Rhubarb inhibits hepatocellular carcinoma cell metastasis via GSK-3-β activation to enhance protein degradation and attenuate nuclear translocation of β-catenin

Food Chemistry

Volumn 138, Issue 1, 2013, Pages 278-285

  Tsai, Kun Hsi ^a,b   Hsien, Hau Hsueh ^c   Chen, Li Mien ^d   Ting, Wei Jen ^c   Yang, Yuh Shyong ^b   Kuo, Chia Hua ^e   Tsai, Chang Hai ^f   Tsai, Fuu Jen ^c   Tsai, Henry J ^f   Huang, Chih Yang ^c,f  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e Taipei Sports University   (Taiwan)

^f ASIA UNIVERSITY   (Taiwan)

Author keywords

Catenin; GSK 3 ; Hepatocellular carcinoma (HCC); Rhubarb

Indexed keywords

CELL MIGRATION; DOSE-DEPENDENT MANNER; HEPATOCELLULAR; HEPATOCELLULAR CARCINOMA; HEPATOCELLULAR CARCINOMA CELL; NUCLEAR ACCUMULATION; NUCLEAR TRANSLOCATIONS; PROTEIN DEGRADATION; PROTEIN LEVEL; RHUBARB; WNT SIGNALLING; WOUND HEALING;

PATHOLOGY; PROTEINS;

PLANTS (BOTANY);

BETA CATENIN; CONTACTIN 1; CYCLIN D; GELATINASE B; GLYCOGEN SYNTHASE KINASE 3BETA; MYC PROTEIN; PROTEIN; RHUBARB EXTRACT; TBX3 PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CELL MIGRATION; CELL NUCLEUS; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; METASTASIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; WOUND HEALING;

ACTIVE TRANSPORT, CELL NUCLEUS; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL NUCLEUS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LIVER NEOPLASMS; NEOPLASM METASTASIS; PLANT EXTRACTS; PROTEOLYSIS; RHEUM;

RHEUM X HYBRIDUM;

EID: 84870199455     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.10.038     Document Type: Article

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