Local inflammation is associated with aortic thrombus formation in abdominal aortic aneurysms relationship to clinical risk factors

Thrombosis and Haemostasis

Volumn 108, Issue 5, 2012, Pages 812-823

  Sagan, Agnieszka ^a   Mrowiecki, Wojciech ^b   Mikolajczyk, Tomasz P ^a   Urbanski, Karol ^a   Siedlinski, Mateusz ^a   Nosalski, Ryszard ^a   Korbut, Ryszard ^a   Guzik, Tomasz J ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b Department of Surgery   (Poland)

Author keywords

Aortic abdominal aneurysm; Inflammation; Monocyte; T cell; Thrombus

Indexed keywords

CD11B ANTIGEN; CD28 ANTIGEN; CD45 ANTIGEN; CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN P 15095; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

ABDOMINAL AORTA ANEURYSM; AGED; AORTA THROMBOSIS; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GRANULOCYTE; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; HYPERTENSION; INFLAMMATION; LEUKOCYTE; MALE; MONOCYTE; NATURAL KILLER CELL; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; SMOKING; T LYMPHOCYTE;

AGED; AORTIC ANEURYSM, ABDOMINAL; AORTITIS; FEMALE; HUMANS; INFLAMMATION; LEUKOCYTES; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, NULL; MALE; MIDDLE AGED; MONOCYTES; RECEPTORS, CCR5; RISK FACTORS; T-LYMPHOCYTE SUBSETS; THROMBOSIS;

EID: 84870013124     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-05-0339     Document Type: Article

References (45)

