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Volumn 153, Issue 12, 2012, Pages 5735-5745

Suppression of food intake by glucagon-like peptide-1 receptor agonists: Relative potencies and role of dipeptidyl peptidase-4

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; VILDAGLIPTIN;

EID: 84870225620     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1358     Document Type: Article
Times cited : (25)

References (56)
  • 1
    • 1542708286 scopus 로고    scopus 로고
    • Gut peptides in the treatment of diabetes mellitus
    • Vahl TP, D'Alessio DA 2004 Gut peptides in the treatment of diabetes mellitus. Expert Opin Investig Drugs 13:177-188
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 177-188
    • Vahl, T.P.1    D'Alessio, D.A.2
  • 2
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ 2006 The biology of incretin hormones. Cell Metab 3:153-165
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 3
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
    • Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ 1995 Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 44:1126-1131
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3    Pridal, L.4    Willms, B.5    Holst, J.J.6
  • 4
    • 0037787851 scopus 로고    scopus 로고
    • Dipeptidylpeptidase IV from bench to bedside: An update on structural properties, functions, and clinical aspects of the enzyme DPP IV
    • Lambeir AM, Durinx C, Scharpé S, De Meester I 2003 Dipeptidylpeptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci 40:209-294
    • (2003) Crit Rev Clin Lab Sci , vol.40 , pp. 209-294
    • Lambeir, A.M.1    Durinx, C.2    Scharpé, S.3    De Meester, I.4
  • 5
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36) amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE 1993 Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36) amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 214:829-835
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 6
    • 79953040963 scopus 로고    scopus 로고
    • An overview of once-weekly glucagon-like peptide-1 receptor agonists: Available efficacy and safety data and perspectives for the future
    • Madsbad S, Kielgast U, Asmar M, Deacon CF, Torekov SS, Holst JJ 2011 An overview of once-weekly glucagon-like peptide-1 receptor agonists: available efficacy and safety data and perspectives for the future. Diabetes Obes Metab 13:394-407
    • (2011) Diabetes Obes Metab , vol.13 , pp. 394-407
    • Madsbad, S.1    Kielgast, U.2    Asmar, M.3    Deacon, C.F.4    Torekov, S.S.5    Holst, J.J.6
  • 7
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H 2006 Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 49:2564-2571
    • (2006) Diabetologia , vol.49 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3    Caria, C.4    Williams-Herman, D.5    Khatami, H.6
  • 8
    • 34249902025 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: Preclinical biology and mechanisms of action
    • Drucker DJ 2007 Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action. Diabetes Care 30:1335-1343
    • (2007) Diabetes Care , vol.30 , pp. 1335-1343
    • Drucker, D.J.1
  • 9
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA 2006 The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368:1696-1705
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 11
    • 80052049014 scopus 로고    scopus 로고
    • GLP-1 and energy balance: An integrated model of short-term and long-term control
    • Barrera JG, Sandoval DA, D'Alessio DA, Seeley RJ 2011 GLP-1 and energy balance: an integrated model of short-term and long-term control. Nat Rev Endocrinol 7:507-516
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 507-516
    • Barrera, J.G.1    Sandoval, D.A.2    D'Alessio, D.A.3    Seeley, R.J.4
  • 12
    • 79952394105 scopus 로고    scopus 로고
    • Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function
    • Barrera JG, Jones KR, Herman JP, D'Alessio DA, Woods SC, Seeley RJ 2011 Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. J Neurosci 31:3904-3913
