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Volumn 58, Issue 12, 2009, Pages 2820-2827

Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats

Author keywords

[No Author keywords available]

Indexed keywords

ANOREXIGENIC AGENT; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; PROTEIN C FOS;

EID: 73249132605     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0281     Document Type: Article
Times cited : (51)

References (57)
  • 2
    • 0021849270 scopus 로고
    • Localization of glucagon-like peptide (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry
    • Varndell IM, Bishop AE, Sikri KL, Uttenthal LO, Bloom SR, Polak JM. Localization of glucagon-like peptide (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry. J Histochem Cytochem 1985;33:1080-1086
    • (1985) J Histochem Cytochem , vol.33 , pp. 1080-1086
    • Varndell, I.M.1    Bishop, A.E.2    Sikri, K.L.3    Uttenthal, L.O.4    Bloom, S.R.5    Polak, J.M.6
  • 3
    • 0033545166 scopus 로고    scopus 로고
    • Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    • Merchenthaler I, Lane M, Shughrue P. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol 1999;403:261-280
    • (1999) J Comp Neurol , vol.403 , pp. 261-280
    • Merchenthaler, I.1    Lane, M.2    Shughrue, P.3
  • 4
    • 0023266561 scopus 로고
    • Identification and localization of glucagon-like peptide-1 and its receptor in the brain
    • Shimizu I, Hirota M, Ohboshi C, Shima K. Identification and localization of glucagon-like peptide-1 and its receptor in the brain. Endocrinology 1987;121:1076-1082
    • (1987) Endocrinology , vol.121 , pp. 1076-1082
    • Shimizu, I.1    Hirota, M.2    Ohboshi, C.3    Shima, K.4
  • 8
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Ghatei MA, Williams G, Bloom SR. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987;2:1300-1303
    • (1987) Lancet , vol.2 , pp. 1300-1303
    • Kreymann, B.1    Ghatei, M.A.2    Williams, G.3    Bloom, S.R.4
  • 9
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36) amide, petide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36) amide, petide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993;214:829-835
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 10
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
    • Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ. Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 1995;44:1126-1131
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3    Pridal, L.4    Willms, B.5    Holst, J.J.6
  • 11
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer TJ, McIntosh CH, Pederson RA. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 1995;136:3585-3596
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 12
    • 0032908654 scopus 로고    scopus 로고
    • Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    • Young AA, Gedulin BR, Bhavsar S, Bodkin N, Jodka C, Hansen B, Denaro M. Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 1999;48:1026-1034
    • (1999) Diabetes , vol.48 , pp. 1026-1034
    • Young, A.A.1    Gedulin, B.R.2    Bhavsar, S.3    Bodkin, N.4    Jodka, C.5    Hansen, B.6    Denaro, M.7
  • 13
    • 0032932825 scopus 로고    scopus 로고
    • Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations
    • Greig NH, Holloway HW, De Ore KA, Jani D, Wang Y, Zhou J, Garant MJ, Egan JM. Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations. Diabetologia 1999;42:45-50
    • (1999) Diabetologia , vol.42 , pp. 45-50
    • Greig, N.H.1    Holloway, H.W.2    De Ore, K.A.3    Jani, D.4    Wang, Y.5    Zhou, J.6    Garant, M.J.7    Egan, J.M.8
  • 14
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J, Zhuang D, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005;28:1083-1091
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3    Zhuang, D.4    Kim, D.D.5    Fineman, M.S.6    Baron, A.D.7
  • 15
    • 33749871472 scopus 로고    scopus 로고
    • Herman GA, Bergman A, Stevens C, Kotey P, Yi B, Zhao P, Dietrich B, Golor G, Schrodter A, Keymeulen B, Lasseter KC, Kipnes MS, Snyder K, Hilliard D, Tanen M, Cilissen C, De Smet M, de Lepeleire I, Van Dyck K, Wang AQ, Zeng W, Davies MJ, Tanaka W, Holst JJ, Deacon CF, Gottesdiener KM, Wagner JA. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab 2006;91:4612-4619
