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Volumn 76, Issue , 2012, Pages 36-42

Clinical use of phosphorylated proteins in blood serum analysed by immobilised metal ion affinity chromatography and mass spectrometry

Author keywords

Biomarker; Drug response monitoring; Phosphoproteome; Phosphorylation; Serum

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; ALPHA 2 MACROGLOBULIN; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; APOLIPOPROTEIN B; CERULOPLASMIN; COMPLEMENT COMPONENT C4A; COMPLEMENT COMPONENT C4B; COMPLEMENT COMPONENT C5; COMPLEMENT FACTOR H; FIBRONECTIN; INTER ALPHA TRYPSIN INHIBITOR; PHOSPHOPROTEIN;

EID: 84869883685     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.02.015     Document Type: Article
Times cited : (21)

References (60)
  • 1
    • 3042526342 scopus 로고    scopus 로고
    • An investigation into the human serum "interactome"
    • Zhou M., Lucas D.A., Chan K.C., Issaq H.J., et al. An investigation into the human serum "interactome". Electrophoresis 2004, 25:1289-1298.
    • (2004) Electrophoresis , vol.25 , pp. 1289-1298
    • Zhou, M.1    Lucas, D.A.2    Chan, K.C.3    Issaq, H.J.4
  • 2
    • 75749130354 scopus 로고    scopus 로고
    • The clinical plasma proteome: a survey of clinical assays for proteins in plasma and serum
    • Anderson N.L. The clinical plasma proteome: a survey of clinical assays for proteins in plasma and serum. Clin Chem 2010, 56:177-185.
    • (2010) Clin Chem , vol.56 , pp. 177-185
    • Anderson, N.L.1
  • 4
    • 79951518985 scopus 로고    scopus 로고
    • Mining the plasma proteome for disease applications across seven logs of protein abundance
    • Zhang Q., Faca V., Hanash S. Mining the plasma proteome for disease applications across seven logs of protein abundance. J Proteome Res 2011, 10:46-50.
    • (2011) J Proteome Res , vol.10 , pp. 46-50
    • Zhang, Q.1    Faca, V.2    Hanash, S.3
  • 5
    • 0001644020 scopus 로고    scopus 로고
    • The human plasma proteome: history, character, and diagnostic prospects
    • Anderson N.L., Anderson N.G. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics 2002, 1:845-867.
    • (2002) Mol Cell Proteomics , vol.1 , pp. 845-867
    • Anderson, N.L.1    Anderson, N.G.2
  • 6
    • 76149133112 scopus 로고    scopus 로고
    • Characterization of the human plasma phosphoproteome using linear ion trap mass spectrometry and multiple search engines
    • Carrascal M., Gay M., Ovelleiro D., Casas V., et al. Characterization of the human plasma phosphoproteome using linear ion trap mass spectrometry and multiple search engines. J Proteome Res 2010, 9:876-884.
    • (2010) J Proteome Res , vol.9 , pp. 876-884
    • Carrascal, M.1    Gay, M.2    Ovelleiro, D.3    Casas, V.4
  • 7
    • 71549137428 scopus 로고    scopus 로고
    • An initial characterization of the serum phosphoproteome
    • Zhou W., Ross M.M., Tessitore A., Ornstein D., et al. An initial characterization of the serum phosphoproteome. J Proteome Res 2009, 8:5523-5531.
    • (2009) J Proteome Res , vol.8 , pp. 5523-5531
    • Zhou, W.1    Ross, M.M.2    Tessitore, A.3    Ornstein, D.4
  • 8
  • 9
    • 0034614490 scopus 로고    scopus 로고
    • Signaling and beyond
    • Hunter T. Signaling and beyond. Cell 2000, 113-127.
    • (2000) Cell , pp. 113-127
    • Hunter, T.1
  • 11
    • 10944227282 scopus 로고    scopus 로고
    • Tau phosphorylation: physiological and pathological consequences
    • Stoothoff W.H., Johnson G.V. Tau phosphorylation: physiological and pathological consequences. Biochim Biophys Acta 2005, 1739:280-297.
