27:364-9.
    • (2007) Shock , vol.27 , pp. 364-369
    • Tsung, A.1
  • 10
    • 0033588018 scopus 로고    scopus 로고
    • Multiple protein kinase pathways are involved in gastrinreleasing peptide receptor-regulated secretion
    • Hellmich MR, Ives KL, Udupi V. (1999) Multiple protein kinase pathways are involved in gastrinreleasing peptide receptor-regulated secretion. J. Biol. Chem. 274:23901-9.
    • (1999) J. Biol. Chem , vol.274 , pp. 23901-23909
    • Hellmich, M.R.1    Ives, K.L.2    Udupi, V.3
  • 11
    • 31344481400 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis
    • Alves-Filho JC, de Freitas A, Russo M, Cunha FQ. (2006) Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis. Crit. Care Med. 34:461-70.
    • (2006) Crit. Care Med , vol.34 , pp. 461-470
    • Alves-Filho, J.C.1    de Freitas, A.2    Russo, M.3    Cunha, F.Q.4
  • 12
    • 0015224130 scopus 로고
    • Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes
    • Anastasi A, Erspamer V, Bucci M. (1971) Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia. 27:166-7.
    • (1971) Experientia , vol.27 , pp. 166-167
    • Anastasi, A.1    Erspamer, V.2    Bucci, M.3
  • 13
    • 0041374121 scopus 로고    scopus 로고
    • Bombesin-like peptides and mast cell responses: Relevance to bronchopulmonary dysplasia
    • Subramaniam M, et al. (2003) Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? Am. J. Respir. Crit. Care Med. 168:601-11.
    • (2003) Am. J. Respir. Crit. Care Med , vol.168 , pp. 601-611
    • Subramaniam, M.1
  • 14
    • 20144370371 scopus 로고    scopus 로고
    • Levels of gastrin releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis
    • Grimsholm O, Rantapaa-Dahlqvist S, Forsgren S. (2005) Levels of gastrin releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis. Arthritis Res. Ther. 7:R416-26.
    • (2005) Arthritis Res. Ther , vol.7
    • Grimsholm, O.1    Rantapaa-Dahlqvist, S.2    Forsgren, S.3
  • 16
    • 41149176081 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: Nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states
    • Jensen RT, Battey JF, Spindel ER, Benya RV. (2008) International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol. Rev. 60:1-42.
    • (2008) Pharmacol. Rev , vol.60 , pp. 1-42
    • Jensen, R.T.1    Battey, J.F.2    Spindel, E.R.3    Benya, R.V.4
  • 17
    • 33744502117 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptor as a molecular target for psychiatric and neurological disorders
    • Roesler R, Henriques JA, Schwartsmann G. (2006) Gastrin-releasing peptide receptor as a molecular target for psychiatric and neurological disorders. C.N.S. Neurol. Disord. Drug Targets. 5:197-204.
    • (2006) C.N.S. Neurol. Disord. Drug Targets , vol.5 , pp. 197-204
    • Roesler, R.1    Henriques, J.A.2    Schwartsmann, G.3
  • 18
    • 45549089546 scopus 로고    scopus 로고
    • New approaches to the therapy of various tumors based on peptide analogues
    • Schally AV. (2008) New approaches to the therapy of various tumors based on peptide analogues. Horm. Metab. Res. 40:315-22.
    • (2008) Horm. Metab. Res , vol.40 , pp. 315-322
    • Schally, A.V.1
  • 19
    • 0141612894 scopus 로고    scopus 로고
    • Interactions between the enteric nervous system and the immune system: Role of neuropeptides and nutrition
    • Genton L, Kudsk KA. (2003) Interactions between the enteric nervous system and the immune system: role of neuropeptides and nutrition. Am. J. Surg. 186:253-8.
    • (2003) Am. J. Surg , vol.186 , pp. 253-258
    • Genton, L.1    Kudsk, K.A.2
  • 20
    • 33745053099 scopus 로고    scopus 로고
    • A phase I trial of the bombesin/gastrin-releasing peptide (BN/ GRP) antagonist RC3095 in patients with advanced solid malignancies
    • Schwartsmann G, et al. (2006) A phase I trial of the bombesin/gastrin-releasing peptide (BN/ GRP) antagonist RC3095 in patients with advanced solid malignancies. Invest New Drugs. 24:403-12.
    • (2006) Invest New Drugs , vol.24 , pp. 403-412
    • Schwartsmann, G.1
  • 21
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • Guha M, Mackman N. (2001) LPS induction of gene expression in human monocytes. Cell Signal. 13:85-94.
    • (2001) Cell Signal , vol.13 , pp. 85-94
    • Guha, M.1    Mackman, N.2
  • 22
    • 30344433265 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptor antagonist effects on an animal model of sepsis
    • Dal-Pizzol F, et al. (2006) Gastrin-releasing peptide receptor antagonist effects on an animal model of sepsis. Am. J. Respir. Crit. Care Med. 173:84-90.
