Serum procalcitonin and other biologic markers to distinguish between bacterial and aseptic meningitis

Journal of Pediatrics

Volumn 149, Issue 1, 2006, Pages 72-76

  Dubos, Francois ^a   Moulin, Florence ^a   Gajdos, Vincent ^a   De Suremain, Nathalie ^a   Biscardi, Sandra ^a   Lebon, Pierre ^a   Raymond, Josette ^a   Breart, Gerard ^a   Gendrel, Dominique ^a   Chalumeau, Martin ^a  

^a Clinical Epidemiology Unit   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; GLUCOSE; PROCALCITONIN; PROTEIN;

ADOLESCENT; ARTICLE; ASEPTIC MENINGITIS; BACTERIAL MENINGITIS; CEREBROSPINAL FLUID; CHILD; CHILD HOSPITALIZATION; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; EMERGENCY WARD; FEMALE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NEUTROPHIL COUNT; PREDICTION AND FORECASTING; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; RETROSPECTIVE STUDY; ROC CURVE; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; STAINING; TIME SERIES ANALYSIS; UNIVARIATE ANALYSIS;

ADOLESCENT; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CALCITONIN; CEREBROSPINAL FLUID PROTEINS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DIAGNOSIS, DIFFERENTIAL; FEMALE; GLUCOSE; HUMANS; INFANT; LEUKOCYTE COUNT; MALE; MENINGITIS, ASEPTIC; MENINGITIS, BACTERIAL; NEUTROPHILS; PROTEIN PRECURSORS; RETROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 33746161578     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2006.02.034     Document Type: Article

References (36)