    • (2005) Biochim Biophys Acta , vol.1739 , pp. 280-297
    • Stoothoff, W.H.1    Johnson, G.V.2
  • 13
    • 72149119458 scopus 로고    scopus 로고
    • Multidimensional protein fractionation of blood proteins coupled to data-independent nanoLC-MS/MS analysis
    • Levin Y., Jaros J.A., Schwarz E., Bahn S. Multidimensional protein fractionation of blood proteins coupled to data-independent nanoLC-MS/MS analysis. J Proteomics 2010, 73:689-695.
    • (2010) J Proteomics , vol.73 , pp. 689-695
    • Levin, Y.1    Jaros, J.A.2    Schwarz, E.3    Bahn, S.4
  • 14
    • 84869885095 scopus 로고    scopus 로고
    • Enhanced nanoLC/MS analysis of phosphopeptides
    • Waters Corporation, Milford, USA
    • Yu Y.Q., Campuzano I., Gilar M. Enhanced nanoLC/MS analysis of phosphopeptides. Application Note 2006, Waters Corporation, Milford, USA.
    • (2006) Application Note
    • Yu, Y.Q.1    Campuzano, I.2    Gilar, M.3
  • 15
    • 0036636552 scopus 로고    scopus 로고
    • A novel precursor ion discovery method on a hybrid quadrupole orthogonal acceleration time-of-flight (Q-TOF) mass spectrometer for studying protein phosphorylation
    • Bateman R.H., Carruthers R., Hoyes J.B., Jones C., et al. A novel precursor ion discovery method on a hybrid quadrupole orthogonal acceleration time-of-flight (Q-TOF) mass spectrometer for studying protein phosphorylation. J Am Soc Mass Spectrom 2002, 13:792-803.
    • (2002) J Am Soc Mass Spectrom , vol.13 , pp. 792-803
    • Bateman, R.H.1    Carruthers, R.2    Hoyes, J.B.3    Jones, C.4
  • 16
    • 63049138916 scopus 로고    scopus 로고
    • Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixtures
    • Li G.-Z., Vissers J.P.C., Silva J.C., Golick D., et al. Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixtures. Proteomics 2009, 9:1696-1719.
    • (2009) Proteomics , vol.9 , pp. 1696-1719
    • Li, G.-Z.1    Vissers, J.P.C.2    Silva, J.C.3    Golick, D.4
  • 17
    • 79251519659 scopus 로고    scopus 로고
    • Comprehensive two-dimensional liquid chromatography mass spectrometric profiling of the rat hippocampal proteome
    • Yang X., Levin Y., Rahmoune H., Ma D., et al. Comprehensive two-dimensional liquid chromatography mass spectrometric profiling of the rat hippocampal proteome. Proteomics 2011, 11:501-505.
    • (2011) Proteomics , vol.11 , pp. 501-505
    • Yang, X.1    Levin, Y.2    Rahmoune, H.3    Ma, D.4
  • 18
    • 84855179752 scopus 로고    scopus 로고
    • Proteomic changes induced by anaesthesia and muscle relaxant treatment prior to electroconvulsive therapy
    • Stelzhammer V., Rothermundt M., Guest P.C., Michael N., et al. Proteomic changes induced by anaesthesia and muscle relaxant treatment prior to electroconvulsive therapy. Proteomics Clin Appl 2011, 5:644-649.
    • (2011) Proteomics Clin Appl , vol.5 , pp. 644-649
    • Stelzhammer, V.1    Rothermundt, M.2    Guest, P.C.3    Michael, N.4
  • 19
    • 79251509589 scopus 로고    scopus 로고
    • Analysis of the human pituitary proteome by data independent label-free liquid chromatography tandem mass spectrometry
    • Krishnamurthy D., Levin Y., Harris L.W., Umrania Y., et al. Analysis of the human pituitary proteome by data independent label-free liquid chromatography tandem mass spectrometry. Proteomics 2011, 11:495-500.
    • (2011) Proteomics , vol.11 , pp. 495-500
    • Krishnamurthy, D.1    Levin, Y.2    Harris, L.W.3    Umrania, Y.4
  • 20
    • 33846165487 scopus 로고    scopus 로고
    • Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation
    • Lu P., Vogel C., Wang R., Yao X., Marcotte E.M. Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nat Biotechnol 2007, 25:117-124.
