Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy

Epilepsy Research

Volumn 102, Issue 3, 2012, Pages 153-159

  Buckmaster, Paul S ^a   Haney, Megan M ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

Age; Body weight; Mice; Pilocarpine; Sex; Status epilepticus

Indexed keywords

ATROPINE METHYL BROMIDE; PILOCARPINE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANIMAL WELFARE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; EPILEPTIC STATE; EXPERIMENTAL MODEL; FEMALE; LATENT PERIOD; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SEX DIFFERENCE; SURVIVAL RATE; TEMPORAL LOBE EPILEPSY;

AGE FACTORS; ANIMALS; ANTICONVULSANTS; ATROPINE; BODY WEIGHT; DIAZEPAM; DISEASE MODELS, ANIMAL; EPILEPSY, TEMPORAL LOBE; FEMALE; GLUTAMATE DECARBOXYLASE; GREEN FLUORESCENT PROTEINS; MALE; MICE; MICE, TRANSGENIC; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; PILOCARPINE; REACTION TIME; SEX FACTORS; TIME FACTORS;

EID: 84870296746     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2012.05.012     Document Type: Article

References (43)

1. Albala B.J., Moshé S.L., Okada R. Kainic-acid-induced seizures: a developmental study. Dev. Brain Res. 1984, 13:139-148.
2. Borges K., Gearing M., McDermott D.L., Smith A.B., Almonte A.G., Wainer B.H., Dingledine R. Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. Exp. Neurol. 2003, 182:21-34.
3. Boyd E.M., Fulford R.A. Pilocarpine-induced convulsions and delayed psychotic-like reaction. Can. J. Biochem. Physiol. 1961, 39:1287-1294.
4. Buckmaster P.S., Lew F.H. Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J. Neurosci. 2011, 31:2337-2347.
5. Buckmaster P.S., Wen X. Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy. Epilepsia 2011, 52:2057-2064.
6. Cavalheiro E.A., Naffah-Mazzacoratti M.G., Mello L.E., Leite J.P. The pilocarpine model of seizures. Models of Seizures and Epilepsy 2006, 433-448. Elsevier, New York. A. Pitkänen, P.A. Schwartzkroin, S.L. Moshé (Eds.).
7. Cavalheiro E.A., Santos N.F., Priel M.R. The pilocarpine model of epilepsy in mice. Epilepsia 1996, 37:1015-1019.
8. Cavalheiro E.A., Silva D.F., Turski W.A., Calderazzo-Filho L.S., Bortolotto Z.A., Turski L. The susceptibility of rats to pilocarpine-induced seizures is age-dependent. Dev. Brain Res. 1987, 37:43-58.
9. Crusio W.E., Goldowitz D., Holmes A., Wolfer D. Standards for the publication of mouse mutant studies. Genes Brain Behav. 2009, 8:1-4.
10. Curia G., Longo D., Biagini G., Jones R.S.G., Avoli M. The pilocarpine model of temporal lobe epilepsy. J. Neurosci. Methods 2008, 172:143-157.
11. Engstrom F.L., Woodbury D.M. Seizure susceptibility in DBA and C57 mice: the effects of various convulsants. Epilepsia 1988, 29:389-395.
12. Frankel W.N., Taylor L., Beyer B., Tempel B.L., White H.S. Electroconvulsive thresholds of inbred mouse strains. Genomics 2001, 74:306-312.
13. Furtado M.A., Braga G.K., Oliveira J.A.C., Del Vecchio F., Garcia-Cairasco N. Behavioral, morphologic, and electroencephalographic evaluation of seizures induced by intrahippocampal microinjection of pilocarpine. Epilepsia 2002, 43(suppl 5):37-39.
14. Glien M., Brandt C., Potschka H., Voigt H., Ebert U., Löscher W. Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy. Epilepsy Res. 2001, 46:111-119.
15. Goelz M.F., Mahler J., Harry J., Myers P., Clark J., Thigpen J.E., Forsythe D.B. Neuropathologic findings associated with seizures in FVB mice. Lab. Anim. Sci. 1998, 48:34-37.
16. Gröticke I., Hoffmann K., Loscher W. Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice. Exper. Neurol. 2007, 207:329-349.
17. Halabisky B., Parada I., Buckmaster P.S., Prince D.A. Excitatory input onto hilar somatostatin interneurons is increased in a chronic model of epilepsy. J. Neurophysiol. 2010, 104:2214-2223.
18. Hamilton S.E., Loose M.D., Qi M., Levey A., Hille B., McKnight G.S., Idzerda R.L., Nathanson N.M. Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:13311-13316.
