Insights and hopes in umbilical cord blood stem cell transplantations

Journal of Biomedicine and Biotechnology

Volumn 2012, Issue , 2012, Pages

  Shahrokhi, Somayeh ^a   Menaa, Farid ^b,c   Alimoghaddam, Kamran ^d   McGuckin, Colin ^e   Ebtekar, Massoumeh ^f  

^a LORESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c Fluorotronics Inc   (United States)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e Cell Therapy Research Institue   (France)

^f TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CELL ADHESION MOLECULE; FLT3 LIGAND; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 3; INTERLEUKIN 6; NOTCH1 RECEPTOR; STEM CELL FACTOR; SUBSTANCE P; THROMBOPOIETIN;

COCULTURE; COLONY FORMING UNIT; CORD BLOOD STEM CELL TRANSPLANTATION; ENGRAFTMENT; GRAFT VERSUS HOST REACTION; HEMATOLOGIC DISEASE; HUMAN; LEUKEMIA; MORTALITY; REDUCED INTENSITY CONDITIONING; REVIEW; STEM CELL EXPANSION; STROMA CELL; THALASSEMIA MAJOR; TREATMENT OUTCOME; CELL PROLIFERATION; CYTOLOGY; FETUS BLOOD; HEMATOPOIETIC STEM CELL TRANSPLANTATION; STEM CELL;

CELL PROLIFERATION; CORD BLOOD STEM CELL TRANSPLANTATION; FETAL BLOOD; HEMATOLOGIC DISEASES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; STEM CELLS;

EID: 84870220319     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2012/572821     Document Type: Review

References (98)

1. Halbrecht J., Transfusion with placental blood. The Lancet 1939 233 6022 202 203 2-s2.0-50349146904
2. Ende M., Ende N., Hematopoietic transplantation by means of fetal (cord) blood. A new method. Virginia Medical Monthly 1972 99 3 276 280 2-s2.0-0015312249
3. Gluckman E., Broxmeyer H. E., Auerbach A. D., Friedman H. S., Douglas G. W., Devergie A., Esperou H., Thierry D., Socie G., Lehn P., Cooper S., English D., Kurtzberg J., Bard J., Boyse E. A., Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. New England Journal of Medicine 1989 321 17 1174 1178 2-s2.0-0024396816 (Pubitemid 19255814)
4. Broxmeyer H. E., Smith F. O., Cord blood hematopoietic cell transplantation. Thomas' Hematopoietic Cell Transplantation 2009 Malden, Mass, USA Wiley-Blackwell 559 576
5. Hough R., Rocha V., Transplant outcomes in acute leukemia (II). Seminars in Hematology 2010 47 1 51 58 2-s2.0-72449141109 10.1053/j.seminhematol.2009.10. 005
6. MacMillan M. L., Walters M. C., Gluckman E., Transplant outcomes in bone marrow failure syndromes and hemoglobinopathies. Seminars in Hematology 2010 47 1 37 45 2-s2.0-72649101967 10.1053/j.seminhematol.2009.10.004
7. Wagner J. E., Kernan N. A., Steinbuch M., Broxmeyer H. E., Gluckman E., Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease. The Lancet 1995 346 8969 214 219 2-s2.0-0029036129
8. Gluckman E., Rocha V., Boyer-Chammard A., Outcome of cord-blood transplantation from related and unrelated donors. Eurocord transplant group and the European blood and marrow transplantation group. New England Journal of Medicine 1997 337 6 373 381 10.1056/NEJM199708073370602 (Pubitemid 27328367)
9. Locatelli F., Rocha V., Chastang C., Arcese W., Michel G., Abecasis M., Messina C., Ortega J., Badell-Serra I., Plouvier E., Souillet G., Jouet J. P., Pasquini R., Ferreira E., Garnier F., Gluckman E., Factors associated with outcome after cord blood transplantation in children with acute leukemia. Blood 1999 93 11 3662 3671 2-s2.0-0033152326 (Pubitemid 29249812)
10. Rocha V., Gluckman E., Improving outcomes of cord blood transplantation: HLA matching, cell dose and other graft- and transplantation-related factors. British Journal of Haematology 2009 147 2 262 274 2-s2.0-70349671147 10.1111/j.1365-2141.2009.07883.x
11. Broxmeyer H. E., Umbilical cord transplantation: epilogue. Seminars in Hematology 2010 47 1 97 103 2-s2.0-72449162691 10.1053/j.seminhematol.2009.10. 002