    • (2007) Nat Biotechnol , vol.25 , pp. 117-124
    • Lu, P.1    Vogel, C.2    Wang, R.3    Yao, X.4    Marcotte, E.M.5
  • 21
    • 79958124136 scopus 로고    scopus 로고
    • Identification of proteins secreted by head and neck cancer cell lines using LC-MS/MS: strategy for discovery of candidate serological biomarkers
    • Ralhan R., Masui O., Desouza L.V., Matta A., et al. Identification of proteins secreted by head and neck cancer cell lines using LC-MS/MS: strategy for discovery of candidate serological biomarkers. Proteomics 2011, 11:2363-2376.
    • (2011) Proteomics , vol.11 , pp. 2363-2376
    • Ralhan, R.1    Masui, O.2    Desouza, L.V.3    Matta, A.4
  • 22
    • 79956270352 scopus 로고    scopus 로고
    • Characterizing the proteome of the human dorsolateral prefrontal cortex by shotgun mass spectrometry
    • Martins-de-Souza D., Guest P.C., Steeb H., Pietsch S., et al. Characterizing the proteome of the human dorsolateral prefrontal cortex by shotgun mass spectrometry. Proteomics 2011, 11:2347-2353.
    • (2011) Proteomics , vol.11 , pp. 2347-2353
    • Martins-de-Souza, D.1    Guest, P.C.2    Steeb, H.3    Pietsch, S.4
  • 23
    • 0042861519 scopus 로고    scopus 로고
    • Phosphospecific proteolysis for mapping sites of protein phosphorylation
    • Knight Z.A., Schilling B., Row R.H., Kenski D.M., et al. Phosphospecific proteolysis for mapping sites of protein phosphorylation. Nat Biotechnol 2003, 21:1047-1054.
    • (2003) Nat Biotechnol , vol.21 , pp. 1047-1054
    • Knight, Z.A.1    Schilling, B.2    Row, R.H.3    Kenski, D.M.4
  • 24
    • 0035863653 scopus 로고    scopus 로고
    • Analysis of protein phosphorylation by a combination of elastase digestion and neutral loss tandem mass spectrometry
    • Schlosser A., Pipkorn R., Bossemeyer D., Lehmann W.D. Analysis of protein phosphorylation by a combination of elastase digestion and neutral loss tandem mass spectrometry. Anal Chem 2001, 73:170-176.
    • (2001) Anal Chem , vol.73 , pp. 170-176
    • Schlosser, A.1    Pipkorn, R.2    Bossemeyer, D.3    Lehmann, W.D.4
  • 25
    • 33847782587 scopus 로고    scopus 로고
    • Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry
    • Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A 2007, 104:2199-2204.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2199-2204
    • Molina, H.1    Horn, D.M.2    Tang, N.3    Mathivanan, S.4    Pandey, A.5
  • 27
    • 3042662113 scopus 로고    scopus 로고
    • In silico proteome analysis to facilitate proteomics experiments using mass spectrometry
    • Cagney G., Amiri S., Premawaradena T., Lindo M., Emili A. In silico proteome analysis to facilitate proteomics experiments using mass spectrometry. Proteome Sci 2003, 1:5.
    • (2003) Proteome Sci , vol.1 , pp. 5
    • Cagney, G.1    Amiri, S.2    Premawaradena, T.3    Lindo, M.4    Emili, A.5
  • 28
    • 0032577051 scopus 로고    scopus 로고
    • The phosphorylation of proteins on tyrosine: its role in cell growth and disease
    • The Croonian Lecture
    • Hunter T. The phosphorylation of proteins on tyrosine: its role in cell growth and disease. Philos Trans R Soc Lond B Biol Sci 1998, 353:583-605. The Croonian Lecture.
    • (1998) Philos Trans R Soc Lond B Biol Sci , vol.353 , pp. 583-605
    • Hunter, T.1
  • 29
    • 0000109995 scopus 로고
    • Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
    • Hunter T., Sefton B.M. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A 1980, 77:1311-1315.