19. Hellier J.L., Patrylo P.R., Buckmaster P.S., Dudek F.E. Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy. Epilepsy Res. 1998, 31:73-84.
20. Honchar M.P., Olney J.W., Sherman W.R. Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. Science 1983, 220:323-325.
21. Lemos T., Cavalheiro E.A. Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats. Exp. Brain Res. 1995, 102:423-428.
22. Lew F.H., Buckmaster P.S. Is there a critical period for mossy fiber sprouting in a mouse model of temporal lobe epilepsy?. Epilepsia 2011, 52:2326-2332.
23. Mahler J.F., Stokes W., Mann P.C., Takaoka M., Maronpot R.R. Spontaneous lesions in aging FVB/N mice. Toxicol. Pathol. 1996, 24:710-716.
24. Maslanski J.A., Powelt R., Deirmengiant C., Patelt J. Assessment of the muscarinic receptor subtypes involved in pilocarpine-induced seizures in mice. Neurosci. Lett. 1994, 168:225-228.
25. McKhann G.M.II, Wenzel H.J., Robbins C.A., Sosunov A.A., Schwartzkroin P.A. Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology. Neuroscience 2003, 122:551-561.
26. Mejías-Aponte C.A., Jiménez-Rivera C.A., Segarra A.C. Sex differences in models of temporal lobe epilepsy: role of testosterone. Brain Res. 2002, 944:210-218.
27. Mohajeri M.H., Madani R., Saini K., Lipp H.-P., Nitsch R.M., Wolfer D.P. The impact of genetic background on neurodegeneration and behavior in seizured mice. Genes Brain Behav. 2004, 3:228-239.
28. Müller C.J., Bankstahl M., Gröticke I., Löscher W. Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage. Eur. J. Pharmacol. 2009, 619:15-24.
29. Müller C.J., Gröticke I., Bankstahl M., Löscher W. Behavioral and cognitive alterations, spontaneous seizures and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. Exp. Neurol. 2009, 219:284-297.
30. Müller C.J., Gröticke I., Hoffmann K., Schughart K., Löscher W. Differences in sensitivity to the convulsants pilocarpine in substrains and sublines of C57BL/6 mice. Genes Brain Behav. 2009, 8:481-492.
31. Oliva A.A., Jiang M., Lam T., Smith K.L., Swann J.W. Novel hippocampal interneuronal subtypes identified using transgenic mice that express green fluorescent protein in GABAergic interneurons. J. Neurosci. 2000, 20:3354-3368.
32. Patel S., Meldrum B.S., Fine A. Susceptibility to pilocarpine-induced seizures in rats increases with age. Behav. Brain Res. 1988, 31:165-167.
33. Priel M.R., Santos N.F., Cavalheiro E.A. Developmental aspects of the pilocarpine model of epilepsy. Epilepsy Res. 1996, 26:115-121.
34. Racine R.J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 1972, 32:281-294.
35. Schauwecker P.E. Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus. Neurobiol. Dis. 2012, 45:297-304.
36. Schauwecker P.E., Steward O. Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:4103-4108.
37. Shibley H., Smith B.N. Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice. Epilepsy Res. 2002, 49:109-120.
38. Turski W.A., Cavalheiro E.A., Bortolotto Z.A., Mello L.M., Schwarz M., Turski L. Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis. Brain Res. 1984, 321:237-253.
39. Turski L., Ikonomidou C., Turski W.A., Bortolotto Z.A., Calalheiro E.A. Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. Synapse 1989, 3:154-171.
40. Winawer M.R., Kuperman R., Niethammer M., Sherman S., Rabinowitz D., Guell I.P., Ponder C.A., Palmer A.A. Use of chromosome substitution strains to identify seizure susceptibility loci in mice. Mamm. Genome 2007, 18:23-31.
41. Winawer M.R., Makarenko N., McCloskey D.P., Hintz T.M., Nair N., Palmer A.A., Scharfman H.E. Acute and chronic responses to the convulsants pilocarpine in DBA/2J and A/J mice. Neuroscience 2007, 149:465-475.
42. Zablocka B., Esplin D.W. Central excitatory and depressant effects of pilocarpine in rats and mice. J. Pharmacol. Exp. Ther. 1963, 140:162-169.
43. Zhang W., Yamawaki R., Wen X., Uhl J., Diaz J., Prince D.A., Buckmaster P.S. Surviving hilar somatostatin interneurons enlarge, sprout axons, and form new synapses with granule cells in a mouse model of temporal lobe epilepsy. J. Neurosci. 2009, 29:14247-14256.