The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation

Endocrinology

Volumn 153, Issue 12, 2012, Pages 5961-5971

  Fernandez Twinn, Denise S ^a   Blackmore, Heather L ^a   Siggens, Lee ^a   Giussani, Dino A ^a   Cross, Christine M ^a   Foo, Roger ^a   Ozanne, Susan E ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; CATALASE; E1A ASSOCIATED P300 PROTEIN; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MANGANESE SUPEROXIDE DISMUTASE; MICRORNA; MICRORNA 1; MICRORNA 133A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN; PROTEIN KINASE B; PROTEIN P22PHOX; PROTEIN P47PHOX; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SIRTUIN 3; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; LIPID PEROXIDATION; MALE; MATERNAL OBESITY; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIBIA; UPREGULATION;

ANIMALS; BODY COMPOSITION; BODY WEIGHT; CARDIOMEGALY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HYPERINSULINISM; LIPID PEROXIDATION; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MICE; MICE, INBRED C57BL; MOTHERS; OBESITY; OXIDATIVE STRESS; PHENOTYPE; PREGNANCY; PREGNANCY, ANIMAL; PRENATAL EXPOSURE DELAYED EFFECTS; PROTO-ONCOGENE PROTEINS C-AKT; TOR SERINE-THREONINE KINASES;

EID: 84870180467     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1508     Document Type: Article

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