    • (2006) Am. J. Respir. Crit. Care Med , vol.173 , pp. 84-90
    • Dal-Pizzol, F.1
  • 24
    • 1242342767 scopus 로고    scopus 로고
    • Treatment with Nacetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis
    • Ritter C, et al. (2004) Treatment with Nacetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis. Crit. Care. 32:342-9.
    • (2004) Crit. Care , vol.32 , pp. 342-349
    • Ritter, C.1
  • 25
    • 0344683235 scopus 로고    scopus 로고
    • Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Research Council of the National Academies, 8th edition. Washington (DC): National Academies Press. [cited 2012 Oct 12]. Available from
    • Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Research Council of the National Academies. (2011) Guide for the Care and Use of Laboratory Animals. 8th edition. Washington (DC): National Academies Press. [cited 2012 Oct 12]. Available from: http://oacu.od.nih.gov/regs/
    • (2011) Guide For the Care and Use of Laboratory Animals
  • 26
    • 0026724481 scopus 로고
    • The ACCP-SCCM consensus conference on sepsis and organ failure
    • Bone RC, Sibbald WJ, Sprung CL. (1992) The ACCP-SCCM consensus conference on sepsis and organ failure. Chest. 101:1481-3.
    • (1992) Chest , vol.101 , pp. 1481-1483
    • Bone, R.C.1    Sibbald, W.J.2    Sprung, C.L.3
  • 27
    • 0026338583 scopus 로고
    • Biological effects and receptor binding affinities of new pseudononapeptide bombesin/GRP receptor antagonists with Nterminal d-Trp or d-Tpi
    • Radulovic S, et al. (1991) Biological effects and receptor binding affinities of new pseudononapeptide bombesin/GRP receptor antagonists with Nterminal d-Trp or d-Tpi. Int. J. Pept. Protein Res. 38:593-600.
    • (1991) Int. J. Pept. Protein Res , vol.38 , pp. 593-600
    • Radulovic, S.1
  • 29
    • 75549087827 scopus 로고    scopus 로고
    • STITCH 2: An interaction network database for small molecules and proteins
    • Kuhn M, et al. (2010) STITCH 2: an interaction network database for small molecules and proteins. Nucleic Acids Res. 38:D552-6.
    • (2010) Nucleic Acids Res , vol.38
    • Kuhn, M.1
  • 30
    • 0035861675 scopus 로고    scopus 로고
    • The sequence-specific DNA binding of NF-αB is reversibly regulated by the automodification reaction of poly (ADP-ribose) polymerase I
    • Chang W, Alvarez-Gonzalez R. (2001) The sequence-specific DNA binding of NF-αB is reversibly regulated by the automodification reaction of poly (ADP-ribose) polymerase I. J. Biol. Chem. 276:47664-70.
    • (2001) J. Biol. Chem , vol.276 , pp. 47664-47670
    • Chang, W.1    Alvarez-Gonzalez, R.2
  • 31
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding
    • Bradford MM. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal. Biochem. 72:248-54.
    • (1976) Anal. Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 32
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680-5.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 33
    • 0345548705 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: A novel pathway for neural control of insulin secretion
    • De Souza CT, et al. (2003) Peroxisome proliferatoractivated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion. Diabetologia. 46:1522-31.
    • (2003) Diabetologia , vol.46 , pp. 1522-1531
    • de Souza, C.T.1
  • 34
    • 0033929552 scopus 로고    scopus 로고
    • Role of nitric oxide in the failure of neutrophil migration in sepsis
    • Benjamim CF, Ferreira SH, Cunha FQ. (2000) Role of nitric oxide in the failure of neutrophil migration in sepsis. J. Infect. Dis. 182:214-23.
    • (2000) J. Infect. Dis , vol.182 , pp. 214-223
    • Benjamim, C.F.1    Ferreira, S.H.2    Cunha, F.Q.3
  • 35
    • 0036350778 scopus 로고    scopus 로고
    • Genetic background determines susceptibility during murine septic peritonitis
    • Godshall CJ, et al. (2002) Genetic background determines susceptibility during murine septic peritonitis. J. Surg. Res. 102:45-9.
    • (2002) J. Surg. Res , vol.102 , pp. 45-49
    • Godshall, C.J.1
  • 36
    • 34548429606 scopus 로고    scopus 로고
    • Antiinflammatory neuropeptide receptors: New therapeutic targets for immune disorders? Trends Pharmacol
    • Gonzalez-Rey E, Delgado M. (2007) Antiinflammatory neuropeptide receptors: new therapeutic targets for immune disorders? Trends Pharmacol. Sci. 28:482-91.
    • (2007) Sci , vol.28 , pp. 482-491
    • Gonzalez-Rey, E.1    Delgado, M.2
  • 37
    • 54049136026 scopus 로고    scopus 로고
    • The role of neutrophils in severe sepsis
    • Alves-Filho JC, et al. (2008) The role of neutrophils in severe sepsis. Shock. 30(Suppl 1):3-9.
    • (2008) Shock , vol.30 , Issue.SUPPL. 1 , pp. 3-9
    • Alves-Filho, J.C.1
  • 39
    • 0038047587 scopus 로고    scopus 로고
    • Modulation of tissue toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality
    • Williams DL, et al. (2003) Modulation of tissue toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality. Crit. Care Med. 31:1808-18.
