A rapid and accurate UPLC/MS/MS method for the determination of benzodiazepines in human urine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 5-6, 2011, Pages 421-428

  Ming, Dong Sheng ^a   Heathcote, John ^a  

^a BC Biomedical Laboratories Ltd   (Canada)

Author keywords

Benzodiazepines; UPLC MS MS; Urine analysis

Indexed keywords

ANALYTICAL COLUMNS; ASSAY METHODS; BENZODIAZEPINES; CALIBRATION CURVES; CHROMATOGRAPHIC SEPARATIONS; HIGH THROUGHPUT SCREENING; HUMAN URINE; LIMIT OF QUANTIFICATIONS; LOW LIMITS OF DETECTIONS; METHOD VALIDATIONS; MOBILE PHASIS; MULTIPLE REACTION MONITORING; POSITIVE MODE; SIMULTANEOUS DETERMINATIONS; SINGLE-STEP; ULTRAPERFORMANCE LIQUID CHROMATOGRAPHY; UPLC/MS/MS; URINE ANALYSIS;

ELECTROSPRAY IONIZATION; FORMIC ACID; ION SOURCES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL;

BODY FLUIDS;

7 AMINOCLONAZEPAM; ALPHA HYDROXYALPRAZOLAM; ALPHA HYDROXYTRIAZOLAM; BENZODIAZEPINE DERIVATIVE; BROMAZEPAM; CLOBAZAM; DEALKYLFLURAZEPAM; DIAZEPAM; FLURAZEPAM; LORAZEPAM; METHANOL; NITRAZEPAM; NORDAZEPAM; OXAZEPAM; TEMAZEPAM; UNCLASSIFIED DRUG; WATER;

ARTICLE; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY; FLOW RATE; HUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS;

BENZODIAZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; METHANOL; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TEMPERATURE;

EID: 79451475815     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.12.029     Document Type: Article

References (14)

1. Umene-Nakano W., Yoshimura R. Nippon Rinsho 2009, 67:1581.
2. Lenhart S.E., Buysse D.J. Ann. Pharmacother. 2001, 35:1449.
3. Kudoh A., Takase H., Takahira Y., Takazawa T. Anesth. Analg. 2004, 99:1674.
4. Arbanas G., Arbanas D., Dujam K. Psychiatr. Danub. 2009, 21:103.
5. Kravitz H.M., Fawcett J., Newman A.J. J. Clin. Psychiatry 1993, 54(Suppl.):77.
6. Meyler L., Aronson J.K. Meyler's Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions 2006, Elsevier, p. 429. 15th ed.
7. Mandrioli R., Mercolini L., Raggi M.A. Curr. Drug Metab. 2008, 9:827.
8. Martin S.J., Coles R., Merrell M., McMillin G.A. J. Anal. Toxicol. 2008, 32:491.
9. Smink B.E., Mathijssen M.P.M., Lusthof K.J., de Gier J.J., Egberts A.C.G., Uges D.R.A. J. Anal. Toxicol. 2006, 30:478.
10. Smink B.E., Brandsma J.E., Dijkhuizen A., Lusthof K.J., de Gier J.J., Egberts A.C.G., Uges D.R.A. J. Chromatogr. B 2004, 811:13.
11. Hegstad S., Qiestad E.L., Johansen U., Christophersen A.S. J. Anal. Toxicol. 2006, 30:31.
12. Feng J., Wang L., Dai I., Harmon T., Bernert J.T. J. Anal. Toxicol. 2007, 31:359.
13. Kratzsch C., Tenberken O., Peters F.T., Weber A.A., Kraemer T., Maurer H.H. J. Mass Spectrom. 2004, 39:856.
14. Food and Drug Administrtion (FDA), Center for Drug Evaluation and Research (CDER). Guidance for Industry - Bioanalytical Method Validation, May, 2001.