Lipopolysaccharide binding protein inhibitory peptide alters hepatic inflammatory response post-hemorrhagic shock

Innate Immunity

Volumn 18, Issue 6, 2012, Pages 866-875

  Cotroneo, Tara M ^a   Nemzek Hamlin, Jean A ^a,b   Bayliss, Jill ^b   Su, Grace L ^b,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c Veterans Administration Ann Arbor Healthcare Systems   (United States)

Author keywords

hemorrhagic shock; LBP; liver; LPS; TLR4

Indexed keywords

BETA INTERFERON; CXCL1 CHEMOKINE; ENDOTOXIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 10; INTERLEUKIN 6; LBPK 95A; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE BINDING PROTEIN; LIPOPOLYSACCHARIDE BINDING PROTEIN INHIBITORY PEPTIDE; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; RINGER LACTATE SOLUTION; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; GASTROINTESTINAL MUCOSA; HEMORRHAGIC SHOCK; INFLAMMATION; LIVER INJURY; LIVER ISCHEMIA; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; RECEPTOR UPREGULATION; RESUSCITATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEPATITIS; HUMANS; INTERFERON-BETA; LIVER; MALE; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDES; RNA, MESSENGER; SHOCK, HEMORRHAGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

MURINAE; MUS;

EID: 84870051485     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425912444641     Document Type: Article

References (31)

1. Kauvar D, Lefering R, Wade C. Impact of hemorrhage on trauma outcome: An overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma. 2006 ; 60: S3 - S9
2. Douzinas EE, Andrianakis I, Livaditi O, et al. The level of hypotension during hemorrhagic shock is a major determinant of the post-resuscitation systemic inflammatory response: an experimental study. BMC Physiol. 2008 ; 8: 15-15
3. Glantzounis GK, Salacinski HJ, Yang W, et al. The contemporary role of antioxidant therapy in attenuating liver ischemia-reperfusion injury: a review. Liver Transpl. 2005 ; 11: 1031-1047
4. Teoh NC, Farrell GC. Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection. J Gastroen Hepatol. 2003 ; 18: 891-902
5. Dewar D, Moore FA, Moore EE, Balogh Z. Postinjury multiple organ failure. Injury Int J Care Inj. 2009 ; 40: 912-918
6. Rush BF, Sori AJ, Murphy TF, et al. Endotoxemia and bacteremia during hemorrhagic-shock-the link between trauma and sepsis. Ann Surg. 1988 ; 207: 549-554
7. Lehnert M, Uehara T, Bradford BU, et al. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol. 2006 ; 291: G456 - G463
8. Sauaia A, Moore FA, Moore EE, et al. Epidemiology of trauma deaths-A reassessment. J Trauma. 1995 ; 38: 185-193
9. Arumugam T, Okun E, Tang S-C, et al. Toll-like receptors in ischemia-reperfusion injury. Shock. 2009 ; 32: 4-16
10. Fiorini R, Shafizadeh S, Polito C, et al. Anti-endotoxin monoclonal antibodies are protective against hepatic ischemia/reperfusion injury in steatotic mice. Am J Transplant. 2004 ; 4: 1567-1573
11. Yao YM, Bahrami S, Leichtfried G, et al. Pathogenesis of hemorrhage-induced bacteria/endotoxin translocation in rats-Effects of recombinant bactericidal/permeability-increasing protein. Ann Surg. 1995 ; 221: 398-405
12. Zweigner J, Schumann RR, Weber JR. The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes Infect. 2006 ; 8: 946-952
13. Fitzgerald K, Rowe D, Barnes B, et al. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med. 2003 ; 198: 1043-1055
14. Flannery S, Bowie AG. The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling. Biochem Pharmacol. 2010 ; 80: 1981-1991
15. Zhai Y, Shen X-d, O'Connell R, et al. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol. 2004 ; 173: 7115-7119
16. Zhai Y, Qiao B, Shen XD, et al. Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury. Transplantation. 2008 ; 85: 1016-1022
17. Su GL, Gong KQ, Fan MH, et al. Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice. Hepatology. 2005 ; 41: 187-195
18. Su GL, Hoesel LM, Bayliss J, et al. Lipopolysaccharide binding protein inhibitory peptide protects against acetaminophen-induced hepatotoxicity. Am J Physiol Gastrointest Liver Physiol. 2010 ; 299: G1319 - G13125
19. Araña MdJ , Vallespi M, Chinea G, et al. Inhibition of LPS-responses by synthetic peptides derived from LBP associates with the ability of the peptides to block LBP-LPS interaction. J Endotoxin Res. 2003 ; 9: 281-291
20. Minter R, Bi X, Ben Josef G, et al. LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction. Am J Physiol Gastrointest Liver Physiol. 2009 ; 296: G45 - G54
21. Nemzek JA, Siddiqui J, Remick DG. Development and optimization of cytokine ELISAs using commercial antibody pairs. J Immunol Methods. 2001 ; 255: 149-157
22. McGhan LJ, Jaroszewski DE. The role of toll-like receptor-4 in the development of multi-organ failure following traumatic haemorrhagic shock and resuscitation. Injury. 2012 ; 43: 129-136
23. Frink M, Hsieh YC, Thobe BM, et al. TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage. Mol Immunol. 2007 ; 44: 2625-2630
24. Hildebrand F, Hubbard WJ, Choudhry MA, et al. Kupffer cells and their mediators-The culprits in producing distant organ damage after trauma-hemorrhage. Am J Pathol. 2006 ; 169: 784-794
25. Ayala A, Lehman DL, Herdon CD, Chaudry IH. Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release. Arch Surg. 1994 ; 129: 1172-1178
26. Floh S, Floh S, Schade FU. Invited review: deterioration of the immune system after trauma: signals and cellular mechanisms. Innate Immun. 2008 ; 14: 333-344
27. Kato A, Ogasawara T, Homma T, et al. Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes. J Immunol. 2004 ; 172: 6185-6194
28. Chang E, Guo B, Doyle S, Cheng G. Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J Immunol. 2007 ; 178: 6705-6709
29. Chang J, Kunkel SL, Chang CH. Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells. Proc Natl Acad Sci USA. 2009 ; 106: 18327-18332
30. Grutz G. New insights into the molecular mechanism of interleukin-10-mediated immunosuppression. J Leukoc Biol. 2005 ; 77: 3-15
31. Hu J, Jacinto R, McCall C, Li L. Regulation of IL-1 receptor-associated kinases by lipopolysaccharide. J Immunol. 2002 ; 168: 3910-3914