    • (2011) J Neurosci , vol.31 , pp. 3904-3913
    • Barrera, J.G.1    Jones, K.R.2    Herman, J.P.3    D'Alessio, D.A.4    Woods, S.C.5    Seeley, R.J.6
  • 13
    • 0033545166 scopus 로고    scopus 로고
    • Distribution of pre-proglucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    • Merchenthaler I, Lane M, Shughrue P 1999 Distribution of pre-proglucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol 403:261-280
    • (1999) J Comp Neurol , vol.403 , pp. 261-280
    • Merchenthaler, I.1    Lane, M.2    Shughrue, P.3
  • 14
    • 0023266561 scopus 로고
    • Identification and localization of glucagon-like peptide-1 and its receptor in rat brain
    • Shimizu I, Hirota M, Ohboshi C, Shima K 1987 Identification and localization of glucagon-like peptide-1 and its receptor in rat brain. Endocrinology 121:1076-1082
    • (1987) Endocrinology , vol.121 , pp. 1076-1082
    • Shimizu, I.1    Hirota, M.2    Ohboshi, C.3    Shima, K.4
  • 16
    • 73249132605 scopus 로고    scopus 로고
    • Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats
    • Barrera JG, D'Alessio DA, Drucker DJ, Woods SC, Seeley RJ 2009 Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats. Diabetes 58:2820-2827
    • (2009) Diabetes , vol.58 , pp. 2820-2827
    • Barrera, J.G.1    D'Alessio, D.A.2    Drucker, D.J.3    Woods, S.C.4    Seeley, R.J.5
  • 17
    • 0035713010 scopus 로고    scopus 로고
    • Glucagon-like peptide containing pathways in the regulation of feeding behaviour
    • Tang-Christensen M, Vrang N, Larsen PJ 2001 Glucagon-like peptide containing pathways in the regulation of feeding behaviour. Int J Obes Relat Metab Disord 25(Suppl 5):S42-S47
    • (2001) Int J Obes Relat Metab Disord , vol.25 , Issue.SUPPL. 5
    • Tang-Christensen, M.1    Vrang, N.2    Larsen, P.J.3
  • 20
    • 34548390977 scopus 로고    scopus 로고
    • The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size
    • Scott KA, Moran TH 2007 The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size. Am J Physiol Regul Integr Comp Physiol 293:R983-R987
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293
    • Scott, K.A.1    Moran, T.H.2
  • 21
    • 19344375318 scopus 로고    scopus 로고
    • Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats
    • Chelikani PK, Haver AC, Reidelberger RD 2005 Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats. Am J Physiol Regul Integr Comp Physiol 288:R1695-R1706
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.288
    • Chelikani, P.K.1    Haver, A.C.2    Reidelberger, R.D.3
  • 23
    • 77954102250 scopus 로고    scopus 로고
    • Hepatic-portal vein infusions of glucagon-like peptide-1 reduce meal size and increase c-Fos expression in the nucleus tractus solitarii, area postrema and central nucleus of the amygdala in rats
    • Baumgartner I, Pacheco-López G, Rüttimann EB, Arnold M, Asarian L, Langhans W, Geary N, Hillebrand JJ 2010 Hepatic-portal vein infusions of glucagon-like peptide-1 reduce meal size and increase c-Fos expression in the nucleus tractus solitarii, area postrema and central nucleus of the amygdala in rats. J Neuroendocrinol 22:557-563
    • (2010) J Neuroendocrinol , vol.22 , pp. 557-563
    • Baumgartner, I.1    Pacheco-López, G.2    Rüttimann, E.B.3    Arnold, M.4    Asarian, L.5    Langhans, W.6    Geary, N.7    Hillebrand, J.J.8
  • 25
    • 63849248275 scopus 로고    scopus 로고
    • Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety
    • Williams DL, Baskin DG, Schwartz MW 2009 Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety. Endocrinology 150:1680-1687
    • (2009) Endocrinology , vol.150 , pp. 1680-1687
    • Williams, D.L.1    Baskin, D.G.2    Schwartz, M.W.3
  • 26
    • 33847072735 scopus 로고    scopus 로고
    • Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not
    • Raun K, von Voss P, Gotfredsen CF, Golozoubova V, Rolin B, Knudsen LB 2007 Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not. Diabetes 56:8-15
    • (2007) Diabetes , vol.56 , pp. 8-15
    • Raun, K.1    Von Voss, P.2    Gotfredsen, C.F.3    Golozoubova, V.4    Rolin, B.5    Knudsen, L.B.6
