Preparation and characterization of polysaccharide-based nanoparticles with anticoagulant activity

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 2975-2986

  da Silva, Luiz Cláudio ^a   Garcia, Thiago ^a   Mori, Michela ^b   Sandri, Giuseppina ^b   Bonferoni, Maria Cristina ^b   Finotelli, Priscila V ^a   Cinelli, Leonardo P ^a   Caramella, Carla ^b   Cabral, Lúcio M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

aPTT; Caco 2; Chitosan; Chondroitin sulfate; Fucoidan; Nanoparticles

Indexed keywords

CHITOSAN; CHONDROITIN SULFATE; FUCOIDIN; NANOPARTICLE;

ANTICOAGULATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD CLOTTING TIME; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CELL VIABILITY; CHEMICAL PARAMETERS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG SCREENING; DRUG SYNTHESIS; ENDOCYTOSIS; LIGHT SCATTERING; MEAN DIAMETER; NONHUMAN; PARTICLE SIZE; PH; POLYDISPERSITY INDEX; RAT; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ANTICOAGULANTS; CACO-2 CELLS; CELL SURVIVAL; CHITOSAN; CHONDROITIN SULFATES; HUMANS; NANOPARTICLES; PARTIAL THROMBOPLASTIN TIME; PARTICLE SIZE; POLYSACCHARIDES;

EID: 84870312788     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S31632     Document Type: Article

References (51)