12. Rocha V., Broxmeyer H. E., New approaches for improving engraftment after cord blood transplantation. Biology of Blood and Marrow Transplantation 2010 16 supplement 1 S126 S132 2-s2.0-77953044213
13. Cohen G., Carter S. L., Weinberg K. I., Masinsin B., Guinan E., Kurtzberg J., Wagner J. E., Kernan N. A., Parkman R., Antigen-specific T-lymphocyte function after cord blood transplantation. Biology of Blood and Marrow Transplantation 2006 12 12 1335 1342 2-s2.0-33845249124 10.1016/j.bbmt.2006.08. 036 (Pubitemid 44858266)
14. Rocha V., Locatelli F., Searching for alternative hematopoietic stem cell donors for pediatric patients. Bone Marrow Transplantation 2008 41 2 207 214 2-s2.0-38849112548 10.1038/sj.bmt.1705963 (Pubitemid 351188919)
15. Eapen M., Rubinstein P., Zhang M. J., Stevens C., Kurtzberg J., Scaradavou A., Loberiza F. R., Champlin R. E., Klein J. P., Horowitz M. M., Wagner J. E., Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. The Lancet 2007 369 9577 1947 1954 2-s2.0-34249899377 10.1016/S0140-6736(07)60915-5 (Pubitemid 46874578)
16. Prasad V. K., Kurtzberg J., Umbilical cord blood transplantation for non-malignant diseases. Bone Marrow Transplantation 2009 44 10 643 651 2-s2.0-75149118147 10.1038/bmt.2009.290
17. Gluckman E., Rocha V., Ionescu I., Bierings M., Harris R. E., Wagner J., Kurtzberg J., Champagne M. A., Bonfim C., Bittencourt M., Darbyshire P., Fernandez M. N., Locatelli F., Pasquini R., Results of unrelated cord blood transplant in Fanconi anemia patients: risk factor analysis for engraftment and survival. Biology of Blood and Marrow Transplantation 2007 13 9 1073 1082 2-s2.0-34547673245 10.1016/j.bbmt.2007.05.015 (Pubitemid 47215564)
18. Willasch A., Hoelle W., Kreyenberg H., Niethammer D., Handgretinger R., Lang P., Beck J. F., Klingebiel T., Bader P., Outcome of allogeneic stem cell transplantation in children with non-malignant diseases. Haematologica 2006 91 6 788 794 2-s2.0-33745754470 (Pubitemid 44014545)
19. Michel G., Rocha V., Chevret S., Arcese W., Chan K. W., Filipovich A., Takahashi T. A., Vowels M., Ortega J., Bordigoni P., Shaw P. J., Yaniv I., Machado A., Pimentel P., Fagioli F., Verdeguer A., Jouet J. P., Diez B., Ferreira E., Pasquini R., Rosenthal J., Sievers E., Messina C., Iori A. P., Garnier F., Ionescu I., Locatelli F., Gluckman E., Unrelated cord blood transplantation for childhood acute myeloid leukemia: a Eurocord Group analysis. Blood 2003 102 13 4290 4297 2-s2.0-10744222952 10.1182/blood-2003-04-1288 (Pubitemid 37494086)
20. Rubinstein P., Carrier C., Scaradavou A., Kurtzberg J., Adamson J., Migliaccio A. R., Berkowitz R. L., Cabbad M., Dobrila N. L., Taylor P. E., Rosenfield R. E., Stevens C. E., Outcomes among 562 recipients of placental-blood transplants from unrelated donors. New England Journal of Medicine 1998 339 22 1565 1577 2-s2.0-0032569779 10.1056/NEJM199811263392201 (Pubitemid 28536131)
21. Wagner J. E., Barker J. N., DeFor T. E., Scott Baker K., Blazar B. R., Eide C., Goldman A., Kersey J., Krivit W., MacMillan M. L., Orchard P. J., Peters C., Weisdorf D. J., Ramsay N. K. C., Davies S. M., Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002 100 5 1611 1618 2-s2.0-0036721158 10.1182/blood-2002-01-0294 (Pubitemid 34925136)
22. Rocha V., Sanz G., Gluckman E., Umbilical cord blood transplantation. Current Opinion in Hematology 2004 11 6 375 385 2-s2.0-8544269345 10.1097/01.moh.0000145933.36985.eb (Pubitemid 39491430)
23. Gluckman E., Rocha V., Arcese W., Michel G., Sanz G., Chan K. W., Takahashi T. A., Ortega J., Filipovich A., Locatelli F., Asano S., Fagioli F., Vowels M., Sirvent A., Laporte J. P., Tiedemann K., Amadori S., Abecassis M., Bordigoni P., Diez B., Shaw P. J., Vora A., Caniglia M., Garnier F., Ionescu I., Garcia J., Koegler G., Rebulla P., Chevret S., Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Experimental Hematology 2004 32 4 397 407 2-s2.0-12144287126 10.1016/j.exphem.2004.01.002 (Pubitemid 38410917)
