Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 2, 2010, Pages 590-596

  De, Surya K ^a   Chen, Vida ^a   Stebbins, John L ^a   Chen, Li Hsing ^a   Cellitti, Jason F ^a   Machleidt, Thomas ^b   Barile, Elisa ^a   Riel Mehan, Megan ^a   Dahl, Russell ^a   Yang, Li ^a   Emdadi, Aras ^a   Murphy, Ria ^a   Pellecchia, Maurizio ^a  

^a BURNHAM INSTITUTE   (United States)

^b INVITROGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (5 NITROTHIAZOL 2 YLTHIO) N [(TETRAHYDROFURAN 2 YL)METHYL] 1,3,4 THIADIAZOL 2 AMINE; 5 (5 NITROTHIAZOL 2 YLTHIO) N PROPYL 1,3,4 THIADIAZOL 2 AMINE; N (2 METHOXYETHYL) 5 (5 NITROTHIAZOL 2 YLTHIO) 1,3,4 THIADIAZOL 2 AMINE; N (3,4 DIMETHOXYPHENETHYL) 5 (5 NITROTHIAZOL 2 YLTHIO) 1,3,4 THIADIAZOL 2 AMINE; N (4 METHOXYBENZYL) 5 (5 NITROTHIAZOL 2 YLTHIO) 1,3,4 THIADIAZOL 2 AMINE; N ETHYL 5 (5 NITROTHIAZOL 2 YLTHIO) 1,3,4 THIADIAZOL 2 AMINE; N SEC BUTYL 5 (5 NITROTHIAZOL 2 YLTHIO) 1,3,4 THIADIAZOL 2 AMINE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL;

DRUG DESIGN; HELA CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 76449090858     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.013     Document Type: Article

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