Discovery of a novel series of 4-quinolone JNK inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7381-7387

  Gong, Leyi ^a   Tan, Yun Chou ^a   Boice, Genevieve ^a   Abbot, Sarah ^a   McCaleb, Kristen ^a   Iyer, Pravin ^a   Zuo, Fengrong ^b   Porto, Joseph Dal ^b   Wong, Brian ^b   Jin, Sue ^b   Chang, Alice ^b   Tran, Patricia ^b   Hsieh, Gary ^b   Niu, Linghao ^b   Shao, Ada ^a   Reuter, Deborah ^a   Lukacs, Christine M ^a   Ursula Kammlott, R ^a   Kuglstatter, Andreas ^a   Goldstein, David ^a  

^a Roche Palo Alto ^*  (United States)

^b Inflammation Therapeutic Area   (United States)

Author keywords

4 Quinolone; c Jun N terminus kinase; JNK; JNK inhibitors; Kinase inhibitors

Indexed keywords

4 QUINOLONE DERIVATIVE; JANUS KINASE 1; JANUS KINASE 2;

ANIMAL EXPERIMENT; ARTICLE; ASTHMA; CELL INFILTRATION; DOG; DRUG DESIGN; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; INFLAMMATORY CELL; NONHUMAN; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE;

4-QUINOLONES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

RODENTIA;

EID: 84870255764     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.066     Document Type: Article

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