Phosphatidylserine decarboxylase 1 (Psd1) promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of mitochondrial genome maintenance protein 1 (Mgm1)

Journal of Biological Chemistry

Volumn 287, Issue 48, 2012, Pages 40131-40139

  Chan, Eliana Y L ^a   McQuibban, G Angus ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATP LEVEL; BIOPHYSICAL PROPERTIES; CARDIOLIPINS; DECARBOXYLASES; LIPID COMPOSITION; LIPID MIXING; MEMBRANE CURVATURE; MEMBRANE FUSION; MITOCHONDRIAL ACTIVITY; MITOCHONDRIAL FUSION; MITOCHONDRIAL GENOMES; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL MORPHOLOGY; OXIDATIVE PHOSPHORYLATION; PHOSPHATIDIC ACIDS; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; TOPOGENESIS; YEAST CELL;

BIOSYNTHESIS; CELL MEMBRANES; DEFECTS; LIPOSOMES; PHOSPHOLIPIDS; PHOSPHORYLATION; PROTEINS; YEAST;

MITOCHONDRIA;

ADENOSINE TRIPHOSPHATE; LIPOSOME; MITOCHONDRIAL GENOME MAINTENANCE PROTEIN 1; MITOCHONDRIAL PROTEIN; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE DECARBOXYLASE; PHOSPHATIDYLSERINE DECARBOXYLASE 1; UNCLASSIFIED DRUG;

ARTICLE; BIOGENESIS; BIOPHYSICS; CONTROLLED STUDY; LIPID COMPOSITION; LIPID METABOLISM; MEMBRANE FUSION; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; SACCHAROMYCES CEREVISIAE;

CARBOXY-LYASES; GTP-BINDING PROTEINS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84870018735     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.399428     Document Type: Article

References (33)