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 1311-1315
    • Hunter, T.1    Sefton, B.M.2
  • 30
    • 34250878954 scopus 로고    scopus 로고
    • Mechanisms of specificity in protein phosphorylation
    • Ubersax J.A., Ferrell J.E. Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol 2007, 8:530-541.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 530-541
    • Ubersax, J.A.1    Ferrell, J.E.2
  • 31
    • 33750456519 scopus 로고    scopus 로고
    • Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
    • Olsen J.V., Blagoev B., Gnad F., Macek B., et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2006, 127:635-648.
    • (2006) Cell , vol.127 , pp. 635-648
    • Olsen, J.V.1    Blagoev, B.2    Gnad, F.3    Macek, B.4
  • 32
    • 0035067251 scopus 로고    scopus 로고
    • Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome
    • Oda Y., Nagasu T., Chait B.T. Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome. Nat Biotechnol 2001, 19:379-382.
    • (2001) Nat Biotechnol , vol.19 , pp. 379-382
    • Oda, Y.1    Nagasu, T.2    Chait, B.T.3
  • 33
    • 0037305895 scopus 로고    scopus 로고
    • Tackling the phosphoproteome: tools and strategies
    • Kalume D.E., Molina H., Pandey A. Tackling the phosphoproteome: tools and strategies. Curr Opin Chem Biol 2003, 7:64-69.
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 64-69
    • Kalume, D.E.1    Molina, H.2    Pandey, A.3
  • 34
    • 0034651752 scopus 로고    scopus 로고
    • Protein phosphorylation and protein phosphatases. De Panne, Belgium, September 19-24, 1999
    • Zolnierowicz S., Bollen M. Protein phosphorylation and protein phosphatases. De Panne, Belgium, September 19-24, 1999. EMBO J 2000, 19:483-488.
    • (2000) EMBO J , vol.19 , pp. 483-488
    • Zolnierowicz, S.1    Bollen, M.2
  • 35
    • 0034797512 scopus 로고    scopus 로고
    • The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture
    • Cohen P. The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture. Eur J Biochem 2001, 268:5001-5010.
    • (2001) Eur J Biochem , vol.268 , pp. 5001-5010
    • Cohen, P.1
  • 36
    • 17444419757 scopus 로고    scopus 로고
    • Protein identification in complex mixtures
    • Eriksson J., Fenyö D. Protein identification in complex mixtures. J Proteome Res 2005, 4:387-393.
    • (2005) J Proteome Res , vol.4 , pp. 387-393
    • Eriksson, J.1    Fenyö, D.2
  • 37
    • 79959469887 scopus 로고    scopus 로고
    • Characterization of the human serum depletome by label-free shotgun proteomics
    • Koutroukides T.A., Guest P.C., Leweke F.M., Bailey D.M.D., et al. Characterization of the human serum depletome by label-free shotgun proteomics. J Sep Sci 2011, 34:1621-1626.
    • (2011) J Sep Sci , vol.34 , pp. 1621-1626
    • Koutroukides, T.A.1    Guest, P.C.2    Leweke, F.M.3    Bailey, D.M.D.4
  • 38
    • 13244279455 scopus 로고    scopus 로고
    • Comparison of different depletion strategies for improved resolution in proteomic analysis of human serum samples
    • Björhall K., Miliotis T., Davidsson P. Comparison of different depletion strategies for improved resolution in proteomic analysis of human serum samples. Proteomics 2005, 5:307-317.
    • (2005) Proteomics , vol.5 , pp. 307-317
    • Björhall, K.1    Miliotis, T.2    Davidsson, P.3
  • 39
    • 67749085910 scopus 로고    scopus 로고
    • Depletion of one, six, twelve or twenty major blood proteins before proteomic analysis: the more the better?
    • Roche S., Tiers L., Provansal M., Seveno M., et al. Depletion of one, six, twelve or twenty major blood proteins before proteomic analysis: the more the better?. J Proteomics 2009, 72:945-951.
