Substance P and calcitonin gene-related neuropeptides as novel growth factors for ex vivo expansion of cord blood CD34+ hematopoietic stem cells

Growth Factors

Volumn 28, Issue 1, 2010, Pages 66-73

  Shahrokhi, Somayeh ^a   Ebtekar, Massoumeh ^a   Alimoghaddam, Kamran ^b   Pourfathollah, Ali Akbar ^a   Kheirandish, Maryam ^c   Ardjmand, Alireza ^d   Shamshiri, Ahmad Reza ^b   Ghavamzadeh, Ardeshir ^b  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c IRANIAN BLOOD TRANSFUSION ORGANIZATION   (Iran)

^d UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

CGRP; Cord blood; Expansion; SP; Stem cell

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CD133 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; SUBSTANCE P;

ARTICLE; BONE MARROW CELL; CELL GROWTH; CELL PROLIFERATION; CLINICAL ARTICLE; COLONY FORMATION; CULTURE MEDIUM; ERYTHROID CELL; EX VIVO STUDY; FLOW CYTOMETRY; GRANULOCYTE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; STEM CELL EXPANSION; UMBILICAL CORD BLOOD;

ANTIGENS, CD34; CALCITONIN GENE-RELATED PEPTIDE; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CULTURE MEDIA; CYTOKINES; FETAL BLOOD; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDES; SUBSTANCE P;

EID: 75749108856     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.3109/08977190903369404     Document Type: Article

References (33)