1. Choi, S. Y., Huang, P., Jenkins, G. M., Chan, D. C., Schiller, J., and Frohman, M. A. (2006) A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Nat. Cell Biol. 8, 1255-1262 (Pubitemid 44660590)
2. Tamura, Y., Endo, T., Iijima, M., and Sesaki, H. (2009) Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. J. Cell Biol. 185, 1029-1045
3. Sakamoto, T., Inoue, T., Otomo, Y., Yokomori, N., Ohno, M., Arai, H., and Nakagawa, Y. (2012) Deficiency of cardiolipin synthase causes abnormal mitochondrial function and morphology in germ cells of Caenorhabditis elegans. J. Biol. Chem. 287, 4590-4601
4. Kuroda, T., Tani, M., Moriguchi, A., Tokunaga, S., Higuchi, T., Kitada, S., and Kuge, O. (2011) FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis. Mol. Microbiol. 80, 248-265
5. Joshi, A. S., Thompson, M. N., Fei, N., Hüttemann, M., and Greenberg, M. L. (2012) Cardiolipin and mitochondrial phosphatidylethanolamine have overlapping functions in mitochondrial fusion in Saccharomyces cerevisiae. J. Biol. Chem. 287, 17589-17597
6. Steenbergen, R., Nanowski, T. S., Beigneux, A., Kulinski, A., Young, S. G., and Vance, J. E. (2005) Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects. J. Biol. Chem. 280, 40032-40040 (Pubitemid 41779137)
7. van den Brink-van der Laan, E., Killian, J. A., and de Kruijff, B. (2004) Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile. Biochim. Biophys. Acta 1666, 275-288
8. 2+-triggered membrane fusion. Biophys. J. 94, 3976-3986
9. Hermann, G. J., Thatcher, J. W., Mills, J. P., Hales, K. G., Fuller, M. T., Nunnari, J., and Shaw, J. M. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J. Cell Biol. 143, 359-373 (Pubitemid 28487856)
10. Eura, Y., Ishihara, N., Yokota, S., and Mihara, K. (2003) Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion. J. Biochem. 134, 333-344 (Pubitemid 37288331)
11. Sesaki, H., Southard, S. M., Yaffe, M. P., and Jensen, R. E. (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol. Biol. Cell 14, 2342-2356 (Pubitemid 36724325)
12. Cipolat, S., Martins de Brito, O., Dal Zilio, B., and Scorrano, L. (2004) OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc. Natl. Acad. Sci. U.S.A. 101, 15927-15932 (Pubitemid 39507904)
13. Sesaki, H., and Jensen, R. E. (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J. Biol. Chem. 279, 28298-28303 (Pubitemid 38900108)
14. Herlan, M., Vogel, F., Bornhovd, C., Neupert, W., and Reichert, A. S. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J. Biol. Chem. 278, 27781-27788 (Pubitemid 36899969)
15. Zick, M., Duvezin-Caubet, S., Schäfer, A., Vogel, F., Neupert, W., and Reichert, A. S. (2009) Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion. FEBS Lett. 583, 2237-2243
16. McQuibban, G. A., Saurya, S., and Freeman, M. (2003) Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature 423, 537-541 (Pubitemid 36648577)
17. Herlan, M., Bornhövd, C., Hell, K., Neupert, W., and Reichert, A. S. (2004) Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. J. Cell Biol. 165, 167-173 (Pubitemid 38544519)
18. Westermann, B., and Neupert, W. (2000) Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae. Yeast 16, 1421-1427
19. Bürgermeister, M., Birner-Grünberger, R., Nebauer, R., and Daum, G. (2004) Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta 1686, 161-168 (Pubitemid 39446888)
20. Gregg, C., Kyryakov, P., and Titorenko, V. I. (2009) Purification of mitochondria from yeast cells. J. Vis. Exp. e1417
21. Birner, R., Bürgermeister, M., Schneiter, R., and Daum, G. (2001) Roles of phosphatidylethanolamine and of its several biosynthetic pathways in Saccharomyces cerevisiae. Mol. Biol. Cell 12, 997-1007 (Pubitemid 33051994)
22. Dimmer, K. S., Fritz, S., Fuchs, F., Messerschmitt, M., Weinbach, N., Neupert, W., and Westermann, B. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol. Biol. Cell 13, 847-853 (Pubitemid 34250350)
23. Chen, H. K., Ji, Z. S., Dodson, S. E., Miranda, R. D., Rosenblum, C. I., Reynolds, I. J., Freedman, S. B., Weisgraber, K. H., Huang, Y., and Mahley, R. W. (2011) Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. J. Biol. Chem. 286, 5215-5221
24. Daum, G., Lees, N. D., Bard, M., and Dickson, R. (1998) Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast 14, 1471-1510 (Pubitemid 29015365)
25. Osman, C., Haag, M., Potting, C., Rodenfels, J., Dip, P. V., Wieland, F. T., Brügger, B., Westermann, B., and Langer, T. (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J. Cell Biol. 184, 583-596
26. Sesaki, H., Southard, S. M., Hobbs, A. E., and Jensen, R. E. (2003) Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion. Biochem. Biophys. Res. Commun. 308, 276-283 (Pubitemid 36937176)
27. Fritz, S., Weinbach, N., and Westermann, B. (2003) Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. Mol. Biol. Cell 14, 2303-2313 (Pubitemid 36724322)
28. Kornmann, B., Currie, E., Collins, S. R., Schuldiner, M., Nunnari, J., Weissman, J. S., and Walter, P. (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325, 477-481
29. Daum, G. (1985) Lipids of mitochondria. Biochim. Biophys. Acta 822, 1-42
30. Epand, R. M., Fuller, N., and Rand, R. P. (1996) Role of the position of unsaturation on the phase behavior and intrinsic curvature of phosphatidylethanolamines. Biophys. J. 71, 1806-1810 (Pubitemid 26325962)
31. Yang, Q., Guo, Y., Li, L., and Hui, S. W. (1997) Effects of lipid headgroup and packing stress on poly(ethylene glycol)-induced phospholipid vesicle aggregation and fusion. Biophys. J. 73, 277-282 (Pubitemid 27274125)
32. Siegel, D. P., and Epand, R. M. (1997) The mechanism of lamellar-to-inverted hexagonal phase transitions in phosphatidylethanolamine: implications for membrane fusion mechanisms. Biophys. J. 73, 3089-3111 (Pubitemid 27525774)
33. Ramsey, R. B. (1976) Leucine and D-3-hydroxybutyrate as lipid precursors in developing rat spinal cord and liver. Biochem. J. 158, 501-504