24. Brunstein C. G., Barker J. N., Weisdorf D. J., DeFor T. E., Miller J. S., Blazar B. R., McGlave P. B., Wagner J. E., Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease. Blood 2007 110 8 3064 3070 2-s2.0-35548984981 10.1182/blood-2007-04-067215 (Pubitemid 350006962)
25. Barker J. N., Weisdorf D. J., DeFor T. E., Blazar B. R., McGlave P. B., Miller J. S., Verfaillie C. M., Wagner J. E., Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005 105 3 1343 1347 2-s2.0-12844273651 10.1182/blood-2004-07-2717 (Pubitemid 40170912)
26. Delaney C., Ratajczak M. Z., Laughlin M. J., Strategies to enhance umbilical cord blood stem cell engraftment in adult patients. Expert Review of Hematology 2010 3 3 273 283 2-s2.0-77953505292 10.1586/ehm.10.24
27. Stanevsky A., Shimoni A., Yerushalmi R., Nagler A., Cord blood stem cells for hematopoietic transplantation. Stem Cell Reviews and Reports 2011 7 2 425 433 2-s2.0-79955046314 10.1007/s12015-010-9183-9
28. Gutman J. A., Riddell S. R., McGoldrick S., Delaney C., Double unit cord blood transplantation: who wins-and why do we care? Chimerism 2010 1 1 21 22 2-s2.0-79952256617 10.4161/chim.1.1.12141
29. Rocha V., Wagner J. E., Sobocinski K. A., Klein J. P., Zhang M. J., Horowitz M. M., Gluckman E., Graft-versus-host disease in children who have received a cord blood or bone marrow transplant from an HLA-identical sibling. New England Journal of Medicine 2000 342 25 1846 1854 2-s2.0-0034702284 10.1056/NEJM200006223422501 (Pubitemid 30419048)
30. Lazarus H. M., Acute leukemia in adults: novel allogeneic transplant strategies. Hematology 2012 17 supplement 1 47 51
31. Zhang M.-J., Davies S. M., Camitta B. M., Logan B., Tiedemann K., Eapen M., Comparison of outcomes after HLA-matched sibling and unrelated donor transplantation for children with high-risk acute lymphoblastic leukemia. Biology of Blood and Marrow Transplantation 2012 18 8 1204 1210 10.1016/j.bbmt.2012.01.007
32. Perez L. E., Outcomes from unrelated donor hematopoietic stem cell transplantation. Cancer Control 2011 18 4 216 221
33. Eapen M., Rocha V., Sanz G., Scaradavou A., Zhang M. J., Arcese W., Sirvent A., Champlin R. E., Chao N., Gee A. P., Isola L., Laughlin M. J., Marks D. I., Nabhan S., Ruggeri A., Soiffer R., Horowitz M. M., Gluckman E., Wagner J. E., Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. The Lancet Oncology 2010 11 7 653 660 2-s2.0-77954031042 10.1016/S1470-2045(10) 70127-3
34. Laughlin M. J., Eapen M., Rubinstein P., Wagner J. E., Zhang M. J., Champlin R. E., Stevens C., Barker J. N., Gale R. P., Lazarus H. M., Marks D. I., Van Rood J. J., Scaradavou A., Horowitz M. M., Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. New England Journal of Medicine 2004 351 22 2265 2275 2-s2.0-9244256765 10.1056/NEJMoa041276 (Pubitemid 39552742)
35. Kurtzberg J., Laughlin M., Graham M. L., Smith C., Olson J. F., Halperin E. C., Ciocci G., Carrier C., Stevens C. E., Rubinstein P., Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. New England Journal of Medicine 1996 335 3 157 166 2-s2.0-8944228913 10.1056/NEJM199607183350303 (Pubitemid 26249452)
36. Ghavamzadeh A., Alimoghaddam K., Naderi A., Hamidieh A. A., Bahar B., Mousavi S. A., Iravani M., Outcome of related and unrelated cord-blood transplantation in children at hematopoietic stem cell transplantation research center of Shariati Hospital. International Journal of Hematology-Oncology and Stem Cell Research 2009 3 1 17 20 2-s2.0-79952428952