    • (2003) Crit. Care Med , vol.31 , pp. 1808-1818
    • Williams, D.L.1
  • 40
    • 20644432642 scopus 로고    scopus 로고
    • The nervous system and innate immunity: The neuropeptide connection
    • Brogden KA, Guthmiller JM, Salzet M, Zasloff M. (2005) The nervous system and innate immunity: the neuropeptide connection. Nat. Immunol. 6:558-64.
    • (2005) Nat. Immunol , vol.6 , pp. 558-564
    • Brogden, K.A.1    Guthmiller, J.M.2    Salzet, M.3    Zasloff, M.4
  • 41
    • 31144475602 scopus 로고    scopus 로고
    • Corticotropin releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1
    • Tsatsanis C, et al. (2006) Corticotropin releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1. J. Immunol. 176:1869-77.
    • (2006) J. Immunol , vol.176 , pp. 1869-1877
    • Tsatsanis, C.1
  • 42
    • 17044392279 scopus 로고    scopus 로고
    • The immunomodulating neuropeptide alpha-melanocytestimulating hormone (alpha-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages
    • Taylor AW. (2005) The immunomodulating neuropeptide alpha-melanocytestimulating hormone (alpha-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages. J. Neuroimmunol. 162:43-50.
    • (2005) J. Neuroimmunol , vol.162 , pp. 43-50
    • Taylor, A.W.1
  • 43
    • 0141612894 scopus 로고    scopus 로고
    • Interactions between the enteric nervous system and the immune system: Role of neuropeptides and nutrition
    • Genton L, Kudsk KA. (2003) Interactions between the enteric nervous system and the immune system: role of neuropeptides and nutrition. Am. J. Surg. 186:253-8.
    • (2003) Am. J. Surg , vol.186 , pp. 253-258
    • Genton, L.1    Kudsk, K.A.2
  • 44
    • 4444355085 scopus 로고    scopus 로고
    • Alternative activated macrophage: A new key for systemic inflammatory response syndrome and sepsis treatment? Crit
    • Dal-Pizzol F. (2004) Alternative activated macrophage: a new key for systemic inflammatory response syndrome and sepsis treatment? Crit. Care Med. 32:1971-2.
    • (2004) Care Med , vol.32 , pp. 1971-1972
    • Dal-Pizzol, F.1
  • 45
    • 56649103857 scopus 로고    scopus 로고
    • Gastrin-releasing peptide, immune responses, and lung disease
    • Degan S, Lopez GY, Kevill K, Sunday ME. (2008) Gastrin-releasing peptide, immune responses, and lung disease. Ann. N. Y. Acad. Sci. 1144:136-47.
    • (2008) Ann. N. Y. Acad. Sci , vol.1144 , pp. 136-147
    • Degan, S.1    Lopez, G.Y.2    Kevill, K.3    Sunday, M.E.4
  • 46
    • 20044373663 scopus 로고    scopus 로고
    • Local coordination verses systemic deregulation: Complexities in leukocyte recruitment revealed by local and systemic activation of TLR4 in vivo
    • Kerfoot SM, Kubes P. (2005) Local coordination verses systemic deregulation: complexities in leukocyte recruitment revealed by local and systemic activation of TLR4 in vivo. J. Leukoc. Biol. 77:862-7.
    • (2005) J. Leukoc. Biol , vol.77 , pp. 862-867
    • Kerfoot, S.M.1    Kubes, P.2
  • 47
    • 0037380645 scopus 로고    scopus 로고
    • Endothelium-derived toll-like receptor-4 is the key molecule in LPSinduced neutrophil sequestration into lungs
    • Andonegui G, et al. (2003) Endothelium-derived toll-like receptor-4 is the key molecule in LPSinduced neutrophil sequestration into lungs. J. Clin. Invest. 111:1011-20.
    • (2003) J. Clin. Invest , vol.111 , pp. 1011-1020
    • Andonegui, G.1
  • 48
    • 59649104517 scopus 로고    scopus 로고
    • Toll-like receptor pathway signaling is differently regulated in neutrophils and peripheral mononuclear cells of patients with sepsis, severe sepsis, and septic shock
    • Salomao R, et al. (2009). Toll-like receptor pathway signaling is differently regulated in neutrophils and peripheral mononuclear cells of patients with sepsis, severe sepsis, and septic shock. Crit. Care Med. 37:132-9.
    • (2009) Crit. Care Med , vol.37 , pp. 132-139
    • Salomao, R.1
  • 50
    • 41849087644 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide
    • Arranz A, et al. (2008) Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide. Mol. Immunol. 45:2970-80.
    • (2008) Mol. Immunol , vol.45 , pp. 2970-2980
    • Arranz, A.1
  • 51
  • 52
    • 84856018299 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils
    • Czepielewski RS, et al. (2012) Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils. Proc. Natl. Acad. Sci. U. S. A. 109:547-52.
    • (2012) Proc. Natl. Acad. Sci. U. S. A , vol.109 , pp. 547-552
    • Czepielewski, R.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.