Androgen depletion augments antibacterial prostate host defences in rats

International Journal of Andrology

Volumn 35, Issue 6, 2012, Pages 845-859

  Quintar, A A ^a   Leimgruber, C ^a   Pessah, O A ^b   Doll, A ^c   Maldonado, C A ^a  

^a Centro de Microscopía Electrónica   (Argentina)

^b FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Androgens; Cytokines; Immunohistochemistry; Immunology; Microscopy; Prostate

Indexed keywords

ANDROGEN; LIPOPOLYSACCHARIDE; STROMAL CELL DERIVED FACTOR 1; TESTOSTERONE; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; ESCHERICHIA COLI; EX VIVO STUDY; IMMUNOCYTOCHEMISTRY; INNATE IMMUNITY; MALE; MOLECULAR RECOGNITION; NONHUMAN; ORCHIECTOMY; PRIORITY JOURNAL; PROSTATE; PROTEIN EXPRESSION; RAT;

ANDROGEN ANTAGONISTS; ANIMALS; BACTERIAL INFECTIONS; IMMUNOHISTOCHEMISTRY; MALE; PROSTATE; RATS; RATS, WISTAR;

EID: 84869881829     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2012.01288.x     Document Type: Article

References (59)

1. Akins EJ, Moore ML, Tang S, Willingham MC, Tooze JA & Dubey P. (2010) In situ vaccination combined with androgen ablation and regulatory t-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout mice. Cancer Res 70, 3473-3482.
2. Antonioli E, Della-Colleta HH & Carvalho HF. (2004) Smooth muscle cell behavior in the ventral prostate of castrated rats. J Androl 25, 50-56.
3. Avellar MC, Honda L, Hamil KG, Yenugu S, Grossman G, Petrusz P, French FS & Hall SH. (2004) Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta). Biol Reprod 71, 1453-1460.
4. Benten WP, Becker A, Schmitt-Wrede HP & Wunderlich F. (2002) Developmental regulation of intracellular and surface androgen receptors in t cells. Steroids 67, 925-931.
5. Benten WP, Guo Z, Krucken J & Wunderlich F. (2004) Rapid effects of androgens in macrophages. Steroids 69, 585-590.
6. Bhushan S, Schuppe HC, Tchatalbachev S, Fijak M, Weidner W, Chakraborty T & Meinhardt A. (2009) Testicular innate immune defense against bacteria. Mol Cell Endocrinol 306, 37-44.
7. Bullard RS, Gibson W, Bose SK, Belgrave JK, Eaddy AC, Wright CJ et al. (2008) Functional analysis of the host defense peptide human beta defensin-1: new insight into its potential role in cancer. Mol Immunol 45, 839-848.
8. Collin M, Linge HM, Bjartell A, Giwercman A, Malm J & Egesten A. (2008) Constitutive expression of the antibacterial cxc chemokine gcp-2/cxcl6 by epithelial cells of the male reproductive tract. J Reprod Immunol 79, 37-43.
9. Cowan LA, Barsanti JA, Crowell W & Brown J. (1991) Effects of castration on chronic bacterial prostatitis in dogs. J Am Vet Med Assoc 199, 346-350.
10. Cutolo M, Sulli A, Capellino S, Villaggio B, Montagna P, Seriolo B & Straub RH. (2004) Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity. Lupus 13, 635-638.
11. D'Agostino P, Milano S, Barbera C, Di Bella G, La Rosa M, Ferlazzo V et al. (1999) Sex hormones modulate inflammatory mediators produced by macrophages. Ann N Y Acad Sci 876, 426-429.
12. Deitch EA, Ananthakrishnan P, Cohen DB, Xu da Z, Feketeova E & Hauser CJ. (2006) Neutrophil activation is modulated by sex hormones after trauma-hemorrhagic shock and burn injuries. Am J Physiol Heart Circ Physiol 291, H1456-H1465.
13. Desai KV, Michalowska AM, Kondaiah P, Ward JM, Shih JH & Green JE. (2004) Gene expression profiling identifies a unique androgen-mediated inflammatory/immune signature and a PTEN (phosphatase and tensin homolog deleted on chromosome 10)-mediated apoptotic response specific to the rat ventral prostate. Mol Endocrinol 18, 2895-2907.
14. Drake CG, Doody AD, Mihalyo MA, Huang CT, Kelleher E, Ravi S et al. (2005) Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer Cell 7, 239-249.