1. Nigrovic L.E., Kuppermann N., and Malley R. Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. Pediatrics 110 (2002) 712-719
2. Negrini B., Kelleher K.J., and Wald E.R. Cerebrospinal fluid findings in aseptic versus bacterial meningitis. Pediatrics 105 (2000) 316-319
3. McKinney W.P., Heudebert G.R., Harper S.A., Young M.J., and McIntire D.D. Validation of a clinical prediction rule for the differential diagnosis of acute meningitis. J Gen Intern Med 9 (1994) 8-12
4. Dubos F., Moulin F., Raymond J., Gendrel D., Bréart G., and Chalumeau M. Distinguishing between bacterial and viral meningitis in children in the emergency room. reproducibility and comparison of five clinical decision rules (2005) 1352 Presented at Pediatric Academic Societies Annual Meeting, Washington, DC, May 14-17
5. El Bashir H., Laundy M., and Booy R. Diagnosis and treatment of bacterial meningitis. Arch Dis Child 88 (2003) 615-620
6. Saez-Llorens X., and McCracken G.H. Bacterial meningitis in children. Lancet 361 (2003) 2139-2148
7. Tunkel A.R., Hartman B.J., Kaplan S.L., Kaufman B.A., Roos K.L., Scheld W.M., et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 39 (2004) 1267-1284
8. Feigin R.D., McCracken G.H., and Klein J.O. Diagnosis and management of meningitis. Pediatr Infect Dis J 11 (1992) 785-814
9. Swingler G., Delport S., and Hussey G. An audit of the use of antibiotics in presumed viral meningitis in children. Pediatr Infect Dis J 13 (1994) 1107-1110
10. Raymond J. Epidemiology of nosocomial infections in pediatrics. Pathol Biol 48 (2000) 879-884
11. Parasuraman T.V., Frenia K., and Romero J. Enteroviral meningitis. Cost of illness and considerations for the economic evaluation of potential therapies. Pharmacoeconomics 19 (2001) 3-12
12. Haruda F.D. Meningitis-viral versus bacterial. Pediatrics 112 (2003) 447-448
13. Michelow I.C., Nicol M., Tiemessen C., Chezzi C., and Pettifor J.M. Value of cerebrospinal fluid leukocyte aggregation in distinguishing the causes of meningitis in children. Pediatr Infect Dis J 19 (2000) 66-72
14. Tatara R., and Imai H. Serum C-reactive protein in the differential diagnosis of childhood meningitis. Pediatr Int 42 (2000) 541-546
15. Maxson S., Lewno M.J., and Schutze G.E. Clinical usefulness of cerebrospinal fluid bacterial antigen studies. J Pediatr 125 (1994) 235-238
16. Assicot M., Gendrel D., Carsin H., Raymond J., Guilbaud J., and Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 341 (1993) 515-518
17. Gendrel D., Raymond J., Assicot M., Moulin F., Iniguez J.L., Lebon P., et al. Measurement of procalcitonin levels in children with bacterial or viral meningitis. Clin Infect Dis 24 (1997) 1240-1242
18. van Rossum A.M., Wulkan R.W., and Oudesluys-Murphy A.M. Procalcitonin as an early marker of infection in neonates and children. Lancet Infect Dis 4 (2004) 620-630
19. Simon L., Gauvin F., Amre D.K., Saint-Louis P., and Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection. a systematic review and meta-analysis. Clin Infect Dis 39 (2004) 206-217
20. Viallon A., Zeni F., Lambert C., Pozzetto B., Tardy B., Venet C., et al. High sensitivity and specificity of serum procalcitonin levels in adults with bacterial meningitis. Clin Infect Dis 28 (1999) 1313-1316
21. Schwarz S., Bertram M., Schwab S., Andrassy K., and Hacke W. Serum procalcitonin levels in bacterial and abacterial meningitis. Crit Care Med 28 (2000) 1828-1832
22. Korczowski B., Bijos A., and Rybak A. Procalcitonin in diagnosis of purulent and aseptic meningitis in children. Pol Merkuriusz Lek 9 (2000) 755-757
23. Prat C., Dominguez J., Rodrigo C., Gimenez M., Azuara M., Blanco S., et al. Use of quantitative and semiquantitative procalcitonin measurements to identify children with sepsis and meningitis. Eur J Clin Microbiol Infect Dis 23 (2004) 136-138
24. Bonsu B.K., and Harper M.B. Differentiating acute bacterial meningitis from acute viral meningitis among children with cerebrospinal fluid pleocytosis. a multivariable regression model. Pediatr Infect Dis J 23 (2004) 511-517
25. Freedman S.B., Marrocco A., Pirie J., and Dick P.T. Predictors of bacterial meningitis in the era after Haemophilus influenzae. Arch Pediatr Adolesc Med 155 (2001) 1301-1306
26. Greenlee J.E. Approach to diagnosis of meningitis. Cerebrospinal fluid evaluation. Infect Dis Clin North Am 4 (1990) 583-598
27. Saez-Llorens X., and McCracken G.H. Bacterial meningitis in neonates and children. Infect Dis Clin North Am 4 (1990) 623-644
28. Hanley J.A., and McNeil B.J. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 148 (1983) 839-843
29. Bonadio W.A. The cerebrospinal fluid. physiologic aspects and alterations associated with bacterial meningitis. Pediatr Infect Dis J 11 (1992) 423-431
30. Spanos A., Harrell F.E., and Durack D.T. Differential diagnosis of acute meningitis. an analysis of the predictive value of initial observations. JAMA 262 (1989) 2700-2707
31. Nigrovic L.E., Kuppermann N., McAdam A.J., and Malley R. Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis. Pediatr Infect Dis J 23 (2004) 786-788
32. Saravolatz L.D., Manzor O., VanderVelde N., Pawlak J., and Belian B. Broad-range bacterial polymerase chain reaction for early detection of bacterial meningitis. Clin Infect Dis 36 (2003) 40-45
33. Hoen B., Viel J.F., Paquot C., Gerard A., and Canton P. Multivariate approach to differential diagnosis of acute meningitis. Eur J Clin Microbiol Infect Dis 14 (1995) 267-274
34. Jaeger F., Leroy J., Duchene F., Baty V., Baillet S., Estavoyer J.M., et al. Validation of a diagnosis model for differentiating bacterial from viral meningitis in infants and children under 3.5 years of age. Eur J Clin Microbiol Infect Dis 19 (2000) 418-421
35. Dandona P., Nix D., Wilson M.F., Aljada A., Love J., Assicot M., et al. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 79 (1994) 1605-1608
36. Kleine T.O., Zwerenz P., Zofel P., and Shiratori K. New and old diagnostic markers of meningitis in cerebrospinal fluid (CSF). Brain Res Bull 61 (2003) 287-297