A rapid flow cytometric method for distinguishing between febrile bacterial and viral infections

Journal of Microbiological Methods

Volumn 92, Issue 1, 2013, Pages 64-72

  Nuutila, Jari ^a   Jalava Karvinen, Päivi ^b   Hohenthal, Ulla ^b   Kotilainen, Pirkko ^b   Pelliniemi, Tarja Terttu ^b   Nikoskelainen, Jukka ^b   Lilius, Esa Matti ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Bacterial infection; Cell surface receptors on neutrophils and monocytes; Differential diagnosis; Flow cytometry; Viral infection

Indexed keywords

CD32 ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C5A RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

2009 H1N1 INFLUENZA; ADOLESCENT; ADULT; AGED; ARTICLE; BACTERIAL INFECTION; BACTERIAL INFECTION SCORE; BACTERIAL PNEUMONIA; CLINICAL EFFECTIVENESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; FEMALE; FEVER; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NEUTROPHIL COUNT; PILOT STUDY; PREDICTIVE VALUE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; VIRUS INFECTION; VIRUS PNEUMONIA;

ADULT; ANTIGENS, SURFACE; BACTERIAL INFECTIONS; BIOLOGICAL MARKERS; CLINICAL LABORATORY TECHNIQUES; FEMALE; FEVER; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; PHAGOCYTES; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; VIRUS DISEASES; YOUNG ADULT;

BACTERIA (MICROORGANISMS);

EID: 84870316095     PISSN: 01677012     EISSN: 18728359     Source Type: Journal    
DOI: 10.1016/j.mimet.2012.11.005     Document Type: Article

References (42)