15. Farzadegan H, Hoover DR, Astemborski J, Lyles CM, Margolick JB, Markham RB, Quinn TC & Vlahov D. (1998) Sex differences in HIV-1 viral load and progression to aids. Lancet 352, 1510-1514.
16. Fleming A. (1922) On a remarkable bacteriolytic element found in tissues and secretions. Proc R Soc Lond B 93, 306-317.
17. Gatti G, Rivero V, Motrich RD & Maccioni M. (2006) Prostate epithelial cells can act as early sensors of infection by up-regulating TLR4 expression and proinflammatory mediators upon LPS stimulation. J Leukoc Biol 79, 989-998.
18. Gatti G, Quintar AA, Andreani V, Nicola JP, Maldonado CA, Masini-Repiso AM, Rivero VE & Maccioni M. (2009) Expression of toll-like receptor 4 in the prostate gland and its association with the severity of prostate cancer. Prostate 69, 1387-1397.
19. Girling JE & Hedger MP. (2007) Toll-like receptors in the gonads and reproductive tract: emerging roles in reproductive physiology and pathology. Immunol Cell Biol 85, 481-489.
20. Halin S, Hammarsten P, Wikstrom P & Bergh A. (2007) Androgen-insensitive prostate cancer cells transiently respond to castration treatment when growing in an androgen-dependent prostate environment. Prostate 67, 370-377.
21. Hall SH, Hamil KG & French FS. (2002) Host defense proteins of the male reproductive tract. J Androl 23, 585-597.
22. Hou J & Zheng WF. (1988) Effect of sex hormones on NK and ADCC activity of mice. Int J Immunopharmacol 10, 15-22.
23. Jacobson DL, Gange SJ, Rose NR & Graham NM. (1997) Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 84, 223-243.
24. Kaplan L, Lee C & Schaeffer AJ. (1983) Effect of castration on experimental bacterial prostatitis in rats. Prostate 4, 625-630.
25. Kawai T & Akira S. (2007) Signaling to NF-kappaB by toll-like receptors. Trends Mol Med 13, 460-469.
26. Kawai T & Akira S. (2010) The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol 11, 373-384.
27. Koh YT, Gray A, Higgins SA, Hubby B & Kast WM. (2009) Androgen ablation augments prostate cancer vaccine immunogenicity only when applied after immunization. Prostate 69, 571-584.
28. Kundu SD, Lee C, Billips BK, Habermacher GM, Zhang Q, Liu V, Wong LY, Klumpp DJ & Thumbikat P. (2008) The toll-like receptor pathway: a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells. Prostate 68, 223-229.
29. Leimgruber C, Quintar AA, Sosa LD, Garcia LN, Figueredo M & Maldonado CA. (2011) Dedifferentiation of prostate smooth muscle cells in response to bacterial LPS. Prostate 71, 1097-1107.
30. Mardh PA & Colleen S. (1975) Antimicrobial activity of human seminal fluid. Scand J Urol Nephrol 9, 17-23.
31. Martin JT. (2000) Sexual dimorphism in immune function: the role of prenatal exposure to androgens and estrogens. Eur J Pharmacol 405, 251-261.
32. Meier A, Chang JJ, Chan ES, Pollard RB, Sidhu HK, Kulkarni S et al. (2009) Sex differences in the toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat Med 15, 955-959.
33. Mercader M, Bodner BK, Moser MT, Kwon PS, Park ES, Manecke RG et al. (2001) T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer. Proc Natl Acad Sci USA 98, 14565-14570.
34. Miller L & Hunt JS. (1996) Sex steroid hormones and macrophage function. Life Sci 59, 1-14.
35. Moller AP, Sorci G & Erritzoe J. (1998) Sexual dimorphism in immune defense. Am Nat 152, 605-619.
36. Munoz-Cruz S, Togno-Pierce C & Morales-Montor J. (2012) Non-reproductive effects of sex steroids: their immunoregulatory role. Curr Top Med Chem 11, 1714-1727.
37. Norata GD, Tibolla G, Seccomandi PM, Poletti A & Catapano AL. (2006) Dihydrotestosterone decreases tumor necrosis factor-alpha and lipopolysaccharide-induced inflammatory response in human endothelial cells. J Clin Endocrinol Metab 91, 546-554.