    • Herman GA, Bergman A, Stevens C, Kotey P, Yi B, Zhao P, Dietrich B, Golor G, Schrodter A, Keymeulen B, Lasseter KC, Kipnes MS, Snyder K, Hilliard D, Tanen M, Cilissen C, De Smet M, de Lepeleire I, Van Dyck K, Wang AQ, Zeng W, Davies MJ, Tanaka W, Holst JJ, Deacon CF, Gottesdiener KM, Wagner JA. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab 2006;91:4612-4619
  • 16
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 2006;49:2564-2571
    • (2006) Diabetologia , vol.49 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3    Caria, C.4    Williams-Herman, D.5    Khatami, H.6
  • 17
    • 20244385394 scopus 로고    scopus 로고
    • Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors
    • Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F, Drucker DJ. Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors. Diabetes 2004;53:1326-1335
    • (2004) Diabetes , vol.53 , pp. 1326-1335
    • Hansotia, T.1    Baggio, L.L.2    Delmeire, D.3    Hinke, S.A.4    Yamada, Y.5    Tsukiyama, K.6    Seino, Y.7    Holst, J.J.8    Schuit, F.9    Drucker, D.J.10
  • 18
    • 4143116741 scopus 로고    scopus 로고
    • Oxyntomodulin and glucagonlike peptide-1 differentially regulate murine food intake and energy expenditure
    • Baggio LL, Huang Q, Brown TJ, Drucker DJ. Oxyntomodulin and glucagonlike peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 2004;127:546-558
    • (2004) Gastroenterology , vol.127 , pp. 546-558
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3    Drucker, D.J.4
  • 19
    • 4344667831 scopus 로고    scopus 로고
    • A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis
    • Baggio LL, Huang Q, Brown TJ, Drucker DJ. A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis. Diabetes 2004;53:2492-2500
    • (2004) Diabetes , vol.53 , pp. 2492-2500
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3    Drucker, D.J.4
  • 21
    • 41349098117 scopus 로고    scopus 로고
    • An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis
    • Baggio LL, Huang Q, Cao X, Drucker DJ. An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis. Gastroenterology 2008;134:1137-1147
    • (2008) Gastroenterology , vol.134 , pp. 1137-1147
    • Baggio, L.L.1    Huang, Q.2    Cao, X.3    Drucker, D.J.4
  • 22
    • 0036728332 scopus 로고    scopus 로고
    • Preproglucagon derived peptides and thyrotropin (TSH) secretion in the rat: Robust and sustained lowering of blood TSH levels in exendin-4 injected animals
    • Malendowicz LK, Nowak KW. Preproglucagon derived peptides and thyrotropin (TSH) secretion in the rat: robust and sustained lowering of blood TSH levels in exendin-4 injected animals. Int J Mol Med 2002;10:327-331
    • (2002) Int J Mol Med , vol.10 , pp. 327-331
    • Malendowicz, L.K.1    Nowak, K.W.2
  • 23
    • 0141907370 scopus 로고    scopus 로고
    • Exendin-4, a GLP-1 receptor agonist, stimulates pituitary- adrenocortical axis in the rat: Investigations into the mechanism(s) underlying Ex4 effect
    • Malendowicz LK, Nussdorfer GG, Nowak KW, Ziolkowska A, Tortorella C, Trejter M. Exendin-4, a GLP-1 receptor agonist, stimulates pituitary- adrenocortical axis in the rat: investigations into the mechanism(s) underlying Ex4 effect. Int J Mol Med 12:237-241, 2003
    • (2003) Int J Mol Med , vol.12 , pp. 237-241
    • Malendowicz, L.K.1    Nussdorfer, G.G.2    Nowak, K.W.3    Ziolkowska, A.4    Tortorella, C.5    Trejter, M.6
  • 26
    • 33845448933 scopus 로고    scopus 로고
    • Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
    • Brown LM, Clegg DJ, Benoit SC, Woods SC. Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Physiol Behav 2006;89:687-691
    • (2006) Physiol Behav , vol.89 , pp. 687-691
    • Brown, L.M.1    Clegg, D.J.2    Benoit, S.C.3    Woods, S.C.4
  • 29
    • 0024355498 scopus 로고
    • Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures
    • D'Alessio DA, Fujimoto WY, Ensinck JW. Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures. Diabetes 1989;38:1534-1538
    • (1989) Diabetes , vol.38 , pp. 1534-1538
    • D'Alessio, D.A.1    Fujimoto, W.Y.2    Ensinck, J.W.3