37. Barker J. N., Krepski T. P., DeFor T. E., Davies S. M., Wagner J. E., Weisdorf D. J., Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow. Biology of Blood and Marrow Transplantation 2002 8 5 257 260 2-s2.0-0036270561 (Pubitemid 34619076)
38. Broxmeyer H. E., Gluckman E., Auerbach A., Douglas G. W., Friedman H., Cooper S., Hangoc G., Kurtzberg J., Bard J., Boyse E. A., Human umbilical cord blood: a clinically useful source of transplantable hematopoietic stem/progenitor cells. International Journal of Cell Cloning 1990 8 supplement 1 76 91 2-s2.0-0025031787 (Pubitemid 20305542)
39. Deacock S. J., Schwarer A. P., Bridge J., Batchelor J. R., Goldman J. M., Lechler R. I., Evidence that umbilical cord blood contains a higher frequency of HLA class II-specific alloreactive T cells than adult peripheral blood: a limiting dilution analysis. Transplantation 1992 53 5 1128 1134 2-s2.0-0026628388
40. Roncarolo M. G., Bigler M., Ciuti E., Martino S., Tovo P. A., Immune responses by cord blood cells. Blood Cells 1994 20 2-3 573 586 2-s2.0-0028596362
41. Bensussan A., Gluckman E., El Marsafy S., Schiavon V., Mansur I. G., Dausset J., Boumsell L., Carosella E., BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity. Proceedings of the National Academy of Sciences of the United States of America 1994 91 19 9136 9140 2-s2.0-0028598537 10.1073/pnas.91.19.9136
42. Huang X. J., Liu D. H., Liu K. Y., Xu L. P., Chen H., Han W., Chen Y. H., Zhang X. H., Lu D. P., Treatment of acute leukemia with unmanipulated HLA-mismatched/haploidentical blood and bone marrow transplantation. Biology of Blood and Marrow Transplantation 2009 15 2 257 265 2-s2.0-58249132219 10.1016/j.bbmt.2008.11.025
43. Ciceri F., Labopin M., Aversa F., Rowe J. M., Bunjes D., Lewalle P., Nagler A., Di Bartolomeo P., Lacerda J. F., Stangheilini M. T. L., Polge E., Frassoni F., Martelli M. F., Rocha V., A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation. Blood 2008 112 9 3574 3581 2-s2.0-55749091291 10.1182/blood-2008-02-140095
44. Aversa F., Terenzi A., Tabilio A., Falzetti F., Carotti A., Ballanti S., Felicini R., Falcinelli F., Velardi A., Ruggeri L., Aloisi T., Saab J. P., Santucci A., Perruccio K., Martelli M. P., Mecucci C., Reisner Y., Martelli M. F., Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. Journal of Clinical Oncology 2005 23 15 3447 3454 2-s2.0-20644470338 10.1200/JCO.2005.09. 117
45. Naparstek E., Delukina M., Or R., Nagler A., Kapelushnik J., Varadi G., Strauss N., Cividalli G., Aker M., Brautbar C., Waldmann H., Hale G., Slavin S., Engraftment of marrow allografts treated with Campath-1 monoclonal antibodies. Experimental Hematology 1999 27 7 1210 1218 2-s2.0-20244383278 10.1016/S0301-472X(99)00052-1 (Pubitemid 29284329)
46. Prigozhina T. B., Gurevitch O., Slavin S., Nonmyeloablative conditioning to induce bilateral tolerance after allogeneic bone marrow transplantation in mice. Experimental Hematology 1999 27 10 1503 1510 2-s2.0-0032836940 10.1016/S0301-472X(99)00088-0 (Pubitemid 29458424)
47. Ruggeri L., Mancusi A., Capanni M., Urbani E., Carotti A., Aloisi T., Stern M., Pende D., Perruccio K., Burchielli E., Topini F., Bianchi E., Aversa F., Martelli M. F., Velardi A., Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value. Blood 2007 110 1 433 440 2-s2.0-34347396957 10.1182/blood-2006-07-038687 (Pubitemid 47026866)
48. Perruccio K., Tosti A., Burchielli E., Topini F., Ruggeri L., Carotti A., Capanni M., Urbani E., Mancusi A., Aversa F., Martelli M. F., Romani L., Velardi A., Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood 2005 106 13 4397 4406 2-s2.0-28844459420 10.1182/blood-2005-05-1775 (Pubitemid 41775954)
