Cubosomes containing the adjuvants imiquimod and monophosphoryl lipid A stimulate robust cellular and humoral immune responses

Journal of Controlled Release

Volumn 165, Issue 1, 2013, Pages 16-21

  Rizwan, S B ^c   McBurney, W T ^a   Young, K ^b   Hanley, T ^c   Boyd, B J ^d   Rades, T ^e   Hook, S ^b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cubosomes; Imiquimod and monophosphoryl lipid A; Liposomes; Liquid crystals; Vaccines

Indexed keywords

CELLULAR RESPONSE; CUBOSOMES; HUMORAL IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOLOGICAL ACTIVITY; IN-VITRO; IN-VIVO; LIPID A; NANOSTRUCTURED PARTICULATE; OVALBUMINS; PHYSICO-CHEMICAL CHARACTERIZATION; SUBUNIT VACCINE; SUSTAINED RELEASE; T CELL PROLIFERATION; TOLL-LIKE RECEPTORS; VACCINE DELIVERY SYSTEM;

ANTIGENS; CELL PROLIFERATION; INTERFERONS; LIPOSOMES; LIQUID CRYSTALS;

VACCINES;

CUBOSOME; GAMMA INTERFERON; IMIQUIMOD; NANOPARTICLE; OVALBUMIN; PHOSPHORYL LIPID A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELLULAR IMMUNITY; FEMALE; HUMORAL IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; AMINOQUINOLINES; ANIMALS; ANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DRUG DELIVERY SYSTEMS; FEMALE; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; LIPID A; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NANOSTRUCTURES; OVALBUMIN; VACCINES;

EID: 84869885729     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.10.020     Document Type: Article

References (35)

