Characteristics of cord blood stem cells: Role of substance P (SP) and calcitonin gene-related peptide (CGRP)

Stem Cells and Cancer Stem Cells, Volume 2: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 2

Volumn , Issue , 2012, Pages 27-36

  Ebtekar, Massoumeh ^a   Shahrokhi, Somayeh ^b   Alimoghaddam, Kamran ^c  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b LORESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Adhesion molecule expression; Cord blood; Expansion; Hematopoietic stem cells; Neuropeptide

Indexed keywords

EID: 84870171165     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-2016-9_3     Document Type: Chapter

References (34)

1. Alimoghaddam K, Khalili M, Soleimani M, Moezi L, Ghodsi P, Arjmand A, Ghavamzadeh A (2006) Evaluation of the effects of MIP1-α on ex vitro expansion of hematopoietic progenitor cells in different culture media for the purpose of cord blood transplantation. Molecular Therapy 13(S1): S138-S
2. Bandari PS, Qian J, Oh HS, Potian JA, Yehia G, Harrison JS, Rameshwar P (2003) Crosstalk between neurokinin receptors is relevant to hematopoietic regulation: cloning and characterization of neurokinin-2 promoter. J Neuroimmunol 138: 65-75
3. Brain SD, Cox HM (2006) Neuropeptides and their receptors: innovative science providing novel therapeutic targets. Br J Pharmacol 147(Suppl 1): S202-S211
4. Broome CS, Miyan JA (2000) Neuropeptide control of bone marrow neutrophil production. A key axis for neuroimmunomodulation Ann N Y Acad Sci 917: 424-434
5. Cohen PA, Gower AC, Stucchi AF, Leeman SE, Becker JM, Reed KL (2007) A neurokinin-1 receptor antagonist that reduces intraabdominal adhesion formation increases peritoneal matrix metalloproteinase activity. Wound Repair Regen 15: 800-808
6. Corcoran KE, Patel N, Rameshwar P (2007) Stromal derived growth factor-1 alpha: another mediator in neural-emerging immune system through Tac1 expression in bone marrow stromal cells. J Immunol 178: 2075-2082
7. Denning-Kendall P, Singha S, Bradley B, Hows J (2003) Cytokine expansion culture of cord blood CD34+ cells induces marked and sustained changes in adhesion receptor and CXCR4 expressions. Stem Cells 21: 61-70
8. Dravid G, Rao SG (2002) Ex vivo expansion of stem cells from umbilical cord blood: expression of cell adhesion molecules. Stem Cells 20: 183-189
9. Gluckman E, Koegler G, Rocha V (2005) Human leukocyte antigen matching in cord blood transplantation. Semin Hematol 42: 85-90
10. Greco SJ, Corcoran KE, Cho KJ, Rameshwar P (2004) Tachykinins in the emerging immune system: relevance to bone marrow homeostasis and maintenance of hematopoietic stem cells. Front Biosci 9: 1782-1793
11. Harzenetter MD, Keller U, Beer S, Riedl C, Peschel C, Holzmann B (2002) Regulation and function of the CGRP receptor complex in human granulopoiesis. Exp Hematol 30: 306-312
12. Hutton JF, D’andrea RJ, Lewis ID (2007) Potential for clinical ex vivo expansion of cord blood haemopoietic stem cells using non-haemopoietic factor supplements. Curr Stem Cell Res Ther 2: 229-237
13. Joshi DD, Dang A, Yadav P, Qian J, Bandari PS, Chen K, Donnelly R, Castro T, Gascon P, Haider A, Rameshwar P (2001) Negative feedback on the effects of stem cell factor on hematopoiesis is partly mediated through neutral endopeptidase activity on substance P: a combined functional and proteomic study. Blood 98: 2697-2706
14. Kawakami M, Kimura T, Kishimoto Y, Tatekawa T, Baba Y, Nishizaki T, Matsuzaki N, Taniguchi Y, Yoshihara S, Ikegame K, Shirakata T, Nishida S, Masuda T, Hosen N, Tsuboi A, Oji Y, Oka Y, Ogawa H, Sonoda Y, Sugiyama H, Kawase I, Soma T (2004) Preferential expression of the vasoactive intestinal peptide (VIP) receptor VPAC1 in human cord blood-derived CD34+CD38-cells: possible role of VIP as a growth-promoting factor for hematopoietic stem/progenitor cells. Leukemia 18: 912-921
15. Lerner UH (2002) Neuropeptidergic regulation of bone resorption and bone formation. J Musculoskelet Neuronal Interact 2: 440-447