1. Weintraub NL. Understanding abdominal aortic aneurysm. N Engl J Med 2009; 361: 1114-1116.
2. Satta J, Laara E, Juvonen T. Intraluminal thrombus predicts rupture of an abdominal aortic aneurysm. J Vasc Surg 1996; 23: 737-739.
3. Parr A, McCann M, Bradshaw B, et al. Thrombus volume is associated with cardiovascular events and aneurysm growth in patients who have abdominal aortic aneurysms. J Vasc Surg 2011; 53: 28-35.
4. Speelman L, Schurink GW, Bosboom EM, et al. The mechanical role of thrombus on the growth rate of an abdominal aortic aneurysm. J Vasc Surg 2010; 51: 19-26.
5. Ashton JH, Vande Geest J P, Simon BR, et al. Compressive mechanical properties of the intraluminal thrombus in abdominal aortic aneurysms and fibrin-based thrombus mimics. J Biomech 2009; 42: 197-201.
6. Matusik P, Mazur P, Stepien E, et al. Architecture of intraluminal thrombus removed from abdominal aortic aneurysm. J Thromb Thrombolysis 2010; 30: 7-9.
7. Silvain J, Collet J P, Nagaswami C, et al. Composition of coronary thrombus in acute myocardial infarction. J Am Coll Cardiol 2011; 57: 1359-1367.
8. Adolph R, Vorp DA, Steed DL, et al. Cellular content and permeability of intra-luminal thrombus in abdominal aortic aneurysm. J Vasc Surg 1997; 25: 916-926.
9. Fontaine V, Jacob M P, Houard X, et al. Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms. Am J Pathol 2002; 161: 1701-1710.
10. Fontaine V, Touat Z, Mtairag el M, et al. Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus. Am J Pathol 2004; 164: 2077-2087.
11. Kato K, Matsubara T, Iida K, et al. Elevated levels of pro-inflammatory cytokines in coronary artery thrombi. Int J Cardiol 1999; 70: 267-273.
12. Aho PS, Niemi T, Piilonen A, et al. Interplay between coagulation and inflammation in open and endovascular abdominal aortic aneurysm repair--impact of intra-aneurysmal thrombus. Scand J Surg 2007; 96: 229-235.
13. Wyss CA, Neidhart M, Altwegg L, et al. Cellular actors, Toll-like receptors, and local cytokine profile in acute coronary syndromes. Eur Heart J 2010; 31: 1457-1469.
14. Davies RS, Abdelhamid M, Vohra RK, et al. The relationship between aortic aneu-rysm sac thrombus volume on coagulation, fibrinolysis and platelet activity. Thromb Res 2012; 130: 463-466.
15. Ramos-Mozo P, Madrigal-Matute J, Martinez-Pinna R, et al. Proteomic analysis of polymorphonuclear neutrophils identifies catalase as a novel biomarker of abdominal aortic aneurysm: potential implication of oxidative stress in abdominal aortic aneurysm progression. Arterioscler Thromb Vasc Biol 2011; 31: 3011-3019.
16. Houard X, Ollivier V, Louedec L, et al. Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus. FASEB J 2009; 23: 1376-1383.
17. Tanaseanu C, Neagu M, Popescu M, et al. Peripheral leukocytes activation in aortic aneurysmal disease. Rom J Intern Med 1998; 36: 167-174.
18. Davies MJ. Reactive oxygen species, metalloproteinases, and plaque stability. Circulation 1998; 97: 2382-2383.
19. Rajagopalan S, Meng X P, Ramasamy S, et al. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metallo-proteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 1996; 98: 2572-2579.
20. Ulrich C, Heine GH, Gerhart MK, et al. Proinflammatory CD14+CD16+ mono-cytes are associated with subclinical atherosclerosis in renal transplant patients. Am J Transplant 2008; 8: 103-110.
21. Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol 2007; 81: 584-592.
22. Schlitt A, Heine GH, Blankenberg S, et al. CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels. Thromb Hae-most 2004; 92: 419-424.
23. von Bubnoff D, Scheler M, Hinz T, et al. Comparative immunophenotyping of monocytes from symptomatic and asymptomatic atopic individuals. Allergy 2004; 59: 933-939.
24. Berg KE, Ljungcrantz I, Andersson L, et al. Elevated CD14++CD16- monocytes predict cardiovascular events. Circ Cardiovasc Genet 2012; 5: 122-131.
25. Harrison DG, Guzik TJ, Lob HE, et al. Inflammation, immunity, and hypertension. Hypertension 2011; 57: 132-140.
26. Anand A, Dean GS, Quereshi K, et al. Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: activation markers. Lupus 2002; 11: 493-500.
27. Ascon DB, Ascon M, Satpute S, et al. Normal mouse kidneys contain activated and CD3+CD4- CD8- double-negative T lymphocytes with a distinct TCR repertoire. J Leukoc Biol 2008; 84: 1400-1409.
28. D'Acquisto F, Crompton T. CD3+CD4-CD8- (double negative) T cells: saviours or villains of the immune response? Biochem Pharmacol 2011; 82: 333-340.
29. Papiernik M, Pontoux C. In vivo and in vitro repertoire of CD3+CD4-CD8- thy-mocytes. Int Immunol 1990; 2: 407-412.
30. Gollob KJ, Antonelli LR, Faria DR, et al. Immunoregulatory mechanisms and CD4-CD8- (double negative) T cell subpopulations in human cutaneous leish-maniasis: a balancing act between protection and pathology. Int Immunoph-armacol 2008; 8: 1338-1343.
31. Guzik TJ, Hoch NE, Brown KA, et al. Role of the T cell in the genesis of angioten-sin II induced hypertension and vascular dysfunction. J Exp Med 2007; 204: 2449-2460.
32. Yin M, Zhang J, Wang Y, et al. Deficient CD4+CD25+ T regulatory cell function in patients with abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2010; 30: 1825-1831.
33. Liuzzo G, Biasucci LM, Trotta G, et al. Unusual CD4+CD28null T lymphocytes and recurrence of acute coronary events. J Am Coll Cardiol 2007; 50: 1450-1458.
34. Mause SF, von Hundelshausen P, Zernecke A, et al. Platelet microparticles: a trans-cellular delivery system for RANTES promoting monocyte recruitment on en-dothelium. Arterioscler Thromb Vasc Biol 2005; 25: 1512-1518.
35. Badimon L, Storey RF, Vilahur G. Update on lipids, inflammation and athero-thrombosis. Thromb Haemost 2011; 105 (Suppl 1): S34-42.
36. Levi M, van der Poll T. Inflammation and coagulation. Crit Care Med 2010; 38: S26-34.
37. Weber C. Chemokines in atherosclerosis, thrombosis, and vascular biology. Arte-rioscler Thromb Vasc Biol 2008; 28: 1896.
38. Cerletti C, Tamburrelli C, Izzi B, et al. Platelet-leukocyte interactions in thrombosis. Thromb Res 2012; 129: 263-266.
39. Seizer P, Gawaz M, May AE. Platelet-monocyte interactions--a dangerous liaison linking thrombosis, inflammation and atherosclerosis. Curr Med Chem 2008; 15: 1976-1980.
40. Hirahashi J, Hishikawa K, Kaname S, et al. Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury. Circulation 2009; 120: 1255-1265.
41. Shebuski RJ, Kilgore KS. Role of inflammatory mediators in thrombogenesis. J Pharmacol Exp Ther 2002; 300: 729-735.
42. Marvar PJ, Thabet SR, Guzik TJ, et al. Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension. Circ Res 2010; 107: 263-270.
43. Urbonavicius S, Urbonaviciene G, Honore B, et al. Potential circulating biom-arkers for abdominal aortic aneurysm expansion and rupture--a systematic review. Eur J Vasc Endovasc Surg 2008; 36: 273-282.
44. Duftner C, Seiler R, Klein-Weigel P, et al. High prevalence of circulating CD4+CD28- T-cells in patients with small abdominal aortic aneurysms. Arte-rioscler Thromb Vasc Biol 2005; 25: 1347-1352.
45. Matusik P, Guzik B, Weber C, e t al. Do we know enough about the immune p at ho-genesis of acute coronary syndromes to improve clinical practice? Thromb Hae-most 2012; 108: 443-456.