Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7523-7529

  Bhattacharya, Samit K ^a   Aspnes, Gary E ^a   Bagley, Scott W ^a   Boehm, Markus ^a   Brosius, Arthur D ^a   Buckbinder, Leonard ^a   Chang, Jeanne S ^a   Dibrino, Joseph ^a   Eng, Heather ^a   Frederick, Kosea S ^a   Griffith, David A ^a   Griffor, Matthew C ^a   Guimarães, Cristiano R W ^a   Guzman Perez, Angel ^a   Han, Seungil ^a   Kalgutkar, Amit S ^a   Klug Mcleod, Jacquelyn ^a   Garcia Irizarry, Carmen ^a   Li, Jianke ^a   Lippa, Blaise ^a   Price, David A ^a   Southers, James A ^a   Walker, Daniel P ^a   Wei, Liuqing ^a   Xiao, Jun ^a   Zawistoski, Michael P ^a   Zhao, Xumiao ^a   more..

^a PFIZER INC   (United States)

Author keywords

BIRB 796; DFG out; FAK; Kinase inhibitor; Osteoporosis; PYK2

Indexed keywords

AMIDE; ENZYME INHIBITOR; FOCAL ADHESION KINASE 2; INDOLE; INDOLE UREA; PYRAZOLE; PYRAZOLE UREA; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ARTICLE; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; FOCAL ADHESION KINASE 2; HEK293 CELLS; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84870244642     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.039     Document Type: Article

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