Transplantation of unrelated donor umbilical cord blood utilizing double-unit grafts for five teenagers with transfusion-dependent thalassemia

Bone Marrow Transplantation

Volumn 40, Issue 4, 2007, Pages 307-311

  Jaing, T H ^a   Yang, C P ^a   Hung, I J ^a   Chen, S H ^a   Sun, C F ^b   Chow, R ^c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c StemCyte Taiwan National Cord Blood Center   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; CD34 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DEFEROXAMINE; IMMUNOGLOBULIN; LINEZOLID; MESNA; METHYLPREDNISOLONE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RITUXIMAB; STEROID; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG WITHDRAWAL; ENGRAFTMENT; ERYTHROCYTE TRANSFUSION; FEMALE; FOLLOW UP; GRAFT RECIPIENT; HLA MATCHING; HUMAN; MALE; MYELOABLATIVE CONDITIONING; PRIORITY JOURNAL; SCHOOL CHILD; STEM CELL TRANSPLANTATION; THALASSEMIA; UMBILICAL CORD BLOOD;

ADOLESCENT; CHILD; CORD BLOOD STEM CELL TRANSPLANTATION; ERYTHROCYTE TRANSFUSION; FEMALE; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; HUMANS; MALE; THALASSEMIA; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS;

EID: 34547644479     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/sj.bmt.1705737     Document Type: Article

References (18)

1. La Nasa G, Caocci G, Argiolu F, Giardini C, Locatelli F, Vacca A et al. Unrelated donor stem cell transplantation in adult patients with thalassemia. Bone Marrow Transplant 2005; 36: 971-975.
2. Bosi A, Bartolozzi B, Guidi S. Allogeneic stem cell transplantation. Transplant Proc 2005; 37: 2667-2669.
3. Fleischhauer K, Locatelli F, Zecca M, Orofino MG, Giardini C, De Stefano P et al. Graft rejection after unrelated donor hematopoietic stem cell transplantation for thalassemia is associated with nonpermissive HLA-DPB1 disparity in host-versus-graft direction. Blood 2006; 107: 2984-2992.
4. Hongeng S, Pakakasama S, Chaisiripoomkere W, Chuansumrit A, Sirachainan N, Ungkanont A et al. Outcome of transplantation with unrelated donor bone marrow in children with severe thalassemia. Bone Marrow Transplant 2004; 33: 377-379.
5. Wagner JE, Barker JN, DeFor TE, Barker KS, Blazar BR, Eide C et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: Influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002; 100: 1611-1618.
6. Benito AI, Diaz MA, Gonzalez-Vicent M, Sevilla J, Madero L. Hematopoietic stem cell transplantation using umbilical cord blood progenitors: Review of current clinical results. Bone Marrow Transplant 2004; 33: 675-690.
7. Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001; 344: 1815-1822.
8. Goldstein G, Toren A, Nagler A. Human umbilical cord blood biology, transplantation and plasticity. Curr Med Chem 2006; 13: 1249-1259.
9. Majhail NS, Brunstein CG, Wagner JE. Double umbilical cord blood transplantation. Curr Opin Immunol 2006; 18: 571-575.
10. Moroff G, Eichler H, Brand A, Kekomaki R, Kurtz J, Letowska M et al. Multiple-laboratory comparison of in vitro assays utilized to characterize hematopoietic cells in cord blood. Transfusion 2006; 46: 498-500.
11. Grewal SS, Barker JN, Davies SM, Wagner JE. Unrelated donor hematopoietic cell transplantation: Marrow or umbilical cord blood? Blood 2003; 101: 4233-4244.
12. Tse W, Laughlin MJ. Umbilical cord blood transplantation: A new alternative option. Hematology (Am Soc Hematol Educ Program) 2005, 377-383.
13. Locatelli F, Rocha V, Reed W, Bernaudin F, Ertem M, Grafakos S et al. Related umbilical cord blood transplantation in thalassemia and sickle cell anemia. Blood 2003; 101: 2137-2143.
14. Goussetis E, Peristeri J, Kitra V, Kattamis A, Petropoulos D, Papassotiriou I et al. Combined Cord-Blood and Bone Marrow Transplantation for Beta-Thalassemia. Pediatr Hematol Oncol 2000; 17: 307-314.
15. Ho WL, Lin KH, Wang JD, Hwang JS, Chung CW, Lin DT et al. Financial burden of national health insurance for treating patients with transfusion-dependent thalassemia in Taiwan. Bone Marrow Transplant 2006; 37: 569-574.
16. Li CK, Lai DH, Shing MM, Chik KW, Lee V, Yuen PM. Early iron reduction programme for thalassaemia patients after bone marrow transplantation. Bone Marrow Transplant 2000; 25: 653-656.
17. Bornstein R, Flores AI, Montalbán MA, del Rey MJ, de la Serna J, Gilsanz F. A modified cord blood collection method achieves sufficient cell levels for transplantation in most adult patients. Stem Cells 2005; 23: 324-334.
18. Migliaccio AR, Adamson JW, Stevens CE, Dobrila NL, Carrier CM, Rubinstein P. Cell dose and speed of engraftment in placental/umbilical cord blood transplantation: Graft progenitor cell content is a better predictor than nucleated cell quantity. Blood 2000; 96: 2717-2722.