Preparation and characterization of salmon calcitonin-sodium triphosphate ionic complex for oral delivery

Journal of Controlled Release

Volumn 143, Issue 2, 2010, Pages 251-257

  Lee, Hea Eun ^a   Lee, Min Jung ^a   Park, Cho Rong ^a   Kim, A Young ^a   Chun, Kyung Hwa ^a   Hwang, Hee Jin ^a   Oh, Dong Ho ^a   Jeon, Sang Ok ^a   Kang, Jae Seon ^b   Jung, Tae Sung ^c   Choi, Guang Jin ^a   Lee, Sangkil ^a  

^a Inje University   (South Korea)

^b Kyungsung University   (South Korea)

^c Cell Medicine Co   (South Korea)

Author keywords

Ionic complex; Oral delivery; Salmon calcitonin; Sodium tripolyphosphate

Indexed keywords

ANIMAL DATA; AQUEOUS MEDIA; ENZYMATIC ATTACK; IN-VITRO; IN-VIVO; INCUBATION TIME; INTESTINAL FLUID; IONIC COMPLEX; IONIC INTERACTION; MOLAR RATIO; ORAL DELIVERY; SALMON CALCITONIN; SEM IMAGE; SODIUM TRIPOLYPHOSPHATE; TRIPHOSPHATE;

LEAKAGE (FLUID); SODIUM;

COMPLEXATION;

SALCATONIN; TRIPOLYPHOSPHATE;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM BLOOD LEVEL; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG STABILITY; FREEZE DRYING; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SURFACE PROPERTY; SUSTAINED DRUG RELEASE;

ADMINISTRATION, ORAL; ANIMALS; CALCITONIN; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG STABILITY; HYPOCALCEMIA; IONS; MALE; PARTICLE SIZE; POLYPHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 77950340226     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.12.011     Document Type: Article

References (27)

1. Sigurjonsdottir J.F., Loftsson T., Masson M. Influence of cyclodextrins on the stability of the peptide salmon calcitonin in aqueous solution. Int. J. Pharm. 1999, 186(2):205-213.
2. Song K.H., Chung S.J., Shim C.K. Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts. J. Control. Release 2005, 106(3):298-308.
3. Lamprecht A., Yamamoto H., Takeuchi H., Kawashima Y. pH-sensitive microsphere delivery increases oral bioavailability of calcitonin. J. Control. Release 2004, 98(1):1-9.
4. Sinswat P., Tengamnuay P. Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl- and dimethyl-β-cyclodextrins. Int. J. Pharm. 2003, 257(1-2):15-22.
5. Chang S.L., Hofmann G.A., Zhang L., Deftos L.J., Banga A.K. Transdermal iontophoretic delivery of salmon calcitonin. Int. J. Pharm. 2000, 200(1):107-113.
6. Nakamura K., Katagai K., Mori K., Higo N., Sato S., Yamamoto K. Transdermal administration of salmon calcitonin by pulse depolarization-iontophoresis in rats. Int. J. Pharm. 2001, 218(1-2):93-102.
7. Chaturvedula A., Joshi D.P., Anderson C., Morris R.L., Sembrowich W.L., Banga A.K. In vivo iontophoretic delivery and pharmacokinetics of salmon calcitonin. Int. J. Pharm. 2005, 297(1-2):190-196.
8. Takeuchi H., Matsui Y., Yamamoto H., Kawashima Y. Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats. J. Control. Release 2003, 86(2-3):235-242.
9. Yoo H.S., Park T.G. Biodegradable nanoparticles containing protein-fatty acid complexes for oral delivery of salmon calcitonin. J. Pharm. Sci. 2004, 93(2):488-495.
10. Manca M.L., Mourtas S., Dracopoulos V., Fadda A.M., Antimisiaris S.G. PLGA, chitosan or chitosan-coated PLGA microparticles for alveolar delivery? A comparative study of particle stability during nebulization. Coll. Surf. B: Biointerfaces 2008, 62(2):220-231.
11. Song K.H., Chung S.J., Shim C.K. Preparation and evaluation of proliposomes containing salmon calcitonin. J. Control. Release 2002, 84(1-2):27-37.
12. Yoo H.S., Choi H.K., Park T.G. Protein-fatty acid complex for enhanced loading and stability within biodegradable nanoparticles. J. Pharm. Sci. 2001, 90(2):194-201.
13. Guo J., Ping Q., Jiang G., Huang L., Tong Y. Chitosan-coated liposomes: characterization and interaction with leuprolide. Int. J. Pharm. 2003, 260(2):167-173.
14. Morimoto K., Katsumatab H., Yabutab T., Iwanagab K., Kakemi M., Tabata Y., Ikada Y. Evaluation of gelatin microspheres for nasal and intramuscular administrations of salmon calcitonin. Eur. J. Pharm. Sci. 2001, 13(2):179-185.
15. Lee D.Y., Lee J., Lee S., Kim S.K., Byun Y. Liphophilic complexation of heparin based on bile acid for oral delivery. J. Control. Release 2007, 123(1):39-45.
16. Mi F.L., Sung H.W., Shyu S.S., Su C.C., Peng C.K. Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads. Polymer 2003, 44(21):6521-6530.
17. Prego C., Torres D., Fernandez-Megia E., Novoa-Carballal R., Quiñoá E., Alonso M.J. Chitosan-PEG nanocapsules as new carriers for oral peptide delivery: effect of chitosan pegylation degree. J. Control. Release 2006, 111(3):299-308.
18. Lee S.T., Mi F.L., Shen Y.J., Shyu S.S. Equilibrium and kinetic studies of copper (II) ion uptake by chitosan-tripolyphosphate chelating resin. Polymer 2001, 42(5):1879-1892.
19. Garcia-Fuentes M., Prego C., Torres D., Alonso M.J. A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery. Eur. J. Pharm. Sci. 2005, 25(1):133-143.
20. Gan Q., Wang T. Chitosan nanoparticle as protein delivery carrier-systematic examination of fabrication conditions for efficient loading and release. Coll. Surf. B: Biointerfaces 2007, 59(1):24-34.
21. Shu X.Z., Zhu K.J. A novel approach to prepare tripolyphosphate: chitosan complex beads for controlled release drug delivery. Int. J. Pharm. 2000, 201(1):51-58.
22. López-León T., Carvalho E.L.S., Seijo B., Ortega-Vinuesa J.L., Bastos-González D. Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior. J. Colloid and Interface Science 2005, 283(2):344-351.
23. Florence A.T., Hillery A.M., Hussain N., Jani P.U. Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate. J. Control. Release 1995, 36(1-2):39-46.
24. Lefevre M.E., Vanderhoff J.W., Laussue J.A., Joel D.D. Accumulation of 2-μm latex particles in mouse Peyer's patches during chronic latex feeding. Experomentia 1978, 34(1):120-122.
25. Samders E., Ashworth C.T. A study of particulate intestinal absorption and hepatocellular uptake: use of polystyrene latex particles. Experimental Cell Research 1961, 22:137-145.
26. Youn Y.S., Kwon M.J., Na D.H., Chae S.Y., Lee S., Lee K.C. Improved intrapulmonary delivery of site-specific PEGylated salmon calcitonin: optimization by PEG size selection. J. Control. Release 2008, 125(1):68-75.
27. Ryan S.M., Wang X., Mantovani G., Sayers C.T., Haddleton D.M., Brayden D.J. Conjugation of salmon calcitonin to a combed-shaped end functionalized poly(poly(ethylene glycol) methyl ether methacrylate) yields a bioactive stable conjugate. J. Control. Release 2009, 135(1):51-59.