1. Beaugerie L., Petit J.C. Microbial-gut interactions in health and disease. Antibiotic-associated diarrhoea. Best Pract. Res. Clin. Gastroenterol. 2004, 18:337-352.
2. Bewick V., Cheek L., Ball J. Statistics review 13: receiver operating characteristic curves. Crit. Care 2004, 8:508-512.
3. Boss B., Neeck G. Correlation of IL-6 with the classical humoral disease activity parameters ESR and CRP and with serum cortisol, reflecting the activity of the HPA axis in active rheumatoid arthritis. Z. Rheumatol. 2000, 59(Suppl. 2):II/62-II/64.
4. Cunha B.A., Syed U., Hamid N. Fever of unknown origin caused by late-onset rheumatoid arthritis. Heart Lung 2006, 35:70-73.
5. Dubos F., Moulin F., Gajdos V., De Suremain N., Biscardi S., Lebon P., Raymond J., Breart G., Gendrel D., Chalumeau M. Serum procalcitonin and other biologic markers to distinguish between bacterial and aseptic meningitis. J. Pediatr. 2006, 149:72-76.
6. El Solh A., Pineda L., Bouquin P., Mankowski C. Determinants of short and long term functional recovery after hospitalization for community-acquired pneumonia in the elderly: role of inflammatory markers. BMC Geriatr. 2006, 6:12.
7. Fischer J.E., Benn A., Harbarth S., Nadal D., Fanconi S. Diagnostic accuracy of G-CSF, IL-8, and IL-1ra in critically ill children with suspected infection. Intensive Care Med. 2002, 28:1324-1331.
8. Fjaertoft G., Pauksen K., Hakansson L., Xu S., Venge P. Cell surface expression of FcgammaRI (CD64) on neutrophils and monocytes in patients with influenza A, with and without complications. Scand. J. Infect. Dis. 2005, 37:882-889.
9. French G.L. Clinical impact and relevance of antibiotic resistance. Adv. Drug Deliv. Rev. 2005, 57:1514-1527.
10. Gendrel D., Raymond J., Coste J., Moulin F., Lorrot M., Guerin S., Ravilly S., Lefevre H., Royer C., Lacombe C., Palmer P., Bohuon C. Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections. Pediatr. Infect. Dis. J. 1999, 18:875-881.
11. Gould I.M. Costs of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) and its control. Int. J. Antimicrob. Agents 2006, 28:379-384.
12. Guarner F., Malagelada J.R. Gut flora in health and disease. Lancet 2003, 361:512-519.
13. Haas P.J., de Haas C.J., Poppelier M.J., van Kessel K.P., van Strijp J.A., Dijkstra K., Scheek R.M., Fan H., Kruijtzer J.A., Liskamp R.M., Kemmink J. The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of Staphylococcus aureus is related to a group of immune evasive molecules. J. Mol. Biol. 2005, 353:859-872.
14. Hansen T.H., Bouvier M. MHC class I antigen presentation: learning from viral evasion strategies. Nat. Rev. Immunol. 2009, 9:503-513.
15. Hohenthal U., Nuutila J., Lilius E.M., Laitinen I., Nikoskelainen J., Kotilainen P. Measurement of complement receptor 1 on neutrophils in bacterial and viral pneumonia. BMC Infect. Dis. 2006, 6:11.
16. Jalava-Karvinen P., Hohenthal U., Laitinen I., Kotilainen P., Rajamaki A., Nikoskelainen J., Lilius E.M., Nuutila J. Simultaneous quantitative analysis of Fc gamma RI (CD64) and CR1 (CD35) on neutrophils in distinguishing between bacterial infections, viral infections, and inflammatory diseases. Clin. Immunol. 2009, 133:314-323.
17. Kilkkinen A., Rissanen H., Klaukka T., Pukkala E., Heliovaara M., Huovinen P., Mannisto S., Aromaa A., Knekt P. Antibiotic use predicts an increased risk of cancer. Int. J. Cancer 2008, 123:2152-2155.
18. Kim D.D., Song W.C. Membrane complement regulatory proteins. Clin. Immunol. 2006, 118:127-136.
19. Kitanovski L., Jazbec J., Hojker S., Gubina M., Derganc M. Diagnostic accuracy of procalcitonin and interleukin-6 values for predicting bacteremia and clinical sepsis in febrile neutropenic children with cancer. Eur. J. Clin. Microbiol. Infect. Dis. 2006, 25:413-415.
20. Korppi M., Heiskanen-Kosma T., Leinonen M. White blood cells, C-reactive protein and erythrocyte sedimentation rate in pneumococcal pneumonia in children. Eur. Respir. J. 1997, 10:1125-1129.
21. Kotter I., Wacker A., Koch S., Henes J., Richter C., Engel A., Gunaydin I., Kanz L. Anakinra in patients with treatment-resistant adult-onset Still's disease: four case reports with serial cytokine measurements and a review of the literature. Semin. Arthritis Rheum. 2007, 37:189-197.
22. Krych M., Hauhart R., Atkinson J.P. Structure-function analysis of the active sites of complement receptor type 1. J. Biol. Chem. 1998, 273:8623-8629.
23. Livermore D.M. Minimising antibiotic resistance. Lancet Infect. Dis. 2005, 5:450-459.
24. Lutfiyya M.N., Henley E., Chang L.F., Reyburn S.W. Diagnosis and treatment of community-acquired pneumonia. Am. Fam. Physician 2006, 73:442-450.
25. Mandell L.A., Bartlett J.G., Dowell S.F., File T.M., Musher D.M., Whitney C. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin. Infect. Dis. 2003, 37:1405-1433.
26. Moayyedi P., Axon A.T. The usefulness of the likelihood ratio in the diagnosis of dyspepsia and gastroesophageal reflux disease. Am. J. Gastroenterol. 1999, 94:3122-3125.
27. Monk P.N., Scola A.M., Madala P., Fairlie D.P. Function, structure and therapeutic potential of complement C5a receptors. Br. J. Pharmacol. 2007, 152:429-448.
28. Mqadmi A., Abdullah Y., Yazdanbakhsh K. Characterization of complement receptor 1 domains for prevention of complement-mediated red cell destruction. Transfusion 2005, 45:234-244.
29. Mukai A.O., Krebs V.L., Bertoli C.J., Okay T.S. TNF-alpha and IL-6 in the diagnosis of bacterial and aseptic meningitis in children. Pediatr. Neurol. 2006, 34:25-29.
30. Ng P.C., Li K., Wong R.P., Chui K.M., Wong E., Fok T.F. Neutrophil CD64 expression: a sensitive diagnostic marker for late-onset nosocomial infection in very low birthweight infants. Pediatr. Res. 2002, 51:296-303.
31. Nuutila J., Hohenthal U., Laitinen I., Kotilainen P., Rajamaki A., Nikoskelainen J., Lilius E.M. Quantitative analysis of complement receptors, CR1 (CD35) and CR3 (CD11b), on neutrophils improves distinction between bacterial and viral infections in febrile patients: comparison with standard clinical laboratory data. J. Immunol. Methods 2006, 315:191-201.
32. Nuutila J., Hohenthal U., Laitinen I., Kotilainen P., Rajamaki A., Nikoskelainen J., Lilius E.M. Simultaneous quantitative analysis of FcgammaRI (CD64) expression on neutrophils and monocytes: a new, improved way to detect infections. J. Immunol. Methods 2007, 328:189-200.
33. Rheology, E.P.o.B. ICSH recommendations for measurement of erythrocyte sedimentation rate. International Council for Standardization in Haematology (Expert Panel on Blood Rheology). J. Clin. Pathol. 1993, 46:198-203.
34. Rivers E.P., McIntyre L., Morro D.C., Rivers K.K. Early and innovative interventions for severe sepsis and septic shock: taking advantage of a window of opportunity. CMAJ 2005, 173:1054-1065.
35. Steinman M.A., Landefeld C.S., Gonzales R. Predictors of broad-spectrum antibiotic prescribing for acute respiratory tract infections in adult primary care. JAMA 2003, 289:719-725.
36. Sutterwala F.S., Rosenthal L.A., Mosser D.M. Cooperation between CR1 (CD35) and CR3 (CD 11b/CD18) in the binding of complement-opsonized particles. J. Leukoc. Biol. 1996, 59:883-890.
37. van Rossum A.M., Wulkan R.W., Oudesluys-Murphy A.M. Procalcitonin as an early marker of infection in neonates and children. Lancet Infect. Dis. 2004, 4:620-630.
38. Vanderweil S.G., Pelletier A.J., Hamedani A.G., Gonzales R., Metlay J.P., Camargo C.A. Declining antibiotic prescriptions for upper respiratory infections, 1993-2004. Acad. Emerg. Med. 2007, 14:366-369.
39. Wang S.S., Lee F.Y., Chan C.C., Lu R.H., Chao Y., Lin H.C., Wu S.L., Tsai Y.T., Lee S.D. Sequential changes in plasma cytokine and endotoxin levels in cirrhotic patients with bacterial infection. Clin. Sci. (Lond) 2000, 98:419-425.
40. Worth R.G., Mayo-Bond L., van de Winkel J.G., Todd R.F., Petty H.R. CR3 (alphaM beta2; CD11b/CD18) restores IgG-dependent phagocytosis in transfectants expressing a phagocytosis-defective FcgammaRIIA (CD32) tail-minus mutant. J. Immunol. 1996, 157:5660-5665.
41. Yang S., Rothman R.E. PCR-based diagnostics for infectious diseases: uses, limitations, and future applications in acute-care settings. Lancet Infect. Dis. 2004, 4:337-348.
42. Zipfel P.F., Skerka C. Complement regulators and inhibitory proteins. Nat. Rev. Immunol. 2009, 9:729-740.