    • (2009) J Proteomics , vol.72 , pp. 945-951
    • Roche, S.1    Tiers, L.2    Provansal, M.3    Seveno, M.4
  • 40
    • 79956260679 scopus 로고    scopus 로고
    • A systematic analysis of the effects of increasing degrees of serum immunodepletion in terms of depth of coverage and other key aspects in top-down and bottom-up proteomic analyses
    • Smith M.P.W., Wood S.L., Zougman A., Ho J.T.C., et al. A systematic analysis of the effects of increasing degrees of serum immunodepletion in terms of depth of coverage and other key aspects in top-down and bottom-up proteomic analyses. PROTEOMICS 2011.
    • (2011) PROTEOMICS
    • Smith, M.P.W.1    Wood, S.L.2    Zougman, A.3    Ho, J.T.C.4
  • 41
    • 23944520883 scopus 로고    scopus 로고
    • HUPO Plasma Proteome Project specimen collection and handling: towards the standardization of parameters for plasma proteome samples
    • Rai A.J., Gelfand C.A., Haywood B.C., Warunek D.J., et al. HUPO Plasma Proteome Project specimen collection and handling: towards the standardization of parameters for plasma proteome samples. Proteomics 2005, 5:3262-3277.
    • (2005) Proteomics , vol.5 , pp. 3262-3277
    • Rai, A.J.1    Gelfand, C.A.2    Haywood, B.C.3    Warunek, D.J.4
  • 42
    • 0036893555 scopus 로고    scopus 로고
    • Stability studies of twenty-four analytes in human plasma and serum
    • Boyanton B.L., Blick K.E. Stability studies of twenty-four analytes in human plasma and serum. Clin Chem 2002, 48:2242-2247.
    • (2002) Clin Chem , vol.48 , pp. 2242-2247
    • Boyanton, B.L.1    Blick, K.E.2
  • 43
    • 0030776114 scopus 로고    scopus 로고
    • Serum stability of phosphopeptides
    • Hoffmann R., Vasko M., Otvos L. Serum stability of phosphopeptides. Anal Chim Acta 1997, 352:319-325.
    • (1997) Anal Chim Acta , vol.352 , pp. 319-325
    • Hoffmann, R.1    Vasko, M.2    Otvos, L.3
  • 44
    • 0035478709 scopus 로고    scopus 로고
    • Analysis of phosphorylated proteins and peptides by mass spectrometry
    • McLachlin D.T., Chait B.T. Analysis of phosphorylated proteins and peptides by mass spectrometry. Curr Opin Chem Biol 2001, 5:591-602.
    • (2001) Curr Opin Chem Biol , vol.5 , pp. 591-602
    • McLachlin, D.T.1    Chait, B.T.2
  • 45
    • 79957653840 scopus 로고    scopus 로고
    • Protease inhibitors as possible pitfalls in proteomic analyses of complex biological samples
    • Clifton J., Huang F., Rucevic M., Cao L., et al. Protease inhibitors as possible pitfalls in proteomic analyses of complex biological samples. J Proteomics 2011, 74:935-941.
    • (2011) J Proteomics , vol.74 , pp. 935-941
    • Clifton, J.1    Huang, F.2    Rucevic, M.3    Cao, L.4
  • 46
    • 56749096679 scopus 로고    scopus 로고
    • The value of biochemical markers for risk stratification prior to hospital admission in acute chest pain
    • Herlitz J., Svensson L. The value of biochemical markers for risk stratification prior to hospital admission in acute chest pain. Acute Card Care 2008, 10:197-204.
    • (2008) Acute Card Care , vol.10 , pp. 197-204
    • Herlitz, J.1    Svensson, L.2
  • 50
    • 33747873541 scopus 로고    scopus 로고
    • C-Abl expression in chronic lymphocytic leukemia cells: clinical and therapeutic implications
    • Lin K., Glenn M.A., Harris R.J., Duckworth A.D., et al. c-Abl expression in chronic lymphocytic leukemia cells: clinical and therapeutic implications. Cancer Res 2006, 66:7801-7809.