  • 27
    • 55549136417 scopus 로고    scopus 로고
    • Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: A randomized, cross-over study
    • DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L 2008 Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study. Curr Med Res Opin 24:2943-2952
    • (2008) Curr Med Res Opin , vol.24 , pp. 2943-2952
    • DeFronzo, R.A.1    Okerson, T.2    Viswanathan, P.3    Guan, X.4    Holcombe, J.H.5    MacConell, L.6
  • 28
    • 77954870787 scopus 로고    scopus 로고
    • The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4
    • Mann RJ, Nasr NE, Sinfield JK, Paci E, Donnelly D 2010 The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4. Br J Pharmacol 160:1973-1984
    • (2010) Br J Pharmacol , vol.160 , pp. 1973-1984
    • Mann, R.J.1    Nasr, N.E.2    Sinfield, J.K.3    Paci, E.4    Donnelly, D.5
  • 29
    • 0037518197 scopus 로고    scopus 로고
    • The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1
    • López de Maturana R, Willshaw A, Kuntzsch A, Rudolph R, Donnelly D 2003 The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1. J Biol Chem 278:10195-10200
    • (2003) J Biol Chem , vol.278 , pp. 10195-10200
    • López De Maturana, R.1    Willshaw, A.2    Kuntzsch, A.3    Rudolph, R.4    Donnelly, D.5
  • 30
    • 84857772149 scopus 로고    scopus 로고
    • The structure and function of the glucagon-like peptide-1 receptor and its ligands
    • Donnelly D 2012 The structure and function of the glucagon-like peptide-1 receptor and its ligands. Br J Pharmacol 166:27-41
    • (2012) Br J Pharmacol , vol.166 , pp. 27-41
    • Donnelly, D.1
  • 31
    • 79959675075 scopus 로고    scopus 로고
    • Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats
    • Hayes MR, Kanoski SE, Alhadeff AL, Grill HJ 2011 Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats. Obesity 19:1342-1349
    • (2011) Obesity , vol.19 , pp. 1342-1349
    • Hayes, M.R.1    Kanoski, S.E.2    Alhadeff, A.L.3    Grill, H.J.4
  • 33
    • 64949131978 scopus 로고    scopus 로고
    • Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery
    • Lond
    • Cummings DE 2009 Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery. Int J Obes (Lond) 33(Suppl 1):S33-S40
    • (2009) Int J Obes , vol.33 , Issue.SUPPL. 1
    • Cummings, D.E.1
  • 37
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ 2007 Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131-2157
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 39
    • 77952956504 scopus 로고    scopus 로고
    • GLP-1 antagonism with exendin (9-39) fails to increase spontaneous meal size in rats
    • Rüttimann EB, Arnold M, Geary N, Langhans W 2010 GLP-1 antagonism with exendin (9-39) fails to increase spontaneous meal size in rats. Physiol Behav 100:291-296
    • (2010) Physiol Behav , vol.100 , pp. 291-296
    • Rüttimann, E.B.1    Arnold, M.2    Geary, N.3    Langhans, W.4
  • 40
    • 41149118550 scopus 로고    scopus 로고
    • (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl- quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors
    • Thomas L, Eckhardt M, Langkopf E, Tadayyon M, Himmelsbach F 2008 (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2- ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther 325:175-182
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 175-182
    • Thomas, L.1    Eckhardt, M.2    Langkopf, E.3    Tadayyon, M.4    Himmelsbach, F.5
  • 43
    • 0345726358 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites
    • Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK 2003 Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci 23:2939-2946
    • (2003) J Neurosci , vol.23 , pp. 2939-2946
    • Yamamoto, H.1    Kishi, T.2    Lee, C.E.3    Choi, B.J.4    Fang, H.5    Hollenberg, A.N.6    Drucker, D.J.7    Elmquist, J.K.8
  • 44
    • 79960741385 scopus 로고    scopus 로고
    • Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
    • Kanoski SE, Fortin SM, Arnold M, Grill HJ, Hayes MR 2011 Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology 152:3103-3112