16. Li Y, Douglas SD, Ho W (2000) Human stem cells express substance P gene and its receptor. J Hematother Stem Cell Res 9: 445-452
17. Liu B, Liao C, Chen J, Gu S, Wu S, Xu Z (2003) Significance of increasing adhesion of cord blood hematopoietic cells and a new method: platelet microparticles. Am J Hematol 74: 216-217
18. Lu J, Aggarwal R, Pompili VJ, Das H (2010) A novel technology for hematopoietic stem cell expansion using combination of nanofiber and growth factors. Recent Pat Nanotechnol 4: 125-135
19. Mcniece IK, Almeida-Porada G, Shpall EJ, Zanjani E (2002) Ex vivo expanded cord blood cells provide rapid engraftment in fetal sheep but lack long-term engrafting potential. Exp Hematol 30: 612-616
20. Patah PA, Parmar S, Mcmannis J, Sadeghi T, Karandish S, Rondon G, Tarrand J, Champlin R, De Lima M, Shpall EJ (2007) Microbial contamination of hematopoietic progenitor cell products: clinical outcome. Bone Marrow Transplant 40: 365-368
21. Rameshwar P, Ganea D, Gascon P (1993) In vitro stimulatory effect of substance P on hematopoiesis. Blood 81: 391-398
22. Rameshwar P, Gascon P, Oh HS, Denny TN, Zhu G, Ganea D (2002) Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor. Exp Hematol 30: 1001-1009
23. Robinson S, Niu T, De Lima M, Ng J, Yang H, Mcmannis J, Karandish S, Sadeghi T, Fu P, Del Angel M, O’connor S, Champlin R, Shpall E (2005) Ex vivo expansion of umbilical cord blood. Cytotherapy 7: 243-250
24. Shahrokhi S, Alimoghaddam K, Ebtekar M, Pourfathollah AA, Kheirandish M, Ardjmand A, Ghavamzadeh A (2010a) Effects of neuropeptide substance P on the expression of adhesion molecules in cord blood hematopoietic stem cells. Ann Hematol 89: 1197-1205
25. Shahrokhi S, Alimoghaddam K, Ghavamzadeh A (2010b) Role of substance P (SP) and calcitonin gene-related peptide (CGRP) in gibbon-ape-leukemia virus (GALV) transduction of CD34+ cells. Neuropeptides 44: 491-494
26. Shahrokhi S, Ebtekar M, Alimoghaddam K, Pourfathollah AA, Kheirandish M, Ardjmand A, Shamshiri AR, Ghavamzadeh A (2010c) Substance P and calcitonin gene-related neuropeptides as novel growth factors for ex vivo expansion of cord blood CD34(+) hematopoietic stem cells. Growth Factors 28: 66-73
27. Shahrokhi S, Ebtekar M, Alimoghaddam K, Sharifi Z, Ghaffari SH, Pourfathollah AA, Kheirandish M, Mohseni M, Ghavamzadeh A (2010d) Communication of substance P, calcitonin-gene-related neuropeptides and chemokine receptor 4 (CXCR4) in cord blood hematopoietic stem cells. Neuropeptides 44: 385-389
28. Verfaillie CM (1998) Adhesion receptors as regulators of the hematopoietic process. Blood 92: 2609-2612
29. Wang H, Xing L, Li W, Hou L, Guo J, Wang X (2002) Production and secretion of calcitonin gene-related peptide from human lymphocytes. J Neuroimmunol 130: 155-162
30. Watt SM, Forde SP (2008) The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders?. Vox Sang 94: 18-32
31. Williams DA (1993) Ex vivo expansion of hematopoietic stem and progenitor cells-Robbing Peter to pay Paul?. Blood 81: 3169-3172
32. Wu H, Guan C, Qin X, Xiang Y, Qi M, Luo Z, Zhang C (2007) Upregulation of substance P receptor expression by calcitonin gene-related peptide, a possible cooperative action of two neuropeptides involved in airway inflammation. Pulm Pharmacol Ther 20: 513-524
33. Zhai QL, Qiu LG, Li Q, Meng HX, Han JL, Herzig RH, Han ZC (2004) Short-term ex vivo expansion sustains the homingrelated properties of umbilical cord blood hematopoietic stem and progenitor cells. Haematologica 89: 265-273
34. Zheng Y, Watanabe N, Nagamura-Inoue T, Igura K, Nagayama H, Tojo A, Tanosaki R, Takaue Y, Okamoto S, Takahashi TA (2003) Ex vivo manipulation of umbilical cord bloodderived hematopoietic stem/progenitor cells with recombinant human stem cell factor can up-regulate levels of homing-essential molecules to increase their transmigratory potential. Exp Hematol 31: 1237-1246