Role of innate immune receptors TLR2 and TLR4 as mediators of the inflammatory reaction in human visceral adipose tissue

Romanian Journal of Morphology and Embryology

Volumn 53, Issue 3 SUPPL., 2012, Pages 693-701

  Fusaru, Ana Marina ^a   Stǎnciulescu, Camelia Elena ^a   Surlin V ^a   Taisescu, C ^a   Bold, Adriana ^a   Pop, O T ^a   Baniţǎ, Ileana Monica ^a   Crǎiţoiu, Ştefania ^a   Pisoschi, Cǎtǎlina Gabriela ^a  

^a UNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA   (Romania)

Author keywords

Human adipose tissue; Inflammation; Macrophages; TLR2; TLR4; TNF

Indexed keywords

CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

AGED; ARTICLE; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INNATE IMMUNITY; INTRAABDOMINAL FAT; MALE; METABOLISM; MIDDLE AGED;

AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; FEMALE; HUMANS; IMMUNITY, INNATE; IMMUNOHISTOCHEMISTRY; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84870312295     PISSN: 12200522     EISSN: 20668279     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Cinti S, The adipose organ: morphological perspectives of adipose tissues, Proc Nutr Soc, 2001, 60(3):319-328.
2. Hausman DB, DiGirolamo M, Bartness TJ, Hausman GJ, Martin RJ, The biology of white adipocyte proliferation, Obes Rev, 2001, 2(4):239-254.
3. Gesta S, Tseng YH, Kahn CR, Developmental origin of fat: tracking obesity to its source, Cell, 2007, 131(2):242-256.
4. Levine JA, Jensen MD, Eberhardt NL, O'Brien T, Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth, J Clin Invest, 1998, 101(8):1557-1564.
5. Mohamed-Ali V, Pinkney JH, Coppack SW, Adipose tissue as an endocrine and paracrine organ, Int J Obes Relat Metab Disord, 1998, 22(12):1145-1158.
6. Trayhurn P, Endocrine and signalling role of adipose tissue: new perspectives on fat, Acta Physiol Scand, 2005, 184(4): 285-293.
7. Villena JA, Cousin B, Pénicaud L, Casteilla L, Adipose tissues display differential phagocytic and microbicidal activities depending on their localization, Int J Obes Relat Metab Disord, 2001, 25(9):1275-1280.
8. Trayhurn P, The biology of obesity, Proc Nutr Soc, 2005, 64(1):31-38.
9. Messerli FH, Christie B, DeCarvalho JG, Aristimuno GG, Suarez DH, Dreslinski GR, Frohlich ED, Obesity and essential hypertension. Hemodynamics, intravascular volume, sodium excretion, and plasma renin activity, Arch Intern Med, 1981, 141(1):81-85.
10. Liu Z, Brooks RS, Ciappio ED, Kim SJ, Crott JW, Bennett G, Greenberg AS, Mason JB, Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colo-rectal cancer, J Nutr Biochem, 2011, Dec 29.
11. Janssen I, Katzmarzyk PT, Ross R, Body mass index, waist circumference, and health risk: evidence in support of current National Institutes of Health guidelines, Arch Intern Med, 2002, 162(18):2074-2079.
12. Khandekar MJ, Cohen P, Spiegelman BM, Molecular mechanisms of cancer development in obesity, Nat Rev Cancer, 2011, 11(12):886-895.
13. Antuna-Puente B, Feve B, Fellahi S, Bastard JP, Adipokines: the missing link between insulin resistance and obesity, Diabetes Metab, 2008, 34(1):2-11.
14. Hotamisligil GS, Mechanisms of TNF-alpha-induced insulin resistance, Exp Clin Endocrinol Diabetes, 1999, 107(2):119-125.
15. Lafontan M, Berlan M, Do regional differences in adipocyte biology provide new pathophysiological insights? Trends Pharmacol Sci, 2003, 24(6):276-283.
16. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B, Recent advances in the relationship between obesity, inflammation, and insulin resistance, Eur Cytokine Netw, 2006, 17(1):4-12.
17. Hotamisligil GS, Shargill NS, Spiegelman BM, Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance, Science, 1993, 259(5091): 87-91.
18. Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, Fischer-Posovszky P, Barth TF, Dragun D, Skurk T, Hauner H, Blüher M, Unger T, Wolf AM, Knippschild U, Hombach V, Marx N, T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance, Arterioscler Thromb Vasc Biol, 2008, 28(7):1304-1310.
19. Ross SE, Erickson RL, Gerin I, DeRose PM, Bajnok L, Longo KA, Misek DE, Kuick R, Hanash SM, Atkins KB, Andresen SM, Nebb HI, Madsen L, Kristiansen K, MacDougald OA, Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism, Mol Cell Biol, 2002, 22(16):5989-5999.
20. Fain JN, Cheema PS, Bahouth SW, Lloyd Hiler M, Resistin release by human adipose tissue explants in primary culture, Biochem Biophys Res Commun, 2003, 300(3):674-678.
21. Skurk T, Alberti-Huber C, Herder C, Hauner H, Relationship between adipocyte size and adipokine expression and secretion, J Clin Endocrinol Metab, 2007, 92(3):1023-1033.
22. Wang B, Jenkins JR, Trayhurn P, Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alpha, Am J Physiol Endocrinol Metab, 2005, 288(4):E731-E740.
23. Isakson P, Hammarstedt A, Gustafson B, Smith U, Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation, Diabetes, 2009, 58(7):1550-1557.
