Proinflammatory CD14+CD16+ monocytes are associated with subclinical atherosclerosis in renal transplant patients

American Journal of Transplantation

Volumn 8, Issue 1, 2008, Pages 103-110

  Ulrich, C ^a   Heine, G H ^a   Gerhart, M K ^a   Kohler H ^a   Girndt, M ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Atherosclerosis; CD14+CD16+; Intima media thickness; Monocytes; Renal transplant recipients

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; METHYLPREDNISOLONE;

ADULT; AGED; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CELL SUBPOPULATION; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; HUMAN; HUMAN CELL; KIDNEY FAILURE; KIDNEY GRAFT; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRIORITY JOURNAL; RECIPIENT;

ANTIGENS, CD; ANTIGENS, CD14; ATHEROSCLEROSIS; FEMALE; HUMANS; INFLAMMATION MEDIATORS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MONOCYTES; RECEPTORS, IGG;

EID: 37549068586     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.02035.x     Document Type: Article

References (27)

1. Kasiske BL, Guijarro C, Massy ZA, Wiederkehr MR, Ma JZ. Cardiovascular disease after renal transplantation. J Am Soc Nephrol 1996 7 : 158 165.
2. Pascual M, Theruvath T, Kawai T, Tolkoff-Rubin N, Cosimi AB. Strategies to improve long-term outcomes after renal transplantation. N Engl J Med 2002 346 : 580 590.
3. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005 352 : 1685 1695.
4. Passlick B, Flieger D, Ziegler-Heitbrock HW. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 1989 74 : 2527 2534.
5. Belge KU, Dayyani F, Horelt A et al. The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF. J Immunol 2002 168 : 3536 3542.
6. Frankenberger M, Sternsdorf T, Pechumer H, Pforte A, Ziegler-Heitbrock HW. Differential cytokine expression in human blood monocyte subpopulations: A polymerase chain reaction analysis. Blood 1996 87 : 373 377.
7. Schlitt A, Heine GH, Blankenberg S et al. CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels. Thromb Haemost 2004 92 : 419 424.
8. Nockher WA, Scherberich JE. Expanded CD14+ CD16+ monocyte subpopulation in patients with acute and chronic infections undergoing hemodialysis. Infect Immun 1998 66 : 2782 2790.
9. Saionji K, Ohsaka A. Expansion of CD4+CD16+ blood monocytes in patients with chronic renal failure undergoing dialysis: Possible involvement of macrophage colony-stimulating factor. Acta Haematol 2001 105 : 21 26.
10. Scherberich JE. Proinflammatory blood monocytes: main effector and target cells in systemic and renal disease; background and therapeutic implications. Int J Clin Pharmacol Ther 2003 41 : 459 464.
11. Scherberich JE, Estner H, Segerer W. Impact of different immunosuppressive regimens on antigen-presenting blood cells in kidney transplant patients. Kidney Blood Press Res 2004 27 : 177 180.
12. Sester U, Sester M, Heine G, Kaul H, Girndt M, Kohler H. Strong depletion of CD14(+)CD16(+) monocytes during haemodialysis treatment. Nephrol Dial Transplant 2001 16 : 1402 1408.
13. Heine GH, Gerhart MK, Ulrich C, Kohler H, Girndt M. Renal Doppler resistance indices are associated with systemic atherosclerosis in kidney transplant recipients. Kidney Int 2005 68 : 878 885.
14. K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis 2002 39 (2 Suppl 1 S1 S266.
15. Ulrich C, Heine GH, Garcia P et al. Increased expression of monocytic angiotensin-converting enzyme in dialysis patients with cardiovascular disease. Nephrol Dial Transplant 2006 21 : 1596 1602.
16. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005 352 : 1685 1695.
17. Huang ZS, Wang CH, Yip PK, Yang CY, Lee TK. In hypercholesterolemia, lower peripheral monocyte count is unique among the major predictors of atherosclerosis. Arterioscler Thromb Vasc Biol 1996 16 : 256 261.
18. Nasir K, Guallar E, Navas-Acien A, Criqui MH, Lima JA. Relationship of monocyte count and peripheral arterial disease: Results from the National Health and Nutrition Examination Survey 1999-2002. Arterioscler Thromb Vasc Biol 2005 25 : 1966 1971.
19. Horne BD, Anderson JL, John JM et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol 2005 45 : 1638 1643.
20. Olivares R, Ducimetiere P, Claude JR. Monocyte count: A risk factor for coronary heart disease? Am J Epidemiol 1993 137 : 49 53.
21. Haumer M, Amighi J, Exner M et al. Association of neutrophils and future cardiovascular events in patients with peripheral artery disease. J Vasc Surg 2005 41 : 610 617.
22. Passlick B, Flieger D, Ziegler-Heitbrock HW. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 1989 74 : 2527 2534.
23. Tacke F, Randolph GJ. Migratory fate and differentiation of blood monocyte subsets. Immunobiology 2006 211 : 609 618.
24. Ancuta P, Rao R, Moses A et al. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J Exp Med 2003 197 : 1701 1707.
25. Scherberich JE, Estner H, Segerer W. Impact of different immunosuppressive regimens on antigen-presenting blood cells in kidney transplant patients. Kidney Blood Press Res 2004 27 : 177 180.
26. Thompson J, van FR. The effect of glucocorticosteroids on the kinetics of mononuclear phagocytes. J Exp Med 1970 131 : 429 442.
27. Dayyani F, Belge KU, Frankenberger M, Mack M, Berki T, Ziegler-Heitbrock L. Mechanism of glucocorticoid-induced depletion of human CD14+CD16+ monocytes. J Leukoc Biol 2003 74 : 33 39.