1. T. Storni, T. Kundig, G. Senti, and P. Johansen Immunity in response to particulate antigen-delivery systems Adv. Drug Deliv. Rev. 57 2005 333 355 (Pubitemid 39555501)
2. D.T. O'Hagan Recent developments in vaccine delivery systems Curr. Drug Targets Infect. Disord. 1 2001 273 286
3. D.T. O'Hagan, and R. Rappuoli Novel approaches to vaccine delivery Pharm. Res. 21 2004 1519 1530 (Pubitemid 41184379)
4. V.W. Bramwell, and Y. Perrie The rational design of vaccines Drug Discov. Today 10 2005 1527 1534 (Pubitemid 41527195)
5. K. White, T. Rades, P. Kearns, I. Toth, and S. Hook Immunogenicity of liposomes containing lipid core peptides and the adjuvant Quil A Pharm. Res. 23 2006 1473 1481 (Pubitemid 43993810)
6. S.B. Rizwan, Y. Dong, B.J. Boyd, T. Rades, and S. Hook Characterisation of bicontinuous cubic liquid crystalline systems of phytantriol and water using cryo field emission scanning electron microscopy (cryo FESEM) Micron 38 2007 478 485 (Pubitemid 46413070)
7. P. Spicer Progress in liquid crystalline dispersions: cubosomes Curr. Opin. Colloid Interface Sci. 10 2005 274 279 (Pubitemid 41682495)
8. S.B. Rizwan, D. Assmus, A. Boehnke, T. Hanley, B.J. Boyd, T. Rades, and S. Hook Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines Eur J. Pharm. Biopharm. 79 2011 15 22
9. S.B. Rizwan, T. Hanley, B.J. Boyd, and S. Hook Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: characterisation, swelling and release kinetics J. Pharm. Sci. 98 2009 4191 4204
10. S.B. Rizwan, W.T. McBurney, B.J. Boyd, T. Rades, and S. Hook In-vitro activity of phytantriol cubosomes containing the adjuvants imiquimod or monophosphoryl lipid A in bone marrow derived dendritic cells Controlled Release Society 35th Annual Meeting & Exposition 2008 (New York)
11. E. Esposito, R. Cortesi, M. Drechsler, L. Paccamiccio, P. Mariani, C. Contado, E. Stellin, E. Menegatti, F. Bonina, and C. Puglia Cubosome dispersion as delivery systems for percutaneous administration of indomethacin Pharm. Res. 22 2005 2163 2173 (Pubitemid 41821596)
12. F. Tiberg Improving drug delivery by use of lipid self-assembly particle structures - beyond liposomes and emulsions Business Briefing: Pharma Outsourcing 2005 62 65
13. M.J. Barnden, J. Allison, W.R. Heath, and F.R. Carbone Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements Immunol. Cell Biol. 76 1998 34 40 (Pubitemid 28194695)
14. S. Könnings, M. Copland, N. Davies, and T. Rades A method for the incorporation of ovalbumin into immune stimulating complexes prepared by the hydration method Int. J. Pharm. 241 2002 385 389 (Pubitemid 34718040)
15. W.T. McBurney, D.G. Lendemans, J. Myschik, T. Hennessy, T. Rades, and S. Hook In vivo activity of cationic immune stimulating complexes (PLUSCOMs) Vaccine 26 2008 4549 4556
16. S. Hyde Identification of lyotropic liquid crystal mesophases, chapter 16 K. Holmberg, Handbook of Applied Surface and Colloid Chemistry 2001 John Wilet & Sons Ltd 299 331
17. T. Kaisho, and S. Akira Toll-like receptors as adjuvant receptors Biochim. Biophys. Acta 1589 2002 1 13 (Pubitemid 34242898)
18. E. Schlosser, M. Mueller, S. Fischer, S. Basta, D.H. Busch, B. Gander, and M. Groettrup TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses Vaccine 26 2008 1626 1637
19. Y. Perrie Gregory Gregoriadis: introducing liposomes to drug delivery J. Drug Target. 16 2008 7 8
20. G.D. Sprott, C.J. Diciare, K. Gurnani, L.A. Deschatelets, and L. Krishnan Liposome adjuvants prepared from the total polar lipids of Haloferax volcanii Planococcus spp. and Bacillus firmus Differ in Ability to Elicit and Sustain Immune Responses Vaccine 22 2004 2154 2162
21. K.L. White, T. Rades, R.H. Furneaux, P.C. Tyler, and S. Hook Mannosylated liposomes as antigen delivery vehicles for targeting to dendritic cells J. Pharm. Pharmacol. 58 2006 729 737 (Pubitemid 43836160)
22. S.W. Howland, and K.D. Wittrup Antigen release kinetics in the phagosome are critical to cross-presentation efficiency J. Immunol. 180 2008 1576 1583
23. R. Obst, H.-M. van Santen, D. Mathis, and C. Benoist Antigen persistence is required throughout the expansion phase of a CD4 + T cell response J. Exp. Med. 201 2005 1555 1565 (Pubitemid 40721001)
24. M. Li, G.M. Davey, R.M. Sutherland, C. Kurts, A.M. Lew, C. Hirst, F.R. Carbone, and W.R. Heath Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo J. Immunol. 166 2001 6099 6103 (Pubitemid 32440737)
25. F.A. Sharp, D. Ruane, B. Claass, E. Creagh, J. Harris, P. Malyala, M. Singh, D.T. O'Hagan, V. Ptrilli, J. Tschopp, L.A.J. O'Neill, and E.C. Lavelle Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome Proc. Natl. Acad. Sci. 106 2009 870 875
26. H. Li, S.B. Willingham, J.P.Y. Ting, and F. Re Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3 J. Immunol. 181 2008 17 21
27. V. Hornung, F. Bauernfeind, A. Halle, E.O. Samstad, H. Kono, K.L. Rock, K.A. Fitzgerald, and E. Latz Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization Nat. Immunol. 9 2008 847 856
28. S.C. Eisenbarth, O.R. Colegio, W. O'Connor, F.S. Sutterwala, and R.A. Flavell Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants Nature 453 2008 1122 1126 (Pubitemid 351871731)
29. M.A. Williams, and M.J. Bevan Effector and memory CTL differentiation Annu. Rev. Immunol. 25 2007 171 192 (Pubitemid 46697906)
30. N. Cools, P. Ponsaerts, V.F.I. Van Tendeloo, and Z.N. Berneman Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells J. Leukoc. Biol. 82 2007 1365 1374 (Pubitemid 350276946)
31. + T cells Immunol. Rev. 211 2006 81 92 (Pubitemid 43882963)
32. E. de Jong, H. Smits, and M. Kapsenberg Dendritic cell-mediated T cell polarization Springer Semin. Immunopathol. 26 2005 289 307
33. B. Guy The perfect mix: recent progress in adjuvant research Nat. Rev. Microbiol. 5 2007 505 517 (Pubitemid 46925379)
34. A. Macagno, G. Napolitani, A. Lanzavecchia, and F. Sallusto Duration, combination and timing: the signal intergration model of dendritic cell activation Trends Immunol. 28 2007 227 233 (Pubitemid 46654873)
35. G. Trinchieri, and A. Sher Cooperation of toll-like receptor signals in innate immune defence Nat. Rev. Immunol. 7 2007 179 181