  • 30
    • 0034652302 scopus 로고    scopus 로고
    • The role of CNS GLP-1-(7-36) amide receptors in mediating the visceral illness effects of lithium chloride
    • Seeley RJ, Blake K, Rushing PA, Benoit SC, Eng J, Woods SC, D'Alessio D. The role of CNS GLP-1-(7-36) amide receptors in mediating the visceral illness effects of lithium chloride. J Neurosci 2000;20:1616-1621
    • (2000) J Neurosci , vol.20 , pp. 1616-1621
    • Seeley, R.J.1    Blake, K.2    Rushing, P.A.3    Benoit, S.C.4    Eng, J.5    Woods, S.C.6    D'Alessio, D.7
  • 33
    • 10244241840 scopus 로고    scopus 로고
    • Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: Evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake
    • Navarro M, Rodriquez de Fonseca F, Alvarez E, Chowen JA, Zueco JA, Gomez R, Eng J, Blazquez E. Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J Neurochem 1996;67:1982-1991
    • (1996) J Neurochem , vol.67 , pp. 1982-1991
    • Navarro, M.1    Rodriquez de Fonseca, F.2    Alvarez, E.3    Chowen, J.A.4    Zueco, J.A.5    Gomez, R.6    Eng, J.7    Blazquez, E.8
  • 34
    • 0036896243 scopus 로고    scopus 로고
    • The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness
    • Kinzig KP, D'Alessio DA, Seeley RJ. The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness. J Neurosci 2002;22:10470-10476
    • (2002) J Neurosci , vol.22 , pp. 10470-10476
    • Kinzig, K.P.1    D'Alessio, D.A.2    Seeley, R.J.3
  • 35
    • 0027184119 scopus 로고
    • Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulinsecreting beta-cells
    • Goke R, Fehmann HC, Linn T, Schmidt H, Krause M, Eng J, Goke B. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulinsecreting beta-cells. J Biol Chem 1993;268:19650-19655
    • (1993) J Biol Chem , vol.268 , pp. 19650-19655
    • Goke, R.1    Fehmann, H.C.2    Linn, T.3    Schmidt, H.4    Krause, M.5    Eng, J.6    Goke, B.7
  • 36
    • 0028358615 scopus 로고
    • Stable expression of the rat GLP-I receptor in CHO cells: Activation and binding characteristics utilizing GLP-I(7-36)-amide, oxyntomodulin, exendin-4, and exendin(9-39)
    • Fehmann HC, Jiang J, Schweinfurth J, Wheeler MB, Boyd AE 3rd, Goke B. Stable expression of the rat GLP-I receptor in CHO cells: activation and binding characteristics utilizing GLP-I(7-36)-amide, oxyntomodulin, exendin-4, and exendin(9-39). Peptides 1994;15:453-456
    • (1994) Peptides , vol.15 , pp. 453-456
    • Fehmann, H.C.1    Jiang, J.2    Schweinfurth, J.3    Wheeler, M.B.4    Boyd 3rd, A.E.5    Goke, B.6
  • 37
    • 0029007063 scopus 로고
    • Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary
    • Goke R, Larsen PJ, Mikkelsen JD, Sheikh SP. Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary. Neuroendocrinology 1995;62:130-134
    • (1995) Neuroendocrinology , vol.62 , pp. 130-134
    • Goke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3    Sheikh, S.P.4
  • 38
    • 0028867442 scopus 로고
    • Distribution of GLP-1 binding sites in the rat brain: Evidence that exendin-4 is a ligand of brain GLP-1 binding sites
    • Goke R, Larsen PJ, Mikkelsen JD, Sheikh SP. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 1995;7:2294-2300
    • (1995) Eur J Neurosci , vol.7 , pp. 2294-2300
    • Goke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3    Sheikh, S.P.4
  • 39
    • 9444231814 scopus 로고    scopus 로고
    • Chronic exposure to GLP-1r agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1r-dependent glucose homeostasis in vivo
    • Baggio LL, Kim J-G, Drucker DJ. Chronic exposure to GLP-1r agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1r-dependent glucose homeostasis in vivo. Diabetes 2004;53(Suppl. 3):S205-S214
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Baggio, L.L.1    Kim, J.-G.2    Drucker, D.J.3
  • 40
    • 0028883257 scopus 로고
    • Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide
    • Kolligs F, Fehmann HC, Goke R, Goke B. Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide. Diabetes 1995;44:16-19
    • (1995) Diabetes , vol.44 , pp. 16-19
    • Kolligs, F.1    Fehmann, H.C.2    Goke, R.3    Goke, B.4
  • 41
    • 0030583731 scopus 로고    scopus 로고