1. Barker JN, Wagner JE. 2003. Umbilical cord blood transplantation: Current practice and future innovations. Crit Rev Oncol Hematol 48(1):35-43.
2. Boxall SA, Cook GP, Pearce D, Bonnet D, El-Sherbiny YM, Blundell MP, et al. 2008. Haematopoietic repopulating activity in human cord blood CD133(+) quivhescent cells. Bone Marrow Transplant 43: 627-635.
3. Bracci-Laudiero L, Celestino D, Starace G, Antonelli A, Lambiase A, Procoli A, et al. 2003. CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA. J Neuroimmunol 136(1-2):130-139.
4. Broome CS, Miyan JA. 2000. Neuropeptide control of bone marrow neutrophil production. A key axis for neuroimmunomodulation. Ann N Y Acad Sci 917:424-434.
5. Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D, et al. 1989. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci USA 86(10):3828-3832.
6. Charrier S, Boiret N, Fouassier M, Berger J, Rapatel C, Pigeon P, et al. 2002. Normal human bone marrow CD34(+)CD133(+) cells contain primitive cells able to produce different categories of colony-forming unit megakaryocytes in vitro. Exp Hematol 30(9):1051-1060.
7. Eridani S, Mazza U, Massaro P, La Targia ML, Maiolo AT, Mosca A. 1998. Cytokine effect on ex vivo expansion of haemopoietic stem cells from different human sources. Biotherapy 11(4): 291-296. (Pubitemid 29044697)
8. Fernandez MN, Regidor C, Cabrera R, Garcia-Marco J, Briz M, Fores R, et al. 2001. Cord blood transplants: Early recovery of neutrophils from co-transplanted sibling haploidentical progenitor cells and lack of engraftment of cultured cord blood cells, as ascertained by analysis of DNA polymorphisms. Bone Marrow Transplant 28(4):355-363.
9. Gilmore GL, DePasquale DK, Lister J, Shadduck RK. 2000. Ex vivo expansion of human umbilical cord blood and peripheral blood CD34(+) hematopoietic stem cells. Exp Hematol 28(11): 1297-1305.
10. Gratama JW, Orfao A, Barnett D, Brando B, Huber A, Janossy G, et al. 1998. Flow cytometric enumeration of CD34+ hematopoietic stem and progenitor cells. European Working Group on Clinical Cell Analysis. Cytometry 34(3):128-142.
11. Greco SJ, Corcoran KE, Cho KJ, Rameshwar P. 2004. Tachykinins in the emerging immune system: Relevance to bone marrow homeostasis and maintenance of hematopoietic stem cells. Front Biosci 9:1782-1793.
12. HarzenetterMD, KellerU, Beer S, Riedl C, Peschel C, Holzmann B. 2002. Regulation and function of the CGRP receptor complex in human granulopoiesis. Exp Hematol 30(4):306-312.
13. Hiramoto M, Aizawa S, Iwase O, Nakano M, Toyama K, Hoque M, et al. 1998. Stimulatory effects of substance P on CD34 positive cell proliferation and differentiation in vitro are mediated by the modulation of stromal cell function. Int J Mol Med 1(2): 347-354.
14. Irie K, Hara-Irie F, Ozawa H, Yajima T. 2002. Calcitonin generelated peptide (CGRP)-containing nerve fibers in bone tissue and their involvement in bone remodeling. Microsc Res Tech 58(2):85-90.
15. Kaushansky K, Karplus PA. 1993. Hematopoietic growth factors: Understanding functional diversity in structural terms. Blood 82(11):3229-3240.
16. Kawakami M, Kimura T, Kishimoto Y, Tatekawa T, Baba Y, Nishizaki T, et al. 2004. Preferential expression of the vasoactive intestinal peptide (VIP) receptor VPAC1 in human cord bloodderived CD34+CD382 cells: Possible role of VIP as a growthpromoting factor for hematopoietic stem/progenitor cells. Leukemia 18(5):912-921.
17. Kohler T, Plettig R, Wetzstein W, Schaffer B, Ordemann R, Nagels HO, et al. 1999. Defining optimum conditions for the ex vivo expansion of human umbilical cord blood cells. Influences of progenitor enrichment, interference with feeder layers, earlyacting cytokines and agitation of culture vessels. Stem Cells 17(1):19-24.
18. Li Y, Douglas SD, HoW. 2000. Human stem cells express substance P gene and its receptor. J Hematother Stem Cell Res 9(4): 445-452. (Pubitemid 30707239)
19. Liu K, Castillo MD, Murthy RG, Patel N, Rameshwar P. 2007. Tachykinins and hematopoiesis. Clin Chim Acta 385(1-2): 28-34.
20. Madkaikar M, Ghosh K, Gupta M, Swaminathan S, Mohanty D. 2007. Ex vivo expansion of umbilical cord blood stem cells using different combinations of cytokines and stromal cells. Acta Haematol 118(3):153-159.
21. McGuckin CP, Pearce D, Forraz N, Tooze JA, Watt SM, Pettengell R. 2003. Multiparametric analysis of immature cell populations in umbilical cord blood and bone marrow. Eur J Haematol 71(5): 341-350.
22. McGuckin CP, Forraz N, Pettengell R, Thompson A. 2004. Thrombopoietin, flt3-ligand and c-kit-ligand modulate HOX gene expression in expanding cord blood CD133 cells. Cell Prolif 37(4):295-306.
23. Mohamed AA, Ibrahim AM, El-Masry MW, Mansour IM, Khroshied MA, Gouda HM, et al. 2006. Ex vivo expansion of stem cells: Defining optimum conditions using various cytokines. Lab Hematol 12(2):86-93.
24. Nowicki M, Ostalska-Nowicka D, Kondraciuk B, Miskowiak B. 2007. The significance of substance P in physiological and malignant haematopoiesis. J Clin Pathol 60(7):749-755.
25. Rameshwar P, Gascon P. 1995. Substance P (SP) mediates production of stem cell factor and interleukin-1 in bone marrow stroma: Potential autoregulatory role for these cytokines in SP receptor expression and induction. Blood 86(2):482-490.
26. Rameshwar P, Ganea D, Gascon P. 1993. In vitro stimulatory effect of substance P on hematopoiesis. Blood 81(2):391-398.
27. Rameshwar P, Zhu G, Donnelly RJ, Qian J, Ge H, Goldstein KR, et al. 2001. The dynamics of bone marrow stromal cells in the proliferation of multipotent hematopoietic progenitors by substance P: An understanding of the effects of a neurotransmitter on the differentiating hematopoietic stem cell. J Neuroimmunol 121(1-2):22-31.
28. Robinson S, Niu T, de Lima M, Ng J, Yang H, McMannis J, et al. 2005. Ex vivo expansion of umbilical cord blood. Cytotherapy 7(3):243-250.
29. Shpall EJ, Quinones R, Giller R, Zeng C, Baron AE, Jones RB, et al. 2002. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant 8(7):368-376.
30. da Silva CL, Gonçalves R, Crapnell KB, Cabral JMS, Zanjani ED, Almeida-Porada G. 2005. A human stromal-based serum-free culture system supports the ex vivo expansion/maintenance of bone marrow and cord blood hematopoietic stem/progenitor cells. Exp Hematol 33(7):828-835.
31. Weihe E, Nohr D, Michel S, Muller S, Zentel HJ, Fink T, et al. 1991. Molecular anatomy of the neuro-immune connection. Int J Neurosci 59(1-3):1-23.
32. Wu H, Guan C, Qin X, Xiang Y, Qi M, Luo Z, et al. 2007. Upregulation of substance P receptor expression by calcitonin gene-related peptide, a possible cooperative action of two neuropeptides involved in airway inflammation. Pulm Pharmacol Ther 20(5):513-524.
33. Yaraee R, Ebtekar M, Ahmadiani A, Sabahi F. 2003. Neuropeptides (SP and CGRP) augment pro-inflammatory cytokine production in HSV-infected macrophages. Int Immunopharmacol 3(13-14):1883-1887.