49. McGuckin C. P., Forraz N., Baradez M. O., Navran S., Zhao J., Urban R., Tilton R., Denner L., Production of stem cells with embryonic characteristics from human umbilical cord blood. Cell Proliferation 2005 38 4 245 255 2-s2.0-23844523442 10.1111/j.1365-2184.2005.00346.x (Pubitemid 41176577)
50. Basford C., Forraz N., McGuckin C., Optimized multiparametric immunophenotyping of umbilical cord blood cells by flow cytometry. Nature Protocols 2010 5 7 1337 1346 2-s2.0-77954303361 10.1038/nprot.2010.88
51. McGuckin C. P., Basford C., Hanger K., Habibollah S., Forraz N., Cord blood revelations: the importance of being a first born girl, big, on time and to a young mother! Early Human Development 2007 83 12 733 741 10.1016/j.earlhumdev.2007.09.001 (Pubitemid 350016668)
52. Mancinelli F., Tamburini A., Spagnoli A., Malerba C., Suppo G., Lasorella R., de Fabritiis P., Calugi A., Optimizing umbilical cord blood collection: impact of obstetric factors versus quality of cord blood units. Transplantation Proceedings 2006 38 4 1174 1176 2-s2.0-33744511820 10.1016/j.transproceed.2006. 03.052 (Pubitemid 43815915)
53. McGuckin C. P., Pearce D., Forraz N., Tooze J. A., Watt S. M., Pettengell R., Multiparametric analysis of immature cell populations in umbilical cord blood and bone marrow. European Journal of Haematology 2003 71 5 341 350 2-s2.0-0142184934 10.1034/j.1600-0609.2003.00153.x (Pubitemid 37330506)
54. Tommiska V., Heinonen K., Ikonen S., Kero P., Pokela M. L., Renlund M., Virtanen M., Fellman V., A national short-term follow-Up study of extremely low birth weight infants born in Finland in 1996-1997. Pediatrics 2001 107 1 E2 2-s2.0-0035219874
55. Adkins B., T-cell function in newborn mice and humans. Immunology Today 1999 20 7 330 335 2-s2.0-0033166040 10.1016/S0167-5699(99)01473-5 (Pubitemid 29331539)
56. Li J., Barreda D. R., Zhang Y. A., Boshra H., Gelman A. E., LaPatra S., Tort L., Sunyer J. O., B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities. Nature Immunology 2006 7 10 1116 1124 2-s2.0-33748875713 10.1038/ni1389 (Pubitemid 44420657)
57. Liao Y., Geyer M. B., Yang A. J., Cairo M. S., Cord blood transplantation and stem cell regenerative potential. Experimental Hematology 2011 39 4 393 412 2-s2.0-79952639189 10.1016/j.exphem.2011.01.002
58. Tung S. S., Parmar S., Robinson S. N., De Lima M., Shpallemail E. J., Ex vivo expansion of umbilical cord blood for transplantation. Best Practice & Research Clinical Haematology 2010 23 2 245 257 10.1016/j.beha.2010.06.004
59. McNiece I., Kubegov D., Kerzic P., Shpall E. J., Gross S., Increased expansion and differentiation of cord blood products using a two-step expansion culture. Experimental Hematology 2000 28 10 1181 1186 2-s2.0-0033797531 10.1016/S0301-472X(00)00520-8
60. Shpall E. J., Quinones R., Giller R., Zeng C., Baron A. E., Jones R. B., Bearman S. I., Nieto Y., Freed B., Madinger N., Hogan C. J., Slat-Vasquez V., Russell P., Blunk B., Schissel D., Hild E., Malcolm J., Ward W., McNiece I. K., Transplantation of ex vivo expanded cord blood. Biology of Blood and Marrow Transplantation 2002 8 7 368 376 2-s2.0-0036049672
61. Ebtekar M., Shahrokhi S., Alimoghaddam K., Characteristics of Cord Blood Stem Cells: Role of Substance P, (SP) and Calcitonin Gene-Related Peptide (CGRP), Stem Cells and Cancer Stem Cells 2012 2 Heidelberg, Germany Springer Netherlands
62. Shahrokhi S., Ebtekar M., Alimoghaddam K., Pourfathollah A. A., Kheirandish M., Ardjmand A., Shamshiri A. R., Ghavamzadeh A., Substance P and calcitonin gene-related neuropeptides as novel growth factors for ex vivo expansion of cord blood CD34+ hematopoietic stem cells. Growth Factors 2010 28 1 66 73 2-s2.0-75749108856 10.3109/08977190903369404
63. Rameshwar P., Ganea D., Gascon P., In vitro stimulatory effect of Substance P on hematopoiesis. Blood 1993 81 2 391 398 2-s2.0-0027464306 (Pubitemid 23027155)