24. Chazenbalk G, Bertolotto C, Heneidi S, Jumabay M, Trivax B, Aronowitz J, Yoshimura K, Simmons CF, Dumesic DA, Azziz R, Novel pathway of adipogenesis through cross-talk between adipose tissue macrophages, adipose stem cells and adipocytes: evidence of cell plasticity, PLoS One, 2011, 6(3):e17834.
25. Bès-Houtmann S, Roche R, Hoareau L, Gonthier MP, Festy F, Caillens H, Gasque P, Lefebvre d'Hellencourt C, Cesari M, Presence of functional TLR2 and TLR4 on human adipocytes, Histochem Cell Biol, 2007, 127(2):131-137.
26. Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araújo EP, Vassallo J, Curi R, Velloso LA, Saad MJ, Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance, Diabetes, 2007, 56(8):1986-1998.
27. Poulain-Godefroy O, Le Bacquer O, Plancq P, Lecoeur C, Pattou F, Frühbeck G, Froguel P, Inflammatory role of Toll-like receptors in human and murine adipose tissue, Mediators Inflamm, 2010, 2010:823486.
28. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr, A human homologue of the Drosophila Toll protein signals activation of adaptive immunity, Nature, 1997, 388(6640):394-397.
29. Akira S, Sato S, Toll-like receptors and their signaling mechanisms, Scand J Infect Dis, 2003, 35(9):555-562.
30. DeFranco AL, Locksley RM, Robertson M, Chapter 3. Innate immunity. In: DeFranco AL, Locksley RM, Robertson M, Immunity: the immune response in infectious and inflam-matory disease, Primers in Biology, New Science Press, Oxford University Press, London, 2007, 74-75.
31. Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, Marshak-Rothstein A, Toll-like receptors, endogenous ligands, and systemic autoimmune disease, Immunol Rev, 2005, 204:27-42.
32. Binder RJ, Vatner R, Srivastava P, The heat-shock protein receptors: some answers and more questions, Tissue Antigens, 2004, 64(4):442-451.
33. Erridge C, The roles of Toll-like receptors in atherosclerosis, J Innate Immun, 2009, 1(4):340-349.
34. Erridge C, Samani NJ, Saturated fatty acids do not directly stimulate Toll-like receptor signaling, Arterioscler Thromb Vasc Biol, 2009, 29(11):1944-1949.
35. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr; International Diabetes Federation Task Force on Epidemiology and Prevention; Hational Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; Interna-tional Association for the Study of Obesity, Harmonizing the metabolic syndrome: a joint interim statement of the Inter-national Diabetes Federation Task Force on Epidemiologyand Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity, Circulation, 2009, 120(16):1640-1645.
36. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr, Obesity is associated with macrophage accumulation in adipose tissue, J Clin Invest, 2003, 112(12):1796-1808.
37. Cancello R, Tordjman J, Poitou C, Guilhem G, Bouillot JL, Hugol D, Coussieu C, Basdevant A, Bar Hen A, Bedossa P, Guerre-Millo M, Clément K, Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity, Diabetes, 2006, 55(6):1554-1561.
38. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS, Obin MS, Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans, J Lipid Res, 2005, 46(11):2347-2355.
39. Duffield JS, The inflammatory macrophage: a story of Jekyll and Hyde, Clin Sci (Lond), 2003, 104(1):27-38.
40. Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S, Visceral fat adipokine secretion is associated with systemic inflammation in obese humans, Diabetes, 2007, 56(4):1010-1013.
41. Winkler G, Kiss S, Keszthelyi L, Sápi Z, Ory I, Salamon F, Kovács M, Vargha P, Szekeres O, Speer G, Karádi I, Sikter M, Kaszás E, Dworak O, Gerö G, Cseh K, Expression of tumor necrosis factor (TNF)-alpha protein in the sub-cutaneous and visceral adipose tissue in correlation with adipocyte cell volume, serum TNF-alpha, soluble serum TNF-receptor-2 concentrations and C-peptide level, Eur J Endocrinol, 2003, 149(2):129-135.
42. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW, Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo, J Clin Endocrinol Metab, 1997, 82(12):4196-4200.
43. Riordan SM, Skinner NA, Kurtovic J, Locarnini S, McIver CJ, Williams R, Visvanathan K, Toll-like receptor expression in chronic hepatitis C: correlation with pro-inflammatory cytokine levels and liver injury, Inflamm Res, 2006, 55(7): 279-285.
44. Hoareau L, Bencharif K, Rondeau P, Murumalla R, Ravanan P, Tallet F, Delarue P, Cesari M, Roche R, Festy F, Signaling pathways involved in LPS induced TNFalpha production in human adipocytes, J Inflamm (Lond), 2010, 7:1.
45. Halberg N, Wernstedt-Asterholm I, Scherer PE, The adipocyte as an endocrine cell, Endocrinol Metab Clin North Am, 2008, 37(3):753-768, x-xi.
46. Lee JY, Zhao L, Youn HS, Weatherill AR, Tapping R, Feng L, Lee WH, Fitzgerald KA, Hwang DH, Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1, J Biol Chem, 2004, 279(17):16971-16979.
47. Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW, Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity, Circ Res, 2007, 100(11): 1589-1596.