    • (2006) Cancer Res , vol.66 , pp. 7801-7809
    • Lin, K.1    Glenn, M.A.2    Harris, R.J.3    Duckworth, A.D.4
  • 51
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker B.J., Tamura S., Buchdunger E., Ohno S., et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996, 2:561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3    Ohno, S.4
  • 52
    • 0036527429 scopus 로고    scopus 로고
    • Protein kinases-the major drug targets of the twenty-first century? Nature reviews
    • Cohen P. Protein kinases-the major drug targets of the twenty-first century? Nature reviews. Drug Discov 2002, 1:309-315.
    • (2002) Drug Discov , vol.1 , pp. 309-315
    • Cohen, P.1
  • 53
    • 84871064388 scopus 로고    scopus 로고
    • Topoisomerase II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated with single-agent doxorubicin or single-agent docetaxel
    • 2004
    • Desmedt C., Durbecq V., Paesmans M., Sotiriou C., et al. Topoisomerase II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated with single-agent doxorubicin or single-agent docetaxel. AACR Meeting Abstracts 2004, 263. 2004.
    • (2004) AACR Meeting Abstracts , pp. 263
    • Desmedt, C.1    Durbecq, V.2    Paesmans, M.3    Sotiriou, C.4
  • 55
    • 84871083882 scopus 로고    scopus 로고
    • Topoisomerase 2{alpha} plays a pivotal role in the tumor biology of advanced thymic neoplasia
    • 2006
    • Liu J.M., Hwang B.S., Wang L.S., Huang M.H., et al. Topoisomerase 2{alpha} plays a pivotal role in the tumor biology of advanced thymic neoplasia. AACR Meeting Abstracts 2006, 125. 2006.
    • (2006) AACR Meeting Abstracts , pp. 125
    • Liu, J.M.1    Hwang, B.S.2    Wang, L.S.3    Huang, M.H.4
  • 56
    • 77951721529 scopus 로고    scopus 로고
    • Combined functional genome survey of therapeutic targets for hepatocellular carcinoma
    • Satow R., Shitashige M., Kanai Y., Takeshita F., et al. Combined functional genome survey of therapeutic targets for hepatocellular carcinoma. Clin Cancer Res 2010, 16:2518-2528.
    • (2010) Clin Cancer Res , vol.16 , pp. 2518-2528
    • Satow, R.1    Shitashige, M.2    Kanai, Y.3    Takeshita, F.4
  • 57
    • 69949151729 scopus 로고    scopus 로고
    • JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma
    • Chang Q., Chen J., Beezhold K.J., Castranova V., et al. JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma. Mol Cancer 2009, 8:64.
    • (2009) Mol Cancer , vol.8 , pp. 64
    • Chang, Q.1    Chen, J.2    Beezhold, K.J.3    Castranova, V.4
  • 58
    • 79957916529 scopus 로고    scopus 로고
    • Assessment of Chk1 phosphorylation as a pharmacodynamic biomarker of Chk1 inhibition
    • Parsels L.A., Qian Y., Tanska D.M., Gross M., et al. Assessment of Chk1 phosphorylation as a pharmacodynamic biomarker of Chk1 inhibition. Clin Cancer Res 2011.
    • (2011) Clin Cancer Res
    • Parsels, L.A.1    Qian, Y.2    Tanska, D.M.3    Gross, M.4
  • 59
    • 79951988792 scopus 로고    scopus 로고
    • Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a Gynecologic Oncology Group trial
    • Matei D., Sill M.W., Lankes H.A., Degeest K., et al. Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a Gynecologic Oncology Group trial. J Clin Oncol 2010, 29:69-75.
    • (2010) J Clin Oncol , vol.29 , pp. 69-75
    • Matei, D.1    Sill, M.W.2    Lankes, H.A.3    Degeest, K.4
  • 60
    • 77956460186 scopus 로고    scopus 로고
    • Use of γH2AX and other biomarkers of double-strand breaks during radiotherapy
    • Sak A., Stuschke M. Use of γH2AX and other biomarkers of double-strand breaks during radiotherapy. Semin Radiat Oncol 2010, 20:223-231.
    • (2010) Semin Radiat Oncol , vol.20 , pp. 223-231
    • Sak, A.1    Stuschke, M.2


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