64. McKenna D., Sheth J., Umbilical cord blood: current status and promise for the future. Indian Journal of Medical Research 2011 134 261 269
65. Peled T., Mandel J., Goudsmid R. N., Landor C., Hasson N., Harati D., Austin M., Hasson A., Fibach E., Shpall E. J., Nagler A., Pre-clinical development of cord blood-derived progenitor cell graft expanded ex vivo with cytokines and the polyamine copper chelator tetraethylenepentamine. Cytotherapy 2004 6 4 344 355 2-s2.0-4544362434 10.1080/14653240410004916 (Pubitemid 39214054)
66. Delaney C., Heimfeld S., Brashem-Stein C., Voorhies H., Manger R. L., Bernstein I. D., Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nature Medicine 2010 16 2 232 236 2-s2.0-76349113345 10.1038/nm.2080
67. Verfaillie C. M., Adhesion receptors as regulators of the hematopoietic process. Blood 1998 92 8 2609 2612 2-s2.0-0032532648 (Pubitemid 28469071)
68. Shahrokhi S., Ebtekar M., Alimoghaddam K., Sharifi Z., Ghaffari S. H., Pourfathollah A. A., Kheirandish M., Mohseni M., Ghavamzadeh A., Communication of substance P, calcitonin-gene-related neuropeptides and chemokine receptor 4 (CXCR4) in cord blood hematopoietic stem cells. Neuropeptides 2010 44 5 385 389 2-s2.0-77956191812 10.1016/j.npep.2010.06.002
69. Shahrokhi S., Alimoghaddam K., Ebtekar M., Pourfathollah A. A., Kheirandish M., Ardjmand A., Ghavamzadeh A., Effects of neuropeptide substance P on the expression of adhesion molecules in cord blood hematopoietic stem cells. Annals of Hematology 2010 89 12 1197 1205 2-s2.0-78549261032 10.1007/s00277-010-1006-1
70. Laughlin M. J., Barker J., Bambach B., Koc O. N., Rizzieri D. A., Wagner J. E., Gerson S. L., Lazarus H. M., Cairo M., Stevens C. E., Rubinstein P., Kurtzberg J., Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. New England Journal of Medicine 2001 344 24 1815 1822 2-s2.0-0035859201 10.1056/NEJM200106143442402 (Pubitemid 32538694)
71. Barker J. N., Davies S. M., DeFor T., Ramsay N. K. C., Weisdorf D. J., Wagner J. E., Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis. Blood 2001 97 10 2957 2961 2-s2.0-0035874535 10.1182/blood.V97.10.2957
72. Pinto F. O., Roberts I., Cord blood stem cell transplantation for haemoglobinopathies. British Journal of Haematology 2008 141 3 309 324 2-s2.0-42049107587 10.1111/j.1365-2141.2008.07016.x (Pubitemid 351521145)
73. Locatelli F., Rocha V., Reed W., Bernaudin F., Ertem M., Grafakos S., Brichard B., Li X., Nagler A., Giorgiani G., Haut P. R., Brochstein J. A., Nugent D. J., Blatt J., Woodard P., Kurtzberg J., Rubin C. M., Miniero R., Lutz P., Raja T., Roberts I., Will A. M., Yaniv I., Vermylen C., Tannoia N., Garnier F., Ionescu I., Walters M. C., Lubin B. H., Gluckman E., Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease. Blood 2003 101 6 2137 2143 2-s2.0-0037443543 10.1182/blood-2002-07-2090 (Pubitemid 36302049)
74. Adamkiewicz T. V., Szabolcs P., Haight A., Baker K. S., Staba S., Kedar A., Chiang K. Y., Krishnamurti L., Boyer M. W., Kurtzberg J., Wagner J. E., Wingard J. R., Yeager A. M., Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience. Pediatric Transplantation 2007 11 6 641 644 2-s2.0-34547428427 10.1111/j.1399-3046.2007. 00725.x (Pubitemid 47174392)
75. Wagner J. E., Rosenthal J., Sweetman R., Shu X. O., Davies S. M., Ramsay N. K. C., McGlave P. B., Sender L., Cairo M. S., Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft- versus-host disease. Blood 1996 88 3 795 802 2-s2.0-0029742950 (Pubitemid 26333297)
76. Kurtzberg J., Graham M., Casey J., Olson J., Stevens C. E., Rubinstein P., The use of umbilical cord blood in mismatched related and unrelated hemopoietic stem cell transplantation. Blood Cells 1994 20 2-3 275 284 2-s2.0-0028597587
