Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist

Journal of Medicinal Chemistry

Volumn 55, Issue 22, 2012, Pages 10302-10306

  Spetea, Mariana ^a   Berzetei Gurske, Ilona P ^b   Guerrieri, Elena ^a   Schmidhammer, Helmut ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b SRI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; DIPHENETHYLAMINE DERIVATIVE; HS 665; KAPPA OPIATE RECEPTOR AGONIST; PHENETHYLAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; MOUSE; NONHUMAN; PAIN;

ACETIC ACID; ANALGESICS; ANIMALS; DRUG DISCOVERY; MICE; NOCICEPTION; PAIN; PHENETHYLAMINES; RECEPTORS, OPIOID, KAPPA;

EID: 84870033103     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301258w     Document Type: Article

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