1. Mourao PA, Pereira MS, Pavao MS, etal. Structure and anticoagulant activity of a fucosylated chondroitin sulfate from echinoderm. Sulfated fucose branches on the polysaccharide account for its high anticoagulant action. J Biol Chem. 1996;271(39):23973-23984.
2. Becker CF, Guimaraes JA, Mourao PA, Verli H. Conformation of sulfated galactan and sulfated fucan in aqueous solutions: implications to their anticoagulant activities. J Mol Graph Model. 2007;26(1):391-399.
3. Mulloy B, Mourao PA, Gray E. Structure/function studies of anticoagulant sulphated polysaccharides using NMR. J Biotechnol. 2000;77(1):123-135.
4. Oefner PJ, Chiesa C. Capillary electrophoresis of carbohydrates. Glycobiology. 1994;4(4):397-412.
5. Sui W, Huang LL, Wang J, Bo QB. Preparation and properties of chitosan chondroitin sulfate complex microcapsules. Colloids Surf B Biointerfaces. 2008;65(1):69-73.
6. Honda S. Separation of neutral carbohydrates by capillary electrophoresis. J Chromatogr A. 1996;720(1-2):337-351.
7. Park W, Na K. Polyelectrolyte complex of chondroitin sulfate and peptide with lower pI value in poly(lactide-co-glycolide) microsphere for stability and controlled release. Colloids Surf B Biointerfaces. 2009;72(2):193-200.
8. Bali JP, Cousse H, Neuzil E. Biochemical basis of the pharmacologic action of chondroitin sulfates on the osteoarticular system. Semin Arthritis Rheum. 2001;31(1):58-68.
9. Barkalow FJ, Schwarzbauer JE. Interactions between fibronectin and chondroitin sulfate are modulated by molecular context. J Biol Chem. 1994;269(6):3957-3962.
10. Dace R, McBride E, Brooks K, Gander J, Buszko M, Doctor VM. Comparison of the anticoagulant action of sulfated and phosphorylated polysaccharides. Thromb Res. 1997;87(1):113-121.
11. Mourao PAS, Pereira MS. Searching for alternatives to heparin: sulfated fucans from marine invertebrates. Trends Cardiovasc Med. 1999;9(8):225-232.
12. Kariya Y, Mulloy B, Imai K, etal. Isolation and partial characterization of fucan sulfates from the body wall of sea cucumber Stichopus japonicus and their ability to inhibit osteoclastogenesis. Carbohydr Res. 2004;339(7):1339-1346.
13. Denuziere A, Ferrier D, Domard A. Chitosan-chondroitin sulfate and chitosan-hyaluronate polyelectrolyte complexes. Physico-chemical aspects. Carbohydr Polym. 1996;29(4):317-323.
14. Ganza-Gonzalez A, Anguiano-Igea S, Otero-Espinar FJ, Blanco Mendez JB. Chitosan and chondroitin microspheres for oral-administration controlled release of metoclopramide. Eur J Pharm Biopharm. 1999;48(2):149-155.
15. Muzzarelli RAA, Muzzarelli C. Chitosan chemistry: relevance to the biomedical sciences. Polysaccharides 1: Structure, Characterization and Use. 2005;186:151-209.
16. Rinaudo M. Chitin and chitosan: properties and applications. Prog Polym Sci. 2006;31(7):603-632.
17. Silva HSRC, Santos KSCRd, Ferreira EI. Quitosana: derivados hidrossolúveis, aplicações farmacêuticas e avanços. Química Nova. 2006;29(4):776-785.
18. Liu ZH, Jiao YP, Wang YF, Zhou CR, Zhang ZY. Polysaccharides-based nanoparticles as drug delivery systems. Adv Drug Deliv Rev. 2008;60(15):1650-1662.
19. Oh JK, Lee DI, Park JM. Biopolymer-based microgels/nanogels for drug delivery applications. Prog Polym Sci. 2009;34(12):1261-1282.
20. Dudhani AR, Kosaraju SL. Bioadhesive chitosan nanoparticles: preparation and characterization. Carbohydr Polym. 2010;81(2):243-251.
21. Takeuchi H, Yamamoto H, Kawashima Y. Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv Drug Deliv Rev. 2001;47(1):39-54.
22. Vasiliu S, Popa M, Rinaudo M. Polyelectrolyte capsules made of two biocompatible natural polymers. Eur Polym J. 2005;41(5):923-932.
23. Koo OM, Rubinstein I, Onyuksel H. Role of nanotechnology in targeted drug delivery and imaging: a concise review. Nanomedicine. 2005;1(3):193-212.
24. Mohanraj V, Chen Y. Nanoparticles-a review. Trop J Pharm Res. 2006;5(1):561-573.
25. Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev. 2001;47(1):65-81.
26. Kreuter J. Nanoparticles-a historical perspective. Int J Pharm. 2007;331(1):1-10.
27. Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces. 2010;75(1):1-18.
28. Mitra S, Gaur U, Ghosh PC, Maitra AN. Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. J Control Release. 2001;74(1-3):317-323.
29. El-Shabouri MH. Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A. Int J Pharm. 2002;249(1-2):101-108.
30. Canton I, Battaglia G. Endocytosis at the nanoscale. Chem Soc Rev. 2012;41(7):2718-2739.
31. Huang LL, Sui WP, Wang YX, Jiao Q. Preparation of chitosan/chondroitin sulfate complex microcapsules and application in controlled release of 5-fluorouracil. Carbohydr Polym. 2010;80(1):168-173.
32. Sezer AD, Cevher E, Hatipoglu F, Ogurtan Z, Bas AL, Akbuga J. The use of fucosphere in the treatment of dermal burns in rabbits. Eur J Pharm Biopharm. 2008;69(1):189-198.
33. Chen MC, Wong HS, Lin KJ, etal. The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin. Biomaterials. 2009;30(34):6629-6637.
34. Boddohi S, Almodovar J, Zhang H, Johnson PA, Kipper MJ. Layer-by-layer assembly of polysaccharide-based nanostructured surfaces containing polyelectrolyte complex nanoparticles. Colloids Surf B Biointerfaces. 2010;77(1):60-68.
35. Calvo P, Remunan Lopez C, Vila-Jato JL, Alonso MJ. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res. 1997;14(10):1431-1436.
36. Janes KA, Fresneau MP, Marazuela A, Fabra A, Alonso MJ. Chitosan nanoparticles as delivery systems for doxorubicin. J Control Release. 2001;73(2-3):255-267.
37. Douglas KL, Piccirillo CA, Tabrizian M. Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles. J Control Release. 2006;115(3):354-361.
38. De SJ, Robinson D. Polymer relationships during preparation of chitosan-alginate and poly-l-lysine-alginate nanospheres. J Control Release. 2003;89(1):101-112.
39. Sarmento B, Ribeiro A, Veiga F, Ferreira D. Development and characterization of new insulin containing polysaccharide nanoparticles. Colloids Surf B Biointerfaces. 2006;53(2):193-202.
40. Lee HE, Lee MJ, Park CR, etal. Preparation and characterization of salmon calcitonin-sodium triphosphate ionic complex for oral delivery. J Control Release. 2010;143(2):251-257.
41. Lee CT, Kung PH, Lee YD. Preparation of poly(vinyl alcohol)-chondroitin sulfate hydrogel as matrices in tissue engineering. Carbohydr Polym. 2005;61(3):348-354.
42. Costa LS, Fidelis GP, Cordeiro SL, etal. Biological activities of sulfated polysaccharides from tropical seaweeds. Biomed Pharmacother. 2010;64(1):21-28.
43. Mendes-Silva W, Assafim M, Ruta B, Monteiro RQ, Guimaraes JA, Zingali RB. Antithrombotic effect of Glycyrrhizin, a plant-derived thrombin inhibitor. Thromb Res. 2003;112(1-2):93-98.
44. Nishino T, Nishioka C, Ura H, Nagumo T. Isolation and partial characterization of a novel amino sugar-containing fucan sulfate from commercial fucus vesiculosus fucoidan. Carbohydr Res. 1994;255:213-224.
45. Sandri G, Bonferoni MC, Rossi S, Ferrari F, Boselli C, Caramella C. Insulin-loaded nanoparticles based on N-trimethyl chitosan: in vitro (Caco-2model) and ex vivo (excised rat jejunum, duodenum, and ileum) evaluation of penetration enhancement properties. AAPS Pharm Sci Tech. 2010;11(1):362-371.
46. Gaumet M, Vargas A, Gurny R, Delie F. Nanoparticles for drug delivery: the need for precision in reporting particle size parameters. Eur J Pharm Biopharm. 2008;69(1):1-9.
47. Liu ZG, Jiao YP, Liu FN, Zhang ZY. Heparin/chitosan nanoparticle carriers prepared by polyelectrolyte complexation. J Biomed Mater Res A. 2007;83(3):806-812.
48. Vauthier C, Cabane B, Labarre D. How to concentrate nanoparticles and avoid aggregation? Eur J Pharm Biopharm. 2008;69(2):466-475.
49. Iovu M, Dumais G, du Souich P. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage. 2008;16(Suppl 3):S14-S18.
50. Asimakopoulou AP, Theocharis AD, Tzanakakis GN, Karamanos NK. The biological role of chondroitin sulfate in cancer and chondroitin-based anticancer agents. In Vivo. 2008;22(3):385-389.
51. Yang H, Liu S, Cai HW, etal. Chondroitin sulfate as a molecular portal that preferentially mediates the apoptotic killing of tumor cells by penetratin-directed mitochondria-disrupting peptides. J Biol Chem. 2010;285(33):25666-25676.