77. Maschan A. A., Skorobogatova E. V., Samotchatova E. V., Balashov D. N., Yourlova M. I., Bogatcheva N. I., Pashanov E. D., Trakhtman P. E., Timakov A. M., Rumiantzev A. G., A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis. Bone Marrow Transplantation 2000 25 2 213 215 2-s2.0-0033973644 (Pubitemid 30087995)
78. Pecora A. L., Stiff P., Jennis A., Goldberg S., Rosenbluth R., Price P., Goltry K. L., Douville J., Armstrong R. D., Smith A. K., Preti R. A., Prompt and durable engraftment in two older adult patients with high risk chronic myelogenous leukemia (CML) using ex vivo expanded and unmanipulated unrelated umbilical cord blood. Bone Marrow Transplantation 2000 25 7 797 799 2-s2.0-19244369635 (Pubitemid 30189523)
79. Brunstein C., Setubal D., DeFor T., Umbilical cord blood transplantation for adult patients with chronic myeloid leukemia. Biology of Blood and Marrow Transplantation 2007 13 2 84
80. Sanz G. F., Saavedra S., Jiménez C., Senent L., Cervera J., Planelles D., Bolufer P., Larrea L., Martín G., Martínez J., Jarque I., Moscardó F., Plumé G., Andreu R., De La Rubia J., Barragán E., Solves P., Soler M. A., Sanz M. A., Unrelated donor cord blood transplantation in adults with chronic myelogenous leukemia: results in nine patients from a single institution. Bone Marrow Transplantation 2001 27 7 693 701 2-s2.0-17744369066 10.1038/sj.bmt.1702878 (Pubitemid 32409443)
81. Sanz J., Montesinos P., Saavedra S., Lorenzo I., Senent L., Planelles D., Larrea L., Martín G., Palau J., Jarque I., Martínez J., de la Rubia J., Moscardó F., Martinez D., Gómez I., López M., Sanz M. A., Sanz G. F., Single-unit umbilical cord blood transplantation from unrelated donors in adult patients with chronic myelogenous leukemia. Biology of Blood and Marrow Transplantation 2010 16 11 1589 1595 2-s2.0-77957755344 10.1016/j.bbmt.2010.05.014
82. Sato A., Ooi J., Takahashi S., Tsukada N., Kato S., Kawakita T., Yagyu T., Nagamura F., Iseki T., Tojo A., Asano S., Unrelated cord blood transplantation after myeloablative conditioning in adults with advanced myelodysplastic syndromes. Bone Marrow Transplantation 2011 46 2 257 261 2-s2.0-79951682984 10.1038/bmt.2010.91
83. Warlick E. D., Cioc A., DeFor T., Dolan M., Weisdorf D., Allogeneic stem cell transplantation for adults with myelodysplastic syndromes: importance of pretransplant disease burden. Biology of Blood and Marrow Transplantation 2009 15 1 30 38 2-s2.0-58149196171 10.1016/j.bbmt.2008.10.012
84. Wall D. A., Carter S. L., Kernan N. A., Kapoor N., Kamani N. R., Brochstein J. A., Frangoul H., Goyal R. K., Horan J. T., Pietryga D., Wagner J. E., Kurtzberg J., Busulfan/melphalan/antithymocyte globulin followed by unrelated donor cord blood transplantation for treatment of infant leukemia and leukemia in young children: the Cord Blood Transplantation study (COBLT) experience. Biology of Blood and Marrow Transplantation 2005 11 8 637 646 2-s2.0-22344435686 10.1016/j.bbmt.2005.05.003 (Pubitemid 41001639)
85. Kurtzberg J., Prasad V. K., Carter S. L., Wagner J. E., Lee A. B. L., Wall D., Kapoor N., Guinan E. C., Feig S. A., Wagner E. L., Kernan N. A., Results of the cord blood transplantation study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood 2008 112 10 4318 4327 2-s2.0-58149165364 10.1182/blood-2007-06-098020
86. Rocha V., Labopin M., Sanz G., Arcese W., Schwerdtfeger R., Bosi A., Jacobsen N., Ruutu T., De Lima M., Finke J., Frassoni F., Gluckman E., Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. New England Journal of Medicine 2004 351 22 2276 2285 2-s2.0-9244219607 10.1056/NEJMoa041469 (Pubitemid 39552743)