    • Interactions of exendin (9-39) with the effects of GLP-1 (7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats
    • Barragan JM, Rodriguez RE, Eng J, Blazquez E. Interactions of exendin (9-39) with the effects of GLP-1 (7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats. Reg Peptides 1996;67:63-68
    • (1996) Reg Peptides , vol.67 , pp. 63-68
    • Barragan, J.M.1    Rodriguez, R.E.2    Eng, J.3    Blazquez, E.4
  • 42
    • 0031733316 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(7-36)amide increases pulmonary surfactant secretion through a cyclic adenosine 3′, 5′-monophosphate-dependent protein kinase mechanism in rat type II pneumocytes
    • Benito E, Blazquez E, Bosch MA. Glucagon-like peptide-1-(7-36)amide increases pulmonary surfactant secretion through a cyclic adenosine 3′, 5′-monophosphate-dependent protein kinase mechanism in rat type II pneumocytes. Endocrinology 1998;139:2363-2368
    • (1998) Endocrinology , vol.139 , pp. 2363-2368
    • Benito, E.1    Blazquez, E.2    Bosch, M.A.3
  • 43
    • 11144244302 scopus 로고    scopus 로고
    • The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: Differential effects in rats and mice
    • Lachey JL, D'Alessio DA, Rinaman L, Elmquist JK, Drucker DJ, Seeley RJ. The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. Endocrinology 2005;146:458-462
    • (2005) Endocrinology , vol.146 , pp. 458-462
    • Lachey, J.L.1    D'Alessio, D.A.2    Rinaman, L.3    Elmquist, J.K.4    Drucker, D.J.5    Seeley, R.J.6
  • 44
    • 38549123536 scopus 로고    scopus 로고
    • Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and rats
    • Huo L, Gamber KM, Grill HJ, Bjorbaek C. Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and rats. Endocrinology 2008;149:492-497
    • (2008) Endocrinology , vol.149 , pp. 492-497
    • Huo, L.1    Gamber, K.M.2    Grill, H.J.3    Bjorbaek, C.4
  • 45
    • 0030884317 scopus 로고    scopus 로고
    • Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes
    • Montrose-Rafizadeh C, Yang H, Wang Y, Roth J, Montrose MH, Adams LG. Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. J Cell Physiol 1997;172:275-283
    • (1997) J Cell Physiol , vol.172 , pp. 275-283
    • Montrose-Rafizadeh, C.1    Yang, H.2    Wang, Y.3    Roth, J.4    Montrose, M.H.5    Adams, L.G.6
  • 47
    • 23844526330 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats
    • Sancho V, Trigo MV, Gonzalez N, Valverde I, Malaisse WJ, Villanueva-Penacarrillo ML. Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats. J Mol Endocrinol 2005;35:27-38
    • (2005) J Mol Endocrinol , vol.35 , pp. 27-38
    • Sancho, V.1    Trigo, M.V.2    Gonzalez, N.3    Valverde, I.4    Malaisse, W.J.5    Villanueva-Penacarrillo, M.L.6
  • 51
    • 33845518516 scopus 로고    scopus 로고
    • Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation
    • Williams DL, Baskin DG, Schwartz MW. Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation. Diabetes 2006;55:3387-3393
    • (2006) Diabetes , vol.55 , pp. 3387-3393
    • Williams, D.L.1    Baskin, D.G.2    Schwartz, M.W.3
  • 52
    • 0037163906 scopus 로고    scopus 로고
    • The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge
    • Lopez de Maturana R, Donnelly D. The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge. FEBS Lett 2002;530:244-248
    • (2002) FEBS Lett , vol.530 , pp. 244-248
    • Lopez de Maturana, R.1    Donnelly, D.2
  • 53
    • 0037518197 scopus 로고    scopus 로고
    • The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1
    • Lopez de Maturana R, Willshaw A, Kuntzsch A, Rudolph R, Donnelly D. The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1. J Biol Chem 2003;278:10195-10200
    • (2003) J Biol Chem , vol.278 , pp. 10195-10200
    • Lopez de Maturana, R.1    Willshaw, A.2    Kuntzsch, A.3    Rudolph, R.4    Donnelly, D.5
  • 54
    • 0141992171 scopus 로고    scopus 로고
    • A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors
    • Al-Sabah S, Donnelly D. A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors. Br J Pharmacol 2003;140:339-346
    • (2003) Br J Pharmacol , vol.140 , pp. 339-346
    • Al-Sabah, S.1    Donnelly, D.2


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