    • (2011) Endocrinology , vol.152 , pp. 3103-3112
    • Kanoski, S.E.1    Fortin, S.M.2    Arnold, M.3    Grill, H.J.4    Hayes, M.R.5
  • 45
    • 17844399596 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors
    • Holst JJ, Deacon CF 2005 Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors. Diabetologia 48:612-615
    • (2005) Diabetologia , vol.48 , pp. 612-615
    • Holst, J.J.1    Deacon, C.F.2
  • 46
    • 36849094575 scopus 로고    scopus 로고
    • Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: Evidence for selective release of GLP-1 in the lymph system
    • D'Alessio D, Lu W, Sun W, Zheng S, Yang Q, Seeley R, Woods SC, Tso P 2007 Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system. Am J Physiol Regul Integr Com Physiol 293:R2163-R2169
    • (2007) Am J Physiol Regul Integr Com Physiol , vol.293
    • D'Alessio, D.1    Lu, W.2    Sun, W.3    Zheng, S.4    Yang, Q.5    Seeley, R.6    Woods, S.C.7    Tso, P.8
  • 48
    • 84871005992 scopus 로고    scopus 로고
    • Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner
    • (Lond) 10.1038/ijo.2011.265
    • Zhao S, Kanoski SE, Yan J, Grill HJ, Hayes MR 2012 Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner. Int J Obes (Lond) 10.1038/ijo.2011.265
    • (2012) Int J Obes
    • Zhao, S.1    Kanoski, S.E.2    Yan, J.3    Grill, H.J.4    Hayes, M.R.5
  • 49
    • 0036198285 scopus 로고    scopus 로고
    • Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
    • Kastin AJ, Akerstrom V, Pan W 2002 Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J Mol Neurosci 18:7-14
    • (2002) J Mol Neurosci , vol.18 , pp. 7-14
    • Kastin, A.J.1    Akerstrom, V.2    Pan, W.3
  • 50
    • 0027425034 scopus 로고
    • Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
    • Thorens B, Porret A, Bühler L, Deng SP, Morel P, Widmann C 1993 Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42:1678-1682
    • (1993) Diabetes , vol.42 , pp. 1678-1682
    • Thorens, B.1    Porret, A.2    Bühler, L.3    Deng, S.P.4    Morel, P.5    Widmann, C.6
  • 52
    • 68949094297 scopus 로고    scopus 로고
    • Improvement in glucose metabolism after bariatric surgery: Comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: A prospective randomized trial
    • Peterli R, Wölnerhanssen B, Peters T, Devaux N, Kern B, Christoffel-Courtin C, Drewe J, von Flüe M, Beglinger C 2009 Improvement in glucose metabolism after bariatric surgery: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: a prospective randomized trial. Ann Surg 250:234-241
    • (2009) Ann Surg , vol.250 , pp. 234-241
    • Peterli, R.1    Wölnerhanssen, B.2    Peters, T.3    Devaux, N.4    Kern, B.5    Christoffel-Courtin, C.6    Drewe, J.7    Von Flüe, M.8    Beglinger, C.9
  • 54
    • 79961204682 scopus 로고    scopus 로고
    • Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans
    • Salehi M, Prigeon RL, D'Alessio DA 2011 Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans. Diabetes 60:2308-2314
    • (2011) Diabetes , vol.60 , pp. 2308-2314
    • Salehi, M.1    Prigeon, R.L.2    D'Alessio, D.A.3
  • 55
    • 82355187988 scopus 로고    scopus 로고
    • Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: Implications for the effectiveness of Roux-en-Y gastric bypass
    • Dailey MJ, Moghadam AA, Moran TH 2011 Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en-Y gastric bypass. Am J Physiol Endocrinol Metab 301:E1184-E1190
    • (2011) Am J Physiol Endocrinol Metab , vol.301
    • Dailey, M.J.1    Moghadam, A.A.2    Moran, T.H.3
  • 56
    • 84858294193 scopus 로고    scopus 로고
    • Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass
    • Lond
    • Fenske WK, Bueter M, Miras a D, Ghatei M a, Bloom SR, le Roux CW 2012 Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass. Int J Obes (Lond) 36:379-384
    • (2012) Int J Obes , vol.36 , pp. 379-384
    • Fenske, W.K.1    Bueter, M.2    Miras, A.D.3    Ghatei, M.A.4    Bloom, S.R.5    Le Roux, C.W.6


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