87. Takahashi S., Ooi J., Tomonari A., Konuma T., Tsukada N., Oiwa-Monna M., Fukuno K., Uchiyama M., Takasugi K., Iseki T., Tojo A., Yamaguchi T., Asano S., Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen. Blood 2007 109 3 1322 1330 2-s2.0-33846886362 10.1182/blood-2006-04-020172 (Pubitemid 46220686)
88. Kumar P., Defor T. E., Brunstein C., Barker J. N., Wagner J. E., Weisdorf D. J., Burns L. J., Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival. Biology of Blood and Marrow Transplantation 2008 14 12 1394 1400 2-s2.0-56649103742 10.1016/j.bbmt.2008.09.021
89. Tomblyn M. B., Arora M., Baker K. S., Blazar B. R., Brunstein C. G., Burns L. J., Defor T. E., Dusenbery K. E., Kaufman D. S., Kersey J. H., MacMillan M. L., McGlave P. B., Miller J. S., Orchard P. J., Slungaard A., Tomblyn M. R., Vercellotti G. M., Verneris M. R., Wagner J. E., Weisdorf D. J., Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome. Journal of Clinical Oncology 2009 27 22 3634 3641 2-s2.0-68949135788 10.1200/JCO.2008.20.2960
90. Atsuta Y., Suzuki R., Nagamura-Inoue T., Taniguchi S., Takahashi S., Kai S., Sakamaki H., Kouzai Y., Kasai M., Fukuda T., Azuma H., Takanashi M., Okamoto S., Tsuchida M., Kawa K., Morishima Y., Kodera Y., Kato S., Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia. Blood 2009 113 8 1631 1638 2-s2.0-61849109215 10.1182/blood-2008-03-147041
91. Brunstein C. G., Gutman J. A., Weisdorf D. J., Woolfrey A. E., DeFor T. E., Gooley T. A., Verneris M. R., Appelbaum F. R., Wagner J. E., Delaney C., Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood. Blood 2010 116 22 4693 4699 2-s2.0-78649462137 10.1182/blood-2010-05-285304
92. Ooi J., Iseki T., Takahashi S., Tomonari A., Takasugi K., Shimohakamada Y., Yamada T., Ishii K., Ohno N., Nagamura F., Uchimaru K., Tojo A., Asano S., Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia. Blood 2004 103 2 489 491 2-s2.0-9144233484 10.1182/blood-2003-07-2420 (Pubitemid 38140078)
93. Sanz J., Sanz M. A., Saavedra S., Lorenzo I., Montesinos P., Senent L., Planelles D., Larrea L., Martín G., Palau J., Jarque I., Martínez J., de la Rubia J., Moscardó F., Romero M., Luna I., Montava A., Cañabate S., Sanz G. F., Cord blood transplantation from unrelated donors in adults with high-risk acute myeloid leukemia. Biology of Blood and Marrow Transplantation 2010 16 1 86 94 2-s2.0-72649093013 10.1016/j.bbmt.2009.09.001
94. Ballen K. K., Spitzer T. R., Yeap B. Y., McAfee S., Dey B. R., Attar E., Haspel R., Kao G., Liney D., Alyea E., Lee S., Cutler C., Ho V., Soiffer R., Antin J. H., Double unrelated reduced-intensity umbilical cord blood transplantation in adults. Biology of Blood and Marrow Transplantation 2007 13 1 82 89 2-s2.0-33846007695 10.1016/j.bbmt.2006.08.041 (Pubitemid 46044092)
95. Thomas E. D., Buckner C. D., Sanders J. E., Marrow transplantation for thalassaemia. The Lancet 1982 2 8292 227 229 2-s2.0-0019967483 (Pubitemid 12081767)
96. Jaing T. H., Hung I. J., Yang C. P., Chen S. H., Sun C. F., Chow R., Rapid and complete donor chimerism after unrelated mismatched cord blood transplantation in 5 children with β -thalassemia major. Biology of Blood and Marrow Transplantation 2005 11 5 349 353 2-s2.0-17444402874 10.1016/j.bbmt.2005.02.003 (Pubitemid 40542927)
97. Jaing T. H., Yang C. P., Hung I. J., Chen S. H., Sun C. F., Chow R., Transplantation of unrelated donor umbilical cord blood utilizing double-unit grafts for five teenagers with transfusion-dependent thalassemia. Bone Marrow Transplantation 2007 40 4 307 311 2-s2.0-34547644479 10.1038/sj.bmt.1705737 (Pubitemid 47202415)
98. Jaing T. H., Tan P., Rosenthal J., 166: unrelated cord blood transplantation (UCBT) for transfusion-dependent thalassemia-a retrospective audited analysis of 41 consecutive patients. Biology of Blood and Marrow Transplantation 2007 13 2 62