38. Nunn CL, Lindenfors P, Pursall ER & Rolff J. (2009) On sexual dimorphism in immune function. Philos Trans R Soc Lond B Biol Sci 364, 61-69.
39. Oberley RE, Goss KL, Dahmoush L, Ault KA, Crouch EC & Snyder JM. (2005) A role for surfactant protein d in innate immunity of the human prostate. Prostate 65, 241-251.
40. Oberley RE, Goss KL, Quintar AA, Maldonado CA & Snyder JM. (2007) Regulation of surfactant protein D in the rodent prostate. Reprod Biol Endocrinol 5, 42.
41. Palladino MA, Mallonga TA & Mishra MS. (2003) Messenger RNA (MRNA) expression for the antimicrobial peptides beta-defensin-1 and beta-defensin-2 in the male rat reproductive tract: beta-defensin-1 MRNA in initial segment and caput epididymidis is regulated by androgens and not bacterial lipopolysaccharides. Biol Reprod 68, 509-515.
42. Palladino MA, Johnson TA, Gupta R, Chapman JL & Ojha P. (2007) Members of the toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract. Biol Reprod 76, 958-964.
43. Paone A, Galli R, Gabellini C, Lukashev D, Starace D, Gorlach A et al. (2010) Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha. Neoplasia 12, 539-549.
44. Pei Z, Lin D, Song X, Li H & Yao H. (2008) TLR4 signaling promotes the expression of VEGF and TGFbeta1 in human prostate epithelial PC3 cells induced by lipopolysaccharide. Cell Immunol 254, 20-27.
45. Pudney J & Anderson DJ. (2010) Expression of toll-like receptors in genital tract tissues from normal and HIV-infected men. Am J Reprod Immunol, 65, 28-43.
46. Quintar AA, Roth FD, De Paul AL, Aoki A & Maldonado CA. (2006) Toll-like receptor 4 in rat prostate: modulation by testosterone and acute bacterial infection in epithelial and stromal cells. Biol Reprod 75, 664-672.
47. Quintar AA, Doll A, Leimgruber C, Palmeri CM, Roth FD, Maccioni M & Maldonado CA. (2010) Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate. Prostate 70, 1153-1165.
48. Rettew JA, Huet-Hudson YM & Marriott I. (2008) Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod 78, 432-437.
49. Rettew JA, Marriott I & Huet YM. (2010) Sex differences in innate immune responses to bacterial pathogens. In: Sex Hormones and Immunity to Infection (eds SL Klein & CW Roberts), pp. 123-146. Springer-Verlag, Berlin Heidelberg.
50. Roden AC, Moser MT, Tri SD, Mercader M, Kuntz SM, Dong H et al. (2004) Augmentation of T cell levels and responses induced by androgen deprivation. J Immunol 173, 6098-6108.
51. Roubinian J, Talal N, Siiteri PK & Sadakian JA. (1979) Sex hormone modulation of autoimmunity in NZB/NZW mice. Arthritis Rheum 22, 1162-1169.
52. Seo SI, Lee SJ, Kim JC, Choi YJ, Sw SW, Hwang TK & Cho YH. (2003) Effects of androgen deprivation on chronic bacterial prostatitis in a rat model. Int J Urol 10, 485-491.
53. Spinedi E, Gaillard RC & Chisari A. (2002) Sexual dimorphism of neuroendocrine-immune interactions. Front Horm Res 29, 91-107.
54. Stuart LM, Henson PM & Vandivier RW. (2006) Collectins: opsonins for apoptotic cells and regulators of inflammation. Curr Dir Autoimmun 9, 143-161.
55. Takeda K, Kaisho T & Akira S. (2003) Toll-like receptors. Annu Rev Immunol 21, 335-376.
56. Whitmore WF & Gittes RF. (1977) Studies on the prostate and testis as immunologically privileged sites. Cancer Treat Rep 61, 217-222.
57. Wichmann L, Vaalasti A, Vaalasti T & Tuohimaa P. (1989) Localization of lactoferrin in the male reproductive tract. Int J Androl 12, 179-186.
58. Yudin AI, Tollner TL, Treece CA, Kays R, Cherr GN, Overstreet JW & Bevins CL. (2008) Beta-defensin 22 is a major component of the mouse sperm glycocalyx. Reproduction 136, 753-765.
59. Zhao C, Wang I & Lehrer RI. (1996) Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 396, 319-322.