Interruption of CXCL13-CXCR5 Axis Increases Upper Genital Tract Pathology and Activation of NKT Cells following Chlamydial Genital Infection

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Jiang, Janina ^a   Karimi, Ouafae ^d   Ouburg, Sander ^d   Champion, Cheryl I ^a   Khurana, Archana ^f   Liu, Guangchao ^a   Freed, Amanda ^a   Pleijster, Jolein ^g   Rozengurt, Nora ^a,c   Land, Jolande A ^g   Surcel, Helja Marja ^h   Tiitinen, Aila' ⁱ   Paavonen, Jorma ⁱ   Kronenberg, Mitchell ^f   Morré, Servaas A ^d,e   Kelly, Kathleen A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e MAASTRICHT UNIVERSITY   (Netherlands)

^f LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^g UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^h NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

ⁱ HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CD1D ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR5; CXCL13 CHEMOKINE; CYTOSINE; GAMMA INTERFERON; GLYCOLIPID; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 17 ALPHA; THYMINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; BACTERIAL LOAD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR SECRETION; CHLAMYDIA TRACHOMATIS; CHLAMYDIA TRACHOMATIS GENITAL INFECTION; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; FEMALE GENITAL TRACT INFECTION; FEMALE INFERTILITY; FEMALE UPPER GENITAL TRACT PATHOLOGY; FIBROSIS; GENE FREQUENCY; GYNECOLOGIC DISEASE; HUMAN; HYBRIDOMA; IN VITRO STUDY; MAJOR CLINICAL STUDY; MOUSE; NATURAL KILLER T CELL; NEUTROPHIL; NONHUMAN; OVIDUCT; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REMISSION; SINGLE NUCLEOTIDE POLYMORPHISM; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION; TISSUE DISTRIBUTION; UTERUS HORN;

ANIMALS; ANTIGENS, CD1D; CHEMOKINE CXCL13; CHLAMYDIA INFECTIONS; CHLAMYDIA MURIDARUM; COHORT STUDIES; CYTOKINES; DISEASE MODELS, ANIMAL; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; MICE; NATURAL KILLER T-CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CXCR5; REPRODUCTIVE TRACT INFECTIONS; SEXUALLY TRANSMITTED DISEASES; T-LYMPHOCYTE SUBSETS;

BACTERIA (MICROORGANISMS); CHLAMYDIA MURIDARUM; CHLAMYDIA TRACHOMATIS; MUS;

EID: 84869994269     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047487     Document Type: Article

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